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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 3 | Thrombolysis with alteplase 3-4.5 hours after acute ischaemic stroke:the first multicentre,phase III trial in China显示文摘background and purpose Data on the efficacy and safety of alteplase for acute ischaemic stroke(AIS)administered 3-4.5 hours after the onset of stroke symptoms in Chinese patients is limited.We sought to determine whether AIS patients would benefit from thrombolysis with alteplase between 3 and 4.5 hours after the onset of stroke symptoms in a prospective,multicentre,single-arm trial in China.Materials and methods Eligible AIS patients were given 0.9 mg/kg alteplase intravenously.The primary efficacy endpoint was a favourable outcome at 3 months,defined as a score of 0 or 1 on the modified Rankin Scale.Thresholds for the primary efficacy endpoint were determined to be 40%based on the literature review.The primary safety endpoint was symptomatic intracranial haemorrhage(sICH)according to the European Cooperative Acute Stroke Study III(ECASS III)trial definition.Post hoc analysis between this study and the ECASS III trial were compared using the propensity score matching(PSM)method.results A total of 120 eligible AIS patients from 11 sites in China received thrombolysis therapy in this study.The median time from onset of symptoms to needle was 3 hours 54 min.The percentage of patients with a favourable outcome was 63.3%(95%CI 54.4 to 71.4),significantly higher than the predefined threshold(p<0.0001).Three patients(2.5%,95%CI 0.5 to 7.1)had sICH,including two fatal sICH.Six patients died within 3 months after treatment.The post hoc PSM analysis showed a numerically higher rate of the primary efficacy endpoint in this study(63.3%)than the matched placebo arm(56.7%)in the ECASS III trial.Conclusions Intravenous alteplase with a standard dose administered between 3 and 4.5 hours after onset of symptoms is effective and safe for Chinese AIS patients. | Huaguang Zheng Yi Yang Huisheng Chen Chuanling Li Yangkun Chen Fu-Dong Shi Li Yang Xiaoping Cui Zuneng Lu Yanling Liang Songbiao Cui Anding Xu Yiqing Wu Yaqing Sun Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，3： | 4 |
| 4 | Nanocellulose-Assisted Construction of Multifunctional MXene-Based Aerogels with Engineering Biomimetic Texture for Pressure Sensor and Compressible Electrode显示文摘Multifunctional architecture with intriguing structural design is highly desired for realizing the promising performances in wearable sensors and flexible energy storage devices.Cellulose nanofiber(CNF)is employed for assisting in building conductive,hyperelastic,and ultralight Ti_(3)C_(2)T_(x)MXene hybrid aerogels with oriented tracheid-like texture.The biomimetic hybrid aerogels are constructed by a facile bidirectional freezing strategy with CNF,carbon nanotube(CNT),and MXene based on synergistic electrostatic interaction and hydrogen bonding.Entangled CNF and CNT“mortars”bonded with MXene“bricks”of the tracheid structure produce good interfacial binding,and superior mechanical strength(up to 80%compressibility and extraordinary fatigue resistance of 1000 cycles at 50%strain).Benefiting from the biomimetic texture,CNF/CNT/MXene aerogel shows ultralow density of 7.48 mg cm^(-3)and excellent electrical conductivity(~2400 S m^(-1)).Used as pressure sensors,such aerogels exhibit appealing sensitivity performance with the linear sensitivity up to 817.3 kPa^(-1),which affords their application in monitoring body surface information and detecting human motion.Furthermore,the aerogels can also act as electrode materials of compressive solid-state supercapacitors that reveal satisfactory electrochemical performance(849.2 mF cm^(-2)at 0.8 mA cm^(-2))and superior long cycle compression performance(88%after 10,000 cycles at a compressive strain of 30%). | Ting Xu Qun Song Kun Liu Huayu Liu Junjie Pan Wei Liu Lin Dai Meng Zhang Yaxuan Wang Chuanling Si Haishun Du Kai Zhang | 2023 | Nano-Micro Letters2023，15，7： | 2 |
| 5 | Identification of Ubiquitinated Proteins from Human Multiple Myeloma U266 Cells by Proteomics显示文摘Objective To identify ubiquitinated proteins from complex human multiple myeloma (MM) U266 cells,a malignant disorder of differentiated human B cells.Methods Employing a globally proteomic strategy combining of immunoprecipitation,LC-MS/MS and SCX-LC-MS analysis to identified ubiquitination sites,which were identified by detecting signature peptides containing a GG-tag (114.1 Da) and an LRGG-tag (383.2 Da).Results In total,52 ubiquitinated proteins containing 73 ubiquitination sites of which 14 and 59 sites contained LRGG-tag and GG-tag were identified,respectively.Conclusion Classification analysis by of the proteins identified in the study based on the PANTHER showed that they were associated with multiple functional groups.This suggested the involvement of many endogenous proteins in the ubiquitination in MM. | JIA HongLing LIU ChaoWu GE Feng XIAO ChuanLe LU ChunHua WANG Tong HE QingYu | 2011 | Biomedical and Environmental Sciences2011，24，4： | 2 |
| 6 | Protonated ' N -benzyl-N -prolylprohnehydrazlde as highly enantioselective catalyst for direct asymmetric aldol reaetion显示文摘 | Cheng Chuanling Sun Jian Wang Chao | 2006 | Chemical Communication2006，2，： | 1 |
| 7 | Sustainable preparation and characterization of thermally stable and functional cellulose nanocrystals and nanofibrils via formic acid hydrolysis显示文摘In this work,a sustainable method to prepare functional cellulose nanocrystals(CNCs)and cellulose nanofibrils(CNFs)using formic acid(FA)(a recoverable organic acid)was established.After FA hydrolysis,the obtained CNCs could be well dispersed in DMAC.Thus,the CNC products and fibrous cellulosic solid residue(FCSR)in DMAC could be easily separated by a conventional centrifugal process,and the collected FCSR could be further fibrillated to CNFs with relatively low-intensity mechanical fibrillation process.The isolated CNC products showed high crystallinity index(about 75%)and excellent thermal stability(with onset thermal degradation temperature of 325℃).Both the resultant CNCs and CNFs showed better dispersibility in DMSO,DMF and DMAC respectively because of the introduction of ester groups on the surface of the products.The presence of surface ester groups could increase the interface compatibility of nanocelluloses with polymeric matrices and enable their applications in reinforcing polymeric matrix materials(e.g.the composite films like PHVB+CNFs). | Haishun Du Chao Liu Dong Wang Yuedong Zhang Guang Yu Chuanling Si Bin Li Xindong Mu Hui Peng | 2017 | Journal of Bioresources and Bioproducts2017，2，1： | 1 |
| 8 | Evaluation and Improvement of Antioxidant Activity of Water-soluble Lignin Products from Steam Explosion Processing of Corn Stalk显示文摘In this study,corn stalk was pretreated by steam explosion under various processing conditions,and the antioxidant activity of hydrolysates in the post-process washing liquor was analyzed using the 1,1'-diphenyl-2-picrylhydrazyl(DPPH•)scavenging method.The yield and composition of the hydrolysates obtained under different treatment conditions were also determined;the results indicated that the steam explosion extent had a significant effect on both properties.Under optimized conditions(1.5 MPa,20 min),the obtained hydrolysate had the highest phenolic compound yield(18.6 mg/g untreated corn stalk)and the highest radical scavenging capacity(IC_(50)=0.24 mg/mL).To confirm the positive effect of phenolic compounds on the antioxidant activity of the hydrolysate,one-step ethanol fractionation was carried out.Due to the enrichment of phenolic compounds,the ethanolsoluble fraction(ESF)exhibited significantly enhanced antioxidant activity with an IC_(50) value of 0.06 mg/mL,which was close to that of butylated hydroxytoluene(BHT,IC_(50)=0.056 mg/mL).Consequently,this work indicated that phenolic compounds have a significant effect on the antioxidant activity of hydrolysate from steam-exploded corn stalk and that simple one-step ethanol fractionation is an effective way to enrich the phenolic compounds in the hydrolysate and improve the antioxidant activity. | Hao Sun Rui Wang Guanhua Wang Wenjie Sui Chuanling Si | 2021 | Paper And Biomaterials2021，6，3： | 1 |
| 9 | Characterization of wet microalgal cells pretreated with steam for lipid extraction显示文摘Steam pretreatment was employed to disrupt Microalgal cells for lipids extraction.Effects of steam pretreatment on microstructure of microalgal cells were investigated through scanning electron microscopy(SEM)and transmission electron microscopy(TEM).Effect of treatment on lipid extraction was also studied.Microalgal cell walls were distorted after steam pretreatment due to the hydrolysis of organic macromolecules contained in cell wall.Maximum curvature was increased from 1.88×10^(-6) m^(-1) to 1.43×10^(-7) m^(-1) after treatment with the steam at 130℃.The fractal dimension of microalgal cells increased from 1.25 to 1.30 after pretreatment for 15 min,and further increased to 1.47 when the pretreatment time was increased to 60 min.Increased steam pretreatment temperature and time enhanced the hydrolysis of organic macromolecules,and finally destroyed microalgal cell walls at pretreatment temperature of 130℃and pretreatment time of 60 min.Lipid extracted from wet microalgal was significantly increased(2.1-fold)after pretreatment. | Wenlu Song Rui Huang Hao Guo Chunguang Yin Chuanling Wang Jun Cheng Weijuan Yang | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 0 |
| 10 | G_2 Chromosome Radiosensitivity in Human Tumor Cells after γ-rays Irradiation显示文摘It is well established that the radio-sensitivity is dependent of cell cycle progression, and among the each stage of interphase, G2 phase is the most radiosensitive, G1 phase is the second radiosensitive, S phase is the last radiosensitive, while Go phase is radio-resistent for absent oxygen and enough repairing time. Previous studies led to the conclusion that G2 phase is a very important stage. There are two techniques to study the chromosome aberrations in G2-cells, namely, G2-assay and G2-PCC technique. The G2-assay is to analyze the subsequent metaphases after irradiation, and with which studies indicate that | Wang Zhuanzi,Li Wenjian,Yang Jianshe, Jin Xiaodong Xia Jingguang, Wang Jufang and Guo Chuanling | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 11 | Effects of 80 MeV/u ^(12)C^(6+) Ion Radiation Mouse Head on Immunity Cell Cycle Distributions显示文摘After whole head irradiation (WHI) of mice with heavy ions, we study the changes of cycle distribution of bone marrow, spleen and peripheral lymphocyte cells, and the aim is to provide basic data for space radiation protection and biological object oriented ion therapy. The heads of the BALB/c mice were irradiated with 0, 0. 5, 1,2, 4 or 10 Gy by 12C6+ ions (80 MeV/u, 1 Gy/min) and then the cell cycle distribu- | Bing Tao, Dang Bingrong, Xie Yi, Li Wenjian,Ma Qiufeng, Wang Jufang, Qiu Rong Zhou Libin, Guo Chuanling,Jing Xigang, Zhang Hong, Li Qiang Yuan Zhigang and Ma Shuang | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 12 | Hyper-radiosensitivity Effect of Human Hepatoma SMMC-7721 Cell Exposed to Low Dose γ Ray and ^(12)C Ion显示文摘Hypersensitive response of mammalian cells in cell killing to X andγrays has been reported at doses below 1 Gy. The purpose of this study was to examine the low-dose sensitivity of human hepatoma SMMC-7721 cells irradiated with 60Coγrays and 50 MeV/u 12C ions. Experiments-of usingγrays and charged particle irradiation were performed, particularly in the low-dose range from 0 to 2 Gy. The survival | Jin Xiaodong, Li Qiang, Li Wenjian, Wang Jufang, Guo Chuanling and Hao Jifang | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 13 | Theoretical Exploration on Ultra-fractionated Radiotherapy显示文摘Based on the HRS effect, a new tumour radiotherapy method, ultra-fractionation has been devised. Compared with conventional fractionation, the dose per fraction is decreased from 2 to 0. 2-0. 5 Gy for the ultra-fractionation. Although the amount of fractions are increased in order to reach the same therapeutic efficacy, the total dose is significantly reduced. | Jin Xiaodong, Li Qiang,Guo Chuanling, Wang Jufang, Hao Jinfang Li Wenjian,Yan Zheng and Dai Zhongying | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 14 | RBE of Hepatoma Cell Lines and Human Normal Liver Cell Lines Exposed in Vitro to Carbon Ions and Argon Ions at HIRFL显示文摘 | Jing Xigang Li Wenjian Wang Zhuanzi Wei Wei Guo Chuanling Lu Dong Yang Jianshe | 2008 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2008，，1： | 0 |
| 15 | A real-world study of immune checkpoint inhibitors in advanced triple-negative breast cancer显示文摘Background:Triple-negative breast cancer(TNBC)is the most aggressive type of breast cancer.Immune checkpoint inhibitors(ICIs)have been widely used to treat various tumors and have changed the landscape of tumor management,but the data from real-world studies of ICIs for TNBC treatment remain limited.The aim of this study was to evaluate the efficacy of ICIs in the treatment of patients with advanced TNBC in a real-world setting and to explore possible correlates.Methods:The clinical data of advanced TNBC patients who received ICI treatment in the Chinese People's Liberation Army(PLA)General Hospital were collected.Treatment responses,outcomes and adverse events(AEs)were assessed.Results:Eighty-one patients were included in the study.The confirmed objective response rate(ORR)was 32.1%,and the disease control rate(DCR)was 64.2%.The median progression-free survival(PFS)was 4.2 months,and the median overall survival(OS)was 11.0 months.PFS and OS were longer in patients who achieved clinical benefit from ICIs and shorter in patients who received later-line ICIs and higher levels of inflammation;specifically,patients with higher TILs had longer PFS.Overall AEs were tolerable.Conclusions:ICIs are effective in the treatment of advanced TNBC,and the adverse reactions are tolerable.A panel of biomarkers including LDH,ALP,and bNLR were identified to predict the efficacies of ICIs in TNBC treatment. | Zheng Zhang Yadi Zhang Chuanling Liu Jiakang Shao Yimeng Chen Yimin Zhu Li Zhang Boyu Qin Ziqing Kong Xixi Wang Yutong Wang Deqin Huang Liqun Liu Yuxin Zhou Ran Tao Zengjie Yang Mei Liu Weihong Zhao | 2023 | Cancer Innovation2023，2，3： | 0 |
| 16 | Biomass-based materials for advanced supercapacitor:principles,progress,and perspectives显示文摘Supercapacitors exhibit considerable potential as energy storage devices due to their high power density,fast charging and discharging abilities,long cycle life,and ecofriendliness.With the increasing environmental concerns associated with synthetic compounds,the use of environment friendly biopolymers to replace conventional petroleum-based materials has been widely studied.Biomass-based materials are biodegradable,renewable,environment friendly and non-toxic.The unique hierarchical nanostructure,excellent mechanical properties and hydrophilicity allow them to be used to create functional conductive materials with precisely controlled structures and different properties.In this review,the latest development of biomass-based supercapacitor materials is reviewed and discussed.This paper describes the physical and chemical properties of various biopolymers and their impact on supercapacitors,as well as the classification and basic principles of supercapacitors.Then,a comprehensive discussion is presented on the utilization of biomass-based materials in supercapacitors and their recent applications across a range of supercapacitor devices.Finally,an overview of the future prospects and challenges pertaining to the utilization of biomass-based materials in supercapacitors is provided. | Yaxuan Wang Ting Xu Kun Liu Meng Zhang Xu-Min Cai Chuanling Si | 2024 | Aggregate2024，5，1： | 0 |
| 17 | Asymmetric Direct Aldol Reaction of Cyclohexanone Catalyzed by ( N'-BenzyI-N'-D-prolyl)-trans-4- hydroxy-L-proline Hydrazide显示文摘 | Cheng, Chuanling Wang, Wenliang | 2011 | Chinese Journal of Chemistry2011，29，1： | 0 |
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