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| 1 | DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways显示文摘Background:Gastric cancer(GC)is one of the most common malignancies worldwide,particularly in China.DNA damage-inducible transcript 4(DDIT4)is a mammalian target of rapamycin inhibitor and is induced by various cellular stresses;however,its critical role in GC remains poorly understood.The present study aimed to investigate the poten-tial relationship and the underlying mechanism between DDIT4 and GC development.Methods:We used western blotting,real-time polymerase chain reaction,and immunohistochemical or immunoflu-orescence to determine DDIT4 expression in GC cells and tissues.High-content screening,cell counting kit-8 assays,colony formation,and in vivo tumorigenesis assays were performed to evaluate cell proliferation.Flow cytometry was used to investigate cell apoptosis and cell cycle distribution.Results:DDIT4 was upregulated in GC cells and tissue.Furthermore,downregulating DDIT4 in GC cells inhibited proliferation both in vitro and in vivo and increased 5-fluorouracil-induced apoptosis and cell cycle arrest.In contrast,ectopic expression of DDIT4 in normal gastric epithelial cells promoted proliferation and attenuated chemosensitivity.Further analysis indicated that the mitogen-activated protein kinase and p53 signaling pathways were involved in the suppression of proliferation,and increased chemosensitivity upon DDIT4 downregulation.Conclusion:DDIT4 promotes GC proliferation and tumorigenesis,providing new insights into the role of DDIT4 in the tumorigenesis of human GC. | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2018 | Cancer Communications2018，38，1： | 10 |
| 2 | The Prognostic and Chemotherapeutic Value of miR-296 in Esophageal Squamous Cell Carcinoma显示文摘 | Liu Hong Yu Han Hongwei Zhang Mengbin Li Taiqian Gong Li Sun Kaichun Wu Qingchuan Zhao Daiming Fan | 2010 | Annals of Surgery2010，，6： | 3 |
| 3 | Fecal microbiota transplantation through mid‐gut for refractory C rohn’s disease: Safety, feasibility, and efficacy trial results显示文摘 | Bota Cui Qiang Feng Honggang Wang Min Wang Zhaoyuan Peng Pan Li Guangming Huang Zheng Liu Ping Wu Zhining Fan Guozhong Ji Xin Wang Kaichun Wu Daiming Fan Faming Zhang | 2015 | J Gastroenterol Hepatol2015，，1： | 3 |
| 4 | Regulation of drug sensitivity of gastric cancer cells by human calcyclin-binding protein (CacyBP)显示文摘 | Yongquan Shi Wenhua Hu Fang Yin Li Sun Changjiang Liu Mei Lan Daiming Fan | 2004 | Gastric Cancer2004，，3： | 3 |
| 5 | Fish Consumption and Colorectal Cancer Risk in Humans: A Systematic Review and Meta-analysis显示文摘 | Shengjun Wu Bin Feng Kai Li Xia Zhu Shuhui Liang Xufeng Liu Shuang Han Biaoluo Wang Kaichun Wu Danmin Miao Jie Liang Daiming Fan | 2012 | The American Journal of Medicine2012，，6： | 2 |
| 6 | Multi-Agent Modeling and Simulation in the AI Age显示文摘With the rapid development of artificial intelligence(AI)technology and its successful application in various fields,modeling and simulation technology,especially multi-agent modeling and simulation(MAMS),of complex systems has rapidly advanced.In this study,we first describe the concept,technical advantages,research steps,and research status of MAMS.Then we review the development status of the hybrid modeling and simulation combining multi-agent and system dynamics,the modeling and simulation of multi-agent reinforcement learning,and the modeling and simulation of large-scale multi-agent.Lastly,we introduce existing MAMS platforms and their comparative studies.This work summarizes the current research situation of MAMS,thus helping scholars understand the systematic technology development of MAMS in the AI era.It also paves the way for further research on MAMS technology. | Wenhui Fan Peiyu Chen Daiming Shi Xudong Guo Li Kou | 2021 | Tsinghua Science and Technology2021，26，5： | 2 |
| 7 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 8 | MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN显示文摘 | Fang Wang Ting Li Bin Zhang Hong Li Qiong Wu Li Yang Yongzhan Nie Kaichun Wu Yongquan Shi Daiming Fan | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 2 |
| 9 | Challenges to effective cancer control in China, India, and Russia显示文摘 | Paul E Goss Kathrin Strasser-Weippl Brittany L Lee-Bychkovsky Lei Fan Junjie Li Yanin Chavarri-Guerra Pedro E R Liedke C S Pramesh Tanja Badovinac-Crnjevic Yuri Sheikine Zhu Chen You-lin Qiao Zhiming Shao Yi-Long Wu Daiming Fan Louis W C Chow Jun Wang Qio | 2014 | Lancet Oncology2014，，5： | 1 |
| 10 | Transcriptional up-regulation of RhoE by hypoxia-inducible factor (HIF)-1 promotes epithelial to mesenchymal transition of gastric cancer cells during hypoxia显示文摘 | Jinfeng Zhou Kai Li Yong Gu Bin Feng Gui Ren Liyun Zhang Yafang Wang Yongzhan Nie Daiming Fan | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 1 |
| 11 | Successful expression and purification of human CIAPIN1 in baculovirus-insect cell system and application of this system to investigation of its potential methyltransferase activity显示文摘 | Zhiming Hao Xiaohua Li Taidong Qiao Daiming Fan | 2007 | International Journal of Biological Macromolecules2007，，1： | 1 |
| 12 | Establishment and Characterization of a High Metastatic Potential in the Peritoneum for Human Gastric Cancer by Orthotopic Tumor Cell Implantation显示文摘 | Feihu Bai Xinning Guo Li Yang Jun Wang Yongquan Shi Faming Zhang Huihong Zhai Yuanyuan Lu Huahong Xie Kaichun Wu Daiming Fan | 2007 | Digestive Diseases and Sciences2007，，6： | 1 |
| 13 | Osteopontin Contributes to TGF-β1 Mediated Hepatic Stellate Cell Activation显示文摘 | Xiao Xiao Yi Gang Yong Gu Lina Zhao Jindong Chu Jinfeng Zhou Xiqiang Cai Hui Zhang Li Xu Yongzhan Nie Kaichun Wu Zhiguo Liu Daiming Fan | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 14 | Multi-walled carbon nanotube papers as binder-free cathodes for large capacity and reversible non-aqueous Li-O2 batteries显示文摘 | Chen Yong Li Fujun Tang Daiming | 2013 | Journal of Materials Chemistry A2013，1，13： | 1 |
| 15 | RhoE is Associated with Relapse and Prognosis of Patients with Colorectal Cancer显示文摘 | Jinfeng Zhou Jianjun Yang Kai Li Ping Mo Bin Feng Xin Wang Yongzhan Nie Daiming Fan | 2013 | Annals of Surgical Oncology2013，，： | 1 |
| 16 | Decreased Expression of FOXJ1 is a Potential Prognostic Predictor for Progression and Poor Survival of Gastric Cancer显示文摘 | Jing Wang Xiqiang Cai Limin Xia Jinfeng Zhou Jing Xin Muhan Liu Xin Shang Jian Liu Xiaowei Li Zhangqian Chen Yongzhan Nie Daiming Fan | 2015 | Annals of Surgical Oncology2015，，2： | 1 |
| 17 | MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2显示文摘 | Qiong Wu Haifeng Jin Zhiping Yang Guanhong Luo Yuanyuan Lu Kai Li Gui Ren Tao Su Yan Pan Bin Feng Zengfu Xue Xin Wang Daiming Fan | 2010 | Biochemical and Biophysical Research Communications2010，，3： | 1 |
| 18 | DDIT4通过p53和MAPK通路促进胃癌增殖和肿瘤发生显示文摘背景与目的胃癌(gastric cancer,GC)是世界上最常见的恶性肿瘤之一,在我国尤为常见。DNA损伤诱导转录因子4(DNAdamage-inducibletranscript4,DDIT4)是哺乳动物雷帕霉素靶蛋白抑制因子,由多种细胞应激诱导产生;然而,它在胃癌中的关键作用仍然未知。本研究旨在探讨DDIT4与胃癌发展的关系及其作用机制。方法我们采用蛋白免疫印迹法、实时聚合酶链反应、免疫组化或免疫荧光法检测DDIT4在胃癌细胞和组织中的表达情况。采用高通量筛选、细胞计数试剂盒-8、克隆形成和体内成瘤实验检测细胞增殖情况。采用流式细胞术检测细胞凋亡和细胞周期分布情况。结果 DDIT4在胃癌细胞和组织中表达上调。在胃癌细胞中下调DDIT4表达可抑制体外和体内的细胞增殖并增强了5-氟尿嘧啶诱导的细胞凋亡和细胞周期阻滞。与之相反,在正常胃上皮细胞中DDIT4的异位表达促进了细胞增殖、降低了化疗敏感性。进一步研究表明,丝裂原活化蛋白激酶和p53信号通路参与抑制细胞增殖并在DDIT4下调后增强化疗敏感性。结论 DDIT4促进了胃癌细胞增殖和肿瘤发生,为研究DDIT4在人类胃癌发生、发展中的作用提供了新思路。 | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2019 | 癌症2019，38，3： | 1 |
| 19 | Akt1/protein Kinase Bα is Involved in Gastric Cancer Progression and Cell Proliferation显示文摘 | Zheyi Han Kaichun Wu Huiqin Shen Chunying Li Shuang Han Liu Hong Yongquan Shi Na Liu Changcun Guo Yan Xue Taidong Qiao Daiming Fan | 2008 | Digestive Diseases and Sciences2008，，7： | 1 |
| 20 | The malignant phenotype-associated microRNA in gastroenteric, hepatobiliary and pancreatic carcinomas显示文摘 | Liu Hong Yu Han Shujun Li Jianjun Yang Jianyong Zheng Hongwei Zhang Qingchuan Zhao Kaichun Wu Daiming Fan | 2010 | Expert Opinion on Biological Therapy2010，，12： | 1 |
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