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| 1 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 2 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 3 | Relevance between abutment pressure and fractal dimension of crack network induced by mining显示文摘Based on the geological conditions of coal mining face No.15-14120 at No.8 mine of Pingdingshan coal mining group,the real-time evolution of coal-roof crack network with working face advancing was collected with the help of intrinsically safe borehole video instrument.And according to the geology of this working face,a discrete element model was calculated by UDEC.Combining in situ experimental data with numerical results,the relationship between the fractal dimension of boreholes'wall and the distribution of advanced abutment pressure was studied under the condition of mining advance.The results show that the variation tendency of fractal dimension and the abutment pressure has the same characteristic value.The distance between working face and the peak value of the abutment pressure has a slight increasing trend with the advancing of mining-face.When the working face is set as the original point,the trend of fractal dimension from the far place to the origin can be divided into three phases:constant,steady increasing and constant.And the turning points of these phases are the max-influencing distance(50 m)and peak value(15 m)of abutment pressure. | Gao Mingzhong Jin Wencheng Dai Zhixu Xie Jing | 2013 | International Journal of Mining Science and Technology2013，23，6： | 7 |
| 4 | A Contrastive Analysis of Interpersonal Function of Public Service Advertising in English and Chinese显示文摘This paper adopts Halliday’s systemic functional grammar as the theoretical framework to make a contrastive analysis of the interpersonal meaning of Environmental Protection Public Service Advertising from the perspective of mood and modality.It is found that there are both similarities and differences in the realization of interpersonal meaning in the discourse of both English and Chinese environmental protection public service advertising.In terms of mood,both tend to use declarative,imperative,interrogative mood,among which the declarative mood is the most frequently used,while the imperative mood is the second.In the aspect of modality,the use of modal words in English environmental protection advertising language is more abundant,and it is customary to use modal words with low emotional value to realize interpersonal meaning,while Chinese advertisements prefer more modality words with high emotional value. | YANG Xiuye GAO Wencheng | 2020 | Sino-US English Teaching2020，17，3： | 2 |
| 5 | A natural allele of TAW1 contributes to high grain number and grain yield in rice显示文摘Grain number per panicle (GNP) is a complex trait controlled by quantitative trait loci (QTL),directly determining grain yield in rice.Identifying GNP-associated QTL is desirable for increasing rice yield.A rice chromosome segment substitution line (CSSL),F771,which showed increased panicle length and GNP,was identified in a set of CSSLs derived from a cross between two indica cultivars,R498 (recipient) and WY11327 (donor).Genetic analysis showed that the panicle traits in F771 were semidominant and controlled by multiple QTL.Six QTL were consistently identified by QTL-seq analysis.Among them,the major QTL q PLN10 for panicle length and GNP was localized to a 121-kb interval between markers N802 and N909 on chromosome 10.Based on quantitative real-time PCR and sequence analysis,TAWAWA1(TAW1),a known regulator of rice inflorescence architecture,was identified as the candidate gene for q PLN10.A near-isogenic line,NIL-TAW1,was developed to evaluate its effects.In comparison with the recurrent parent R498,NIL-TAW1 showed increased panicle length (14.0%),number of secondary branches (20.9%) and GNP (22.0%),and the final grain yield per plant of NIL-TAW1 was increased by18.6%.Transgenic experiments showed that an appropriate expression level of TAW1 was necessary for panicle development.Haplotype analysis suggested that the favorable F771-type (Hap 13) of TAW1was introduced from aus accessions and had great potential value in high-yield breeding both in indica and japonica varieties.Our results provide a promising genetic resource for rice grain yield improvement. | Hua Yuan Zhengyan Xu Xueqin Tan Peng Gao Mengya Jin Wencheng Song Shiguang Wang Yunhai Kang Peixiong Liu Bin Tu Yuping Wang Peng Qin Shigui Li Bingtian Ma Weilan Chen | 2021 | The Crop Journal2021，9，5： | 2 |
| 6 | Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy显示文摘The low immunogenicity of tumors remains one of the major limitations of cancer immunotherapy.Herein,we report a bacterial metabolisminitiated and photothermal-enhanced nanocatalytic therapy strategy to completely eradicate primary tumor by triggering highly effective antitumor immune responses.Briefly,a microbiotic nanomedicine,designated as Cu_(2)O@ΔSt,has been constructed by conjugating PEGylated Cu_(2)O nanoparticles on the surface of an engineered Salmonella typhimurium strain(ΔSt).Owing to the natural hypoxia tropism ofΔSt,Cu_(2)O@ΔSt could selectively colonize hypoxic solid tumors,thus minimizing the adverse effects of the bacteria on normal tis-sues.Upon bacterial metabolism within the tumor,Cu_(2)O@ΔSt generates H_(2)S gas and other acidic substances in the tumor microenvironment(TME),which will in situ trigger the sulfidation of Cu_(2)O to form CuS facilitating tumor-specific photothermal therapy(PTT)under local NIR laser irradiation on the one hand.Meanwhile,the dissolved Cu+ions from Cu_(2)O into the acidified TME enables the nanocatalytic tumor therapy by catalyzing the Fenton-like reaction of decom-posing endogenous H_(2)O_(2) into cytotoxic hydroxyl radicals(·OH)on the other hand.Such a bacterial metabolism-triggered PTT-enhanced nanocatalytic treatment could effectively destroy tumor cells and induce a massive release of tumor antigens and damage-associated molecular patterns,thereby sensitizing tumors to checkpoint blockade(ICB)therapy.The combined nanocatalytic and ICB therapy results in the much-inhibited growth of distant and metastatic tumors,and more importantly,induces a powerful immunological memory effect after the primary tumor ablation. | Wencheng Wu Yinying Pu Shuang Gao Yucui Shen Min Zhou Heliang Yao Jianlin Shi | 2022 | Nano-Micro Letters2022，14，12： | 1 |
| 7 | The Cognitive Mechanism of Humor―Based on Conceptual Blending Theory and Relevance Theory显示文摘Humor, as a form of interesting interaction, often appears in our daily life. The purpose of this paper is to explore the cognitive mechanism of humor. It is found that humor is dependent on people’s relevance and inference in their minds, and also on the conceptual blending with its emergent structure. The authors hold that these two theories are supplementary to each other;the combination has even more powerful interpretation about the workings of humor generation. | KANG Xinyu GAO Wencheng | 2019 | Sino-US English Teaching2019，16，7： | 1 |
| 8 | On Iconicity in Chinese显示文摘Iconicity principle provides a new framework for linguists to reexamine the relationship between the signifier and the signified.Apart from arbitrariness,iconicity principle also turns out to be true to some extent between form and meaning of linguistic symbols.This paper elaborates the iconicity principle in Chinese—mainly the sequencing iconicity,quantitative iconicity,symmetric iconicity,and asymmetric iconicity. | GAO Wencheng YE Tianyi | 2020 | Sino-US English Teaching2020，17，11： | 0 |
| 9 | Comparative Analysis of Two English Translations of “Moonlight Over the Lotus Pond” From the Perspective of Functional Equivalence显示文摘“Moonlight Over the Lotus Pond” is a prose written by Zhu Ziqing, a famous writer. Many famous translators have translated it into English versions, among which there are many famous works. From the perspective of functional equivalence, this article selects representative fragments to compare the versions of Wang Jiaosheng and Zhu Chunshen, and analyzes their styles and their respective advantages and disadvantages. This article makes an attempt on the review of the translation from the perspective of functional equivalence. | HAN Lu GAO Wencheng | 2023 | US-China Foreign Language2023，21，8： | 0 |
| 10 | Nearly-Resonant Two-Photon Absorption of C6o Thin Film at 633 nm显示文摘We present nieasureinents of two-pho ton absorption(TPA)coefficient of C_(60) thin Hhn at 633nm.Large values of β〜5cm/W were determined.Nearly~resona.nt TPA transition around 3.76eV absorption region was discussed. | HAN Yanong ZHANG Weijun GAO Xiaoming CUI Yiben XIA Yuxing GU Gang ZANG Wencheng DU Youwei FENG Duan | 1993 | Chinese Physics Letters1993，10，8： | 0 |
| 11 | China-EU Summit to offer certainty in uncertain time显示文摘Amid the ravaging COVID-19 pandemic, the 22nd China-EU leaders' meeting held on June 22 boosted much-needed confidence in the global fight against the virus and offered more certainty in a time of unprecedented instability. | Gao Wencheng | 2020 | 一带一路报道2020，，4： | 0 |
| 12 | Experimental Observation of Electrie Field Induced C_(60) Redistribution in Benzene Solution显示文摘We report the experimental observation of electric field induced Gso redistribution,in benzene solution by thermal blooming change of transmitted light.The pol&riz&tion of C_(60) molecules in external field is analyzed. | HAN Yanong GAO Xiaoming ZHANG Weijun DING Hongyu XIA Yuxing ZANG Wencheng GU Gang YANG Ping DU Youwei FENG Duan | 1993 | Chinese Physics Letters1993，10，11： | 0 |
| 13 | A Study of Hedges in Pride and Prejudice显示文摘Human language is fuzzy,which can be reflected by hedges.Prince has divided hedges into adaptor,rounder,plausibility shields,and attribution shields.In a dialogue,hedges can protect face of the speakers and relieve some of the speaker’s responsibilities as well as make linguistic expressions more implicit,polite,and flexible.Based on this classification,the paper analyzes some typical hedges and their functions used in the dialogues of the novel Pride and Prejudice,so as to have a deeper understanding of the major characters and the theme of the novel. | LU Yuwen GAO Wencheng | 2019 | Sino-US English Teaching2019，18，8： | 0 |
| 14 | A Comparative Study on English Child Metaphor“Gift”and Chinese Child Metaphor“Baobei”显示文摘From a perspective of cognitive linguistics,this paper systematically compares and analyzes prototypical child metaphors“gift”and“baobei”in English and Chinese.The analysis,based on corpora and etymologies,shows that English child metaphor“gift”is greatly influenced by its religious factors,while Chinese child metaphor“baobei”is mostly decided by the family value in their culture.Comprehensive explanation on cognitive motivations behind the typical metaphorical expressions provides an effective way for a comparative study of metaphors. | WU Chaoyi GAO Wencheng | 2021 | Sino-US English Teaching2021，18，2： | 0 |
| 15 | A Reliability and Validity Analysis on Vocabulary and Structure of NEPCMSS Test in 2010显示文摘Reliability and validity are two criteria to evaluate whether a test paper is successful. This paper analyzes the vocabulary and structure MCQ (Multiple Choice Question) of National English Proficiency Competition for Middle School Students (NEPCMSS) test in 2010, evaluating the reliability and content validity by using SPSS software. It is concluded that the 20 multiple choice questions are not difficult in terms of difficulty;the reliability is good but the content validity is not so satisfied. | GAO Wencheng WU Xiaohua | 2019 | Sino-US English Teaching2019，16，6： | 0 |
| 16 | Fun30 nucleosome remodeller regulates white-to-opaque switching in Candida albicans显示文摘Candida albicans(C.albicans)is an opportunistic pathogen in humans and possesses a white-opaque heritable switching system.Wor1 is a master regulator of white-opaque switching and is essential for opaque cell formation in C.albicans.However,the regulatory network of Wor1 in white-opaque switching is still vague.In this study,we obtain a series of Wor1-interacting proteins using LexA-Wor1 as bait.Among these proteins,function unknown now 30(Fun30)interacts with Wor1 in vitro and in vivo.Fun30 expression is upregulated in opaque cells at the transcriptional and protein levels.Loss of FUN30 attenuates white-to-opaque switching,while ectopic expression of FUN30 significantly increases white-to-opaque switching in an ATPase activity-dependent manner.Furthermore,FUN30 upregulation is dependent on CO_(2);loss of FLO8,a key CO_(2)-sensing transcriptional regulator,abolishes FUN30 upregulation.Interestingly,deletion of FUN30 affects the WOR1 expression regulation feedback loop.Thus,our results indicate that the chromatin remodeller Fun30 interacts with Wor1 and is required for WOR1 expression and opaque cell formation. | Ning Gao Baodi Dai Xinyi Nie Qun Zhao Wencheng Zhu Jiangye Chen | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 17 | An Empirical Study on Codeswitching of Chinese English Teachers on Tertiary Level显示文摘 | Wencheng Gao | 2005 | Sino-US English Teaching2005，2，9： | 0 |
| 18 | A Study on the English Translation of Culture-Loaded Words From the Perspective of Relevance-Theoretic Translation Theory-A Case Study of Yang Xianyi’s The True Story of Ah Q显示文摘Culture-loaded words reveal the basic features of a country’s social life,customs and habits,religious beliefs,and so on.The meanings of culture-loaded words contain the profound cultural connotation of a country or a nation.However,due to the influence of different cultures,the original author and the target readers lack a common cognitive context,which means they cannot successfully conduct a cultural communication.Therefore,correctly understanding and translating these culture-loaded words have become a major problem for translators in the translation process of literary works.Under the guidance of the dual ostensive-inferential model in relevance-theoretical translation theory,this paper,by emphasizing the importance of common cognitive context to a successful translation,analyzes the translation process of five categories of culture-loaded words and summarizes the translation strategies that can accurately convey the writing intention of the original author,which provides a new perspective for the translation of culture-loaded words. | ZHANG Jia-ni GAO Wencheng | 2023 | Sino-US English Teaching2023，20，7： | 0 |
| 19 | Negative Polarity Item “Renhe” in Chinese and “Koī” in Hindi显示文摘This paper conducts a comparative analysis of negative polarity item“renhe”in Chinese and“koī”in Hindi.In the aspect of licensing conditions,it is found that both“renhe”and“koī”can be licensed by negative sentences,yes-no interrogative sentences,A-not-A interrogative sentences,and the antecedent clause of a conditional.Both“renhe”in Chinese and“koī”in Hindi are strong negative polarity items(NPIs).NPI“renhe”can be focalized by adding“ye”or“dou”;in this case,the modified noun phrase is moved from the right to the left of the negative marker,reinforcing negative effect.NPI“koī”can also be focalized by adding a modal particle“hī”,but the modified noun phrase is not moved,with“koī(-bhī)…hī”collocation reinforcing negative effect. | GAO Xirui GAO Wencheng | 2019 | Sino-US English Teaching2019，16，11： | 0 |
| 20 | A Study of the Functional Equivalence of the Lyell’s Translation of Lu Xun’s“New Year’s Sacrifice”显示文摘In the long development process of translation science,Nida’s functional equivalence translation theory,as the core of its translation stage,is one of the very important theories in the development process of translation science.As a translation theory that was introduced earlier,domestic scholars have also done a lot of research on functional equivalence theory.In this paper,the Lyell’s translation of Mr.Lu Xun’s“New Year’s Sacrifice”is studied from three aspects:words,sentences,and chapters.Among them,it can be found that the Lyell’s translation can not only achieve the functional equivalence between the translation and the original text,but also make the translation better.And the translation can be said to be a very good model of the theory of functional equivalence in translation practice. | LI Qifan GAO Wencheng | 2023 | US-China Foreign Language2023，21，6： | 0 |
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