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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules显示文摘In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound(US), contrastenhanced US(CEUS), combined US and CEUS and magnetic resonance imaging(MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve.The pattern of contrast enhancement and related indexes regarding the time-intensity curve were used to describe the lesions, comparatively with pathological results. Histopathologic examination revealed 46 benign and 74 malignant lesions. Sensitivity, specificity, and accuracy of US in detecting malignant breast lesions were 90.14%, 95.92%, and 92.52%, respectively. Meanwhile, CE-MRI showed sensitivity, specificity, and accuracy of 88.73%, 95.92%, and91.67%, respectively. The area under the ROC curve for combined US and CEUS in discriminating benign from malignant breast lesions was 0.936, while that of MRI was 0.923, with no significant difference between them, as well as among groups. The time-intensity curve of malignant hypervascular fibroadenoma and papillary lesions mostly showed a fast-in/fast-out pattern, with no good correlation between them(kappa <0.20). In conclusion, the combined use of conventional US and CEUS displays good agreement with MRI in differentiating benign from malignant breast lesions. | Cuiying Li Haiyan Gong Lijun Ling Liwen Du Tong Su Shui Wang Jie Wang | 2018 | The Journal of Biomedical Research2018，32，3： | 27 |
| 3 | The fluidity and molding ability of glass-forming Zr-based alloy melt显示文摘The fluidity and filling ability of glass-forming Zr-based alloy melt in copper mould were investigated both theoretically and experimentally. The major factors which affected the flowing behavior of the metallic melt in the mold were determined,which provides the foundation for overcoming the contradiction between the filling and formation of amorphous alloy during the rapid cooling process of the metallic melts. The casting factors to prepare a metallic ring were discussed and selected. As a result,a Zr-based bulk metallic glass ring was prepared successfully. | MA MingZhen ZONG HaiTao WANG HaiYan QI YanPeng LIANG SunXing SONG AiJun ZHANG WeiGuo WANG Qiang ZHANG XinYu JING Qin LI Gong LIU RiPing | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，4： | 6 |
| 4 | Improving Throughput of Communication Link in IEEE 802.15.4 Based Energy-Harvesting Wireless Sensor Network显示文摘It is critical to design a reliable packet transmission scheme to improve throughput in Energy harvesting Wireless sensor network(EH-WSN)or Battery free Wireless sensor network(BF-WSN).We present the Optimal size and rate(OSR)scheme to improve throughput of communication links in the IEEE 802.15.4 based BF-WSN that harvests radio frequency energy.Based on the defined truncated geometrical distribution,we formulate the optimization problem that maximizes the effective throughput of communication link.The solution of the optimization problem yields the optimal triple,namely the optimal packet size,data rate,and Maximum number of transmission trials(MNTT),which is used in the OSR so that throughput is considerably improved.Simulation results show the OSR scheme can improve throughput. | BAI Nana GONG Siliang SHI Haiyan CHENG Zhen ZHU Yihua | 2019 | Chinese Journal of Electronics2019，28，4： | 4 |
| 5 | An infrastructure with user-centered presentation data model for integrated management of materials data and services显示文摘With scientific research in materials science becoming more data intensive and collaborative after the announcement of the Materials Genome Initiative,the need for modern data infrastructures that facilitate the sharing of materials data and analysis tools is compelling in the materials community.In this paper,we describe the challenges of developing such infrastructure and introduce an emerging architecture with high usability.We call this architecture the Materials Genome Engineering Databases(MGED).MGED provides cloud-hosted services with features to simplify the process of collecting datasets from diverse data providers,unify data representation forms with user-centered presentation data model,and accelerate data discovery with advanced search capabilities.MGED also provides a standard service management framework to enable finding and sharing of tools for analyzing and processing data.We describe MGED’s design,current status,and how MGED supports integrated management of shared data and services. | Shilong Liu Yanjing Su Haiqing Yin Dawei Zhang Jie He Haiyou Huang Xue Jiang Xuan Wang Haiyan Gong Zhuang Li Hao Xiu Jiawang Wan Xiaotong Zhang | 2021 | npj Computational Materials2021，，1： | 4 |
| 6 | High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer’s disease mice显示文摘Accumulating evidence indicates the critical importance of cerebrovascular dysfunction in the pathogenesis of Alzheimer’s disease(AD).However,systematic comparative studies on the precise brain vasculature of wild-type and AD model mice are still rare.Using an image-optimization method for analysing Micro-Optical Sectioning Tomography(MOST)data,we generated cross-scale whole-brain 3 D atlases that cover the entire vascular system from large vessels down to smallest capillaries at submicron resolution,for both wild-type mice and a transgenic(APP/PS1)mouse model of AD.In addition to distinct vascular patterns in different brain regions,we found that the main vessels of the molecular layer of the hippocampal dentate gyrus(DG-ml)undergo abrupt changes in both diameter and branch angle,spreading a unique comb-like pattern of capillaries.By using a quantitative analysis workflow,we identified in the hippocampus of AD mice an overall reduction of the mean vascular diameter,volume fraction and branch angle,with most significant impairment in the DG-ml.In addition,virtual endoscopy revealed irregular morphological features in the vessel lumen of the AD mice,potentially contributing to the impairment of blood flow.Our results demonstrate the capability of high-resolution cross-scale evaluation of brain vasculature and underscore the importance of studying hippocampal microcirculation for understanding AD pathogenesis. | Xiaochuan Zhang Xianzhen Yin Jingjing Zhang Anan Li Hui Gong Qingming Luo Haiyan Zhang Zhaobing Gao Hualiang Jiang | 2019 | National Science Review2019，6，6： | 4 |
| 7 | Adoptively transferred donor IL-17-producing CD4^(+) T cells augment, but IL-17 alleviates, acute graft-versus-host disease显示文摘The role of IL-17 and IL-17-producing CD4^(+) T cells in acute graft-versus-host disease(GVHD)has been controversial in recent mouse and human studies.We carried out studies in a murine acute GVHD model of fully major histocompatibility complex-mismatched myeloablative bone marrow transplantation.We showed that donor wild-type CD4^(+) T cells exacerbated acute GVHD compared with IL-17−/−CD4^(+) T cells,while IL-17 reduced the severity of acute GVHD.The augmentation of acute GVHD by transferred donor IL-17-producing CD4^(+) T cells was associated with increased Th1 responses,while IL-17 decreased the percentages of Th1 cells in the GVHD target organs.Furthermore,IL-17 reduced the infiltration of macrophages into the GVHD tissues.In vitro study showed that IL-17 could downregulate Th1 responses,possibly through inhibiting IL-12 production by donor macrophages.Depletion of macrophages in vivo diminished the protective effect of IL-17.Our results demonstrated the differential roles of adoptively transferred donor IL-17-producing CD4^(+) T cells and IL-17 in the same acute GVHD model. | Yifeng Cai Shoubao Ma Yuejun Liu Huanle Gong Qiao Cheng Bo Hu Yan Wu Xiao Yu Chen Dong Kai Sun Depei Wu Haiyan Liu | 2018 | Cellular & Molecular Immunology2018，15，3： | 3 |
| 8 | Epidemiology of toxoplasmosis: role of the tick Haemaphysalis longicornis显示文摘Background:Toxoplasma gondii infection is mainly caused by ingestion of water or food that is contaminated with oocysts excreted by cats,or by eating raw meat containing T.gondii tissue cysts.However,oral transmission does not explain the common occurrence of toxoplasmosis in a variety of hosts,such as herbivorous animals,birds,and wild rodents.Little information exists on the maintenance of T.gondii parasites in nature and routes of transmission to domestic and wild animal hosts.Therefore,this study evaluated the role of Haemaphysalis longicornis ticks in the epidemiology of toxoplasmosis.Methods:The real-time polymerase chain reaction(qPCR)technique was used to detect the presence of T.gondii DNA in ticks collected from the field.To observe the amount of dynamic changes of T.gondii in the tick’s body and its infectivity,microinjection of green fluorescence parasites was performed.Under laboratory conditions,we evaluated if H.longicornis ticks were infected with T.gondii and their potential to transmit the infection to other hosts using traditional parasitological methods coupled with molecular detection techniques.Results:The infection rates of T.gondii parasites among field-collected adult and nymph H.longicornis ticks were 11.26%and 5.95%,respectively.T.gondii can survive and remain infective in a tick’s body for at least 15 days.We found that blood feeding of infected ticks did not transmit T.gondii to hosts,however,ingestion of infected ticks may be a transmission route between ticks and other common hosts.Conclusion:The T.gondii infection in ticks could serve as a reservoir for toxoplasmosis transmission. | Yongzhi Zhou Houshuang Zhang Jie Cao Haiyan Gong Jinlin Zhou | 2016 | Infectious Diseases of Poverty2016，5，1： | 3 |
| 9 | Comparison of Viromes in Ticks from Different Domestic Animals in China显示文摘Ticks are involved in the transmission of various arboviruses and some tick-borne viruses pose significant threats to the health of humans or livestock.This study aimed to investigate the geographical distribution of tick species and tickassociated viruses in central and eastern China.Total 573 ticks from domestic animals including dogs,sheep and cattle were collected in 2017.Two genera of ticks were identified including Rhipicephalus and Haemaphysalis.Sequencing was performed on Miseq Illumina platform to characterize the tick viromes from the four different sampling locations.Following trimming,13,640 reads were obtained and annotated to 19 virus families.From these sequences,above 37.74%of the viral reads were related to the RNA viruses.Virome comparison study revealed that the tick viral diversity was considerably different in the two identified tick genera.The viral diversity of R.microplus was significantly different from that of other Rhipicephalus species.On the other hand,substantial overlap in viral species was observed between the same genera.In addition,we found no evidence that the natural host played a major role in shaping virus diversity based on the comparison of their viromes.Rather,the geographic location seems to significantly influence the viral families.Phylogenetic study indicated that the novel negative-sense RNA viruses identified in this study was closely related to Bole tick virus 1 and 3 viruses.In conclusion,the present study provides a baseline for comparing viruses detected in ticks,according to species,natural hosts,and geographic locations. | Tingting Zhao Haiyan Gong Xiaojuan Shen Wen Zhang Tongling Shan Xiangqian Yu Seong Jin Wang Li Cui | 2020 | Virologica Sinica2020，35，4： | 2 |
| 10 | The S 1P, receptor-selective agonist CYM-5442 reduces the severity of acute GVHD byinhibiting macrophage recruitment显示文摘FTY720,为五已知的 sphingosine-1-phosphate (S1P ) 中的四个的收缩筋受体,被报导了禁止尖锐 graft-versus-host 疾病(aGVHD ) 。因为 FTY720 通过多重 S1P 受体工作,通过至少一这些受体的行动的机制可以说明它的副作用。因此,更选择的 S1P 受体调节的人被需要评估不同 S1P 受体和他们的治疗学的功效的角色。在这研究,我们调查了 S1P 1-selective 收缩筋的效果, CYM-5442,在 aGVHD 的前进上。我们显示出显著地禁止的那 CYM-5442 但是没阻止 aGVHD。CYM-5442 没影响施主 T 细胞的渗入进目标器官,当在 GVHD 器官的巨噬细胞的数字被 CYM-5442 处理显著地减少时。在 vivo 增长,试金证明巨噬细胞的增长没被 CYM-5442 压制。用人的 endothelial 房间的进一步的研究在 endothelial 房间表明了那 CYM-5442 处理 downregulated CCL2 和 CCL7 表情,因此减少单核白血球,从纸巾,巨噬细胞发源的迁居。我们的数据在 aGVHD 和它行动的可能的机制表明 S1P 1-selective 收缩筋的治疗学的功效。结果建议进一步的调查为 aGVHD 作为潜在的治疗学的政体关于 CYM-5442 被需要。 | Qiao Cheng Shoubao Ma Dandan Lin Yu Mei Huanle Gong Lei Lei Yuanyuan Chen Ye Zhao Bo Hut Yan Wu Xiao Yu Lixiang Zhao Haiyan Liu | 2015 | Cellular & Molecular Immunology2015，12，6： | 2 |
| 11 | Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing显示文摘Diabetes mellitus,an epidemic with a rapidly increasing number of patients,always leads to delayed wound healing associated with consistent pro-inflammatory M1 polarization,decreased angiogenesis and increased reactive oxygen species(ROS)in the microenvironment.Herein,a poly(lactic-co-glycolic acid)(PLGA)-based microneedle patch loaded with magnesium hydride(MgH_(2))(MN-MgH_(2))is manufactured for defeating diabetic wounds.The application of microneedle patch contributes to the transdermal delivery and the prolonged release of MgH_(2) that can generate hydrogen(H_(2))and magnesium ions(Mg^(2+))after reaction with body fluids.The released H_(2) reduces the production of ROS,transforming the pathological microenvironment induced by diabetes mellitus.Meanwhile,the released Mg^(2+)promotes the polarization of pro-healing M2 macrophages.Consequently,cell proliferation and migration are improved,and angiogenesis and tissue regeneration are enhanced.Such intelligent microneedle patch provides a novel way for accelerating wound healing through steadily preserving and releasing of H_(2) and Mg^(2+)locally and sustainably. | Pei Wang Jiayingzi Wu Haiyan Yang Hengke Liu Tianyu Yao Chang Liu Yan Gong Mingsong Wang Guangyu Ji Peng Huang Xiansong Wang | 2023 | Bioactive Materials2023，，6： | 2 |
| 12 | Preparation of superhydrophobic silica film on Mg–Nd–Zn–Zr magnesium alloy with enhanced corrosion resistance by combining micro-arc oxidation and sol–gel method显示文摘 | Shaohua Wang Xingwu Guo Yijun Xie Lihua Liu Haiyan Yang Rongyu Zhu Jia Gong Liming Peng Wenjiang Ding | 2012 | Surface & Coatings Technology2012，，： | 2 |
| 13 | A multi-epitope vaccine based on Chlamydia trachomatis major outer membrane protein induces specific immunity in mice显示文摘我们评估了包括主要的外部膜蛋白质(MOMP ) 的一支候选人疫苗的 immunogenicity 和功效 multi-epitopeof Chlamydia trachomatis。从包含多重 T 房间和 B 房间 epitopes 的 MOMP 导出的 multi-epitope 的短基因是人工地,包含 codon 的 synthesized.The recombinant plasmid pET32a (+) 优化了 MOMP multi-epitope 基因被构造。在 Escherichia coli 的 fusionprotein Trx-His-MOMP multi-epitope 的表示被钠 dodecyl sulfatepolyacrylamide 胶化电气泳动和西方的污点分析证实。Balb/c 老鼠是 inoculatedwith 皮下地,三与 2 星期的间隔预定的净化的熔化蛋白质。结果出现了 MOMP multi-epitopeelicited 不仅对 C 的强壮的体液的有免疫力的回答。由显著地产生特定的抗体(IgG1 和 IgG2a ) 的高水平的 trachomatis,而且由 inducingrobust 的细胞的有免疫力的回答在老鼠的细胞毒素的 T 淋巴细胞回答。而且, MOMP multi-epitope 实质地告知 IFN- 的分泌物,表明这支疫苗能导致强壮的 Th1 回答。最后,老鼠与 C 的 MOMP multi-epitope displayeda 减小种牛痘。在 chlamydial 挑战和感染的 C 的一个加速的清理之上流的 trachomatis。trachomatis。在结论, MOMP multi-epitope 疫苗可以对 C 为有效预防 andtherapeutic 疫苗的发展有潜力。trachomatis 感染。 | Jianxin Tu B ailong Hou Bingbing Wang Xiaoyun Lin Wenci Gong Haiyan Dong Shanli Zhu Shao Chen Xiangyang Xue Kong-Nan Zhao Lifang Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 1 |
| 14 | Characterization of an intracellular cystatin homolog from the tick Haemaphysalis longicornis显示文摘 | Jinlin Zhou Min Liao Mami Ueda Haiyan Gong Xuenan Xuan Kozo Fujisaki | 2008 | Veterinary Parasitology2008，，1： | 1 |
| 15 | Isolation and characterization of the GbVIP1 gene and response to Verticillium wilt in cotton and tobacco显示文摘Background: Verticillium wilt is a serious soil-borne vascular disease that causes major losses to upland cotton(Gossypium hirutum L.) worldwidely every year. The protein VIP1(VirE2 interaction protein 1), a bZIP transcription factor, is involved in plant response to many stress conditions, especially pathogenic bacteria. However, its roles in cotton response to Verticillium wilt are poorly understood.Results: The GbVIP1 gene was cloned from resistant sea-island cotton(G. barbadense) cv. Hai 7124. Expression of GbVIP1 was up-regulated by inoculation with Verticillium dahliae and exogenous treatment with ethylene. Results of virus-induced gene silencing suggested that silencing of GbVIP1 weakened cotton resistance to Verticillium wilt. The heterologous expression of GbVIP1 in tobacco showed enhanced resistance to Verticillium wilt. The PR1, PR1-like and HSP70 genes were up-regulated in GbVIP1 transgenic tobacco after Verticillium wilt infection.Conclusion: Our results suggested that GbVIP1 increased plant resistance to Verticillium wilt through up-regulating expressions of PR1, PR1-like, and HSP70. These results provide new approaches to improving resistance to Verticillium wilt in upland cotton and also have great potential for disease-resistance breeding of cotton. | ZHANG Kai ZHAO Pei WANG Hongmei ZHAO Yunlei CHEN Wei GONG Haiyan SANG Xiaohui CUI Yanli | 2018 | Journal of Cotton Research2018，1，4： | 1 |
| 16 | Mo- lecular self-assembly of surfactant-like peptides to form nanotubes and nanovesicles显示文摘 | Sylvain Vauthey Steve Santoso Haiyan Gong | 2002 | PNAS2002，99，8： | 1 |
| 17 | Binuclear Aluminum Complexes Supported by Linked Bis(β-diketiminate) Ligands for Ring-Opening Polymerization of Cyclic Esters显示文摘Binuclear aluminum alkyl complexes 2a–4g supported by linked bis(β-diketiminate) ligands were synthesized via the reaction of AlEt_3 or AlMe_3 and the corresponding proligand in a 2:1 molar ratio with moderate yields. The isolated complexes were well-characterized by ~1H-NMR, ^(13)C-NMR and elemental analysis. The binuclear nature of aluminum complex 2b was further confirmed by an X-ray diffraction study. All complexes 2a–4g could efficiently initiate the ring-opening polymerization(ROP) of ε-caprolactone in toluene. The substituents at the aromatic rings and the linker unit in the auxiliary ligands exerted significant influence on the catalytic behavior of the investigated aluminum complexes. Complex 4g(R^1 = R^2 = Cl) containing propylenyl bridging unit exhibited the highest catalytic activity among these complexes, which might be attributed to the increased electrophilicity of the metal center as well as more opened coordination sphere. The molecular weights of obtained poly(ε-caprolactone)s deviating considerably from the theoretical values indicated that the ROP of ε-caprolactone by complexes 2a–4g was not well-controlled, which was also judged from the broad molecular weight distributions(MWD = 1.47-2.47) of produced poly(ε-caprolactone)s. These complexes proved to be inactive toward the polymerization of rac-lactide alone. In the presence of alcohol the polymerization occurred, which was actually initiated by the decomposition species of the aluminum complex upon the treatment with isopropanol. | Shaogang Gong Peng Du Haiyan Ma | 2018 | Chinese Journal of Polymer Science2018，36，2： | 1 |
| 18 | Development of transgenic zebrafish for ornamental and bioreactor by strong expression of fluorescent proteins in the skeletal muscle显示文摘 | Wan Haiyan Tuan Leng Tay | 2003 | Biochemical and Biophysical Research Communications2003，308，： | 1 |
| 19 | Effects of synthesis conditions on the morphology of hydroxyapatite nanoparticles produced by wet chemical process显示文摘 | Peipei Wang Caihong Li Haiyan Gong Xuerong Jiang Hongqiang Wang Kaixing Li | 2010 | Powder Technology2010，，2： | 1 |
| 20 | Thermogravimetric analysis of co-combustion of biomass and biochar显示文摘 | Qiguo Yi Fangjie Qi Gong Cheng Yongguang Zhang Bo Xiao Zhiquan Hu Shiming Liu Haiyan Cai Shan Xu | 2013 | Journal of Thermal Analysis and Calorimetry2013，，3： | 1 |
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