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| 1 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 2 | Isolation and identification of the thermophilic alkaline desulphuricant strain显示文摘A desulfurization strain that belongs to the thermophilic alkaline desulphuricant is designated as strain GDJ-3 and isolated from Inner Mongolia, China. The colony of the strain shows tiny, yellow, or white-yellow, and it becomes henna with the protracting of cultivated time. The cells are bacilliform (0.3 -0.6 × 1.0-1.2 μm), motive, and Gram negative. The strain GDJ-3 is able to utilize respectively the thiosulphate, sulfate, sulfite, or sulfide as sulfur source, utilize the carbon dioxide as the carbon source, and utilize the ammonium or nitrate as the nitrogen source. According to GenBank data, 16s RNA results of GDJ-3 are in good agreement with Alpha proteobacterrium sp. (97%) and Ochrobactrum sp. (98%). For GDJ-3, the optimum growth temperature is at 45℃, the optimum pH is at 8.5-8.8, and the optimum rocking speed of sorting table is at 150 r/min. Under the optimum culture condition, the cells of the strain can live for about 18 h. In the desulfurization solution, which is prepared according to the composition of DDS solution, the objectionable constituents of sodium thiosulphate and sodium sulfide were added factitiously, and the bacterial cell concentration was set at 107/mL. After the regeneration of the above desulfurization solution by the strain cells, the concentration of sodium thiosulphate was decreased by 14.75 g/L (percentage loss of content 13.21%), the concentration of sodium sulfide was decreased by 0.76 g/L (percentage loss of content 87.36%) in the desulfurization solution in 9.5 hours, and sulfur appeared. Maybe, this kind of strain can be used as the regeneration's bacterial source of DDS solution. | ZHANG JianBin ZHANG Tong MA Kai CHEN GuoHua ZHANG DongYan WEI XiongHui | 2008 | Science China Chemistry2008，51，2： | 9 |
| 3 | Isolation of 2019-nCoV from a Stool Specimen of a Laboratory- Confirmed Case of the Coronavirus Disease 2019 (COVID-19)显示文摘The novel coronavirus(2019-nCoV)is spreading very fast in Hubei Province of China.As of February 14,2020,51,986 confirmed cases(including laboratory-confirmed cases and clinically-confirmed cases)were reported in Hubei Province,and 1,318 of them died.Respiratory droplets and contact transmission are considered to be the most important routes of transmission of 2019-nCoV,but do not fully account for the occurrence of all coronavirus disease 2019(COVID-19)cases,previously known as novel coronavirus pneumonia(NCP),and the reasons for the rapid spread of this virus(1). | Yong Zhang Cao Chen Shuangli Zhu Chang Shu Dongyan Wang Jingdong Song Yang Song Wei Zhen Zijian Feng Guizhen Wu Jun Xu Wenbo Xu | 2020 | China CDC weekly2020，2，8： | 9 |
| 4 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 5 | Enriched Opportunistic Pathogens Revealed by Metagenomic Sequencing Hint Potential Linkages between Pharyngeal Microbiota and COVID-19显示文摘As a respiratory tract virus,SARS-CoV-2 infected people through contacting with the upper respiratory tract first.Previous studies indicated that microbiota could modulate immune response against pathogen infection.In the present study,we performed metagenomic sequencing of pharyngeal swabs from eleven patients with COVID-19 and eleven Non-COVID-19 patients who had similar symptoms such as fever and cough.Through metagenomic analysis of the above two groups and a healthy group from the public data,there are 6502 species identified in the samples.Specifically,the Pielou index indicated a lower evenness of the microbiota in the COVID-19 group than that in the Non-COVID-19 group.Combined with the linear discriminant analysis(LDA)and the generalized linear model,eighty-one bacterial species were found with increased abundance in the COVID-19 group,where 51 species were enriched more than 8 folds.The top three enriched genera were Streptococcus,Prevotella and Campylobacter containing some opportunistic pathogens.More interestingly,through experiments,we found that two Streptococcus strains,S.suis and S.agalactiae,could stimulate the expression of ACE2 of Vero cells in vitro,which may promote SARS-CoV-2 infection.Therefore,these enriched pathogens in the pharynxes of COVID-19 patients may involve in the virus-host interactions to affect SARS-CoV-2 infection and cause potential secondary bacterial infections through changing the expression of the viral receptor ACE2 and/or modulate the host’s immune system. | Dongyan Xiong Caroline Muema Xiaoxu Zhang Xinming Pan Jin Xiong Hang Yang Junping Yu Hongping Wei | 2021 | Virologica Sinica2021，36，5： | 3 |
| 6 | Characterization of the immune defense related tissues,cells,and genes in amphioxus显示文摘Amphioxus is an important animal model for phylogenetic analysis,including comparative immunology.Exploring the immune system in amphioxus contributes to our understanding of the origin and evolution of the vertebrate immune system.We investigated the amphioxus immune system using ultrastructural examination and in situ hybridization.The expression patterns of TLR1(toll-like receptor 1),C1Q(complement component 1,q subcomponent),ECSIT(evolutionarily conserved signaling intermediate in Toll pathways),SoxC,DDAHa(Dimethylarginine dimethylaminohydrolase a),and NOS(nitric oxide synthase) show that these genes play key roles in amphioxus immunity.Our results suggest that the epidermis and alimentary canal epithelium may play important roles in immune defense,while macrophages located in the coelom and so-called lymph spaces may also be crucial immune cells. | LIN YuShuang CHEN DongYan ZHANG Wei CAI ZhaoPing CHEN ZhongKe ZHANG Ning MAO BingYu ZHANG HongWei | 2011 | Science China(Life Sciences)2011，54，11： | 2 |
| 7 | Role of hydrogen peroxide in stress-induced programmed cell death during somatic embryogenesis in Fraxinus mandshurica显示文摘We examined how reactive oxygen species, in the form of hydrogen peroxide (H2O2), affect osmotic stress–induced programmed cell death during somatic embryogenesis from cotyledon explants of Manchurian ash (Fraxinus mandshurica Rupr.). We found that substantial osmotic stress was essential for Manchurian ash somatic cells to obtain embryogenic competence. The explant cells displayed hallmarks of programmed cell death, chromatin condensation, and DNA fragmentation to oligonucleotides during somatic embryogenesis. Increasing concentrations of plant growth regulators and sucrose in the medium increased osmotic stress thereby inducing H2O2 accumulation in the explant cells. We found that H2O2 concentration was significantly decreased in explant cells when the induction medium was modified, i.e., when reducing the concentration of sucrose, which reduces the osmotic pressure of the medium, or by withdrawing plant growth regulators at mid-culture. These treatments also decreased the proportion of explant cells undergoing programmed cell death. Accordingly, a decreased rate of somatic embryo induction was observed. These results show that PCD occurred during tissue browning and death of some explant cells during somatic embryogenesis in F. mandshurica. The ROS contributed to PCD in abiotic stress stimulated F. mandshurica cells. | Ling Yang Cheng Wei Chao Huang Hongnan Liu Dongyan Zhang Hailong Shen Yuhua Li | 2019 | Journal of Forestry Research2019，30，3： | 2 |
| 8 | Effects of a nitric oxide donor and nitric oxide scavengers on Sorbus pohuashanensis embryo germination显示文摘The effects of an exogenous nitric oxide donor(sodium nitroprusside, SNP), a NO scavenger 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxode(PTIO) and carboxy-PTIO potassium salt(c PTIO) on the embryo germination of Sorbus pohuashanensis were studied in a petri dish test. SNP at 0.5–5 mmol L-1 increased germination percentage, mean time to germination, germination index and germination energy compared with the control to different degrees. Treatment with 2 mmol L-1 SNP improved germination most significantly; embryo germination percentage for mother tree 1(91.11%) and mother tree 2(64.44%) were much higher than the control. In addition,excessive SNP levels did not enhance embryo germination.Combined treatment with SNP and an NO scavenger delayed embryo germination. Treatment with c PTIO inhibited embryo germination; germination percentage was 42.22% and was lower than that of the control. These results show that low concentrations of exogenous NO can enhance the embryo germination of S. pohuashanensis,providing a simple, effective way for promoting germination of S. pohuashanensis. | Ling Yang Dongyan Zhang Hongnan Liu Cheng Wei Jianan Wang Hailong Shen | 2018 | Journal of Forestry Research2018，29，3： | 2 |
| 9 | Impacts of El Nino on the somatic condition of Humboldt squid based on the beak morphology显示文摘The Humboldt squid Dosidicus gigas has a short life span, and environmental variability plays a significant role in regulating its population dynamics and distribution. An analysis of 1 096 samples of D. gigas collected by the Chinese commercial fishing vessels during 2013, 2014, and 2016 off the Peruvian Exclusive Economic Zone, was conducted to evaluate the impacts of El Nino events on the somatic condition of D. gigas. This study indicates that the slopes of all beak variables in relation to mantle length (ML) for females were greater than those of males during 2013, 2014, and 2016, and slopes of the upper crest length and the lower rostrum length significantly differed between females and males in 2013 (P<0.05). Variation in the slopes for beak variables among years was studied;no significant difference was observed (ANCOVA, P>0.05). The Fulton's condition coefficients (K) of females and males in 2013 and 2014 were significantly greater than those in 2016 (P<0.01). The K values of females were greater than those of males in 2013, 2014, and 2016, and K values significantly differed between females and males in 2013. In normal years, the chlorophyll a (Chl a) concentration showed an N-shaped variability from January to December. However, in the El Nino period, it tended to weaken the upwelling coupled with warm and low Chl a concentration waters. We suggest that the poor somatic condition of D. gigas during the El Nino year was resulted from the low Chl a concentration in the waters, and the abundance of D. gigas would decrease due to the unfavourable environment and the lack of prey items in the El Nino year. | HU Guanyu YU Wei LI Bai HAN Dongyan CHEN Xinjun CHEN Yong LI Jianhua | 2019 | Journal of Oceanology and Limnology2019，37，4： | 1 |
| 10 | Electro-spark deposition of Fe-based amorphous alloy coatings显示文摘 | Liu Dongyan Gao Wei Li Zhengwei | 2007 | Materials Letters2007，，61： | 1 |
| 11 | Exposure to environmental bisphenol A inhibits HTR-8/SVneo cell migration and invasion显示文摘Environmental pollutants,such as bisphenol A(BPA) have recently been implicated in the development of adverse birth outcomes.However,the underlying teratogenic mechanisms remain unclear.We investigated the effects of BPA on the migration and invasion of human primary extravillous trophoblast HTR-8/SVneo cells.Our results indicated that BPA reduced cell migration and invasion.Moreover,it altered the ratio of matrix metalloproteinases(MMPs) and tissue inhibitors of MMPs(TIMPs) by downregulating MMP-2 and MMP-9,and upregulating TIMP-1 and TIMP-2.Furthermore,BPA suppressed integrin β1,integrin α5,and vimentin.Interestingly,BPA-induced invasion was partially restored by G15,a membrane G-protein-coupled estrogen receptor 30 antagonist.We further revealed that 42 proteins were differentially expressed by mass spectrometry analysis,which could be divided into three categories based on gene ontology including biological process,cellular component,and molecular function.These results suggest that BPA reduces HTR-8/SVneo cell migration and invasion by downregulating MMP-2 and MMP-9,up-regulating TIMP-1 and TIMP-2,and suppressing adhesion molecules. | Pu Wei Dongqing Ru Xiaoqian Li Dongyan Shi Mingshun Zhang Qing Xu Hong Zhou Shuang Wen | 2020 | The Journal of Biomedical Research2020，34，5： | 1 |
| 12 | Electro-spark deposition of Fe-based amorphous alloy coatings显示文摘 | Liu Dongyan Gao Wei Li Zhengwei | 2007 | Materials Letters2007，61，1： | 1 |
| 13 | Global stability of multi-group SEIRS epidemic models with vaccination显示文摘 | Dejun Fan Pengmiao Hao Dongyan Sun Junjie Wei | 2018 | International Journal of Biomathematics2018，11，1： | 0 |
| 14 | Regime shifts of hydrometeorological factors in the Jiaozhou Bay and their potential ecological impacts显示文摘The wavelet transform was applied to studying the regime shifts of hydrometeorological factors(i.e.,precipitation,air temperature,sea surface temperature and sea surface salinity)during the period of 1961–2000 in the Jiaozhou Bay(JZB).The results indicated clearly that these factors show variability of multiple timescales,with interannual and decadal periods.The local abrupt changes such as the 1978–1979 and 1988–1989 shifts feature the physical environment variation,which is consistent with the Southern Oscillation and Arctic Oscillation in the northern hemisphere.In regard to the JZB ecosystem,the benthic diatom cell abundance(BEN)showed a decrease shift in1978–1979,which is closely related to the precipitation abrupt decrease,while the shellfish mortality disaster in the JZB greatly released the predating pressure of diatom growth,possibly resulting in BEN increase shift in 1995. | LIU Zhe ZHANG Jing WEI Hao LIU Dongyan | 2013 | Chinese Journal Of Geochemistry2013，32，4： | 0 |
| 15 | Advanced glycation end-products change placental barrier function and tight junction in rats with gestational diabetes mellitus via the receptor for advanced glycation end products/nuclear factor-κB pathway显示文摘The placenta plays an important role in nutrient transport to maintain the growth and development of the embryo.Gestational diabetes mellitus(GDM),the most common complication during pregnancy,highly affects placental function in late gestation.Advanced glycation end-products(AGEs),a complex and heterogeneous group of compounds engaged by the receptor for AGEs(RAGE),are closely associated with diabetes-related complications.In this study,AGEs induced a decrease in the expression of tight junction(TJ)proteins in BeWo cells and increased the paracellular permeability of trophoblast cells by regulating RAGE/NF-κB.Sprague-Dawley(SD)rats injected with 100 mg/kg AGEs-rat serum albumin(RSA)via the tail vein from embryo day 2 were set as the placental barrier dysfunction model group(n=10).The effect of AGEs on placental permeability was determined using the Evans-Blue dye extravasation method.The ultrastructure of the placenta samples was observed by transmission electron microscopy.The effects of AGEs on the placenta were confirmed by treating rats with RAGE antagonist FPS-ZM1 and soluble forms of RAGE(sRAGE).AGEs treatment increased placental permeability and disrupted the tight junctions in pregnant rat placenta,but has no effect on blood glucose.The expression of TJ-related proteins,including ZO-1,Occludin,and Claudin 5,were downregulated after AGEs treatment.Further,AGEs treatment increased the expression of RAGE and nuclear factor-κB in the placenta of rats and upregulated the levels of vascular endothelial growth factor.The effects of AGEs on the placenta were blocked by RAGE antagonist FPS-ZM1 and sRAGE.This study demonstrates the mechanism underlying AGEs-induced disturbance in placental function in pregnant rats and highlights the potential of AGEs in the treatment of GDM. | YUEHUA SHI QIUYING YAN QIN LI WEI QIAN DONGYAN QIAO DONGDONG SUN HONG YU | 2023 | BIOCELL2023，47，1： | 0 |
| 16 | A High-Altitude Platform Air-Ground Wireless Communication System Based on Beidou显示文摘Aerostat platforms could serve as potential aerial platforms because of their low cost,long flight times,and easy load recovery.They are suitable for emergency communication,early warnings,Earth observations,and other fields.The air-ground communication link between an aerostat platform and the ground is the basic guarantee for aerostat measurement control and service transmission.In traditional aerostat applications,platform measurement control and service transmission usually use different links.The load and ground equipment are complex,and the energy,load,and size of the platform are greatly occupied.In this paper,we propose a Beidou-assisted air-ground communication ground for a near-space platform that uses Beidou's positioning and communication functions to provide tracking and guidance information for the ground station.An air-ground wireless communication mode integrating measurement control and service transmission is achieved.The flight test shows that the system can effectively meet the practical application requirements. | Dongyan Wei Xianghong Li Ge Shen Hong Yuan | 2021 | Journal of Communications and Information Networks2021，6，3： | 0 |
| 17 | Prevention and control strategies for emergency,limited-term,and elective operations in pediatric surgery during the epidemic period of COVID-19显示文摘The outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread to more than 100 countries.Children approved to be susceptible to SARS-CoV-2 infection.Preventing and controlling the epidemic while ensuring orderly flows of pediatric surgery clinical work has proven to be a big challenge for both patients and clinicians during the epidemic.Based on the transmission characteristics of SARS-CoV-2 and the requirements for prevention and control of COVID-19,the authors proposed some concrete measures and practical strategies of managing emergency,limited-term,and elective pediatric surgeries during the epidemic period. | Daxing Tang Jinfa Tou Jinhu Wang Qingjiang Chen Wei Wang Jinjin Huang Hangyan Zhao Jia Wei Zheming Xu Dongyan Zhao Junfen Fu Qiang Shu | 2020 | World Journal of Pediatric Surgery2020，3，1： | 0 |
| 18 | SET1A催化YAP甲基化修饰调控YAP细胞核转运和促进肿瘤发生显示文摘文章简介YAP作为Hippo信号通路主要效应因子之一,在Hippo通路受抑的条件下,从细胞质转运至细胞核调控基因表达和促进肿瘤发生。虽然YAP锚定在细胞质中的调控机制已经被广泛研究,但是YAP激活后入核在细胞核中持续积累的分子机制并不十分清楚。 | 方兰 滕鸿琦 王益林 廖光红 Linjun Weng Yaxu Li Xinbo Wang Jiali Jin Chenchen Jiao Lei Chen Xiaoping Peng Jiayu Chen Yongzhi Yang Houqin Fang Dongyan Han Cheng Li Xueling Jin Shihao Zhang Zhongchen Liu Min Liu Qing Wei Lujian Liao Xin Ge Bin Zhao Dawang Zhou HuanLong Qin Jun Zhou 王平 | 2019 | 科学新闻2019，0，2： | 0 |
| 19 | Effect of Continuous Nursing Intervention on Psychological State and Medication Compliance of Patients with Acute Myocardial Infarction after PCI显示文摘Objective:To explore the effect of continuous nursing intervention on psychological status and medication compliance of patients with acute myocardial infarction after PCI operation.Methods:from February 2013 to September 2016,102 patients with acute myocardial infarction treated by PCI were selected and divided into two groups,51 cases in each group according to the different nursing methods.The observation group was added continuous nursing on the basis of routine nursing,while the control group was the usual nursing mode.The mental state of the two groups before and after treatment was evaluated,and the patients were followed up for 6 months after discharge.The compliance of the two groups at 1,3 and June after discharge was statistically analyzed.Results:before nursing,there was no significant difference in the mental state evaluation between the two groups(P>0.05).After nursing,the mental status of the two groups was improved,while the psychological state of the observation group was better than that of the control group(P<0.05).After 6 months'follow-up,there was no significant difference in the compliance rate between the two groups at 1 months after discharge(P>0.05).In 3 and June,the compliance of the patients in the observation group was better than that in the control group(P<0.05).Conclusion:continuous nursing intervention for patients with acute myocardial infarction after PCI can effectively adjust the unhealthy psychological state of patients,improve medication compliance and promote early rehabilitation of patients. | Dongyan Wei | 2018 | Journal of Advances in Medicine Science2018，1，1： | 0 |
| 20 | Research on the influence of contact surface constraint on mechanical properties of rock-concrete composite specimens under compressive loads显示文摘The contact form of rock-concrete has a crucial influence on the failure characteristics of the stability of rock-concrete engineering.To study the influence of contact surface on the mechanical properties of rock-concrete composite specimens under compressive loads,the two different contact forms of rock-concrete composite specimens are designed,the mechanical properties of these two different specimens are analyzed under triaxial compressive condition,and analysis comparison on the stress-strain curves and failure forms of the two specimens is carried out.The influence of contact surface constraint on the mechanical properties of rock-concrete composite specimens is obtained.Results show that the stress and strain of rock-concrete composite specimens with contact surface constraint are obviously higher than those without.Averagely,compared with composite specimens without the contact surface,the existence of contact surface constraint can increase the axial peak stress of composite specimens by 24%and the axial peak strain by 16%.According to the characteristics of the fracture surface,the theory of microcrack development is used to explain the contact surface constraint of rock-concrete composite specimens,which explains the difference of mechanical properties between the two rock-concrete composite specimens in the experiment.Research results cannot only enrich the research content of the mechanics of rock contact,but also can serve as a valuable reference for the understanding of the corresponding mechanics mechanism of other similar composite specimens. | Baoyun ZHAO Yang LIU Dongyan LIU Wei HUANG Xiaoping WANG Guibao YU Shu LIU | 2020 | Frontiers of Structural and Civil Engineering2020，14，2： | 0 |
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