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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Study on gastric cancer blood plasma based on surface-enhanced Raman spectroscopy combined with multivariate analysis显示文摘A surface-enhanced Raman spectroscopy (SERS) method combined with multivariate analysis was developed for non-invasive gastric cancer detection. SERS measurements were performed on two groups of blood plasma samples: one group from 32 gastric patients and the other group from 33 healthy volunteers. Tentative assignments of the Raman bands in the measured SERS spectra suggest interesting cancer-specific biomolecular changes, including an increase in the relative amounts of nucleic acid, collagen, phospholipids and phenylalanine and a decrease in the percentage of amino acids and saccharide in the blood plasma of gastric cancer patients as compared with those of healthy subjects. Principal components analysis (PCA) and linear discriminant analysis (LDA) were employed to develop effective diagnostic algorithms for classification of SERS spectra between normal and cancer plasma with high sensitivity (79.5%) and specificity (91%). A receiver operating characteristic (ROC) curve was employed to assess the accuracy of diagnostic algorithms based on PCA-LDA. The results from this exploratory study demonstrate that SERS plasma analysis combined with PCA-LDA has tremendous potential for the non-invasive detection of gastric cancers. | FENG ShangYuan PAN JianJi WU YanAn LIN Duo CHEN YanPing XI GangQin LIN JuQiang CHEN Rong | 2011 | Science China(Life Sciences)2011，54，9： | 15 |
| 3 | A New Species of the Genus Xenophrys(Amphibia: Anura: Megophryidae) from Libo County, Guizhou, China显示文摘A new species of the genus Xenophrys is described from a karst cave environment of Libo County, Guizhou Province, Southern China. The new species, Xenophrys liboensis sp. nov., is distinguished from its congeners by a combination of the following characters: 1) tympanum distinct; 2) vomerine teeth present; 3) the length of lower arm and hand larger than the half of snout-vent; 4) heels overlapped slightly when the flexed legs are held at right angles to the body axis; 5) toe tips with rudimentary webs and without grooves; 6) dermal fringes moderate; 7) tubercles on the dorsum forming an X-shaped weak ridge; 8) horn-like tubercle at the edge of the upper eyelid distinct; 9) color of the iris in life is brown. In Bayesian phylogenetic analysis of 22 species of Xenophrys, all the individuals of X. liboensis sp. nov. clustered into a monophyletic clade with high posterior probabilities. In addition, the ranges of genetic divergences of X. liboensis sp. nov. with other species were interspecific rather than intraspecific. Based on the above evidences, we consider that X. liboensis sp. nov. is a valid species in Xenophrys. | Yanan ZHANG Gang LI Ning XIAO Jiaqi LI Tao PAN Hui WANG Baowei ZHANG Jiang ZHOU | 2017 | Asian Herpetological Research2017，18，2： | 9 |
| 4 | A critical review on the chemical wear and wear suppression of diamond tools in diamond cutting of ferrous metals显示文摘Diamond tools play a critical role in ultra-precision machining due to their excellent physical and mechanical material properties,such as that cutting edge can be sharpened to nanoscale accuracy.However,abrasive chemical reactions between diamond and non-diamond-machinable metal elements,including Fe,Cr,Ti,Ni,etc,can cause excessive tool wear in diamond cutting of such metals and most of their alloys.This paper reviews the latest achievements in the chemical wear and wear suppression methods for diamond tools in cutting of ferrous metals.The focus will be on the wear mechanism of diamond tools,and the typical wear reduction methods for diamond cutting of ferrous metals,including ultrasonic vibration cutting,cryogenic cutting,surface nitridation and plasma assisted cutting,etc.Relevant commercially available devices are introduced as well.Furthermore,future research trends in diamond tool wear suppression are discussed and examined. | Guo Jiang Zhang Jianguo Pan Yanan Kang Renke Namba Yoshiharu Shore Paul Yue Xiaobin Wang Baorui Guo Dongming | 2020 | International Journal of Extreme Manufacturing2020，2，1： | 7 |
| 5 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 6 | A New Species of the Genus Rhacophorus (Anura: Rhacophoridae) from Dabie Mountains in East China显示文摘A new species of rhacophorid of the genus Rhacophorus is described from the Dabie Mountains of west Anhui,east China.The new species,Rhacophorus zhoukaiyae sp.nov.is distinguished from its congeners by a combination of the following characters: 1) the ventral surface and front-and-rear of the femur is paler yellowish and decorated with irregular grayish blotching,and without obvious spots on the dorsum of the hand and foot webbing; 2) the outer metatarsal tubercle is small; 3) outer fingers are half-webbed and outer toes two third webbed; 4) the skin on the dorsum is smooth and without compressed warts; 5) the throat,chest and belly are pure paler yellowish; 6) the dorsal part of the fingers and toes are grayish-white; 7) the iris is golden-yellow.In addition,the phylogenetic tree showed that all the individuals of R.zhoukaiyae sp.nov.clustered into one distinct clade which suggested the validity of this species.This results could also be used to the support of species delimitation.Currently,this species is known only from mid-elevation montane evergreen forest in the Dabie Mountains of west Anhui,China. | Tao PAN Yanan ZHANG Hui WANG Jun WU Xing KANG Lifu QIAN Kai LI Yu ZHANG Jinyun CHEN Dingqi RAO Jianping JIANG Baowei ZHANG | 2017 | Asian Herpetological Research2017，18，1： | 5 |
| 7 | Intrinsic polarization coupling in 2Dα‐In_(2)Se_(3)toward artificial synapse with multimode operations显示文摘Emulation of advanced synaptic functions of the human brain with electronic devices contributes an important step toward constructing high‐efficiency neuromorphic systems.Ferroelectric materials are promising candidates as synaptic weight elements in neural network hardware due to their controllable polarization states.However,the increased depolarization field at the na-noscale and the complex fabrication process of the traditional ferroelectric materials hamper the development of high‐density,low‐power,and highly sensitive synaptic devices.Here,we report the implementation of two‐dimensional(2D)ferroelectricα‐In_(2)Se_(3)as an active channel material to emulate typical synaptic functions.Theα‐In_(2)Se_(3)‐based synaptic device fea-tures multimode operations,enabled by the coupled ferroelectric polarization under various voltage pulses applied at both drain and gate terminals.Moreover,the energy consumption can be reduced to~1 pJ by using high‐κdielectric(Al2O3).The successful control of ferroelectric polarizations inα‐In_(2)Se_(3)and its application in artificial synapses are expected to inspire the implementation of 2D ferroelectric materials for future neuromorphic systems. | Jing Gao Yue Zheng Wei Yu Yanan Wang Tengyu Jin Xuan Pan Kian Ping Loh Wei Chen | 2021 | SmartMat2021，2，1： | 4 |
| 8 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 9 | The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China显示文摘Salmonella enterica is one of the most common bacterial pathogens in humans and animals.Systematic studies on the trends and geographical distribution of antimicrobial-resistant Salmonella and dominant serovars have been well studied in European and American countries while not in China.Here,taking the One-Health strategy,we used>35000 Salmonella enterica isolates to explore the temporal and spatial dynamics of dominant serovars in China.We found that Salmonella Typhimurium was the dominant serovar causing human infection in China,which was consistent with Australia but inconsistent with North American and European countries.The proportion of Salmonella serovars Typhimurium,London,Rissen,Corvallis,Meleagridis,Kentucky,and Goldcoast showed an increasing trend during 2006-2019.We randomly selected 1962 isolates for comparative genomics and antimicrobial resistance studies and found that the number of antibiotic resistance genes(ARGs)per isolate increased 1.84 and 2.69 times of human and non-human origins,respectively,spanning 14 years.The proportion of antimicrobial-resistant Salmonella isolates had an increasing trend during 2006-2019,especially beta-lactam,quinolone,tetracycline,and rifampicin resistance.Moreover,we found that higher diversity of sequence types(STs)in S.Typhimurium than in other serovars,ST34 from pig and ST 19 from chicken origin,were mainly associated with isolates causing child and adult gastro-infection,respectively.Our results fill in the data gap on the trends of dominant serovars and antimicrobial resistance of Salmonella enterica in China.These data provide useful information for public health decision-makers prioritizing interventions for foodborne diseases and food safety. | Yanan Wang Yue Liu Na Lyu Zhiyuan Li Sufang Ma Demin Cao Yuanlong Pan Yongfei Hu Hua Huang George F.Gao Xuebin Xu Baoli Zhu | 2023 | National Science Review2023，10，3： | 4 |
| 10 | Research progress in artificial upwelling and its potential environmental effects显示文摘Artificial upwelling, as a geoengineering tool, has received worldwide attention because it may actualize ocean fertilization in a sustainable way, which could potentially alleviate the pressures on the fish stocks and human-driven climate change in the ocean. We reviewed the current knowledge on the development of an artificial upwelling system and its potential environmental effects. Special attention was given to the research progress on the air-lift concept artificial upwelling by Zhejiang University. The research on artificial upwelling over the past few decades has generated a range of devices that have been successfully applied in the field for months. Based on field experiments and the associated modeling results, part of them reported positive effects on increasing primary production and enhancing CO2 sequestration. However, as a significant disturbance to the environment, especially for large-scale applications, the uncertainties related to the potential effects on ecosystem remain unsolved. Zhejiang University has overcome the technical challenges in designing and fabricating a robust and high efficiency artificial upwelling device which has been examined in two field experiments in Qiandao Lake and one sea trial in the East China Sea. It was investigated that cold and hypoxic deep ocean water(DOW) could be uplifted to the euphotic layer, which could potentially change the nutrient distribution and adjust the N/P ratio. Both simulation and field experiments results confirmed that utilizing self-powered energy to inject compressed air to uplift DOW was a valid and efficient method. Therefore, further field-based research on artificial upwelling, especially for long-term field research is required to test the scientific hypothesis. | PAN YiWen FAN Wei ZHANG DaHai CHEN JiaWang HUANG HaoCai LIU ShuXia JIANG ZongPei DI YaNan TONG MengMeng CHEN Ying | 2016 | Science China Earth Sciences2016，59，2： | 3 |
| 11 | Band-tailored van der Waals heterostructure for multilevel memory and artificial synapse显示文摘Two-dimensional(2D)van der Waals heterostructure(vdWH)-based floating gate devices show great potential for next-generation nonvolatile and multilevel data storage memory.However,high program voltage induced substantial energy consumption,which is one of the primary concerns,hinders their applications in lowenergy-consumption artificial synapses for neuromorphic computing.In this study,we demonstrate a three-terminal floating gate device based on the vdWH of tin disulfide(SnS2),hexagonal boron nitride(h-BN),and few-layer graphene.The large electron affinity of SnS2 facilitates a significant reduction in the program voltage of the device by lowering the hole-injection barrier across h-BN.Our floating gate device,as a nonvolatile multilevel electronic memory,exhibits large on/off current ratio(105),good retention(over 104 s),and robust endurance(over 1000 cycles).Moreover,it can function as an artificial synapse to emulate basic synaptic functions.Further,low energy consumption down to7 picojoule(pJ)can be achieved owing to the small program voltage.High linearity(<1)and conductance ratio(80)in long-term potentiation and depression(LTP/LTD)further contribute to the high pattern recognition accuracy(90%)in artificial neural network simulation.The proposed device with attentive band engineering can promote the future development of energy-efficient memory and neuromorphic devices. | Yanan Wang Yue Zheng Jing Gao Tengyu Jin Enlong Li Xu Lian Xuan Pan Cheng Han Huipeng Chen Wei Chen | 2021 | InfoMat2021，3，8： | 3 |
| 12 | The Formation Mechanism and Developmental Characteristics of Tight Oil显示文摘1 Introduction Unconventional oil and gas,a kind of resources of great exploration potential,has a wide application future.Tight oil,an important part of unconventional oil and gas,attracts much more attention.With the continuous improvement of technology exploration and the continuous exploitation of oil and gas,tight oil is widedly concerned in recent years.In order to exploite tight oil effectively,many researchers using different materials and methods to discuss | PAN Yanan JI Youliang WANG Tianyun | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 2 |
| 13 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 14 | GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis显示文摘Intestinal epithelium serves as the first barrier against the infections and injuries that mediate colonic inflammation.Colorectal cancer is often accompanied with chronic inflammation.Differed from its well-known oncogenic role in many malignancies,we present here that Golgi membrane protein 1(G0LM1,also referred to as GP73)suppresses colorectal tumorigenesis via maintenance of intestinal epithelial barrier.G0LM1 deficiency in mice conferred susceptibility to mucosal inflammation and colitis-induced epithelial damage,which consequently promoted colon cancer.Mechanistically,depletion of G0LM1 in intestinal epithelial cells(lECs)led to aberrant Notch activation that interfered with IEC differentiation,maturation,and lineage commitment in mice.Pharmacological inhibition of Notch pathway alleviated epithelial lesions and restrained pro-tumorigenic inflammation in G0LM1-deficient mice.Therefore,G0LM1 maintains IEC homeostasis and protects against colitis and colon tumorigenesis by modulating the equilibrium of Notch signaling pathway. | Yang Pu Ya Song Mengdi Zhang Caifeng Long Jie Li Yanan Wang Yinzhe Xu Fei Pan Na Zhao Xinyu Zhang Yanan Xu Jianxin Cui Hongying Wang Yan Li Yong Zhao Di Jin Hongbing Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 2 |
| 15 | Study on behaviors of functionally graded shape memory alloy cylinder显示文摘For better controllability in actuations,it is desirable to create Functionally Graded Shape Memory Alloys(FG-SMAs)in the actuation direction.It can be achieved by applying different heat treatment processes to create the gradient along the radius of a SMA cylinder.Analytical solutions are derived to predict the macroscopic behaviors of such a functionally graded SMA cylinder.The Tresca yield criterion and linear hardening are used to describe the different phase transformations with different gradient parameters.The numerical results for an example of the model exhibit different pseudo-elastic behaviors from the non-gradient case,as well as a variational hysteresis loop for the transformation,providing a mechanism for easy actuation control.When the gradient disappears,the model can degenerate to the non-gradient case. | Bingfei Liu Qingfei Wang Rui Zhou Chunzhi Du Yanan Zhang Pan Zhang | 2017 | Acta Mechanica Solida Sinica2017，30，6： | 2 |
| 16 | Protein-protein interaction analysis in crude bacterial lysates using combinational method of ^19F site-specific incorporation and ^19F NMR显示文摘 | Dong Li Yanan Zhang Yao He Chengwei Zhang Jiefei Wang Ying Xiong Longhua Zhang Yangzhong Liu Pan Shi Changlin Tian | 2017 | Protein & Cell2017，8，2： | 2 |
| 17 | Working-in-tandem mechanism of multi-dopants in enhancing electrocatalytic nitrogen reduction reaction performance of carbon- based materials显示文摘Developing carbon-based electrocatalysts with excellent N2 adsorption and activation capability holds the key to achieve highly efficient nitrogen reduction reaction(NRR)for reaching its practical application.Here,we report a highly active electrocatalyst--metal-free pyrrolic-N dominated N,S co-doped carbon(pyrr-NSC)for NRR.Based on theoretical and experimental results,it is confirmed that the N and S-dopants practice a working-in-tandem mechanism on pyrr-NSC,where the N-dopants are utilized to create electropositive C sites for enhancing N2 adsorption and the S-dopants are employed to induce electron backdonation for facilitating N2 activation.The synergistic effect of the pyrrolic-N and S-dopants can also suppress the irritating hydrogen evolution reaction,further boosting the NRR performance.This work gives an indication that the combination of two different dopants on electrocatalyst can enhance NRR performance by working in the two tandem steps-the adsorption and activation of N2 molecules,providing a new strategy for NRR electrocatalyst design. | Wenqing Zhang Keke Mao Jingxiang Low Hengjie Liu Yanan Bo Jun Ma Qiaoxi Liu Yawen Jiang Jiuzhong Yang Yang Pan Zeming Qi Ran Long Li Song Yujie Xiong | 2021 | Nano Research2021，14，9： | 2 |
| 18 | A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer显示文摘Protein neddylation is catalyzed by a neddylation activating enzyme(NAE,E1),an E2 conjugating enzyme,and an E3 ligase.In various types of human cancers,the neddylation pathway is abnormally activated.Our previous study validated that the neddylation E2 UBE2F is a promising therapeutic target in lung cancer.Although the NAE inhibitor MLN4924/pevonedistat is currently under clinical investigation as an anti-cancer agent,there are no small molecules available that selectively target UBE2F.Here,we report,for the first time,the discovery,via structure-based virtual screen and chemical optimization,of such a small molecule,designated as HA-9104.HA-9104 binds to UBE2F,reduces its protein levels,and consequently inhibits cullin-5 neddylation.Blockage of cullin-5 neddylation inactivates cullin-RING ligase-5(CRL5)activity,leading to accumulation of the CRL5 substrate,NOXA,to induce apoptosis.Moreover,HA-9104 appears to form the DNA adduct via its 7-azaindole group to induce DNA damage and G2/M arrest.Biologically,HA-9104 effectively suppresses the growth and survival of lung cancer cells and confers radiosensitization in both in vitro cell culture and in vivo xenograft tumor models.In summary,we discovered a small molecule,designated HA-9104,that targets the UBE2F-CRL5 axis with anti-cancer activity alone or in combination with radiation. | Tiantian Xu Qisheng Ma Yanan Li Qing Yu Peichen Pan Yawen Zheng Zhijian Li Xiufang Xiong Tingjun Hou Bin Yu Hongmin Liu Yi Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 2 |
| 19 | Marine bacteria inhibit corrosion of steel via synergistic biomineralization显示文摘Metal corrosion often results in incalculable economic loss and significant safety hazards. Although numerous traditional methods have been used to mitigate the issue, such as coating and corrosion inhibitors, they are environmentally unfriendly and difficult to maintain. Therefore, in this study, an environmental approach was taken to protect steels from corrosion in a multi-species bacterial environment via synergistic biomineralization. The marine bacterium Pseudoalteromonas lipolytica mixed with Bacillus subtilis or Pseudomonas aeruginosa strains offered extraordinary corrosion protection for steel.The surface characterization and electrochemical tests showed that the biomineralized film generated by the mixed bacteria was more compact and protective than that induced by a single bacterium. Herein,we found that the synergistic mechanisms were rather different for the different bacterial groups. For Pseudoalteromonas lipolytica and Bacillus subtilis group, the related mechanisms were due to the increase of pH in the medium, secretion of carbonic anhydrase. As for Pseudoalteromonas lipolytica and Pseudomonas aeruginosa group, the synergistic mechanism was attributed to the inhibiting corrosive bacteria in biofilm by the growth advantage of Pseudoalteromonas lipolytica. Therefore, this study may introduce a new perspective for future use of biomineralization in a real marine environment. | Na Guo Yanan Wang Xinrui Hui Qianyu Zhao Zhenshun Zeng Shuai Pan Zhangwei Guo Yansheng Yin Tao Liu | 2021 | Journal of Materials Science & Technology2021，，7： | 1 |
| 20 | Outbreak patterns of the novel avian influenza(H7N9)显示文摘 | PAN Yanan LOU Jingjing HAN Xiaopu | 2014 | Phys A:Stat Mech Appl2014，401，5： | 1 |
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