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| 1 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 2 | A Brief Introduction to BNU-HESM1.0 and Its Earth Surface Temperature Simulations显示文摘Integrated assessment models and coupled earth system models both have their limitations in understanding the interactions between human activity and the physical earth system. In this paper,a new human–earth system model,BNUHESM1.0,constructed by combining the economic and climate damage components of the Dynamic Integrated Model of Climate Change and Economy to the BNU-ESM model,is introduced. The ability of BNU-HESM1.0 in simulating the global CO2 concentration and surface temperature is also evaluated. We find that,compared to observation,BNU-HESM1.0underestimates the global CO2 concentration and its rising trend during 1965–2005,due to the uncertainty in the economic components. However,the surface temperature simulated by BNU-HESM1.0 is much closer to observation,resulting from the overestimates of surface temperature by the original BNU-ESM model. The uncertainty of BNU-ESM falls within the range of present earth system uncertainty,so it is the economic and climate damage component of BNU-HESM1.0 that needs to be improved through further study. However,the main purpose of this paper is to introduce a new approach to investigate the complex relationship between human activity and the earth system. It is hoped that it will inspire further ideas that prove valuable in guiding human activities appropriate for a sustainable future climate. | YANG Shili DONG Wenjie CHOU Jieming FENG Jinming YAN Xiaodong WEI Zhigang YUAN Wenping GUO Yan TANG Yanli HU Jiacong | 2015 | Advances in Atmospheric Sciences2015，32，12： | 8 |
| 3 | Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses显示文摘Hematopoietic stem cells(HSCs)in adults are believed to be born from hemogenic endothelial cells(HECs)in mid-gestational embryos.Due to the rare and transient nature,the HSC-competent HECs have never been stringently identified and accurately captured,let alone their genuine vascular precursors.Here,we first used high-precision single-cell transcriptomics to unbiasedly examine the relevant EC populations at continuous developmental stages with intervals of 0.5 days from embryonic day(E)9.5 to E11.0.As a consequence,we transcriptomically identified two molecularly different arterial EC populations and putative HSCprimed HECs,whose number peaked at El 0.0 and sharply decreased thereafter,in the dorsal aorta of the aorta-gonadmesonephros(AGM)region.Combining computational prediction and in vivo functional validation,we precisely captured HSCcompetent HECs by the newly constructed Neurl3-EGFP reporter mouse model,and realized the enrichment further by a combination of surface markers(Procr+Kit+CD44+,PK44).Surprisingly,the endothelial-hematopoietic dual potential was rarely but reliably witnessed in the cultures of single HECs.Noteworthy,primitive vascular ECs from E8.0 experienced two-step fate choices to become HSC-primed HECs,namely an Initial arterial fate choice followed by a hemogenic fate conversion.This finding resolves several previously observed contradictions.Taken together,comprehensive understanding of endothelial evolutions and molecular programs underlying HSC-primed HEC specification in vivo will facilitate future investigations directing HSC production in vitro. | Siyuan Hou Zongcheng Li Xiaona Zheng Yun Gao Ji Dong Yanli Ni Xiaobo Wang Yunqiao Li Xiaochen Ding Zhilin Chang Shuaili Li Yuqiong Hu Xiaoying Fan Yu Hou Lu Wen Bing Liu Fuchou Tang Yu Lan | 2020 | Cell Research2020，30，5： | 8 |
| 4 | Huge thick conglomerate movement induced by full thick longwall mining huge thick coal seam显示文摘A discrete elemental method was used to study the thickness of conglomerate layer in a full thick seam mining activities under the influence of the law, pointing out the thickness of the conglomerate at different seam mining, and during the destruction and instability of existing state of laws. At 21141 thick seam mining, the face toward the direction of separation between the thick layer of conglomerate rock and the next bit after reaching its maximum capacity due to pull from the bottom of the plastic zone, formed a stratified and hierarchical down collapse. The shape of caving area is a ''triangular block'', the length of the plastic zone and face advancement from the linear fit between the height of the plastic zone and the advancing face is a quadratic function of distance, while the top layer of thick gravel layer is the overall bending subsidence trend. Tilting the direction of the face, a thick gob of collapsed conglomerate layer is formed in the coal gob entity on both sides of the thick conglomerate at the top of the overall fracture morphology performance, thus forming a mutual extrusion of articulated block structure. The instability, separation and balance of the thick conglomerate layer in the hinged block stope stress leads to abnormal occurrence of rock burst induced by face as the major factor in the accident. This research reveals the form of stress distribution in the destroyed layer of the thick conglomerate rock, analyzes the stope law of coupling for the pressure burst behavior law for the mining work face, and the choice of preventive measures to provide a theoretical basis and implementation. | Ma Liqiang Qiu xiaoxiang Dong Tao Zhang Jixiong Huang Yanli | 2012 | International Journal of Mining Science and Technology2012，22，3： | 7 |
| 5 | Disruption of adipocyte HIF-1α improves atherosclerosis through the inhibition of ceramide generation显示文摘Atherosclerosis is a chronic multifactorial cardiovascular disease.Western diets have been reported to affect atherosclerosis through regulating adipose function.In high cholesterol diet-fed ApoE^(−/−)mice,adipocyte HIF-1αdeficiency or direct inhibition of HIF-1αby the selective pharmacological HIF-1αinhibitor PX-478 alleviates high cholesterol diet-induced atherosclerosis by reducing adipose ceramide generation,which lowers cholesterol levels and reduces inflammatory responses,resulting in improved dyslipidemia and atherogenesis.Smpd3,the gene encoding neutral sphingomyelinase,is identified as a new target gene directly regulated by HIF-1αthat is involved in ceramide generation.Injection of lentivirus-SMPD3 in epididymal adipose tissue reverses the decrease in ceramides in adipocytes and eliminates the improvements on atherosclerosis in the adipocyte HIF-1α-deficient mice.Therefore,HIF-1αinhibition may constitute a novel approach to slow atherosclerotic progression. | Pengcheng Wang Guangyi Zeng Yu Yan Song-yang Zhang Yongqiang Dong Yangming Zhang Xingzhong Zhang Huiying Liu Zhipeng Zhang Changtao Jiang Yanli Pang | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 6 |
| 6 | Pseudocapacitance boosted N-doped carbon coated Fe7S8 nanoaggregates as promising anode materials for lithium and sodium storage显示文摘Herein,the core-shell structured N-doped carbon coated Fe7S8 nano-aggregates(Fe7S8@NC)were controllably prepared via a simple three-step synthesis strategy.The appropriate thickness of N-doped carbon layer outside Fe7S8 nano-aggregates can not only inhibit the particle pulverization induced by the big volume changes of Fe7S8,but can increase the electron transfer efficiency.The hierarchical Fe7S8 nano-aggregates composed of some primary nanoparticles can accelerate the lithium or sodium diffusion kinetics.As anode materials for Li-ion batteries(LIBs),the well-designed Fe7S8@NC nanocomposites exhibit outstanding lithium storage performance,which is better than that of pure Fe7S8,Fe3O4@NC and Fe7S8@C.Among these nanocomposites,the N-doped carbon coated Fe7S8 with carbon content of 26.87 wt.%shows a high reversible specific capacity of 833 mAh·g^−1 after 1,000 cycles at a high current density of 2 A·g^−1.The above electrode also shows excellent high rate sodium storage performance.The experimental and theoretical analyses indicate that the outstanding electrochemical performance could be attributed to the synergistic effect of hierarchical Fe7S8 nanostructure and conductive N-doped carbon layer.The quantitative kinetic analysis indicates that the charge storage of Fe7S8@NC electrode is a combination of diffusion-controlled battery behavior and surface-induced capacitance behavior. | Yanli Zhou Ming Zhang Qi Wang Jian Yang Xingyun Luo Yanlu Li Rong Du Xinsheng Yan Xueqin Sun Caifu Dong Xiaoyu Zhang Fuyi Jiang | 2020 | Nano Research2020，13，3： | 4 |
| 7 | A Novel Strategy to Fabricate Core-Sheath Structure Piezoelectric Yarns for Wearable Energy Harvesters显示文摘Wearable and portable electronic devices based on textile structure have been widely used owing to their wearability and comfortableness.However,yarn fineness and the comfort of the fabric cannot satisfy the requirements of smart wearable devices.This work presents a novel strategy to prepare highly integrated PVDF/conductive nylon core-sheath structure piezoelectric yarns for wearable which is fabricated by combining electrospinning strategy with 2D braiding technology.The fineness of single yarns as well as strength are both improved significantly compared to previous works.The piezoelectric outputs of the yarn are still stable after 800 s fatigue test at a frequency of 4 Hz,and the cycle stability can maintain more than 3200 cycles.Furthermore,the piezoelectric yarns are further woven into piezoelectric plain fabric.According to the electrical performance,the length of the piezoelectric yarn and the thickness of the piezoelectric layer would both affect the output electrical performance.The yarn of the 10 cm in length and 600μm in fineness can produce an output voltage of 120 mV.Meanwhile,Both the piezoelectric yarn and the fabric could generate piezoelectric output signals through human movement,such as bending,walking.Therefore,the electrical and mechanical performance of the piezoelectric yarns prepared in our work could be improved significantly,and the comfortableness and durability performance of the piezoelectric fabric can satisfy most wearing requirements,which would provide some help in the field of piezoelectric wearable devices based on yarns and fabrics. | Lili Xue Wei Fan Yang Yu Kai Dong Chengkun Liu Yanli Sun Cong Zhang Weichun Chen Ruixin Lei Kai Rong Qi Wang | 2021 | Advanced Fiber Materials2021，3，4： | 3 |
| 8 | Occurrence of avian leukosis virus subgroup J in commercial layer flocks in China显示文摘 | Binrui Xu Weixing Dong Chunming Yu Zhaoqing He Yanli Lv Yanzheng Sun Xiaoyu Feng Ning Li L. F. Lee Maoxiang Li | 2004 | Avian Pathology2004，，1： | 3 |
| 9 | Routing Protocol for Heterogeneous FANETs with Mobility Prediction显示文摘In recent years,with the growth in Unmanned Aerial Vehicles(UAVs),UAV-based systems have become popular in both military and civil applications.In these scenarios,the lack of reliable communication infrastructure has motivated UAVs to establish a network as flying nodes,also known as Flying Ad Hoc Networks(FANETs).However,in FANETs,the high mobility degree of flying and terrestrial users may be responsible for constant changes in the network topology,making end-to-end connections in FANETs challenging.Mobility estimation and prediction of UAVs can address the challenge mentioned above since it can provide better routing planning and improve overall FANET performance in terms of continuous service availability.We thus develop a Software Defined Network(SDN)-based heterogeneous architecture for reliable communication in FANETs.In this architecture,we apply an Extended Kalman Filter(EKF)for accurate mobility estimation and prediction of UAVs.In particular,we formulate the routing problem in SDN-based Heterogeneous FANETs as a graph decision problem.As the problem is NP-hard,we further propose a Directional Particle Swarming Optimization(DPSO)approach to solve it.The extensive simulation results demonstrate that the proposed DPSO routing can exhibit superior performance in improving the goodput,packet delivery ratio,and delay. | Qihui Wu Min Zhang Chao Dong Yong Feng Yanli Yuan Simeng Feng Tony Q.S.Quek | 2022 | China Communications2022，19，1： | 3 |
| 10 | Efficient and secure outsourcing of bilinear pairings with single server显示文摘Dear editor,Cloud computing is playing important role at the era of big data,and its availability makes outsourcing computations possible[1].By outsourcing computations,mobile devices with weak computational ability can outsource complex operations to powerful cloud servers so that the time cost can be greatly reduced[2].Despite of unique advantages,there are also some security challenges we need pay attention to. | Min DONG Yanli REN | 2018 | Science China(Information Sciences)2018，61，3： | 3 |
| 11 | High Sensitive Ambipolar Response towards Oxidizing NO2 and Reducing NH3 Based on Bis(phthalocyaninato) Europium Semiconductors显示文摘 | Xia Kong Zhen Dong Yanling Wu Xiyou Li Yanli Chen Jianzhuang Jiang | 2016 | Chinese Journal of Chemistry2016，34，10： | 2 |
| 12 | Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals显示文摘Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients.Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis.However,during early embryonic angiogenesis,the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals.Here,we constructed the single-cell transcriptomic Iandscape of vascular endothelial cells(VECs)during the time window for the occurrenee of key vasculogenic and angiogenic events in both mouse and human embryos.We uncovered two distinct arterial VEC types,the major artery VECs and arterial plexus VECs,and un expectedly diverge nt arteriove nous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically.Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2^(CrexER) | Siyuan Hou Zongcheng Li Ji Dong Yun Gao Zhilin Chang Xiaochen Ding Shuaili Li Yunqiao Li Yang Zeng Qian Xin Baihan Wang Yanli Ni Xiaowei Ning Yuqiong Hu Xiaoying Fan Yu Hou Xianlong Li Lu Wen Bin Zhou Bing Liu Fuchou Tang Yu Lan | 2022 | Cell Research2022，32，4： | 2 |
| 13 | On-chip multiplexed single-cell patterning and controllable intracellular delivery显示文摘Conventional electroporation approaches show limitations in the delivery of macromolecules in vitro and in vivo.These limitations include low efficiency,noticeable cell damage and nonuniform delivery of cells.Here,we present a simple 3D electroporation platform that enables massively parallel single-cell manipulation and the intracellular delivery of macromolecules and small molecules.A pyramid pit micropore array chip was fabricated based on a silicon wet-etching method.A controllable vacuum system was adopted to trap a single cell on each micropore.Using this chip,safe single-cell electroporation was performed at low voltage.Cargoes of various sizes ranging from oligonucleotides(molecular beacons,22 bp)to plasmid DNA(CRISPR-Cas9 expression vectors,>9 kb)were delivered into targeted cells with a significantly higher transfection efficiency than that of multiple benchmark methods(e.g.,commercial electroporation devices and Lipofectamine).The delivered dose of the chemotherapeutic drug could be controlled by adjusting the applied voltage.By using CRISPR-Cas9 transfection with this system,the p62 gene and CXCR7 gene were knocked out in tumor cells,which effectively inhibited their cellular activity.Overall,this vacuum-assisted micropore array platform provides a simple,efficient,high-throughput intracellular delivery method that may facilitate on-chip cell manipulation,intracellular investigation and cancer therapy. | Zaizai Dong Yanli Jiao Bingteng Xie Yongcun Hao Pan Wang Yuanyuan Liu Junfeng Shi Chandani Chitrakar Stephen Black Yu-Chieh Wang LJames Lee Mo Li Yubo Fan Lingqian Chang | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 14 | Expression of Pseudorabies Virus gE Core Epitopes in Escherichia coli Strain BL21 and Utilization of Indirect PRV gE-ELISA显示文摘Pseudorabies virus glycoprotein E( PRV gE) has been recognized as a suitable diagnostic antigen for pseudorabies. In order to produce gE antigen in large quantities and at low cost,a gene fragment encoding PRV gE core epitopes was expressed in E. coli BL21 expression system. SDS-PAGE and Western Blotting revealed that the expression product in culture supernatant of E. coli BL21 was a recombinant protein,approximately 51. 8 Kd. At 5 h post-induction,protein concentration assay showed that the expression product amounted to 1. 65 mg /ml,accounting for 24. 17% of total proteins in the culture supernatant. An indirect PRV gE-ELISA was established by using the recombinant expression product as a coating antigen. Cross-reactivity assay showed that this antigen was PRV specific. In addition,the assay was consistently reproducible. Comparison of detection results of 240 serum samples between PRV gE-ELISA and a commercially available PRV diagnostic kit showed that there was no significant difference between these two methods( P > 0. 05). | Guangjun GUO Sufang LU Guanggang QU Feng LI Lin DONG Yanli BI Jinliang WANG Feng WEI Na TANG Chunling ZHANG Zhuang DING Zhiqiang SHEN | 2014 | Agricultural Biotechnology2014，3，4： | 2 |
| 15 | Responses of benthic foraminifera to changes of temperature and salinity:Results from a laboratory culture experiment显示文摘The effects of temperature and salinity on intertidal foraminiferal community under laboratory conditions are poorly understood. We designed a two-factor crossed experiment in which foraminiferal communities were cultured at different temperatures (6, 12, and 18℃) and salinities (15, 20, 25, and 30 psu) for 10 weeks. In total, 2616 living (stained) specimens were obtained and analyzed. Foraminiferal abundance ranged from 9 to 202 individuals/10 g wet weight of sediment. The highest abundance was obtained at 12℃, 25 psu and the lowest at 6℃, 15 psu. Statistical results demonstrated that temperature affected foraminiferal community more significantly than salinity. Most foraminiferal community parameters (abundance, species richness, Margalef index, and Shannon-Wiener diversity) were significantly positively correlated to temperature, but not to salinity, whereas Pielou's evenness was significantly negatively correlated to both temperature and salinity. The interactive effect of temperature and salinity on foraminiferal abundance was significant. In addition, with increasing temperature, the species composition shifted from hyaline Rotaliida to porcellaneous Miliolida. The abundance of dominant species (e.g., Ammonia aomoriensis, A. beccarii, and Quinqueloculina seminula) showed significant positive correlations to temperature. Our study indicated that the intertidal foraminiferal community responds sensitively and rapidly to the changes of salinity and, especially,temperature by shifting foraminiferal species composition and altering the community parameters. | Shuaishuai DONG Yanli LEI Tiegang LI Zhimin JIAN | 2019 | Science China Earth Sciences2019，62，2： | 2 |
| 16 | Formyl tetrahydrofolate deformylase affects hydrogen peroxide accumulation and leaf senescence by regulating the folate status and redox homeostasis in rice显示文摘It is well established that an abnormal tetrahydrofolate(THF)cycle causes the accumulation of hydrogen peroxide(H_(2)O_(2))and leaf senescence,however,the molecular mechanism underlying this relationship remains largely unknown.Here,we reported a novel rice tetrahydrofolate cycle mutant,which exhibited H_(2)O_(2)accumulation and early leaf senescence phenotypes.Map-based cloning revealed that HPA1 encodes a tetrahydrofolate deformylase,and its deficiency led to the accumulation of tetrahydrofolate,5-formyl tetrahydrofolate and 10-formyl tetrahydrofolate,in contrast,a decrease in 5,10-methenyl-tetrahydrofolate.The expression of tetrahydrofolate cycle-associated genes encoding serine hydroxymethyl transferase,glycine decarboxylase and 5-formyl tetrahydrofolate cycloligase was significantly down-regulated.In addition,the accumulation of H_(2)O_(2)in hpa1 was not caused by elevated glycolate oxidation.Proteomics and enzyme activity analyses further revealed that mitochondria oxidative phosphorylation complex I and complex V were differentially expressed in hpa1,which was consistent with the H_(2)O_(2)accumulation in hpa1.In a further feeding assay with exogenous glutathione(GSH),a non-enzymatic antioxidant that consumes H_(2)O_(2),the H_(2)O_(2)accumulation and leaf senescence phenotypes of hpa1 were obviously compensated.Taken together,our findings suggest that the accumulation of H_(2)O_(2)in hpa1 may be mediated by an altered folate status and redox homeostasis,subsequently triggering leaf senescence. | Erhui Xiong Guojun Dong Fei Chen Chen Zhang Shan Li Yanli Zhang Jahidul Islam Shohag Xiaoe Yang Yihua Zhou Qian Qian Limin Wu Yanchun Yu | 2021 | Science China(Life Sciences)2021，64，5： | 1 |
| 17 | An analysis of the driving forces of CO2 emissions embodied in Japan-China trade 显示文摘 | Dong Yanli Ishikawa M Liu Xianbing | 2010 | Energy Policy2010，38，11： | 1 |
| 18 | Lipopolysaccharide-Induced Proliferation of the Vasa Vasorum in a Rabbit Model of Atherosclerosis as Evaluated by Contrast-Enhanced Ultrasound Imaging and Histology显示文摘 | Jinwei Tian Sining Hu Xue Han Nana Dong Huai Yu Yanli Sun Bo Yu | 2012 | Inflammation2012，，4： | 1 |
| 19 | Aberrant methylation and decreased expression of the TGF‐β/Smad target gene FBXO32 in esophageal squamous cell carcinoma显示文摘 | Wei Guo Minghui Zhang Supeng Shen Yanli Guo Gang Kuang Zhibin Yang Zhiming Dong | 2014 | Cancer2014，，： | 1 |
| 20 | Super Resolution Perception for Improving Data Completeness in Smart Grid State Estimation显示文摘The smart grid is an evolving critical infrastructure,which combines renewable energy and the most advanced information and communication technologies to provide more economic and secure power supply services.To cope with the intermittency of ever-increasing renewable energy and ensure the security of the smart grid,state estimation,which serves as a basic tool for understanding the true states of a smart grid,should be performed with high frequency.More complete system state data are needed to support high-frequency state estimation.The data completeness problem for smart grid state estimation is therefore studied in this paper.The problem of improving data completeness by recovering highfrequency data from low-frequency data is formulated as a super resolution perception(SRP)problem in this paper.A novel machine-learning-based SRP approach is thereafter proposed.The proposed method,namely the Super Resolution Perception Net for State Estimation(SRPNSE),consists of three steps:feature extraction,information completion,and data reconstruction.Case studies have demonstrated the effectiveness and value of the proposed SRPNSE approach in recovering high-frequency data from low-frequency data for the state estimation. | Gaoqi Liang Guolong Liu Junhua Zhao Yanli Liu Jinjin Gu Guangzhong Sun Zhaoyang Dong | 2020 | Engineering2020，6，7： | 1 |
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