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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 3 | Reflective chiral meta-holography: multiplexing holograms for circularly polarized waves显示文摘By allowing almost arbitrary distributions of amplitude and phase of electromagnetic waves to be generated by a layer of sub-wavelength-size unit cells,metasurfaces have given rise to the field of meta-holography.However,holography with circularly polarized waves remains complicated as the achiral building blocks of existing meta-holograms inevitably contribute to holographic images generated by both left-handed and right-handed waves.Here we demonstrate how planar chirality enables the fully independent realization of high-efficiency meta-holograms for one circular polarization or the other.Such circular-polarization-selective meta-holograms are based on chiral building blocks that reflect either left-handed or right-handed circularly polarized waves with an orientation-dependent phase.Using terahertz waves,we experimentally demonstrate that this allows the straightforward design of reflective phase meta-holograms,where the use of alternating structures of opposite handedness yields independent holographic images for circularly polarized waves of opposite handedness with negligible polarization cross-talk. | Qiu Wang Eric Plum Quanlong Yang Xueqian Zhang Quan Xu Yuehong Xu Jiaguang Han Weili Zhang | 2018 | Light(Science & Applications)2018，7，1： | 15 |
| 4 | Terahertz spoof surface-plasmon-polariton subwavelength waveguide显示文摘Surface plasmon polaritons(SPPs) with the features of subwavelength confinement and strong enhancements have sparked enormous interest. However, in the terahertz regime, due to the perfect conductivities of most metals, it is hard to realize the strong confinement of SPPs, even though the propagation loss could be sufficiently low. One main approach to circumvent this problem is to exploit spoof SPPs, which are expected to exhibit useful subwavelength confinement and relative low propagation loss at terahertz frequencies. Here we report the design,fabrication, and characterization of terahertz spoof SPP waveguides based on corrugated metal surfaces. The various waveguide components, including a straight waveguide, an S-bend waveguide, a Y-splitter, and a directional coupler, were experimentally demonstrated using scanning near-field terahertz microscopy. The proposed waveguide indeed enables propagation, bending, splitting, and coupling of terahertz SPPs and thus paves a new way for the development of flexible and compact plasmonic circuits operating at terahertz frequencies. | YING ZHANG YUEHONG XU CHUNXIU TIAN QUAN XU XUEQIAN ZHANG YANFENG LI XIXIANG ZHANG JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，9，1： | 9 |
| 5 | Optical generation,detection and non-destructive testing applications of terahertz waves显示文摘Optoelectronic terahertz generation and detection play a key role in the applications of non-destructive testing,which involves different areas such as physics,biological,material science,imaging,explosions detection,astronomy applications,semiconductor technology and superconductiong electronics. In this article,we present a reviewof the principle and performance of typical terahertz sources,detectors and non-destructive testing applications. On this basis,the newdevelopment and trends of terahertz radiation detectors are also discussed. | ZHANG Weili LIANG Dachuan TIAN Zhen HAN Jiaguang GU Jianqiang HE Mingxia OUYANG Chunmei | 2016 | Instrumentation2016，3，1： | 8 |
| 6 | Terahertz surface plasmonic waves: a review显示文摘Terahertz science and technology promise many cutting-edge applications.Terahertz surface plasmonic waves that propagate at metal–dielectric interfaces deliver a potentially effective way to realize integrated terahertz devices and systems.Previous concerns regarding terahertz surface plasmonic waves have been based on their highly delocalized feature.However,recent advances in plasmonics indicate that the confinement of terahertz surface plasmonic waves,as well as their propagating behaviors,can be engineered by designing the surface environments,shapes,structures,materials,etc.,enabling a unique and fascinating regime of plasmonic waves.Together with the essential spectral property of terahertz radiation,as well as the increasingly developed materials,microfabrication,and time-domain spectroscopy technologies,devices and systems based on terahertz surface plasmonic waves may pave the way toward highly integrated platforms for multifunctional operation,implementation,and processing of terahertz waves in both fundamental science and practical applications.We present a review on terahertz surface plasmonic waves on various types of supports in a sequence of properties,excitation and detection,and applications.The current research trend and outlook of possible research directions for terahertz surface plasmonic waves are also outlined. | Xueqian Zhang Quan Xu Lingbo Xia Yanfeng Li Jianqiang Gu Zhen Tian Chunmei Ouyang Jiaguang Han Weili Zhang | 2020 | Advanced Photonics2020，2，1： | 7 |
| 7 | Influence of Temperature and Salinity on Germination of Eelgrass (Zostera marina L.) Seeds显示文摘Seagrass restoration as part of ocean ecosystem protection has been launched for many years all over the world, but intensive research on this subject in China has just begun in recent years. Seed broadcasting has been widely accepted as the most potentially useful method for seagrass restoration over large areas. We examined the influence of key environmental factors on seed germination to help promote eelgrass bed restoration. Under anoxic conditions, the influence of temperature and salinity on the germination rate of eelgrass (Zostera marina L.) seeds was examined at different combinations of four temperatures (4, 9, 14, and 24℃) and nine salinities (5 to 45, increment of 5). The effect of significant interaction of temperature and salinity on germination rate was observed (ANOVA) (P<0.001). The highest germination rate (83.3 ± 3.5)% was reached in 8 weeks at 14℃ and salinity 5. Higher temperature significantly increased the germination rate at salinity 5 (P<0.001) during the whole observation period except for 24℃, while lower salinity significantly increased the germination rate at 14℃ (P<0.001). Although significant interaction was found between temperature and salinity (P<0.001), the influence of salinity was stronger than that of temperature for the germination of eelgrass seeds. These results provide useful information for the propagation of artificial seedlings for seagrass restoration in China. | PAN Jinhua JIANG Xin LI Xiaojie CONG Yizhou ZHANG Zhuangzhi LI Zhiling ZHOU Weili HAN Houwei LUO Shiju YANG Guanpin | 2011 | Journal of Ocean University of China2011，10，2： | 7 |
| 8 | DESC: enabling secure data exchange based on smart contracts显示文摘Dear editor,As data are one of the most important factors of today’s intelligent systems but are relatively scarce,people try exchanging data with other organizations or public marketplaces.However,data exchange is now lack of a secure execution mecha- | Jiao LIANG Weili HAN Zeqing GUO Yaoliang CHEN Chang CAO Xiaoyang Sean WANG Fenghua LI | 2018 | Science China(Information Sciences)2018，61，4： | 5 |
| 9 | Plasmon-induced transparency in terahertz metamaterials显示文摘The quantum phenomena of electromagnetically induced transparency(EIT)or plasmonic analogue of electromagnetically induced transparency(PIT)can be mimicked in the classical resonators,leading to a unique way to explore the coherent coupling mechanism in metamaterial systems.Various metamaterial structures have been proposed to excite and manipulate the PIT efect with flexibility and performance with geometry-controllable,polarization-independent,broadband-transparency and active-modulated characteristics.These in turn promise the fascinating functionalities and applications of the PIT efects,such as slow-light components,nonlinear devices and high-sensitivity sensors.Here,we present a review on the progress in developing the PIT efect in terahertz metamaterials over the past few years. | JING HuiHui ZHU ZhiHua ZHANG XueQian GU JianQiang TIAN Zhen OUYANG ChunMei HAN JiaGuang ZHANG WeiLi | 2013 | Science China(Information Sciences)2013，56，12： | 5 |
| 10 | Effectiveness of ZiYin Xiehuo granules and Zishen Qinggan granules on partial precocious puberty in girls: a multicenter, randomized, single-blind, controlled trial显示文摘OBJECTIVE: To evaluate the effect of ZiYin Xiehuo granules(ZYXH) and Zishen Qinggan granules(ZSQG) on partial precocious puberty(PPP).METHODS: This was a multicenter, randomized, single-blind, positive-controlled trial. A total of 143 pa-tients were assigned to either the ZYXH group or the ZSQG group using a random number table. The ZYXH group received ZYXH three times daily for 6 months and the ZSQG group received ZSQG three times daily for 6 months. Mammary nucleus diameter; the results of uterus, ovarian, and maximum follicle measures; and Chinese medicine symptom pattern scores were compared at baseline and after 3 months and 6 months of treatment.RESULTS: After 3 months' treatment, there were no significant differences between the two groups in mammary nucleus index changes(left 3.4 ± 3.1 vs3.5 ± 3.1, P = 0.790; right 3.0 ± 2.9 vs 3.6 ± 3.0, P =0.719). The uterine volume in the ZYXH group was smaller than that in the ZSQG group(2.1 ± 1.6 vs2.6 ± 2.2, P = 0.006). There were no significant between-group differences in ovarian volume and maximum follicular diameter on either side(ovarian volume: left 1.2 ± 0.7 vs 1.3 ± 0.6, P = 0.8; right1.2 ± 0.7 vs 1.4 ± 1.1, P = 0.984; maximum follicular diameter: left 3.9 ± 1.7 vs 3.5 ± 2.2, P = 0.158; right3.5 ± 1.7 vs 3.9 ± 2.1, P = 0.314).CONCLUSION: ZYXH granules and ZSQG granules both affected the size of the mammary nucleus in girls with PPP, and improved Chinese medicine symptom patterns. ZYXH granules showed slight advantages over ZSQG granules in terms of the decrease in the size of the uterus, ovaries, and ovarian follicles. | Sun Wen Han Xinghui Wang Yonghong Yu Jian Yan Weili Zhao Jun Chen Weibin Xue Zheng | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 5 |
| 11 | Mechanically reprogrammable Pancharatnam-Berry metasurface for microwaves显示文摘Metasurfaces have enabled the realization of several optical functionalities over an ultrathin platform,fostering the exciting field of flat optics.Traditional metasurfaces are achieved by arranging a layout of static meta-atoms to imprint a desired operation on the impinging wavefront,but their functionality cannot be altered.Reconfigurability and programmability of metasurfaces are the next important step to broaden their impact,adding customized on-demand functionality in which each meta-atom can be individually reprogrammed.We demonstrate a mechanical metasurface platform with controllable rotation at the meta-atom level,which can implement continuous Pancharatnam–Berry phase control of circularly polarized microwaves.As the proof-of-concept experiments,we demonstrate metalensing,focused vortex beam generation,and holographic imaging in the same metasurface template,exhibiting versatility and superior performance.Such dynamic control of electromagnetic waves using a single,low-cost metasurface paves an avenue towards practical applications,driving the field of reprogrammable intelligent metasurfaces for a variety of applications. | Quan Xu Xiaoqiang Su Xueqian Zhang Lijuan Dong Lifeng Liu Yunlong Shi Qiu Wang Ming Kang Andrea Alù Shuang Zhang Jiaguang Han Weili Zhang | 2022 | Advanced Photonics2022，4，1： | 5 |
| 12 | Active terahertz beam steering based on mechanical deformation of liquid crystal elastomer metasurface显示文摘Active metasurfaces are emerging as the core of next-generation optical devices with their tunable optical responses and flat-compact topography.Especially for the terahertz band,active metasurfaces have been developed as fascinating devices for optical chopping and compressive sensing imaging.However,performance regulation by changing the dielectric parameters of the integrated functional materials exhibits severe limitations and parasitic losses.Here,we introduce a C-shape-split-ring-based phase discontinuity metasurface with liquid crystal elastomer as the substrate for infrared modulation of terahertz wavefront.Line-focused infrared light is applied to manipulate the deflection of the liquid crystal elastomer substrate,enabling controllable and broadband wavefront steering with a maximum output angle change of 22°at 0.68THz.Heating as another control method is also investigated and compared with infrared control.We further demonstrate the performance of liquid crystal elastomer metasurface as a beam steerer,frequency modulator,and tunable beam splitter,which are highly desired in terahertz wireless communication and imaging systems.The proposed scheme demonstrates the promising prospects of mechanically deformable metasurfaces,thereby paving the path for the development of reconfigurable metasurfaces. | Xiaolin Zhuang Wei Zhang Kemeng Wang Yangfan Gu Youwen An Xueqian Zhang Jianqiang Gu Dan Luo Jiaguang Han Weili Zhang | 2023 | Light(Science & Applications)2023，12，1： | 4 |
| 13 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 14 | Broadband terahertz wave generation from an epsilon-near-zero material显示文摘Broadband light sources emitting in the terahertz spectral range are highly desired for applications such as noninvasive imaging and spectroscopy.Conventionally,THz pulses are generated by optical rectification in bulk nonlinear crystals with millimetre thickness,with the bandwidth limited by the phase-matching condition.Here we demonstrate broadband THz emission via surface optical rectification from a simple,commercially available 19nmthick indium tin oxide(ITO)thin film.We show an enhancement of the generated THz signal when the pump laser is tuned around the epsilon-near-zero(ENZ)region of ITO due to the pump laser field enhancement associated with the ENZ effect.The bandwidth of the THz signal generated from the ITO film can be over 3 THz,unrestricted by the phasematching condition.This work offers a new possibility for broadband THz generation in a subwavelength thin film made of an ENZ material,with emerging physics not found in existing nonlinear crystals. | Wenhe Jia Meng Liu Yongchang Lu Xi Feng Qingwei Wang Xueqian Zhang Yibo Ni Futai Hu Mali Gong Xinlong Xu Yuanyuan Huang Weili Zhang Yuanmu Yang Jiaguang Han | 2021 | Light(Science & Applications)2021，10，1： | 4 |
| 15 | Polarization-independent all-silicon dielectric metasurfaces in the terahertz regime显示文摘Dielectric metasurfaces have achieved great success in realizing high-efficiency wavefront control in the optical and infrared ranges. Here, we experimentally demonstrate several efficient, polarization-independent, all-silicon dielectric metasurfaces in the terahertz regime. The metasurfaces are composed of cylindrical silicon pillars on a silicon substrate, which can be easily fabricated using etching technology for semiconductors. By locally tailoring the diameter of the pillars, full control over abrupt phase changes can be achieved. To show the controlling ability of the metasurfaces, an anomalous deflector, three Bessel beam generators, and three vortex beam generators are fabricated and characterized. We also show that the proposed metasurfaces can be easily combined to form composite devices with extended functionalities. The proposed controlling method has promising applications in developing low-loss, ultra-compact spatial terahertz modulation devices. | HUIFANG ZHANG XUEQIAN ZHANG QUAN XU QIU WANG YUEHONG XU MINGGUI WEI YANFENG LI JIANQIANG GU ZHEN TIAN CHUNMEI OUYANG XIXIANG ZHANG CONG HU JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，9，1： | 4 |
| 16 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 17 | PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis显示文摘In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson's disease(PD).However,difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivo role of PINK1.Here we report that PINK1 kinase form is selectively expressed in the human and monkey brains.CRISPR/Cas9-mediated deficiency of PINK1 causes similar neurodegeneration in the brains of fetal and adult monkeys as well as cultured monkey neurons without affecting mitochondrial protein expression and morphology.Importantly,PINK1 mutations in the primate brain and human cells reduce protein phosphorylation that is important for neuronal function and survival.Our findings suggest that PINK1 kinase activity rather than its mitochondrial function is essential for the neuronal survival in the primate brains and that its kinase dysfunction could be involved in the pathogenesis of PD. | Weili Yang Xiangyu Guo Zhuchi Tu Xiusheng Chen Rui Han Yanting Liu Sen Yan Qi Wang Zhifu Wang Xianxian Zhao Yunpeng Zhang Xin Xiong Huiming Yang Peng Yin Huida Wan Xingxing Chen Jifeng Guo Xiao-Xin Yan Lujian Liao Shihua Li Xiao-Jiang Li | 2022 | Protein & Cell2022，13，1： | 3 |
| 18 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 19 | Genome Assembly and Pathway Analysis of Edible Mushroom Agrocybe cylindracea显示文摘Agrocybe cylindracea,an edible mushroom,is widely cultivated for its abundance of nutrients and flavor,and many of its metabolites are reported to have beneficial roles,such as medicinal effects on tumors and chronical illnesses.However,the lack of genomic information has hindered further molecular studies on this fungus.Here,we present a genome assembly of A.cylindracea together with comparative genomics and pathway analyses of Agaricales species.The draft,generated from both next-generation sequencing(NGS)and single-molecule real-time(SMRT)sequencing platforms to overcome high genetic heterozygosity,is composed of a56.5 Mb sequence and 15,384 predicted genes.This mushroom possesses a complex reproductive system,including tetrapolar heterothallic and secondary homothallic mechanisms,and harbors several hydrolases and peptidases for gradual and effective degradation of various carbon sources.Our pathway analysis reveals complex processes involved in the biosynthesis of polysaccharides and other active substances,including B vitamins,unsaturated fatty acids,and N-acetylglucosamine.RNA-seq data show that A.cylindracea stipes tend to synthesize carbohydrate for carbon sequestration and energy storage,whereas pilei are more active in carbon utilization and unsaturated fatty acid biosynthesis.These results reflect diverse functions of the two anatomical structures of the fruiting body.Our comprehensive genomic and transcriptomic data,as well as preliminary comparative analyses,provide insights into the molecular details of the medicinal effects in terms of active compounds and nutrient components. | Yuan Liang Dengxue Lu Sen Wang Yuhui Zhao Shenghan Gao Rongbing Han Jun Yu Weili Zheng Jianing Geng Songnian Hu | 2020 | Genomics, Proteomics & Bioinformatics2020，18，3： | 2 |
| 20 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hv6n6wncw5bup6cv9.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
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