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| 1 | Advances in the Pathogenesis of Alzheimer’s Disease:Focusing on Tau-Mediated Neurodegeneration显示文摘In addition to senile plaques and cerebral amyloid angiopathy,the hyperphosphorylation of tau protein and formation of intraneuronal neurofibrillary tangles(NFTs)represents another neuropathological hallmark in AD brain.Tau is a microtubule-associated protein and localizes predominantly in the axons of neurons with the primary function in maintaining microtubules stability.When the balance between tau phosphorylation and dephosphorylation is changed in favor of the former,tau is hyperphosphorylated and the level of the free tau fractions elevated.The hyperphosphorylation of tau protein and formation of NFTs represent a characteristic neuropathological feature in AD brain.We have discussed the role of Aβin AD in our previous review,this review focused on the recent advances in tau-mediated AD pathology,mainly including tau hyperphosphorylation,propagation of tau pathology and the relationship between tau and Aβ. | Yale Duan Suzhen Dong Feng Gu Yinghe Hu Zheng Zhao | 2012 | Translational Neurodegeneration2012，1，1： | 15 |
| 2 | Dynamics of firing patterns,synchronization and resonances in neuronal electrical activities:experiments and analysis显示文摘在 neuronal 的动力学的试验性、理论的学习的最近的进展电的开火活动被考察。第一, neuronal 的一些试验性的现象不规则的开火模式,特别混乱、随机的开火的模式,被介绍,并且实际非线性的时间分析方法被介绍及时区分确定、随机的机制系列。第二,也就是,在一个单个神经原的电的开火的活动的动力学被担心为为发射模式的转变的各种各样的爆炸模式,一个参数或二参数的分叉分析的分类和机制的快慢动力学分析,和发射活动的随机的动力学(随机并且连贯回声,多重的整数和另外的开火的模式由噪音导致了,等等)。第三,有电、化学的触处的联合神经原的同步的不同类型被讨论。因为噪音和时间延期在神经系统是不可避免的,它被发现延期可以导致或提高发射联合神经原的模式的同步和变化的那噪音和时间。在联合 neuronal 网络的导致噪音的回声和空间与时间的模式也被表明。最后,一些前景为未来研究被介绍。在后果,非线性的动力学的想法和方法具有在动态进程的探索和神经系统的生理的函数的大意义。 | Qishao Lu Huaguang Gu Zhuoqin Yang Xia Shi Lixia Duan Yanhong Zheng | 2008 | Acta Mechanica Sinica2008，24，6： | 14 |
| 3 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 4 | Geological and Geochemical Constraints on the Newly Discovered Yangchongli Gold Deposit in Tongling Region, Lower Yangtze Metallogenic Belt显示文摘The newly discovered Yangchongli gold deposit is a unique independent gold deposit in the Tongling ore-cluster region controlled by the tectonic alteration firstly discovered in the Lower Yangtze Metallogenic Belt(LYMB). The host magmatic rocks mainly consist of monzodiorite and K-feldspar granite. The LA-ICP-MS U-Pb zircons dating yielded weighted mean ^(206)Pb/^(238)U ages of 140.7 ± 1.8 Ma and 126.4 ± 1.2 Ma for the monzodiorite and K-feldspar granite, respectively. Monzodiorites are enriched in Sr, Ba, Rb, and depleted in Y, Yb with high Sr/Y and La/Yb ratios, similar to the geochemical features of adakite, considered as products of differentiation of mafic magmas originating from lithospheric mantle melt/fluids caused by metasomatism during paleo-Pacific Plate subduction in the Mesozic. In contrast, the compositions of K-feldspar granites are A-type granites, indicating an extensional tectonic background. Gold ores hosted in the fracture zone occurred as quartz vein within cataclastic rock. Sulfur and lead isotopes from pyrites show crust-mantle mixing characteristics. Metal components from strata also took part in the gold mineralization, and resulted from two episodes of magmatism that were probably related to tectonic transition from a compressive to an extensional setting between 140–126 Ma, which led to the Mesozoic large-scale polymetallic mineralization events in eastern China. | DUAN Liu'an GU Huangling YANG Xiaoyong | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 11 |
| 5 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 6 | Basic performance of BeiDou-2 navigation satellite system used in LEO satellites precise orbit determination显示文摘The visibility for low earth orbit(LEO) satellites provided by the BeiDou-2 system is analyzed and compared with the global positioning system(GPS). In addition, the spaceborne receivers' observations are simulated by the BeiDou satellites broadcast ephemeris and LEO satellites orbits. The precise orbit determination(POD) results show that the along-track component accuracy is much better over the service area than the non-service area, while the accuracy of the other two directions keeps at the same level over different areas. However, the 3-dimensional(3D) accuracy over the two areas shows almost no difference. Only taking into consideration the observation noise and navigation satellite ephemeris errors, the 3D accuracy of the POD is about30 cm. As for the precise relative orbit determination(PROD), the 3D accuracy is much better over the eastern hemisphere than that of the western hemisphere. The baseline length accuracy is 3.4 mm over the service area, and it is still better than 1 cm over the non-service area. This paper demonstrates that the BeiDou regional constellation could provide global service to LEO satellites for the POD and the PROD. Finally, the benefit of geostationary earth orbit(GEO) satellites is illustrated for POD. | Liu Junhong Gu Defeng Ju Bing Yao Jing Duan Xiaojun Yi Dongyun | 2014 | Chinese Journal of Aeronautics2014，27，5： | 9 |
| 7 | Effect of elevated total cholesterol level and hypertension on the risk of fatal cardiovascular disease: a cohort study of Chinese steelworkers显示文摘增加的血压和提高的全部的胆固醇( TC )铺平的背景在 world.Hypertension 和血胆脂醇过多是心血管的疾病( CVD )的二个很重要的可修改的风险因素比的更经常共存将被期望并且是否在提高的 TC 和高血压需要之间的致命的 CVD 上有 synergistic 影响是进一步在我们进行了的中国 population.Methods 检验了招募了男 steelworkers 变老的 5092 中国人的队研究在 1974-1980 的 18-74 | YANG Ying LI Jian-xin CHEN Ji-chun CAO Jie LU Xiang-feng CHEN Shu-feng WU Xi-gui DUAN Xiu-fang MO Xing-bo GU Dong-feng | 2011 | Chinese Medical Journal2011，，22： | 8 |
| 8 | Surgical treatment of brachiocephalic vessel involvement in Takayasu's arteritis显示文摘背景 Takayasu 的动脉炎(TA ) 是影响大、中等的尺寸动脉的长期的自发的煽动性的疾病。brachiocephalic 箱子是在 TA 的最经常深奥的地点,并且多容器损害是普通的。外科的治疗包括容器重建外科和经皮的 transluminal angioplasty (PTA ) 。此处,我们与颈的动脉的损害从 2000 年 1 月由于 TA.Methods 引起到 2007 年 12 月的服的局部缺血的外科的治疗报导我们的初步的经验,有颈的动脉的闭塞的损害由于 TA 引起的服的局部缺血的 38 个病人通过手术被对待。有三男性和 35 女性,与 15-42 年(平均数 26.5 年) 的一个年龄范围。所有病人把起作用的修理承担。接待的 28 个病人绕过手术和 10 个病人收到的经皮的 transluminal angioplasty。有冠的狭窄的一个案例收到了冠的动脉同时绕过。病人们被跟随在上面为到八 years.Results 的 11 个月,在脑血管的重建病人没有仙子起作用的死亡。服的局部缺血的症状在 38 个病人中的 25 个被改进或治好。有服的灌注症候群的低发生。二个病人由于心失败在外科以后在五和七年死了。另一要求的 8 个病人(20%) 为狭窄(5 个病人) 或 anastomotic 动脉瘤(3 个病人) 推进外科。经皮的 transluminal angioplasty 为大动脉、肾的损害的治疗成功地被执行。当服的灌注有潜力被 TA 影响时,为 revascularization 的重复 angioplasty 在 5-24 months.Conclusions 以后与狭窄在六个 PTA 盒子中被执行,当病人是相对稳定的时,一个权威的校正过程被劝告。尽管复发率很高,经皮的 transluminal angioplasty 是第一个选择过程。绕过操作为在 TA 的 brachiocephalic 容器参与是最佳的。服的灌注症候群能被操作方法的小心的选择避免并且改进了手术后的治疗。 | WU Xin DUAN Hong-yong GU Yong-quan LI Jian-xin CHEN Bing WANG Zhong-gao ZHANG Jian | 2010 | Chinese Medical Journal2010，，9： | 8 |
| 9 | The Effect of Total Cholesterol on Myocardial Infarction in Chinese Male Hypertension Population显示文摘Objective Total cholesterol(TC)is an important risk factor for myocardial infarction(MI),but the effect of TC on MI in Chinese male hypertension population has not been well documented.We conducted a prospective cohort study to determine the incidence and relative risk for MI across a wide range of TC levels in Chinese male hypertension population.Methods A cohort of 5 298 male employees aged 18-74 years recruited from Capital Steel and Iron Company in Beijing of China in 1974-1980 was followed up for an average of 20.84 years.A total of 122 incident MI cases were identified during the period of follow-up.Results The incidence of MI among participants with elevated TC and those with desirable TC in male non-hypertension population was 137.20 and 63.81 per 100 000 person-years,respectively and the corresponding incidence in male hypertension population was 279.80 and 130.96 per 100 000 person-years,respectively.After adjustment for important covariables,10.38%,16.71%,and 23.80% of MI cases were attributable to hypertension,elevated TC,and hypertension plus elevated TC,respectively.In male hypertension population,the multivariate adjusted hazard ratios of MI were 1.21,2.39,3.38,and 3.95 for participants with TC level of 5.17-5.68,5.69-6.20,6.21-6.71,and ≥6.72 mmol/L,compared with those with TC<5.17 mmol/L.The corresponding population attributable risks were 2.92%,9.20%,8.87%,and 9.84%,respectively.Conclusion Elevated TC is an important independent risk factor of MI both in male non-hypertension and hypertension populations.There is a linear association between TC level and MI incidence in Chinese male hypertension population. | JIAN-XIN LI JIE CAO XIANG-FENG LU SHU-FENG CHEN DA-HAI YU XIU-FANG DUAN XI-GUI WU DONG-FENG GU | 2010 | Biomedical and Environmental Sciences2010，23，1： | 8 |
| 10 | Do online reviews matter? — An empirical investigation of panel data显示文摘 | Wenjing Duan Bin Gu Andrew B. Whinston | 2008 | Decision Support Systems2008，，4： | 8 |
| 11 | Power electronic transformer with adaptive PLL technique for voltage-disturbance ride through显示文摘The power electronic transformer(PET) has recently emerged as a type of power converter. It features the basic functions of power conversion and isolation as well as additional functions related to power quality control. A novel PET for a distribution grid called a flexible power distribution unit is proposed in this paper, and the energy exchange mechanism between the network and the load is revealed. A 30 kW 600 VAC/220 VAC/110 VDC medium-frequency isolated prototype is developed and demonstrated. This paper also presents key control strategies of the PET for electrical distribution grid applications,especially under grid voltage disturbance conditions.Moreover, stability issues related to the grid-connected three-phase PET are discussed and verified with an impedance-based analysis. The PET prototype is tested, and it passes the voltage-disturbance ride-through function. The experimental results verify the power quality control abilities of the PET. | Jianhua WANG Fangfang LUO Qing DUAN Zhendong JI Binshi GU Jun YOU Wei GU Jianfeng ZHAO | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，5： | 7 |
| 12 | Inhibiting collagen Ⅰ production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles显示文摘The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells. | Yan Yan Cancan Du Xixi Duan Xiaohan Yao Jiajia Wan Ziming Jiang Zhongyu Qin Wenqing Li Longze Pan Zhuoyu Gu Fazhan Wang Ming Wang Zhihai Qin | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 7 |
| 13 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044s96xqxvcoxofk6cpq.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 14 | Monte Carlo simulation based on Geant4 of single event upset induced by heavy ions显示文摘The present work is a computational simulation of single event upset(SEU) induced by heavy ions passing through the device with Geant4-tool based on Monte Carlo transport code.Key parameters affecting SEU occurrence are examined,and related geometrical construction and critical charge are quantified.The MUlti-Functional Package for SEU Analysis(MUFPSA) has been successfully programmed and applied for SEU occurrence after the completion of device geometrical construction,critical charge,and SEU cross section calculation.The proposed MUFPSA has yielded a good agreement with MRED.Specifically,the results show that higher LET incident ions lead to increased SEU vulnerability due to more diffusion and higher energy deposition.In addition,the analytical method of radial ionization profile provides a good complementary interpretation. | GENG Chao LIU Jie ZHANG ZhanGang HOU MingDong SUN YouMei XI Kai GU Song DUAN JingLai YAO HuiJun MO Dan LUO Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 6 |
| 15 | A New Cytotoxic Compound from Penicillium auratiogriseum, Symbiotic or Epiphytic Fungus of Sponge Mycale plumose显示文摘A new compound, (S)-2, 4-dihydroxy-1-butyl (4-hydroxy) benzoate (1), and a known compound, fructigenines A (2), were isolated from fungus Penicillium auratiogriseum derived from sponge Mycale plumose, by bioassay-guided fractionation. Their structures were established by spectroscopic and chemical methods. Both compounds showed cytotoxic activity against tsFT210 cells. | Zhi Hong XIN Wei Ming ZHU Qian Qun GU Yu Chun FANG Lin DUAN Cheng Bin CUI | 2005 | Chinese Chemical Letters2005，16，9： | 6 |
| 16 | Genetic and Antibiotic Resistance Characteristics ofCampylobacterjejuni Isolated from Diarrheal Patients,Poultry and Cattle in Shenzhen显示文摘Objective To investigate genetic and antibiotic resistance characteristics of Campylobacter jejuni(C. jejuni) isolated from Shenzhen. Methods Multilocs sequence typing and agar dilution methods were used to define the genotype and antibiotic resistance of C. jejuni, respectively. Results In total, 126 C. jejuni strains were isolated. The prevalence of C. jejuni was 5.3% in diarrheal patients. The prevalence in poultry meat(36.5%) was higher than that in cattle meat(1.1%). However, the prevalence in poultry cloacal swabs(27.0%) was lower than that in cattle stool(57.3%). Sixty-two sequence types were obtained, among which 27 of the STs and 10 alleles were previously unreported. The most frequently observed clonal complexes were ST-21(11.9%), ST-22(10.3%), and ST-403(7.1%). ST-21, ST-45, ST-354, ST-403, and ST-443 complexes overlapped between isolates from patients and cattle, whereas ST-45 and ST-574 complexes overlapped between isolates from patients and poultry. All C. jejuni were resistant to at least one antibiotic. The highest resistance rate was toward ciprofloxacin(89.7%), followed by tetracycline(74.6%), and nalidixic acid(69.0%). Conclusion This is the first report of the genotypes and antibiotic resistance of C. jejuni in Shenzhen. Overlapping clonal complexes were found between isolates from patients and cattle, and between patients and poultry. | JU Chang Yan ZHANG Mao Jun MA Yan Ping LU Jing Rang YU Mu Hua CHEN Hui LIU Chu Yun GU Yi Xin FU Yan Yan DUAN Yong Xiang | 2018 | Biomedical and Environmental Sciences2018，31，8： | 5 |
| 17 | Surface Modification of Polyamide66 Fabric by Grafting with Vinyltrimethoxysilane显示文摘 | WANG Aijuan DUAN Yuzhe GU Xiaoyu ZHANG Sheng ZANG Wenhui | 2017 | Chemical Research in Chinese Universities2017，33，3： | 5 |
| 18 | In vitro effects of sodium hyaluronate on the proliferation and the apoptosis in chondrocytes from patients with Kashin-Beck disease and osteoarthritis显示文摘Objective:To identify the in vitro effects of sodium hyaluronate(HA) on the proliferation and the apoptosis of chondrocytes from patients with Kashin-Beck disease(KBD) and osteoarthritis(OA). Methods:Samples of articular cartilages from KBD and OA patients, as well as healthy volunteers(6 subjects in each of the 3 groups) were dissected, digested with collagenase and the cells cultured in monolayers. Chondrocytes from each sample were assigned to an untreated group and two HA-treated groups: H0(no HA), H100(HA, 0.1 g/L) and H500(HA, 0.5 g/L). The first passage chondrocytes were used to observe proliferation using the MTT assay, and apoptosis by flow cytometry through Annexin V/PI staining. Results:HA promoted proliferation of chondrocytes in all the three groups, and in KBD and OA groups, for cells cultured for 4 and 6 days, H500 significantly promoted the cell proliferation. The apoptotic rates of both KBD and OA group chondrocytes were in the order H500 < HA100 < H0. Conclusion:Sodium hyaluronate administration has a dose-dependent in vitro effect to promote proliferation and inhibit apoptosis of chondrocytes from patients with KBD and OA. | Zongqiang Gao Xiong Guo Chen Duan Weijuan Ma Peng Xu Ruiyu Liu Qisheng Gu Junchang Chen | 2009 | Journal of Nanjing Medical University2009，23，2： | 5 |
| 19 | An enhanced hybrid and adaptive meta-model based global optimization algorithm for engineering optimization problems显示文摘由于在高效率和精确性之间的好平衡,元模型基于优化算法是一个重要全球优化范畴并且广泛地被使用了。更好解决高度非线性并且集中的工程优化问题,一个提高的混血儿和适应元模型基于的计算全球优化(电子火腿) 首先在这个工作被建议。重要区域更改方法(IRU ) 和不同采样尺寸策略在优化方法被建议提高表演。由使用自动、可伸缩的策略,重要区域将根据搜索结果适应地被更新改进产生精确和集中率。不平的采样策略和集中的采样策略在优化的不同阶段被使用高效地改进搜索并且避免过早地在一个小设计空格聚在一起的结果。新优化算法的有效性被与不同变量凳子标记优化问题作比较到六个优化方法验证。电子火腿优化方法然后被使用优化实际否定泊松比率(NPR ) 的设计参数在这个工作的碰撞盒子。结果显示建议电子火腿在优化计算有高精确性和效率集中的问题和罐头广泛地在设计工业被使用。 | ZHOU Guan DUAN LiBin ZHAO WanZhong WANG ChunYan MA ZhengDong GU JiChao | 2016 | Science China(Technological Sciences)2016，59，8： | 4 |
| 20 | Bamboo charcoal enhances cellulase and urease activities during chicken manure composting:Roles of the bacterial community and metabolic functions显示文摘Microbial enzymes are crucial for material biotransformation during the composting process.In this study,we investigated the effects of adding bamboo charcoal(BC)(i.e.,at 5%,10%,and 20%corresponding to BC5,BC10,and BC20,respectively)on the enzyme activity levels during chicken manure composting.The results showed that BC10 could increase the cellulose and urease activities by 56%and 96%,respectively.The bacterial community structure in BC10 differed from those in the other treatments,and Luteivirga,Lactobacillus,Paenalcaligenes,Ulvibacter,Bacillus,Facklamia,Pelagibacterium,Sporosarcina,Cellvibrio,and Corynebacterium had the most important roles in composting.Compared with other treatments,BC10 significantly enhanced the average rates of degradation of carbohydrates(Dxylose(40%)andα-D-lactose(44%))and amino acids(L-arginine(16%),L-asparagine(14%),and L-threonine(52%)).We also explored the associations among the bacterial community and their metabolic functions with the changes in the activities of enzymes.Network analysis demonstrated that BC10 altered the co-occurrence patterns of the bacterial communities,where Ulvibacter and class Bacilli were the keystone bacterial taxa with high capacities for degrading carbon source,and they were related to increases in the activities of cellulase and urease,respectively.The results obtained in this study may help to further enhance the efficiency of composting. | Yanan Yin Chao Yang Jingrui Tang Jie Gu Haichao Li Manli Duan Xiaochang Wang Rong Chen | 2021 | Journal of Environmental Sciences2021，33，10： | 4 |
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