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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Thermodynamic properties for the alternative refrigerants显示文摘 | Mark O M Eric W L Richard T J | 1998 | Int J Refrig1998，21，4： | 1 |
| 3 | The impact of virtu- al embedded ness on new venture survival:overcoming the Liabilities of Newness 显示文摘 | Eric A M Sally W F Thomas B L | 2007 | Entrepreneurship Theory and Practice2007，31，2： | 1 |
| 4 | Social lifecycle costs of cars with alternative fuels/engines显示文摘 | Joan M O Robert H W Eric D L | 2004 | Energy Policy2004，，32： | 1 |
| 5 | Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism显示文摘 | Timothy A Kimbrell John T Little Robert T Dunn Mark A Frye Benjamin D Greenberg Eric M Wassermann Jennifer D Repella Aimee L Danielson Mark W Willis Brenda E Benson Andrew M Speer Elizabeth Osuch Mark S George Robert M Post | 1999 | Biological Psychiatry1999，，12： | 1 |
| 6 | Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials显示文摘 | Eric Boersma Robert A Harrington David J Moliterno Harvey White Pierre Théroux Frans Van de Werf Anneke de Torbal Paul W Armstrong Lars C Wallentin Robert G Wilcox John Simes Robert M Califf Eric J Topol Maarten L Simoons | 2002 | The Lancet2002，，9302： | 1 |
| 7 | Analysis of material and energy consumption of mobile phones in China 显示文摘 | Yu J L Eric W Ju M T | 2010 | Energy Policy2010，38，8： | 1 |
| 8 | Using geodetic GPS receivers to measure vegetation water content显示文摘 | WEI W KRISTIN M L ERIC E S | 2015 | GPS Solutions2015，19，2： | 1 |
| 9 | Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: the GUSTO-I experience显示文摘 | Matthias Pfisterer Jafna L Cox Christopher B Granger Sorin J Brener C.David Naylor Robert M Califf Frans van de Werf Amanda L Stebbins Kerry L Lee Eric J Topol Paul W Armstrong | 1998 | Journal of the American College of Cardiology1998，，3： | 1 |
| 10 | An intelligent approach to assessing the effect of building occupancy on building cooling load prediction显示文摘 | SIMON S K K RICHARD K K Y ERIC W M L | 2011 | Building and Environment2011，46，： | 1 |
| 11 | Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: an observational study显示文摘 | Herbert D Aronow Eric J Topol Matthew T Roe Penny L Houghtaling Katherine E Wolski A Michael Lincoff Robert A Harrington Robert M Califf E Magnus Ohman Neal S Kleiman Matyas Keltai Robert G Wilcox Alec Vahanian Paul W Armstrong Michael S Lauer | 2001 | The Lancet2001，，9262： | 1 |
| 12 | International differences in evolution of early discharge after acute myocardial infarction显示文摘 | Padma Kaul L Kristin Newby Yuling Fu Daniel B Mark Robert M Califf Eric J Topol Phil Aylward Christopher B Granger Frans Van de Werf Paul W Armstrong | 2004 | The Lancet . 2004 (9408)2004，，： | 1 |
| 13 | The dialysis outcome and practice patterns study(DOPPS) : an international hemodialysis study显示文摘 | Eric W Y David A D Donna L M | 2000 | Kidney International2000，57，74： | 1 |
| 14 | Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials显示文摘 | Michelle L O’Donoghue Eugene Braunwald Elliott M Antman Sabina A Murphy Eric R Bates Yoseph Rozenman Alan D Michelson Raymond W Hautvast Peter N Ver Lee Sandra L Close Lei Shen Jessica L Mega Marc S Sabatine Stephen D Wiviott | 2009 | The Lancet2009，，9694： | 1 |
| 15 | The dialysis outcome And practice patterns study (DOPPS):An internartional hemodialysis study显示文摘 | Eric W Y David A D Dongna L M | 2000 | Kidney Interational2000，57，74： | 1 |
| 16 | Post-explosion observations of experimental mine and laboratory coal dust explosions 显示文摘 | KENNETH L C ERIC S W TERRY G M | 2007 | Journal of Loss Prevention in the Process Industries2007，20，4： | 1 |
| 17 | Classification of CIE standard skies using probabilistic neural networks显示文摘 | DANNY H W LI H L TANG ERIC W M LEE | 2009 | International Journal of Climatology2009，30，2： | 1 |
| 18 | Measurement of porosity in very small samples of plant tissue 显示文摘 | Eric J W Visser L Gerard M B | 2003 | Plant Soil2003，253，： | 1 |
| 19 | Nanobeam mechanics: Elasticity,strength, and toughness of nanorods and nanotubes显示文摘 | Eric W W Paul E S Charles M L | 1997 | Science1997，27，： | 1 |
| 20 | Behavior of braced and unbraced semi - rigid frames 显示文摘 | Eric M L Chen W F | 1988 | International Journal of Solids and Structures1988，24，9： | 1 |
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