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| 1 | Physical exercise in the prevention and treatment of Alzheimer’s disease显示文摘Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Several lifestyle factors may increase,or reduce,an individual’s risk of developing AD.Much has been written over the ages about the benefits of exercise and physical activity.Among the risk factors associated with AD is a low level of physical activity.The relationship between physical and mental health was established several years ago.In this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of AD.Older adults who exercise are more likely to maintain cognition.We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies.We will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood flow.Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide.Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations. | Adrian De la Rosa Gloria Olaso-Gonzalez Coralie Arc-Chagnaud Fernando Millan Andrea Salvador-Pascual Consolacion Garcıa-Lucerga Cristina Blasco-Lafarga Esther Garcia-Dominguez Aitor Carretero Angela G.Correas Jose Vina Mari Carmen Gomez-Cabrera | 2020 | Journal of Sport and Health Science2020，9，5： | 32 |
| 2 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 3 | High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease显示文摘AIM:To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel disease [Crohn's disease(CD) and ulcerative colitis(UC)].METHODS:Thirty patients with CD(15 with at least one NOD2/CARD15 mutation),29 with UC,and 10 with no inflammatory bowel disease(IBD).were tested for MAP by polymerase chain reaction(specific IS900 fragment) and blood culture.RESULTS:MAP DNA was detected in all original blood samples and 8-wk blood cultures(CD,UC and non-IBD).Positive MAP DNA status was confirmed by dot blot assays.All 69 cultures were negative by acid-fast Ziehl-Neelsen staining.Viable MAP,in spheroplast form,was isolated from the 18-mo blood cultures of all 30 CD patients,one UC patient,and none of the non-IBD controls.No association was found between positive MAP cultures and use of immunosuppressive drugs or CDassociated single nucleotide polymorphisms.CONCLUSION:MAP is widely present in our area and MAP DNA can be recovered from the blood of CD,UC and non-IBD patients.However,MAP spheroplasts were only found in CD patients. | Juan L Mendoza Amparo San-Pedro Esther Culebras Raquel Cíes Carlos Taxonera Raquel Lana Elena Urcelay Fernando de la Torre Juan J Picazo Manuel Díaz-Rubio | 2010 | World Journal of Gastroenterology2010，16，36： | 5 |
| 4 | Validation of a new scoring system: Rapid assessment faecal incontinence score显示文摘AIM: To implement a quick and simple test- rapid assessment faecal incontinence score(RAFIS) and show its reliability and validity.METHODS: From March 2008 through March 2010, we evaluated a total of 261 consecutive patients, including 53 patients with faecal incontinence. Demographic and comorbidity information was collected. In a single visit, patients were administered the RAFIS. The results obtained with the new score were compared with those of both Wexner score and faecal incontinence quality of life scale(FIQL) questionnaire. The patient withoutinfluence of the surgeon completed the test. The role of surgeon was explaining the meaning of each section and how he had to fill. Reliability of the RAFIS score was measured using intra-observer agreement and Cronbach's alpha(internal consistency) coefficient. Multivariate analysis of the main components within the different scores was performed in order to determine whether all the scores measured the same factor and to conclude whether the information could be encompassed in a single factor. A sample size of 50 patients with faecal incontinence was estimated to be enough to detect a correlation of 0.55 or better at 5% level of significance with 80% power.RESULTS: We analysed the results obtained by 53 consecutive patients with faecal incontinence(median age 61.55 ± 12.49 years) in the three scoring systems. A total of 208 healthy volunteers(median age 58.41 ± 18.41 years) without faecal incontinence were included in the study as negative controls. Pearson's correlation coefficient between 'state' and 'leaks' was excellent(r = 0.92, P < 0.005). Internal consistency in the comparison of 'state' and 'leaks' yielded also excellent correlation(Cronbach's α = 0.93). Results in each score were compared using regression analysis and a correlation value of r = 0.98 was obtained with Wexner score. As regards FIQL questionnaire, the values of 'r ' for the different subscales of the questionnaire were: 'lifestyle' r =-0.87, 'coping/behaviour' r =-0.91, 'depression' r =-0.36 and 'embarrassment' r =-0.90,(P < 0.01). A multivariate analysis showed that all the scoring systems measured the same factor. A single factor may explain 80.84% of the variability of FI, so all the scoring systems measure the same factor. Patient's continence improves when RAFIS and Jorge-Wexner scores show low values and when the values obtained in the FIQL questionnaire are high.CONCLUSION: RAFIS is a valid and reliable tool to assess Faecal Incontinence. | Fernando de la Portilla Arantxa Calero-Lillo Rosa M Jiménez-Rodríguez Maria L Reyes Manuela Segovia-González María Victoria Maestre Ana M García-Cabrera | 2015 | World Journal of Gastrointestinal Surgery2015，7，9： | 5 |
| 5 | Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome显示文摘Diffuse intestinal ganglioneuromatosis is a hamartomatous polyposis characterized by a disseminated, intramural or transmural proliferation of neural elements involving the enteric plexuses. It has been associated with MEN Ⅱ, neurofibromatosis type 1 and hamartomatous polyposis associated with phosphatase and tensin homolog mutation. We report the case of a female patient with a history of a breast and endometrial tumor who presented in a colonoscopy performed for rectal bleeding diffuse ganglioneuromatosis, which oriented the search for other characteristic findings of Cowden syndrome given the personal history of the patient. The presence of an esophagogastric polyposis was also noted. Cowden syndrome is characterized by skin lesions, but it is rarely diagnosed by these lesions, because they are usually overlooked. Intestinal polyposis is not a major diagnostic criterion but it is very useful for early diagnosis. The combination of colonic polyposis and glucogenic acanthosis should orient the diagnosis to Cowden syndrome. | Maria Teresa Herranz Bachiller Jesus Barrio Andrés Fernando Pons Noelia Alcaide Suárez Rafael Ruiz-Zorrilla Lorena Sancho del Val Sara Lorenzo Pelayo Carlos De La Serna Higuera Ramon Atienza Sánchez Manuel Perez Miranda | 2013 | World Journal of Gastrointestinal Oncology2013，5，2： | 5 |
| 6 | Phonon imaging in 3D with a fibre probe显示文摘We show for the first time that a single ultrasonic imaging fibre is capable of simultaneously accessing 3D spatial information and mechanical properties from microscopic objects.The novel measurement system consists of two ultrafast lasers that excite and detect high-frequency ultrasound from a nano-transducer that was fabricated onto the tip of a single-mode optical fibre.A signal processing technique was also developed to extract nanometric in-depth spatial measurements from GHz frequency acoustic waves,while still allowing Brillouin spectroscopy in the frequency domain.Label-free and non-contact imaging performance was demonstrated on various polymer microstructures.This singular device is equipped with optical lateral resolution,2.5μm,and a depth-profiling precision of 45 nm provided by acoustics.The endoscopic potential for this device is exhibited by extrapolating the single fibre to tens of thousands of fibres in an imaging bundle.Such a device catalyses future phonon endomicroscopy technology that brings the prospect of label-free in vivo histology within reach. | Salvatore La Cavera III Fernando Perez-Cota Richard JSmith Matt Clark | 2021 | Light(Science & Applications)2021，10，6： | 2 |
| 7 | Caspase 3 activity is required for skeletal muscle differentiation显示文摘 | Fernando P Kelly JF Megeney LA | 2002 | PNAS2002，99，11： | 1 |
| 8 | Techniques and Training with GreenLight HPS 120-W Laser Therapy of the Prostate: Position Paper显示文摘 | Gordon Muir Fernando Gómez Sancha Alexander Bachmann Benjamin Choi Edward Collins Jean de la Rosette Oliver Reich Shahin Tabatabaei Henry Woo | 2007 | European Urology Supplements2007，，： | 1 |
| 9 | Photodegradation and Removal of Diclofenac by the Green Alga Nannochloropsis oculata显示文摘The emerging contaminants(ECs)are organic compounds including pharmaceuticals.These products are consumed in large quantities,favoring their continuous entrance to the environment and affecting the health of living beings.Diclofenac is a non-steroidal anti-inflammatory drug with analgesic properties of prolonged release.It is the commonest postoperative analgesic,and it is highly consumed without prescription.In recent years,the capability of microalgae to remove pharmaceuticals in water has been tested as a promising tool.In this work,the removal efficiency of diclofenac(16µg/mL)by the microalga Nannochloropsis oculata CCAP 186/7 was evaluated.The major nutrient concentrations in Bold’s Basal Medium were modified(nitrogen and carbon:50 and 100%of their original concentration)to know their effect in the removal of diclofenac.Drug degradation by light was also evaluated.The maximum removal capacity of diclofenac in the medium was 68.8%.The percentage of diclofenac adsorbed on the cell wall was between 6 and 12.7%.Around 23.6%of diclofenac was degraded by light after 18 days.N.oculata did not show growth inhibition due to the presence of diclofenac.The results obtained point to the promissory application of N.oculata as a bioremediation system for diclofenac removal. | Danaé Samara Sánchez-Sandoval Omar González-Ortega Mara Fernanda Navarro-Martínez Juan Marcos Castro-Tapia Ramón Fernando García de la Cruz Ruth Elena Soria-Guerra | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 1 |
| 10 | An Open-Label, Noncomparative, Multicenter Study to Evaluate Efficacy and Safety of NASHA/Dx Gel as a Bulking Agent for the Treatment of Fecal Incontinence显示文摘 | Giuseppe Dodi Johannes Jongen Fernando de la Portilla Manoj Raval Donato F. Altomare Paul-Antoine Lehur Y. Yamaoka | 2010 | Gastroenterology Research and Practice2010，，： | 1 |
| 11 | Evaluation of a New Synthetic Plug in the Treatment of Anal Fistulas: Results of a Pilot Study显示文摘 | Fernando de la Portilla Ricardo Rada Rosa Jiménez-Rodríguez José Manuel Díaz-Pavón José M. Sánchez-Gil | 2011 | Diseases of the Colon & Rectum2011，，11： | 1 |
| 12 | The use of ion exchange resins for cyanidation tailings part 1 -process development of selective base metal elution显示文摘 | K Fernando T Tran S Laing | 2002 | Minerals Engineering2002，15，： | 1 |
| 13 | Point of collapse methods applied to AC/DC power systems显示文摘 | Claudio A C Fernando LA Christopher L D | 1992 | IEEE Trans on Power System1992，7，2： | 1 |
| 14 | The opening of maitotoxin-sensitive calcium channels induces the acrosome reaction in human spermatozoa: differences from the zona pellucida显示文摘acrosome 反应(AR ) ,为精子的一个绝对要求和卵熔化,通过电压依赖者 Ca2+ 隧道和操作店的隧道要求 Ca2+ 的流入进精子。Maitotoxin (MTx ) ,一个动员 Ca2+ 代理人,被显示了是老鼠精子 AR 的有势力 inducer 与类似于带 pellucida (ZP ) 的药理学,可能为两 inducers 建议一条普通小径。使用的 recombinant 人 ZP3 (rhZP3 ) ,老鼠 ZP 和二 MTx 隧道 blockers (U73122 和 U73343 ) ,我们在人和老鼠精子调查了并且比较导致 MTx 、导致 ZP 的艺术。此处,我们报导 MTx 导致了 AR 并且提高了细胞内部的 Ca2+([Ca2+] 我) 在人的精子,哪个被 U73122 和 U73343 堵住。这二混合物也在老鼠精子禁止了导致 MTx 的 AR。在有我们的以前的建议的争论, AR 由 rhZP3 被触发或老鼠 ZP 没被 U73343 堵住,显示在人和老鼠精子,由生理的 ligands 或由 MTx 的 AR 正式就职通过不同小径发生了。U73122,然而并非 U73343 (不活跃的类似物) ,能堵住 phospholipase C (PLC ) 。另一个 PLC 禁止者, edelfosine,也堵住了导致 rhZP3 、导致 ZP 的艺术。这些调查结果在人和老鼠带证实了一条 PLC 依赖的发信号小径的参予导致蛋白质的 AR。尤其是, edelfosine 也禁止了导致 MTx 的老鼠精子 AR 然而并非人的,建议导致毒素的 AR 在老鼠是 PLC 依赖的并且在人 PLC 独立。 | lulio C Chaivez Gerardo A de Blas Josd L de la Vega-Beltran Takuya Nishigaki Mayel Chirinos Maria Elena Gonzaez-Gonzalez Fernando Larrea Alejandra Soiis Alberto Darszon Claudia L Trevino | 2011 | Asian Journal of Andrology2011，13，1： | 1 |
| 15 | SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity outcome.Although cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral replication.We found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell apoptosis.In addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)patients.The rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung tissue.These results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host. | Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento Camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha Rodrigo T.Calado JoséC.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda | 2022 | Journal of Molecular Cell Biology2022，14，4： | 1 |
| 16 | Review of the El Soplao Amber Outcrop,Early Cretaceous of Cantabria,Spain显示文摘El Soplao 露头,最近在北西班牙(Cantabria ) 发现的早白垩纪琥珀存款,被显示了是有到目前为止在西班牙被发现了的节肢动物包括的琥珀的最大的地点。为琥珀,孢粉学, taphonomy 和那些以前出版了的节肢动物 bioinclusions 补充的 biogeochemistry 此处提供的相关数据。数据的这个集合为 El Soplao 沉积物的琥珀建议至少二植物的来源。? rst (类型 A 琥珀) 强烈支持与 Cheirolepidiaceae 有关的来源,并且第二(类型 B 琥珀) 显示出非特定的针叶树 biomarkers。有 Frenelopsis 的琥珀离开的类型(Cheirolepidiaceae ) 的分子的作文的比较强烈建议一种生物化学的亲密关系和普通植物的起源。初步的 palynologlcal 研究显示地区性的高分类的差异,主要蕨类植物孢子和裸子植物花粉谷物。根据初步的 palynologlcal 数据,这个区域由在副热带的气候下面使适应一个旱季的针叶树森林被住在。在一样的床上与琥珀联系的丰富的 charcoalified 木头是很可能加植物表皮支持了树脂生产和崽,和琥珀的随后的大累积的集中的侵蚀的 paleofires 的证据。另外,第一次在石块记录,在琥珀的 bioinclusions 被报导的 charcoalified 植物纤维。另外的相关 taphonomic 数据在两个都显示长暴露在上的一些琥珀片的表面上是 serpulids 和 bryozoans 的非凡的存在海洋或略有盐味水并且琥珀的一个混合集合。最后,昆虫 bioinclusions 的新调查结果,他们中的一些在石块记录不平常或显示出显著改编,被报导。在结论,为 El Soplao 琥珀露头的起源的一种记录情形被提供。 | María NAJARRO Enrique PENALVER Ricardo PEREZ-DE LA FUENTE Jaime ORTEGA-BLANCO Cesar MENOR-SALVAN Eduardo BARRON Carmen SORIANO Idoia ROSALES Rafael LOPEZ DEL VALLE Francisco VELASCO Fernando TORNOS Véronique DAVIERO-GOMEZ Bernard GOMEZ Xavier DELCLOS | 2010 | Acta Geologica Sinica(English Edition)2010，84，4： | 1 |
| 17 | Metabolomic Profiling for Identification of Novel Potential Biomarkers in Cardiovascular Diseases显示文摘 | Maria G. Barderas Carlos M. Laborde Maria Posada Fernando de la Cuesta Irene Zubiri Fernando Vivanco Gloria Alvarez-Llamas Mika Ala-Korpela | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 18 | High-performance liquid chromatography method using ultraviolet detection for the quantification of aripiprazole and dehydroaripiprazole in psychiatric patients显示文摘 | Pedro Dorado Fernando de Andrés María Eugenia G. Naranjo Eva M. Pe?as-Lledó Idilio González Antonio P. González Alfredo de la Rubia Adrián LLerena | 2012 | Drug Metabolism and Drug Interactions2012，，3： | 1 |
| 19 | Hypertension magnitude and management in the elderly population of Spain显示文摘 | José R Banegas Fernando Rodríguez-Artalejo Luis M Ruilope Auxiliadora Graciani Manuel Luque Juan J de la Cruz-Troca Rafael García-Robles Juan Tamargo Juan Rey-Calero | 2002 | Journal of Hypertension2002，，11： | 1 |
| 20 | Influence of Flap Prefabrication on Seeding of Subcutaneously Injected Mesenchymal Stem Cells in Microvascular Beds in Rats显示文摘 | Andrés Rodríguez-Lorenzo María C. Arufe Alexandre de la Fuente Fernando Fernandez Francisco Blanco | 2014 | Annals of Plastic Surgery2014，，2： | 1 |
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