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| 1 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 2 | MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness显示文摘Asthma is one of the most common heterogeneous airway diseases.Worldwide,the prevale nee of doctor-diagnosed asthma in adults was reported to be 4.3%in 2OO3.^(1)In China,the overall prevalence of asthma duri nq 2012 a nd 2015 was 4.2%,represe nting 45.7 million Chinese adults.^(2)Although comprehensive approaches have been used in clinical practice,a considerable number of people are still hospitalized for acute exacerbation of asthma every year.In China,15.5%of asthmatics reported at least one emergency room visit and 7.2%reported at least one hospital admission due to exacerbation of respiratory symptoms.^(2)A need exists to clarify the mechanism of asthma's pathogenesis and to identify more appropriate and precise therapies for asthma. | Yahui Liu Juan Du Xinnan Liu Lingbiao Wang Yichao Han Chunrong Huang Rui Liang Fang Zheng Guochao Shi Bin Li | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 3 | Conduclance calculalion of LiPF6 in organic solulions based on mean spherical approximation theory显示文摘 | Xiangming He Weihua Pu Jingli Han Jian Chen Jiufang Lu Changyin Jiang Chunrong Wan | 2006 | Chemical Physics2006，324，23： | 1 |
| 4 | Conductance calculation of LiPF6 in organic solutions based on MCT theory 显示文摘 | Xiangming He Weihua Pu Jingli Han Jian Chen Jiufang Lu Changyin Jiang and Chunrong Wan | 2005 | The Journal of Physical Chemistry2005，109，23： | 1 |
| 5 | Distributed implantation of a flexible microelectrode array for neural recording显示文摘Flexible multichannel electrode arrays(fMEAs)with multiple flaments can be flexibly implanted in various patterns.It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands.This study proposed a strategy for reducing the microelectrode volume with integrated packaging.An implantation system was developed specifically for semiautomatic distributed implantation.The feasibility and convenience of the fMEA and implantation platform were verified in rodents.The acute and chronic recording results provied the effectiveness of the packaging and implantation methods.These methods could provide a novel strategy for developing fMEAs with more flaments and recording sites to measure functional interactions across multiple brain regions. | Chunrong Wei Yang Wang Weihua Pei Xinyong Han Longnian Lin Zhiduo Liu Gege Ming Ruru Chen Pingping Wu Xiaowei Yang Li Zheng Yijun Wang | 2022 | Microsystems & Nanoengineering2022，8，3： | 1 |
| 6 | vasculogenic mimicrycontributes to lymph node metastasis of laryngeal squamous cellcarcinoma显示文摘 | Wei Wang Peng Lin Chunrong Han | 2010 | Journal of Experimental & Clinical Cancer Research2010，60，29： | 1 |
| 7 | The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3–dependent Wnt activation显示文摘 | Jin‐Ping Lai Abdul M. Oseini Catherine D. Moser Chunrong Yu Sherine F. Elsawa Chunling Hu Ikuo Nakamura Tao Han Ileana Aderca Hajime Isomoto Megan M. Garrity‐Park Abdirashid M. Shire Jia Li Schuyler O. Sanderson Alex A. Adjei Martin E. Fernandez‐Zapico Le | 2010 | Hepatology2010，，5： | 1 |
| 8 | Tracking and grasping of moving target based on accelerated geometric particle filter on colored image显示文摘Visual tracking and grasping of moving object is a challenging task in the field of robotic manipulation,which also has great potential in applications such as human-robot collaboration.Based on the particle filtering framework and position-based visual servoing,this paper proposes a new method for visual tracking and grasping of randomly moving objects.A geometric particle filter tracker is established for visual tracking.In order to deal with the tracking efficiency issue for particle filter,edge detection and morphological dilation are employed to reduce the computation burden of geometric particle filtering.Meanwhile,the HSV image feature is employed instead of the grayscale feature to improve the tracking algorithm’s robustness to illumination change.A grasping strategy combining tracking and interception is adopted along with the position-based visual servoing(PBVS)method to achieve stable grasp of the target.Comprehensive comparisons on open source dataset and a large number of experiments on real robot system are conducted,which demonstrate the proposed method has competitive performance in random moving object tracking and grasping. | GONG ZeYu QIU ChunRong TAO Bo BAI HaiSheng YIN ZhouPing DING Han | 2021 | Science China(Technological Sciences)2021，64，4： | 0 |
| 9 | Observations on the Effectiveness of Internet+ Nursing Practice in Promoting Exclusive Breastfeeding显示文摘Objective:To analyze the effect of Internet+nursing practice to promote exclusive breastfeeding.Methods:60 new mothers were selected from our hospital between February 2021 and February 2022,randomly divided into two groups,the control group and the observation group.Conventional care was given to the control group and the Internet+care was given to the observation group.The healing of perineal wounds,breastfeeding rate as well as the nursing satisfaction of both groups were compared with each other.Results:The perineal wound healing rate was 100.00%in the observation group and 83.33%in the control group,the healing rate was higher in the observation group(P<0.05).80.00%,with higher nursing satisfaction in the observation group(P<0.05).Conclusion:Internet+nursing guidance during the perinatal care of mothers can improve the success rate of breastfeeding and achieve higher nursing satisfaction. | Duomei Ren Pei Zhang Lei Han Yudan Ma Chunrong Yang | 2022 | Journal of Clinical and Nursing Research2022，6，5： | 0 |
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