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| 1 | Risk factors for the development of vaginal intraepithelial neoplasia显示文摘 | LI Hua GUO Yan-li ZHANG Jing-xu QIAO Jie GENG Li | 2012 | Chinese Medical Journal2012，，7： | 34 |
| 2 | Finite-time sliding mode attitude control for a reentry vehicle with blended aerodynamic surfaces and a reaction control system显示文摘This paper proposes a finite-time robust flight controller, targeting for a reentry vehicle with blended aerodynamic surfaces and a reaction control system(RCS). Firstly, a novel finite-time attitude controller is pointed out with the introduction of a nonsingular finite-time sliding mode manifold. The attitude tracking errors are mathematically proved to converge to zero within finite time which can be estimated. In order to improve the performance, a second-order finite-time sliding mode controller is further developed to effectively alleviate chattering without any deterioration of robustness and accuracy. Moreover, an optimization control allocation algorithm, using linear programming and a pulse-width pulse-frequency(PWPF) modulator, is designed to allocate torque commands for all the aerodynamic surface deflections and on–off switching-states of RCS thrusters.Simulations are provided for the reentry vehicle considering uncertain parameters and external disturbances for practical purposes, and the results demonstrate the effectiveness and robustness of the attitude control system. | Geng Jie Sheng Yongzhi Liu Xiangdong | 2014 | Chinese Journal of Aeronautics2014，27，4： | 19 |
| 3 | Combination of serum inhibin B and follicle-stimulating hormone levels can not improve the diagnostic accuracy on testicular sperm extraction outcomes in Chinese non-obstructive azoospermic men显示文摘 | HUANG Xiang BAI Quan YAN Li-ying ZHANG Qiu-fang GENG Li QIAO Jie | 2012 | Chinese Medical Journal2012，，16： | 17 |
| 4 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 5 | Ginsenoside Rg1 enhances the resistance of hematopoietic stem/progenitor cells to radiation- induced aging in mice显示文摘 | Cui CHEN Xin-yi MU Yue ZHOU Ke SHUN Shan GENG Jun LIU Jian-wei WANG Jie CHEN Tin-yu LI Ya-ping WANG | 2014 | Acta Pharmacologica Sinica2014，35，1： | 15 |
| 6 | Current understanding of ovarian aging显示文摘The reproductive system of human female exhibits a much faster rate of aging than other body systems.Ovarian aging is thought to be dominated by a gradual decreasing numbers of follicles,coinciding with diminished quality of oocytes.Menopause is the final step in the process of ovarian aging.This review focuses on the mechanisms underlying the ovarian aging involving a poor complement of follicles at birth and a high rate of attrition each month,as well as the alternated endocrine factors.We also discuss the possible causative factors that contribute to ovarian aging,e.g.,genetic factors,accumulation of irreparable damage of microenvironment,pathological effect and other factors.The appropriate and reliable methods to assess ovarian aging,such as quantification of follicles,endocrine measurement and genetic testing have also been discussed.Increased knowledge of the ovarian aging mechanisms may improve the prevention of premature ovarian failure. | LI Qian GENG XiaoDan ZHENG Wei TANG Jie XU Bo SHI QingHua | 2012 | Science China(Life Sciences)2012，55，8： | 14 |
| 7 | Role of transforming growth factor-beta signaling pathway in pathogenesis of benign biliary stricture显示文摘AIM: To characterize the expression of members of the transforming growth factor-beta (TGF-β)/Smad/ connective tissue growth factor (CTGF) signaling pathway in the tissue of benign biliary stricture, and to investigate the effect of TGF-β signaling pathway in the pathogenesis of benign biliary stricture. METHODS: Paraffin embedded materials from 23 cases of benign biliary stricture were analyzed for members of the TGF-β/Smad/CTGF signaling pathway. TGF-β_1, TβRⅠ, TβRⅡ, Smad4, Smad7 and CTGF protein were detected by immunohistochemical strepto-advidinbiotin complex method, and CTGF mRNA was evaluated by hybridization in situ, while 6 cases of normal bile duct served as controls. The percentages of positive cells were counted. The correlation between TGF-β_1, Smad4 and CTGF was analyzed. RESULTS: The positive expression ratios of TGF-β_1, TβRⅠ , TβRⅡ , Smad4, CTGF and CTGF mRNA in 23 cases with benign biliary stricture were 91.3%, 82.6%, 87.0%, 78.3%, 82.6% and 65.2%, respectively, signifi cantly higher than that in 6 cases of normal bile duct respectively (vs 33.3%, 16.7%, 50.0%, 33.3%, 50.0%, 16.7%, respectively, P < 0.05). The positiveexpression ratio of Smad7 in cases with benign biliary stricture was 70.0%, higher than that in normal bile duct, but this difference is not statistically signifi cant 70.0% vs 50%, P > 0.05). There was a positive correlation between positive expression of TGF-β_1, Smad4 and CTGF in cases with benign biliary stricture. CONCLUSION: The high expression of TGF-β/Smad/ CTGF signaling pathway plays an important role in the pathogenesis of benign biliary stricture. | Zhi-Min Geng Jian-Bao Zheng Xiao-Xue Zhang Jie Tao Lin Wang | 2008 | World Journal of Gastroenterology2008，14，31： | 12 |
| 8 | Late Quaternary glacial chronology on the eastern slope of Gongga Mountain,eastern Tibetan Plateau,China显示文摘The Gongga Mountain is the largest area of modern glaciation in the Hengduan Mountains and,with a summit elevation of 7556 m,is the highest mountain on the eastern margin of the Tibetan Plateau.During the Quaternary glacial-interglacial cycles the Gongga Mountain was extensively and repeatedly glaciated,and glacial landforms and outwash deposits from multiple glaciations are well-preserved in valleys,in basins,and on piedmonts.To constrain the glacial chronology of the eastern slope of Gongga Mountain,sample sites were selected based on the distribution and weathering of glacial tills,relationships among glacial deposits,and soil development on moraines.Dating of the tills and glaciofluvial deposits was undertaken with electron spin resonance(ESR) and optically stimulated luminescence(OSL).The ages of the glacial deposits can be divided into four clusters:2.2±0.5,11.9±0.6,35.9±2.7-58.0±6.3 and 119.2±15.9-194.2±32.8 ka.Five glacial advances in this region have been identified,which are equivalent in age to the Little Ice Age(LIA),Neoglaciation,marine oxygen isotope stage(MIS) 2,mid-MIS3,and MIS6.The largest local last glacial maximum(LGML) occurred on Gongga Mountain during mid-MIS3,characterized by a cold-humid climate,rather than the global Last Glacial Maximum(LGMG) of MIS2.The Gongga,Nanmenguangou(NMGG) and Yajiageng Glaciations occurred during the late part of the last glacial cycle,the middle of the last glacial cycle and the penultimate glacial cycle,respectively.On the basis of geomorphological,sedimentological,and compositional characteristics,landforms of the Moxi Platform and terraces can be grouped by facies and geochronology.In combination with the dating results,this analysis indicates the basal part of the Moxi Platform between Xinxin and the Moxi Hotel is correlative with the till of the Nanguanmen Glaciation(mid-MIS3).This basal unit has occasional lenses of glaciofluvial sandy gravel and lacustrine sediments.The remainder of the Moxi Platform and the terraces beside the platform are glaciofluvial deposits occasionally mixed with debris flow deposits and range in age from MIS3 to Holocene. | WANG Jie PAN BaoTian ZHANG GuoLiang CUI Hang CAO Bo GENG HaoPeng | 2013 | Science China Earth Sciences2013，56，3： | 11 |
| 9 | Organic composition of gasoline and its potential effects on air pollution in North China显示文摘When gasoline is burned to power an automotive engine, a portion of the fuel remains unburned or is partially burned and leaves the engine as hydrocarbon and oxygenated compounds. In addition, a small portion of the fuel can escape the vehicle through evaporation. Changes in alkanes, olefins and aromatics each affect emissions differently, which could complicate control strategies for air pollution. In this study, we collected 31 gasoline samples over five provinces and cities(Beijing, Tianjin, Hebei, Shandong, and Shaanxi) in North China between 2012 and 2013. The organic composition of the gasoline samples was analyzed using the gas chromatography-mass spectrometry(GC-MS) method, and the aniline compounds were analyzed by solvent extraction and the GC-MS method. The ratios of alkanes, aromatics, olefins and other organic compounds in gasoline were 40.6%, 38.1%, 12.9% and 8.4%, respectively. The aromatic and benzene exceedances were 15 and 8 based on the China's gasoline standards(III), and they accounted for 48.4% and 25.8% of all the gasoline samples, respectively. Strong carcinogen aniline compounds were detected in all 31 samples, and the content of aniline compounds in 3 samples exceeded 1%. The high proportion of aromatics and olefins in the gasoline increased the emissions of carbon monoxide(CO) and toxics, as well as the atmospheric photochemical reactivity of exhaust emissions, which could hasten the formation of secondary pollutants. Our results are helpful for redefining government strategies to control air pollution in North China and relevant for developing new refining technology throughout China. | Guiqian Tang Jie Sun Fangkun Wu Yang Sun Xiaowan Zhu Yejun Geng Yuesi Wang | 2015 | Science China Chemistry2015，58，9： | 10 |
| 10 | Does human papillomavirus infection do harm to in-vitro fertilization outcomes and subsequent pregnancy outcomes?显示文摘 | YANG Rui WANG Ying QIAO Jie LIU Ping GENG Li GUO Yan-li | 2013 | Chinese Medical Journal2013，，4： | 9 |
| 11 | Correlation between BRAF^(V600E) mutation and clinicopathological features in pediatric papillary thyroid carcinoma显示文摘In adults, the presence of the BRAF^(V600E) mutation in papillary thyroid cancer(PTC) has been demonstrated to be strongly associated with aggressive cancer-cell characteristics and poor patient prognosis. In contrast, the frequency of this mutation in pediatric PTC has undergone limited study, and the few available estimates range from 0 to 63%. Furthermore, the role of the BRAF^(V600E) mutation in pediatric PTC is controversial; thus, the present study aimed to investigate the prevalence and role of the BRAF^(V600E) mutation in48 pediatric patients with PTC, aged 3–13 years. Of these patients, 41 were diagnosed with classic PTC, five were found to have a follicular variant of PTC, and two to exhibit a diffuse sclerosing PTC variant. The BRAF^(V600E) mutation was identified to be present in 35.4% of the 48 analyzed patients, and in 41.5% of the patients diagnosed with classical PTC. Furthermore, the presence of the BRAF^(V600E) mutation was found to be associated with a patient age at diagnosis of less than ten years(P=0.011), the performance of a thyroidectomy(P=0.03), exhibited tumor multifocality(P=0.02) and/or extra-thyroidal invasion(P=0.003), and both a low MACIS(Metastases, Age, Completeness of resection, Invasion, Size)(P=0.036) and AMES(Age, Metastasis, Extent of tumor,Size)(P=0.001)score. Together, these data suggest that the presence of the BRAF^(V600E) mutation may be negatively correlated with partial aggressive clinicopathological features of pediatric PTC. | Jiangqiao Geng Huanmin Wang Yuanhu Liu Jun Tai Yaqiong Jin Jie Zhang Lejian He Libing Fu Hong Qin Yingluan Song Jinzhu Su Aiying Zhang Xin Wen Yongli Guo Xin Ni | 2017 | Science China(Life Sciences)2017，60，7： | 9 |
| 12 | A natural variation in Ribonuclease H-like gene underlies Rht8 to confer“Green Revolution”trait in wheat显示文摘Dear Editor,Introduction of gibberellin(GA)-insensitive Reduced height(Rht)genes,Rht-B1b and Rht-D1b,has resulted in the“Green Revolution”in modern wheat cultivars(Triticum aestivum)that has skyrocketed wheat grain yields worldwide since the 1960s(Peng et al.,1999;Velde et al.,2021).However,Rht-B1b/D1b also reduce coleoptiles,which is undesired in dryland regions where deep planting is essential for seedling establishment(Rebetzke et al.,1999,Rebetzke et al.,2001;Ellis et al.,2004). | Lingling Chai Mingming Xin Chaoqun Dong Zhaoyan Chen Huijie Zhai Junhong Zhuang Xuejiao Cheng Naijiao Wang Jia Geng Xiaobo Wang Ruolin Bian Yingyin Yao Weilong Guo Zhaorong Hu Huiru Peng Guihua Bai Qixin Sun Zhenqi Su Jie Liu Zhongfu Ni | 2022 | Molecular Plant2022，15，3： | 8 |
| 13 | Fault plane parameters of Tancheng M81/2 earthquake on the basis of present-day seismological data显示文摘The great Tancheng earthquake of M81/2 occurred in 1668 was the largest seismic event ever recorded in history in eastern China.This study determines the fault geometry of this earthquake by inverting seismological data of present-day moderate-small earthquakes in the focal area.We relocated those earthquakes with the double-difference method and found focal mechanism solutions using gird test method.The inversion results are as follows:the strike is 21.6°,the dip angle is 89.5°,the slip angle is 170°,the fault length is about 160 km,the lower-boundary depth is about 32 km and the buried depth of upper boundary is about 4 km.This shows that the seismic fault is a NNE-trending upright right-lateral strike-slip fault and has cut through the crust.Moreover,the surface seismic fault,intensity distribution of the earthquake,earthquake-depth distribution and seismic-wave velocity profile in the focal area all verified our study result. | Cuiying Zhou Guiling Diao Jie Geng Yonghong Li Ping Xu Xinliang Hu Xiangdong Feng | 2010 | Earthquake Science2010，23，6： | 7 |
| 14 | Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction显示文摘Cockayne syndrome(CS)is a rare autosomal recessive inherited disorder characterized by a variety of clinical features,including increased sensitivity to sunlight,progressive neurological abnormalities,and the appearance of premature aging.However,the pathogenesis of CS remains unclear due to the limitations of current disease models.Here,we generate integration-free induced pluripotent stem cells(iPSCs)from fibroblasts from a CS patient bearing mutations in CSB/ERCC6 gene and further derive isogenic genecorrected CS-iPSCs(GC-iPSCs)using the CRISPR/Cas9 system.CS-associated phenotypic defects are recapitulated in CS-iPSC-derived mesenchymal stem cells(MSCs)and neural stem cells(NSCs),both of which display increased susceptibility to DNA damage stress.Premature aging defects in CS-MSCs are rescued by the targeted correction of mutant ERCC6.We next map the transcriptomic landscapes in CS-iPSCs and GC-iPSCs and their somatic stem cell derivatives(MSCs and NSCs)in the absence or presence of ultraviolet(UV)and replicative stresses,revealing that defects in DNA repair account for CS pathologies.Moreover,we generate autologous GC-MSCs free of pathogenic mutation under a cGMP(Current Good Manufacturing Practice)-compliant condition,which hold potential for use as improved biomaterials for future stem cell replacement therapy for CS.Collectively,our models demonstrate novel disease features and molecular mechanisms and lay a foundation for the development of novel therapeutic strategies to treat CS. | Si Wang Zheying Min Qianzhao Ji Lingling Geng Yao Su Zunpeng Liu Huifang Hu Lixia Wang Weiqi Zhang Keiichiro Suzuiki Yu Huang Puyao Zhang Tie-Shan Tang Jing Qu Yang Yu Guang-Hui Liu Jie Qiao | 2020 | Protein & Cell2020，11，1： | 7 |
| 15 | Heavy-ion and pulsed-laser single event effects in 130-nm CMOS-based thin/thick gate oxide anti-fuse PROMs显示文摘Single event effects of 1-T structure programmable read-only memory(PROM) devices fabricated with a 130-nm complementary metal oxide semiconductorbased thin/thick gate oxide anti-fuse process were investigated using heavy ions and a picosecond pulsed laser. The cross sections of a single event upset(SEU) for radiationhardened PROMs were measured using a linear energy transfer(LET) ranging from 9.2 to 95.6 MeV cm^2mg^(-1).The result indicated that the LET threshold for a dynamic bit upset was ~ 9 MeV cm^2mg^(-1), which was lower than the threshold of ~ 20 MeV cm^2mg^(-1) for an address counter upset owing to the additional triple modular redundancy structure present in the latch. In addition, a slight hard error was observed in the anti-fuse structure when employing209 Bi ions with extremely high LET values(~ 91.6 MeV cm^2mg^(-1)) and large ion fluence(~ 1×10~8 ions cm^(-2)). To identify the detailed sensitive position of a SEU in PROMs, a pulsed laser with a 5-μm beam spot was used to scan the entire surface of the device.This revealed that the upset occurred in the peripheral circuits of the internal power source and I/O pairs rather than in the internal latches and buffers. This was subsequently confirmed by a ^(181)Ta experiment. Based on the experimental data and a rectangular parallelepiped model of the sensitive volume, the space error rates for the used PROMs were calculated using the CRèME-96 prediction tool. The results showed that this type of PROM was suitable for specific space applications, even in the geosynchronous orbit. | Chang Cai Tian-Qi Liu Xiao-Yuan Li Jie Liu Zhan-Gang Zhang Chao Geng Pei-Xiong Zhao Dong-Qing Li Bing Ye Qing-Gang Ji Li-Hua Mo | 2019 | Nuclear Science and Techniques2019，30，5： | 7 |
| 16 | Monte Carlo simulation based on Geant4 of single event upset induced by heavy ions显示文摘The present work is a computational simulation of single event upset(SEU) induced by heavy ions passing through the device with Geant4-tool based on Monte Carlo transport code.Key parameters affecting SEU occurrence are examined,and related geometrical construction and critical charge are quantified.The MUlti-Functional Package for SEU Analysis(MUFPSA) has been successfully programmed and applied for SEU occurrence after the completion of device geometrical construction,critical charge,and SEU cross section calculation.The proposed MUFPSA has yielded a good agreement with MRED.Specifically,the results show that higher LET incident ions lead to increased SEU vulnerability due to more diffusion and higher energy deposition.In addition,the analytical method of radial ionization profile provides a good complementary interpretation. | GENG Chao LIU Jie ZHANG ZhanGang HOU MingDong SUN YouMei XI Kai GU Song DUAN JingLai YAO HuiJun MO Dan LUO Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 6 |
| 17 | New risk factors and new tendency for central nervous system relapse in patients with diffuse large B-cell lymphoma:a retrospective study显示文摘Background: In patients with difuse large B?cell lymphoma(DLBCL), central nervous system(CNS) relapse is uncom?mon but is nearly always fatal. This study aimed to determine the risk factors for CNS relapse in DLBCL patients and to evaluate the eicacy of rituximab and intrathecal chemotherapy prophylaxis for CNS relapse reduction.Methods: A total of 511 patients with newly diagnosed DLBCL treated at the Sun Yat?sen University Cancer Center between January 2003 and December 2012 were included in the study. Among these patients, 376 received R?CHOP regimen(rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) as primary treatment, and 135 received CHOP regimen(cyclophosphamide, doxorubicin, vincristine, and prednisone) as primary treatment. Intrathe?cal chemotherapy prophylaxis(methotrexate plus cytarabine) was administered to those who were deemed at high risk for CNS relapse. In the entire cohort and in the R?CHOP set in particular, the Kaplan–Meier method coupled with the log?rank test was used for univariate analysis, and the Cox proportional hazards model was used for multivariate analysis. Diferences were evaluated using a two?tailed test, and P < 0.05 was considered signiicant.Results: At a median follow?up of 46 months, 25(4.9%) patients experienced CNS relapse. There was a trend of reduced occurrence of CNS relapse in patients treated with rituximab; the 3?year cumulative CNS relapse rates were 7.1% in CHOP group and 2.7% in R?CHOP group(P = 0.045). Intrathecal chemotherapy prophylaxis did not confer much beneit in terms of preventing CNS relapse. Bone involvement [hazard ratio(HR) = 4.21, 95% conidence interval(CI) 1.38–12.77], renal involvement(HR = 3.85, 95% CI 1.05–14.19), alkaline phosphatase(ALP) >110 U/L(HR = 3.59, 95% CI 1.25–10.34), serum albumin(ALB) <35 g/L(HR = 3.63, 95% CI 1.25–10.51), treatment with rituxi?mab(HR = 0.34, 95% CI 0.12–0.96), and a time to complete remission ≤ 108 days(HR = 0.22, 95% CI 0.06–0.78) were independent predictive factors for CNS relapse in the entire cohort. Bone involvement(HR = 4.44, 95% CI 1.08–18.35), bone marrow involvement(HR = 11.70, 95% CI 2.24–60.99), and renal involvement(HR = 10.83, 95% CI 2.27–51.65) were independent risk factors for CNS relapse in the R?CHOP set.Conclusions: In the present study, rituximab decreased the CNS relapse rate of DLBCL, whereas intrathecal chemo?therapy prophylaxis alone was not suicient for preventing CNS relapse. Serum levels of ALB and ALP, and the time to complete remission were new independent predictive factors for CNS relapse in the patients with DLBCL. In the patients received R?CHOP regimen, a trend of increased CNS relapse was found to be associated with extranodal lesions. | Qing-Qing Cai Li-Yang Hu Qi-Rong Geng Jie Chen Zhen-Hai Lu Hui-Lan Rao Qing Liu Wen-Qi Jiang Hui-Qiang Huang Tong-Yu Lin Zhong-Jun Xia | 2016 | Chinese Journal of Cancer2016，35，12： | 6 |
| 18 | Application of defin让ive screening design to quantify the effects of process parameters on key granule characteristics and optimize operating parameters in pulsed-spray fluid-bed granulation显示文摘The pulsed-spray fluid-bed granulation (PSFBG) process was investigated and optimized using definitive scree ning design, a recently proposed new class of three-level desig n of experiment method. Such a design enabled quadratic models to be established that described the effect of six in put process parameters - inlet air temperature, inlet air humidity, binder spray rate, atomization pressure, pulse period, and pulse width - on the granule quality in a PSFBG process. Mathematical models of the mean particle size, relative size distribution width, production yield, and porosity were developed to quantify the relationships between the in flue ncing factors and critical quality attributes. On the basis of con strai nts on the desired granule properties, a design space for PSFBG was determined and ranges of the operating parameters were defined. An acceptable degree of prediction was confirmed by validation experiments, demonstrating the reliability and effectiveness of using definitive screening design to study the PSFBG process. This method can accelerate screening and optimization of this process within a large multidimensional design space. | Jie Zhao Wenlong Li Haibin Qu Geng Tian Yanding Wei | 2019 | Particuology2019，17，2： | 6 |
| 19 | Activating interfacial S sites of MoS_(2) boosts hydrogen evolution electrocatalysis显示文摘The hydrogen evolution reaction(HER)of molybdenum disulfide(MoS_(2))is limited in alkaline and acid solution because the active sites are on the finite edge with extended basal plane remaining inert.Herein,we activated the interfacial S sites by coupling with Ru nanoparticles on the inert basal plane of MoS_(2)nanosheets.The density functional theory(DFT)calculation and experimental results show that the interfacial S electronic structure was modulated.And the results of∆G H*demonstrate that the adsorption of H on the MoS_(2)was also optimized.With the advantage of interfacial S sites activation,the Ru-MoS_(2)needs only overpotential of 110 and 98 mV to achieve 10 mA·cm^(–2)in both 0.5 M H_(2)SO_(4)and ^(1) M KOH solution,respectively.This strategy paves a new way for activating the basal plane of other transition metal sulfide electrocatalysts for improving the HER performance. | Shuo Geng Fenyang Tian Menggang Li Yequn Liu Jie Sheng Weiwei Yang Yongsheng Yu Yanglong Hou | 2022 | Nano Research2022，15，3： | 5 |
| 20 | Adipose-derived stem cells enhance myogenic differentiation in the mdx mouse model of muscular dystrophy via paracrine signaling显示文摘Adipose-derived stem cells have been shown to promote peripheral nerve regeneration through the paracrine secretion of neurotrophic factors. However, it is unclear whether these cells can promote myogenic differentiation in muscular dystrophy. Adipose-derived stem cells(6 × 10~6) were injected into the gastrocnemius muscle of mdx mice at various sites. Dystrophin expression was found in the muscle fibers. Phosphorylation levels of Akt, mammalian target of rapamycin(mT OR), e IF-4E binding protein 1 and S6 kinase 1 were increased, and the Akt/mT OR pathway was activated. Simultaneously, myogenin levels were increased, whereas cleaved caspase 3 and vimentin levels were decreased. Necrosis and fibrosis were reduced in the muscle fibers. These findings suggest that adipose-derived stem cells promote the regeneration and survival of muscle cells by inhibiting apoptosis and fibrosis, thereby alleviating muscle damage in muscular dystrophy. | Ji-qing Cao Ying-yin Liang Ya-qin Li Hui-li Zhang Yu-ling Zhu Jia Geng Li-qing Yang Shan-wei Feng Juan Yang Jie Kong Cheng Zhang | 2016 | Neural Regeneration Research2016，11，10： | 5 |
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