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| 1 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 2 | A Fully Self-Healing Piezoelectric Nanogenerator for Self-Powered Pressure Sensing Electronic Skin显示文摘As an important way of converting mechanical energy into electric energy,a piezoelectric nanogenerator(PENG)has been widely applied in energy harvesting as well as self-powered sensors in recent years.However,its robustness and durability are still severely challenged by frequent and inevitable mechanical impacts in real application environments.Herein,a fully selfhealing PENG(FS-PENG)as a self-powered pressure sensing electronic skin is reported.The self-healing piezoelectric composite and self-healing Ag NW electrode fabricated through mixing piezoelectric PZT particles and conductive Ag NWs into self-healing polydimethylsiloxane(H-PDMS)are assembled into the sandwich structure FS-PENG.The FS-PENG could not only effectively convert external stimulation into electrical signals with a linear response to the pressure but also retain the excellent self-healing and stable sensing property after multiple cycles of cutting and self-healing process.Moreover,a self-healing pressure sensor array composed of 9 FS-PENGs was attached on the back of the human hand to mimic the human skin,and accurate monitoring of the spatial position distribution and magnitude of the pressure was successfully realized. | Maosen Yang Jinmei Liu Dong Liu Jingyi Jiao Nuanyang Cui Shuhai Liu Qi Xu Long Gu Yong Qin | 2021 | Research2021，，1： | 6 |
| 3 | Effects of raw material extrusion and steam conditioning on feed pellet quality and nutrient digestibility of growing meat rabbits显示文摘This study was conducted to investigate the effects of raw material extrusion and steam conditioning on feed pellet quality and nutrient digestibility of growing meat rabbits, in order to determine appropriate rabbit feed processing methods and processing parameters. In Exp. 1, an orthogonal design was adopted.Barrel temperature, material moisture content and feed rate were selected as test factors, and acid detergent fiber(ADF) content was selected as an evaluation index to research the optimum extrusion parameters. In Exp. 2. a two-factor design was adopted. Four kinds of rabbit feeds were processed and raw material extrusion adopted optimum extrusion parameters of Exp. 1. A total of 40 healthy and 42-day-old rabbits with similar weight were used in a randomized design, which consisted of 4 groups and 10 replicates in each group(1 rabbits in each replicate). The adaptation period lasted for 7 d, and the digestion trial lasted for 4 d. The results showed as follows: 1) ADF was significantly affected by barrel temperature(P < 0.05); the optimum extrusion parameters were barrel temperature 125℃, moisture content 16% and feed rate 9 Hz. 2) Raw material extrusion and steam conditioning both significantly decreased powder percentage, pulverization ratio and protein solubility(P < 0.05), significantly improved hardness and starch gelatinization degree of rabbit feed(P < 0.05). They both had significant interaction effects on the processing quality of rabbit feed(P < 0.05). 3) Extrusion significantly improved the apparent digestibility of dry matter and total energy(P < 0.05). Extrusion and steam conditioning both significantly improved the apparent digestibility of crude fiber(CF), ADF and NDF(P < 0.05), but they had no interaction effects on the apparent digestibility of rabbit feed. Thus, using extrusion and steam conditioning technology at the same time in the weaning rabbits feed processing can improve the pellet quality and nutrient apparent digestibility of rabbit feed. | Kuoyao Liao Jingyi Cai Zhujun Shi Gang Tian Dong Yan Delin Chen | 2017 | Animal Nutrition2017，，2： | 6 |
| 4 | An elevated preoperative serum calcium level is a significant predictor for positive peritoneal cytology in endometrial carcinoma显示文摘Objective:To evaluate preoperative serum calcium concentration and investigate the association between calcium level and positive peritoneal cytology in endometrial carcinoma(EC).Methods:A total of 510 patients who were diagnosed with EC and had surgery were initially enrolled in this study at Peking University People's Hospital between January 2012 and December 2016.Clinical characteristics and preoperative serum calcium,albumin,carbohydrate antigen(CA)125,CA19-9,carcinoembryonic antigen(CEA)were extracted from patient records and evaluated according to postoperative peritoneal cytology.Predictive factors were assessed with Cox univariate and multivariate analyses.Factors selected from multivariate analysis results were used to build a predictive model.Results:A total of 510 patients are identified in our database and 444 patients who fulfilled inclusion and exclusion criteria are included in this study.Univariate analysis revealed that ionized calcium concentration was closely related to positive peritoneal cytology,tumor grade and lymph-vascular space invasion(LVSI).Moreover,peritoneal cytology was significantly associated with hypertension,tubal ligation,serum CA125,CA19-9,CEA and ionized calcium level.Multivariate analysis revealed that albumin-adjusted calcium level,CA125 and tubal ligation were independent predictive factors of positive peritoneal cytology(P<0.05).A combination of ionized calcium level with the other two indexes yielded significantly great area under the curve(AUC=0.824).Conclusions:This study enhanced the value of preoperative ionized calcium level.We also identified several potential biomarkers to predict positive peritoneal cytology in EC patients before surgery. | Xingchen Li Yuan Cheng Yangyang Dong Boqiang Shen Xiao Yang Jiaqi Wang Jingyi Zhou Jianliu Wang | 2019 | Chinese Journal of Cancer Research2019，31，6： | 3 |
| 5 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
| 6 | Hybrid Channel Access Mechanism Based on Coexistence Scenario of NR-Unlicensed显示文摘With the rapid development of 5G NR(New Radio),the explosive increment of traffic amount is calling the utilization of unlicensed band.3GPP has proposed LAA(Licensed Assisted Access)to use LTE in unlicensed band and pointed out that NR-U(NR-Unlicensed)can reuse most designs of it.However,the existing channel access mechanism of LAA is conservative under the coexistence scenario of NR-U,which leads to the waste of time resource.To address the problem this paper proposes a hybrid channel access mechanism to take advantage of the LBT(Listen-Before-Talk)mechanism of LAA when channel is quite busy and transmit directly with reduced power when it is relatively idle.The channel busy degree is judged by a series of periodically updated adaptive thresholds.System-level simulation verifies that under the coexistence scenario of NR-U the proposed mechanism can achieve higher UPT(User Perceived Throughput)and lower delay than other channel access mechanisms. | Zhening Zhang Jingyi Chen Mingyang Dong Yuehong Gao Jingjing Wang | 2020 | China Communications2020，17，1： | 2 |
| 7 | Reconsideration of the taxonomy of the marine ciliate Neobakuella aenigmatica Moon et al.,2019(Protozoa,Ciliophora,Hypotrichia)显示文摘The morphology and divisional morphogenesis in a Chinese population of Neobakuella aenigmatica Moon et al.,2019 are reinvestigated.The body size,number and arrangement of parabuccal cirri and development of nuclear nodules in this population are discussed in comparison with closely related genera.The 18S rRNA gene sequence of the Chinese population is identical to that of a Korean population,supporting a distant relationship between N.aenigmatica and the cluster of N.flava and Apobakuella fuse a.We deduce that this may be caused by the differences in the pattern of the parabuccal cirri and the number of parabuccal rows which are important for the phylogeny of Bakuella-like,species. | Tengyue Zhang Jingyi Dong Ting Cheng Lili Duan Chen Shao | 2020 | Marine Life Science & Technology2020，2，2： | 1 |
| 8 | Two-Stage Lesion Detection Approach Based on Dimension-Decomposition and 3D Context显示文摘Lesion detection in Computed Tomography(CT) images is a challenging task in the field of computer-aided diagnosis.An important issue is to locate the area of lesion accurately.As a branch of Convolutional Neural Networks(CNNs),3D Context-Enhanced(3DCE) frameworks are designed to detect lesions on CT scans.The False Positives(FPs) detected in 3DCE frameworks are usually caused by inaccurate region proposals,which slow down the inference time.To solve the above problems,a new method is proposed,a dimension-decomposition region proposal network is integrated into 3DCE framework to improve the location accuracy in lesion detection.Without the restriction of 'anchors' on ratios and scales,anchors are decomposed to independent 'anchor strings'.Anchor segments are dynamically combined in accordance with probability,and anchor strings with different lengths dynamically compose bounding boxes.Experiments show that the accurate region proposals generated by our model promote the sensitivity of FPs and spend less inference time compared with the current methods. | Jiacheng Jiao Haiwei Pan Chunling Chen Tao Jin Yang Dong Jingyi Chen | 2022 | Tsinghua Science and Technology2022，27，1： | 1 |
| 9 | Disease burden of intensive care unit-acquired pneumonia in China: a systematic review and meta-analysis显示文摘 | Yaowen Zhang Zhiyuan Yao Siyan Zhan Zhirong Yang Dong Wei Jing Zhang Jingyi Li Moe H. Kyaw | 2014 | International Journal of Infectious Diseases2014，，： | 1 |
| 10 | Experimental study on the vitrification and xenotransplantation of human ovarian tissue显示文摘Background:Cryopreservation of ovarian tissue is a promising method for preserving fertility.Transmission electron microscopy(TEM)is an evaluation system for cryo-injury during the cooling and warming process which is very laborious and needs to be optimized.Objective:In this study,we evaluated that serum 17β-oestradiol(E2)may be used as an indicator of vitrified ovarian tissue.Methods:Immunodeficient nude mice were used as hosts for xenografting of vitrified-warmed human ovarian tissues.A total of 54 mice were divided into two group:vitrified ovarian xenotransplant(VOX)group(n?45)and non-transplant control group(n?9).The transplanted mice were grouped into vitrified/warmed grafted-4 weeks(VOX-4w,n?15),vitrified/warmed grafted-6weeks(VOX-6w n?15)and vitrified/warmed grafted-12 weeks(VOX-12w n?15)according to the time after transplantation.The viable and functional recovery of grafted ovarian tissue was assessed by light microscopy,transmission electron microscopy,and hormone(E2)assays.Results:Serum E2 concentration was significantly higher in VOX-6w(group(21.07 pg/ml)than that of VOX-12w group(15.59 pg/ml).VOX-12w group showed a lower value(12.61 pg/ml)for E2 concentration.The trend for E2 concentration was consistent with the morphological identification of the grafts.Conclusion:In vivo serum hormone E2 released by cortical biopsies can be used as a functional marker for xenotransplanted vitrified-warmed human ovarian tissue reserve. | Jinghui Zhao Yuping Ge Jingyi Li Yucui Zeng Guoyi Dong Liping Zeng Juanjuan Dai Hui Du Mumin Shao Xuewen Yu Huan Li Fang He Zhouchun Shang Chun Wang Gabor Vajt Huiru Tang Ruifang Wu Yutao Du | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，1： | 1 |
| 11 | Nanoinfiltration behavior of carbon nanotube based nanocomposites with enhanced mechanical and electrical properties显示文摘In this work,carbon nanotube(CNT)based nanocomposites with high mass fraction are proposed by in-situ bridging carbon matrix into CNT paper through optimized chemical vapor infiltration(CVI).Nanoinfiltration behavior of CNTs is basically investigated under the CVI process.The contact between each CNT can be strengthened and the conductive pathways can be established,resulting in the better mechanical and electrical properties.Compared with the pristine CNT paper,the CNT/C composite after pyrolysis process confirms a remarkable advance in tensile strength(up to 310±13 MPa)and Young’s modulus(up to 2.4±0.1 GPa).Besides,a notable feature of electrical conductivity also shows an improvement up to 8.5 S/cm,which can be attributed to the mass fraction of CNT(41 wt%)breaking the limits of percolation thresholds and the efficient densification of this sample to establish the conductive pathways.This study has a broad application in the development of the multi-functional electrical and engineering materials. | Mengmeng Wang Jinshan Yang Xiao You Chunjing Liao Jingyi Yan Jing Ruan Shaoming Dong | 2021 | Journal of Materials Science & Technology2021，，12： | 1 |
| 12 | Ginsenoside R b3 attenuates oxidative stress and preserves endothelial function in renal arteries from hypertensive rats显示文摘 | Youhua Wang Jinghui Dong Ping Liu Chi Wai Lau Zhen Gao Duan Zhou Jingyi Tang Chi Fai Ng Yu Huang | 2014 | Br J Pharmacol2014，，13： | 1 |
| 13 | Detection of SARS-CoV-2 Antibodies in Oral Fluid Using a Magnetic Particle-Based Chemiluminescence Immunoassay-Beijing Municipality,China,2021显示文摘Introduction:Oral fluids(OFs)have been broadly used as non-invasive samples for evaluating protective IgG antibodies from natural infection or vaccination,especially in pediatric populations.Methods:Paired OF and serum were collected from both individuals who received a booster dose of the inactive coronavirus disease 2019(COVID-19)vaccine as well as those who did not have a history of COVID-19 vaccination and infection(as the control group).The total human IgG antibody(HIgG)content was evaluated as a marker of OF sampling quality.An in-house adapted magnetic particle-based chemiluminescence immunoassay was used for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)IgG antibody detection in the OF.The SARS-CoV-2 IgG antibody in the serum samples was detected using a commercial immunoassay.Results:In total,579 paired OF and serum samples were collected.An additional 172 OF samples were collected from preschool children.The results indicated that the HIgG concentration in qualified OF samples should be higher than 0.3μg/mL.Compared to the serum assay,the in-house OF immunoassay for detecting IgG antibodies against SARS-CoV-2 had 95.06%accuracy,95.03%sensitivity,and 100%specificity.Conclusions:Overall,the in-house immunoassay for detecting SARS-CoV-2 IgG antibodies in OF showed high potential for application towards serological surveillance and immunization effect assessment after large-scale,inactive COVID-19 vaccination in China. | Naiying Mao Mei Dong Zhen Zhu Qi Huang Xiali Yu Hui Xie Jianping Dong Jingyi Sun Fang Huang Wenbo Xu | 2022 | China CDC weekly2022，4，40： | 1 |
| 14 | Mating behaviors in ovoviviparous black rockfish(Sebastes schlegelii):molecular function of prostaglandin E2 as both a hormone and pheromone显示文摘Prostaglandins(PGs)are profound hormones in teleost sexual behavior,especially in mating.PGs act as pheromones that affect the olfactory sensory neurons of males,inducing the initiation of a series of mating behaviors.However,the molecular mechanism by which PGs trigger mating behavior in ovoviviparous teleosts is still unclear.In the present study,we employed the ovoviviparous black rockfish(Sebastes schlegelii),an economically important marine species whose reproductive production is limited by incomplete fertilization,as a model species.The results showed that when the dose of PGE2 was higher than 10 nmol/L,a significant(P<0.05)increase in mating behaviors was observed.Dual-fluorescence in situ hybridization indicated that PGE2 could fire specific neurons in different brain regions and receptor cells in the olfactory sac.After combining with specific neurons in the central nervous system(CNS),a series of genes related to reproduction are activated.The intracerebroventricular administration of PGE_(2) significantly increased lhb levels(P<0.05)in both sexes.Moreover,steroidogenesis in gonads was also affected,inducing an increase(P<0.05)in E_(2) levels in males and T levels in females.PGE_(2) levels were also increased significantly(P<0.05)in both sexes.The present study revealed that PGE2 can activate mating behavior in black rockfish in both hormone and pheromone pathways,leading to variations in sex steroid levels and activation of reproductive behaviors.Our results provide not only novel insight into the onset of mating behaviors in ovoviviparous teleosts but also solutions for the incomplete fertilization caused by natural mating in cage aquaculture. | Likang Lyu Yijia Yao Songyang Xie Xiaojie Wang Haishen Wen Yun Li Jianshuang Li Chenpeng Zuo Shaojing Yan Jingyi Dong Xin Qi | 2024 | Marine Life Science & Technology2024，6，1： | 0 |
| 15 | Rapid and label-free classification of pathogens based on light scattering,reduced power spectral features and support vector machine显示文摘The rapid identification of pathogens is crucial in controlling the food quality and safety.The proposed system for the rapid and label-free identification of pathogens is based on the principle of laser scattering from the bacterial microbes.The clinical prototype consists of three parts:the laser beam,photodetectors,and the data acquisition system.The bacterial testing sample was mixed with 10 mL distilled water and placed inside the machine chamber.When the bacterial microbes pass by the laser beam,the scattering of light occurs due to variation in size,shape,and morphology.Due to this reason,different types of pathogens show their unique light scattering patterns.The photo-detectors were arranged at the surroundings of the sample at different angles to collect the scattered light.The photodetectors convert the scattered light intensity into a voltage waveform.The waveform features were acquired by using the power spectral characteristics,and the dimensionality of extracted features was reduced by applying minimal-redundancy-maximal-relevance criterion(mRMR).A support vector machine(SVM)classifier was developed by training the selected power spectral features for the classification of three different bacterial microbes.The resulting average identification accuracies of E.faecalis,E.coli and S.aureus were 99%,87%,and 94%,respectively.The ove rall experimental results yield a higher accuracy of 93.6%,indicating that the proposed device has the potential for label-free identification of pathogens with simplicity,rapidity,and cost-effectiveness. | Mubashir Hussain Zhen Chen Mu Lv Jingyi Xu Xiaohan Dong Jingzhou Zhao Song Li Yan Deng Nongyue He Zhiyang Li Bin Liu | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
| 16 | Internal Polarization Field Induced Hydroxyl Spillover Effect for Industrial Water Splitting Electrolyzers显示文摘The formation of multiple oxygen intermediates supporting efficient oxygen evolution reaction(OER)are affinitive with hydroxyl adsorption.However,ability of the catalyst to capture hydroxyl and maintain the continuous supply at active sits remains a tremendous challenge.Herein,an affordable Ni2P/FeP2 heterostructure is presented to form the internal polarization field(IPF),arising hydroxyl spillover(HOSo)during OER.Facilitated by IPF,the oriented HOSo from FeP2 to Ni2P can activate the Ni site with a new hydroxyl transmission channel and build the optimized reaction path of oxygen intermediates for lower adsorption energy,boosting the OER activity(242 mV vs.RHE at 100 mA cm-2)for least 100 h.More interestingly,for the anion exchange membrane water electrolyzer(AEMWE)with low concentration electrolyte,the advantage of HOSo effect is significantly amplified,delivering 1 A cm^(-2)at a low cell voltage of 1.88 V with excellent stability for over 50 h. | Jingyi Xie Fuli Wang Yanan Zhou Yiwen Dong Yongming Chai Bin Dong | 2024 | Nano-Micro Letters2024，16，2： | 0 |
| 17 | Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue using Deep Learning显示文摘The immunohistochemical(IHC)staining of the human epidermal growth factor receptor 2(HER2)biomarker is widely practiced in breast tissue analysis,preclinical studies,and diagnostic decisions,guiding cancer treatment and investigation of pathogenesis.HER2 staining demands laborious tissue treatment and chemical processing performed by a histotechnologist,which typically takes one day to prepare in a laboratory,increasing analysis time and associated costs.Here,we describe a deep learning-based virtual HER2 IHC staining method using a conditional generative adversarial network that is trained to rapidly transform autofluorescence microscopic images of unlabeled/label-free breast tissue sections into bright-field equivalent microscopic images,matching the standard HER2 IHC staining that is chemically performed on the same tissue sections.The efficacy of this virtual HER2 staining framework was demonstrated by quantitative analysis,in which three board-certified breast pathologists blindly graded the HER2 scores of virtually stained and immunohistochemically stained HER2 whole slide images(WSIs)to reveal that the HER2 scores determined by inspecting virtual IHC images are as accurate as their immunohistochemically stained counterparts.A second quantitative blinded study performed by the same diagnosticians further revealed that the virtually stained HER2 images exhibit a comparable staining quality in the level of nuclear detail,membrane clearness,and absence of staining artifacts with respect to their immunohistochemically stained counterparts.This virtual HER2 staining framework bypasses the costly,laborious,and time-consuming IHC staining procedures in laboratory and can be extended to other types of biomarkers to accelerate the IHC tissue staining used in life sciences and biomedical workflow. | Bijie Bai Hongda Wang Yuzhu Li Kevin de Haan Francesco Colonnese Yujie Wan Jingyi Zuo Ngan B.Doan Xiaoran Zhang Yijie Zhang Jingxi Li Xilin Yang Wenjie Dong Morgan Angus Darrow Elham Kamangar Han Sung Lee Yair Rivenson Aydogan Ozcan | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
| 18 | Contact optimisation strategy for wafer-scale field-effect transistors based on two-dimensional semiconductors显示文摘Two-dimensional(2D)semiconductors can be utilized to continually miniaturize nanoscale electronic de-vices.However,achieving a practical solution for satisfying electrical contact with 2D semiconductors remains challenging.In this study,we developed a novel contact structure with transferred multilayer(t-ML)MoS 2 by integrating both edge and top contact.After in-situ plasma treatment for the edge of the MoS 2 channel and successive metal deposition,we achieved 16 times lower contact resistivity(22.8 kΩμm)than that of the top contacted devices.The thickness-dependent electrical measurement indicates that edge contact is highly effective with thick MoS 2 due to the alleviated current-crowding effect re-sulting from the small contact area.The temperature-dependent transport measurement further confirms the effective minimization of the influence from the Schottky barrier and tunnelling barrier.Finally,the simplified resistor network model and energy-band diagram were proposed to understand the carrier transport mechanism.Our work provides a practical strategy for achieving excellent electrical contact between bulk metals and 2D semiconductors,paving the way for future large-scale 2D electronic devices. | Ling Tong Xiaojiao Guo Zhangfeng Shen Lihui Zhou Jingyi Ma Xinyu Chen Honglei Chen Yin Xia Chuming Sheng Saifei Gou Die Wang Xinyu Wang Xiangqi Dong Yuxuan Zhu Xinzhi Zhang David Wei Zhang Sheng Dai Xi Li Peng Zhou Yangang Wang Wenzhong Bao | 2023 | Journal of Materials Science & Technology2023，，2： | 0 |
| 19 | Air Pollution Health Impact Monitoring and Health Risk Assessment Technology and Its Application-China,2006-2019显示文摘Air pollution is a significant risk factor contributing to the burden of disease in China.Health risk assessment and management are important to reduce the impact of air pollution on public health.To help formulate standardized health risk assessment techniques,a series of studies were conducted from 2006 to 2019.Through systematic review,study of molecular mechanisms,epidemiological investigation,and health effect monitoring,the overall project established a monitoring and evaluation indicator system,a comprehensive information platform,software for automatic data cleaning,and standardized health risk assessment techniques.Technical specifications have been issued by the National Health Commission for promoting health risk assessments across China.This paper introduces the project,the research approach,its main research accomplishments,innovations,and public health significance,and describes directions for further research. | Jingxiu Han Dongqun Xu Donggang Xu Xu Yang Qin Wang Mingqing Chen Wenrong Xia Weiwei Xing Chunyu Xu Yue Liu Junrui Chang Wenliang Fu Shuxin Hao Na Li Xiaoyan Dong Yunpu Li Congshen Meng Jingyi Liu | 2022 | China CDC weekly2022，4，26： | 0 |
| 20 | Control of Surface Wrinkles on Shape Memory PLA/PPDO Micro‑nanofibers and Their Applications in Drug Release and Anti‑scarring显示文摘Micro-and nano-fibers of shape memory polymers(SMP)offer multiple advantages like high specific surface area,poros-ity,and intelligence,and are suitable for biomedical applications.In this study,biodegradable poly(p-dioxanone)(PPDO)materials were incorporated to improve the brittleness of shape memory polylactic acid(PLA),and plasticizers were used to reduce the transition temperature of SMP composites such that their transitions could be induced close to body temperature.Furthermore,an electrostatic spinning technology was applied to prepare SMP fibers with wrinkled structures and regulate their microstructures and morphologies such that the intelligent transition of wrinkled and smooth morphologies can be achieved on the fiber surface.The application of this controllable-morphology fiber membrane in intelligent controlled drug release and scar inhibition after Ahmed Glaucoma Valve(AGV)implantation was also studied.The drug release from the stretched and deformed drug-loaded fiber membranes was faster than those from membranes with the original shape.This membrane with micro-and nano-fibers had good anti-scarring effects that improved after drug loading.The achievement of intelligent controlled drug release and the evident anti-scarring effects of the membrane broaden the application of SMP fibers in the biomedical field. | Lu Wang Jingyi Ma Tao Guo Fenghua Zhang Aimeng Dong Shiqi Zhang Yanju Liu Huiping Yuan Jinsong Leng | 2023 | Advanced Fiber Materials2023，5，2： | 0 |
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