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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Investigation on emission factors of particulate matter and gaseous pollutants from crop residue burning显示文摘微粒物质(下午)的排放因素,元素碳( EC ),器官的碳( OC ), SO2 , NOx ,公司, CO2 ,和十个离子(Na+,NH4+,K+,Mg2+,Ca2+, F ?, Cl ?, NO2 ?, NO3 ?, SO42 ?)从在农村中国的通常生产的罪残茬的四种类型的国内烧被估计:稻秸,麦秸,玉米 stover,和棉花越过中国搜索区域,它从代表是镇定的。一个燃烧塔被设计模仿农民在农村中国在下面烧了他们的罪残茬的煮的条件,到措施排放因素。,结果证明那麦秸在四罪残茬之中有最高的排放因素彻底的下午(8.75 g/kg ) 玉米 stover 和麦秸分别地为 EC (0.95 g/kg ) 和 OC (3.46 g/kg ) 有最高的排放因素。玉米 stover 也作为有最高的排放因素介绍没有, NOx,和 CO2,麦秸,稻秸,和棉花梗分别地有 NO2, SO2,和公司的最高的排放因素。水溶性的离子, K+ 和 Cl ? ,从所有庄稼有最高的排放因素。麦秸有阳离子种类和 F 的一个相对更高的排放因素 ? , Cl ? , NO2 吗?比另外的残余。 | CAO Guoliang ZHANG Xiaoye GONG Sunling ZHENG Fangcheng | 2008 | Journal of Environmental Sciences2008，20，1： | 61 |
| 3 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 4 | Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection显示文摘AIM:To investigate whether the addition of probiotics can improve the eradication effect of triple therapy for Helicobacter pylori (H. pylori ) infection. METHODS:This open randomized trial recruited 234 H. pylori positive gastritis patients from seven local centers. The patients were randomized to one-week standard triple therapy (omeprazole 20 mg bid , clarithromycin 500 mg bid , and amoxicillin 1000 mg bid ; OCA group, n = 79); two weeks of pre-treatment with probiotics, containing 3 × 107 Lactobacillus acidophilus per day, prior to one week of triple therapy (POCA group, n = 78); or one week of triple therapy followed by two weeks of the same probiotics (OCAP group, n = 77). Successful eradication was defined as a negative C13 or C14 urease breath test four weeks after triple therapy. Patients were asked to report associated symptoms at baseline and during follow-up, and side effects related to therapy were recorded. Data were analyzed by both intention-to-treat (ITT) and per-protocol (PP) methods. RESULTS:PP analysis involved 228 patients, 78 in the OCA, 76 in the POCA and 74 in the OCAP group. Successful eradication was observed in 171 patients; by PP analysis, the eradication rates were significantly higher (P = 0.007 each) in the POCA (62/76; 81.6%, 95% CI 72.8%-90.4%) and OCAP (61/74; 82.4%, 95% CI 73.6%-91.2%) groups than in the OCA group (48/78; 61.5%, 95% CI 50.6%-72.4%). ITT analysis also showed that eradication rates were significantly higher in the POCA (62/78; 79.5%, 95% CI 70.4%-88.6%) and OCAP (61/77; 79.2%, 95% CI 70%-88.4%) groups than in the OCA group (48/79; 60.8%, 95% CI 49.9%-71.7%), (P = 0.014 and P = 0.015). The symptom relieving rates in the POCA, OCAP and OCA groups were 85.5%, 89.2% and 87.2%, respectively. Only one of the 228 patients experienced an adverse reaction. CONCLUSION:Administration of probiotics before or after standard triple therapy may improve H. pylori eradication rates. | Yi-Qi Du Tun Su Jian-Gao Fan Yu-Xia Lu Ping Zheng Xing-Hua Li Chuan-Yong Guo Ping Xu Yan-Fang Gong Zhao-Shen Li | 2012 | World Journal of Gastroenterology2012，18，43： | 54 |
| 5 | A Control Strategy for Grid-connected Inverters With LCL Filters显示文摘把LCL滤波器作为电压源型并网逆变器与电网的接口已受到广泛关注。与单电感L滤波器相比,利用电感值较小的LCL滤波器对入网电流的高次谐波具有显著的衰减效果,特别是在低开关频率的大功率并网逆变系统应用中更具明显优势,但是仅采用直接入网电流控制时,LCL滤波器接口的并网逆变器系统存在稳定性问题。该文采用电网侧电感电流和逆变侧电感电流双闭环控制策略对并网电流进行直接控制,电网侧电感电流作为外环更容易抑制并网电流的谐波因素,且可以直接控制入网电流的单位功率因数,采用逆变器侧电感电流作为内环可以增加系统阻尼,从而可抑制系统振荡,增加系统稳定性。对该方案进行系统建模,并深入分析了滤波器参数、控制器参数及系统稳定性之间的精确量化关系。仿真和实验结果表明,该控制策略既可有效抑制入网电流谐振和实现进网电流的高功率因数运行,同时又具有良好的稳态和动态性能。 | HU Xuefeng WEI Zheng CHEN Yihan GONG Chunying ZHANG Jiayan | 2012 | 中国电机工程学报2012，32，27： | 37 |
| 6 | Protection efficacy of national wetland reserves in China显示文摘Wetlands have the most abundant biodiversity,the highest carbon sequestration capacity,and the highest values for ecological services per unit area,of all the world's ecosystems.Practice has shown that establishing reserves is the most effective way of protecting typical ecosystems and their biodiversity,and saving rare or endangered wildlife.The Chinese government's policy is to protect wetland systems by establishing reserves that encompass a massive network of wetlands,including wetland nature re-serves,internationally important wetlands,and wetland parks.Many are already established.The effect of protecting wetland nature reserves at the national level has not yet been reported.We used the latest database evaluating the protection value of wet-land reserves,and remotely sensed wetland maps(1978-2008) ,developed by the same mapping specialists and based on the same classification system,and related environmental data,to evaluate the effects of protecting China's national wetland reserves over the last 30 years.We conclude that(i) the total area of wetland in the national wetland reserves has decreased over the last 30 years to 8152.47 km2,and just 8% of China's net decrease in wetlands;(ii) about 79% of the 91 national wetland reserves are in a poor condition.These are generally located around the Yangtze River,Eastern Coast,the Three Rivers Source,and Southwest China.Protection measures should be undertaken urgently in these areas.Only 15% of national wetland reserves are under sound protection,and these are generally located in the upper reaches of the Songhua River;(iii) although 88% of national wetland re-serves are primitive(relatively natural) ,implying that the site selection has been scientific,a high percentage of national wetland reserves show early warning signs of decline and require urgent attention;(iv) based on our evaluation of protection effects and pressures on ecology,we have made a priority list of national wetland reserves,and propose several protection strategies. | ZHENG YaoMin ZHANG HaiYing NIU ZhenGuo GONG Peng | 2012 | Chinese Science Bulletin2012，57，10： | 29 |
| 7 | Effect of ecoimmunonutrition supports on maintenance of integrity of intestinal mucosal barrier in severe acute pancreatitis in dogs显示文摘Background One of the major causes of death in severe acute pancreatitis (SAP) is severe infection owing to bacterial translocation. Some clinical studies suggested that ecoimmunonutrition (EIN) as a new strategy had better treatment effect on SAP patients. But the experiment studies on the precise mechanism of the effect of EIN were less reported. In this study, we mainly investigated the effects of EIN on bacterial translocation in SAP model of dogs. Methods SAP was induced by retrograde infusion of 5% sodium taurocholate into the pancreatic duct in healthy hybrid dogs. The SAP dogs were supported with either parenteral nutrition (PN) or elemental enteral nutrition (EEN) or EIN. The levels of serum amylase, serum aminotransferase and plasma endotoxin were detected before and after pancreatitis induction. On the 7th day after nutrition supports, peritoneal fluid, mesenteric lymph nodes (MLN), liver, and pancreas were collected for bacterial culture with standard techniques to observe the incidence of bacterial translocation. Pathology changes of pancreas were analyzed by histopathologic grading and scoring of the severity of pancreas, and the degree of intestinal mucosal damage was assessed by measuring mucosal thickness, villus height, and crypt depth of ileum. Results Compared with PN and EEN, EIN significantly decreased the levels of serum amylase, serum aminotransferase, plasma endotoxin, and the incidence of bacterial translocation. Furthermore, compared with the others, the histology scores of inflammation in pancreas and the ileum injury (ileum mocosa thickness, villus height, and crypt depth) were significantly alleviated by EIN (P<0.05). Moreover, concerning liver function, the serum levels of alanine aminotransferase, aspartate aminotransferase and albumin were ameliorating significantly in the EIN group. Conclusion Our results suggested that EIN could maintain the integrity of intestinal mucosal barrier and reducing the incidence of bacterial translocation in SAP dogs. Early EIN was safe and more effective treatment for SAP dogs. | XU Gui-fang LU Zheng GAO Jun LI Zhao-shen GONG Yan-fang | 2006 | Chinese Medical Journal2006，，8： | 23 |
| 8 | Angles-only initial relative orbit determination algorithm for noncooperative spacecraft proximity operations显示文摘This research furthers the development of a closed-form solution to the angles-only initial relative orbit determination problem for non-cooperative target close-in proximity operations when the camera offset from the vehicle center-of-mass allows for range observability.In previous work,the solution to this problem had been shown to be non-global optimal in the sense of least square and had only been discussed in the context of Clohessy–Wiltshire.In this paper,the emphasis is placed on developing a more compact and improved solution to the problem by using state augmentation least square method in the context of the Clohessy–Wiltshire and Tschauner–Hempel dynamics,derivation of corresponding error covariance,and performance analysis for typical rendezvous missions.A two-body Monte Carlo simulation system is used to evaluate the performance of the solution.The sensitivity of the solution accuracy to camera offset,observation period,and the number of observations are presented and discussed. | Baichun Gong Wendan Li Shuang Li Weihua Ma Lili Zheng | 2018 | Astrodynamics2018，2，3： | 20 |
| 9 | Modeling rock specimens through 3D printing: Tentative experiments and prospects显示文摘Current developments in 3D printing (3DP) technology provide the opportunity to produce rock-like specimens and geotechnical models through additive manufacturing, that is, from a file viewed with a computer to a real object. This study investigated the serviceability of3 DP products as substitutes for rock specimens and rock-type materials in experimental analysis of deformation and failure in the laboratory. These experiments were performed on two types of materials as follows:(1) compressive experiments on printed sand-powder specimens in different shapes and structures, including intact cylinders, cylinders with small holes, and cuboids with pre-existing cracks, and(2) compressive and shearing experiments on printed polylactic acid cylinders and molded shearing blocks. These tentative tests for 3DP technology have exposed its advantages in producing complicated specimens with special external forms and internal structures, the mechanical similarity of its product to rock-type material in terms of deformation and failure, and its precision in mapping shapes from the original body to the trial sample(such as a natural rock joint). These experiments and analyses also successfully demonstrate the potential and prospects of 3DP technology to assist in the deformation and failure analysis of rock-type materials, as well as in the simulation of similar material modeling experiments. | Quan Jiang Xiating Feng Lvbo Song Yahua Gong Hong Zheng Jie Cui | 2016 | Acta Mechanica Sinica2016，32，1： | 19 |
| 10 | Plasma miR-216a as a potential marker of pancreatic injury in a rat model of acute pancreatitis显示文摘AIM:To study the potential value and specificity of plasma miR-216a as a marker for pancreatic injury.METHODS:Two rat models were applied in this article:L-arginine-induced acute pancreatitis was used as one model to explore the potential value of plasma miR-216a for detection of pancreatic injury;nonlethal sepsis induced in rats by single puncture cecal ligation and puncture(CLP)was used as the other model to evaluate the specificity of plasma miR-216a compared with twocommonly used markers(amylase and lipase)for acute pancreatitis.Plasmas were sampled from rats at indicated time points and total RNA was isolated.Real-Time Quantitative reverse transcriptase-polymerase chain reaction was used to quantify miR-216a in plasmas.RESULTS:In the acute pancreatitis model,among five time points at which plasmas were sampled,miR-216a concentrations were significantly elevated 24 h after arginine administration and remained significantly increased until 48 h after operation(compared with 0 h time point,P<0.01,Kruskal-Wallis Test).In the CLP model,plasma amylase and lipase,two commonly used biomarkers for acute pancreatitis,were significantly elevated 24 h after operation(compared with 0 h time point,P<0.01 and 0.05 respectively,Pairwise Bonferroni corrected ttests),while miR-216a remained undetectable among four tested time points.CONCLUSION:Our article showed for the first time that plasma miR-216a might serve as a candidate marker of pancreatic injury with novel specificity. | Xiang-Yu Kong,Yi-Qi Du,Lei Li,Xiao-Hua Man,Yan-Fang Gong,Li-Ning Xiao,Yong-Zhi Zheng,Shang-Xin Deng,Jun-Jun Gu,Zhao-Shen Li,Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shang-hai 200433,China Jian-Qiang Liu,Department of Gastroenterology,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,Fujian Province,China Guo-Kun Wang,Jia-Qi Zhu,Department of Cardiology,Changhai Hospital,Second Military Medical University,Shang-hai 200433,China | 2010 | World Journal of Gastroenterology2010，16，36： | 19 |
| 11 | Comparison of glycemic variability and glycated hemoglobin as risk factors of coronary artery disease in patients with undiagnosed diabetes显示文摘背景一个冠的动脉疾病( CAD )风险因素是著名的长期的多糖症的角色,并且 glycemic 可变性仍然是这研究的 debate.The 目的一件事是调查承认 glycemic 的协会有在有 undiagnosed 糖尿病 mellitus ( DM )的病人的 CAD 的存在和严厉的旅行和血红素 A1c ( HbA1c )我们学习了的 .Methods 286 最新诊断了 DM 没有优先的 revascularization 的病人为怀疑的 ischaemic ch 经历冠的 | MI Shu-hua SU Gong LI Zhao YANG Hong-xia ZHENG Hong TAO Hong ZHOU Yun TIAN Lei | 2012 | Chinese Medical Journal2012，，1： | 18 |
| 12 | Association between Ambient Air Pollution and Hospital Emergency Admissions for Respiratory and Cardiovascular Diseases in Beijing: a Time Series Study显示文摘Objective To investigate the association between ambient air pollution and hospital emergency admissions in Beijing. Methods In this study, a semi-parametric generalized additive model(GAM) was used to evaluate the specific influences of air pollutants(PM10, SO2, and NO2) on hospital emergency admissions with different lag structures from 2009 to 2011, the sex and age specific influences of air pollution and the modifying effect of seasons on air pollution to analyze the possible interaction. Results It was found that a 10 μg/m3 increase in concentration of PM10 at lag 03 day, SO2 and NO2 at lag 0 day were associated with an increase of 0.88%, 0.76%, and 1.82% respectively in overall emergency admissions. A 10 μg/m3 increase in concentration of PM10, SO2 and NO2 at lag 5 day were associated with an increase of 1.39%, 1.56%, and 1.18% respectively in cardiovascular disease emergency admissions. For lag 02, a 10 μg/m3 increase in concentration of PM10, SO2 and NO2 were associated with 1.72%, 1.34%, and 2.57% increases respectively in respiratory disease emergency admissions. Conclusion This study further confirmed that short-term exposure to ambient air pollution was associated with increased risk of hospital emergency admissions in Beijing. | ZHANG Ying WANG Shi Gong MA Yu Xia SHANG Ke Zheng CHENG Yi Fan LI Xu NING Gui Cai ZHAO Wen Jing LI Nai Rong | 2015 | Biomedical and Environmental Sciences2015，28，5： | 18 |
| 13 | Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model显示文摘AIM:To investigate the correlation of hyperlipemia(HL) and acute cerebral ischemia/reperfusion(I/R) injury on liver damage and its mechanism.METHODS:Rats were divided into 4 groups:control,HL,I/R and HL+I/R.After the induction of HL via a high-fat diet for 18 wk,middle cerebral artery occlusion was followed by 24 h of reperfusion to capture I/R.Serum alanine transaminase(ALT) and aspartate aminotransferase(AST) were analyzed as part of liver function tests and liver damage was further assessed by histological examination.Hepatocyte apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end labeling(TUNEL) assay.The expression of genes related to apoptosis(caspase-3,bcl-2) was assayed by immunohistochemistry and Western blotting.Serum tumor necrosis factor-(TNF-),interleukin-1(IL-1) and liver mitochondrial superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),malondialdehyde(MDA) and Ca 2+ levels were measured to determine inflammatory and oxidative/antioxidative status respectively.Microsomal hydroxylase activity of the cytochrome P450 2E1(CYP2E1)-containing enzyme was measured with aniline as the substrate,and CYP2E1 expression in the liver tissue and microsome was determined by immunohistochemistry and Western blotting respectively.RESULTS:HL alone induced by high-fat diet for 18 wk resulted in liver damage,indicated by histopathological analysis,and a considerable increase in serum ALT(25.13 ± 16.90 vs 9.56 ± 1.99,P < 0.01) and AST levels(18.01 ± 10.00 vs 11.33 ± 4.17,P < 0.05) compared with control.Moreover,HL alone induced hepatocyte apoptosis,which was determined by increased TUNEL-positive cells(4.47 ± 0.45 vs 1.5 ± 0.22,P < 0.01),higher caspase-3 and lower bcl-2 expression.Interestingly,compared with those in control,HL or I/R groups,massive increases of serum ALT(93.62 ± 24.00 vs 9.56 ± 1.99,25.13 ± 16.90 or 12.93 ± 6.14,P < 0.01) and AST(82.32 ± 26.92 vs 11.33 ± 4.17,18.01 ± 10.00 or 14.00 ± 6.19,P < 0.01) levels in HL+I/R group were observed suggesting severe liver damage,which was confirmed by liver histology.In addition,HL combined with I/R also caused significantly increased hepatocyte apoptosis,as evidenced by increased TUNEL-positive cells(6.20 ± 0.29 vs 1.5 ± 0.22,4.47 ± 0.45 or 1.97 ± 0.47,P < 0.01),elevated expression of caspase-3 and lower expression of bcl-2.Furthermore,when compared to HL or I/R alone,HL plus I/R enhanced serum TNF-,IL-1,liver mitochondrial MDA and Ca 2+ levels,suppressed SOD and GSH-Px in liver mitochondria,and markedly up-regulated the activity(11.76 ± 2.36 vs 4.77 ± 2.31 or 3.11 ± 1.35,P < 0.01) and expression(3.24 ± 0.38 vs 1.98 ± 0.88 or 1.72 ± 0.58,P < 0.01) of CYP2E1 in liver.CONCLUSION:The coexistence of HL and acute cerebral I/R induces severe liver damage,suggesting that cerebral ischemic stroke would exaggerate the damage of liver caused by HL.This effect is possibly due to en-hanced CYP2E1 induction which further promotes oxidative damage,inflammation and hepatocyte apoptosis. | Wei-Hong Gong Wen-Xia Zheng Jun Wang Shi-Hui Chen Bo Pang Xia-Min Hu Xiao-Lu Cao | 2012 | World Journal of Gastroenterology2012，18，35： | 17 |
| 14 | Efficacy and safety of sunitinib in the treatment of metastatic renal cell carcinoma显示文摘背景酷氨酸 kinase 禁止者(TKI ) sunitinib,为变形肾的房间癌(RCC ) 的第一线治疗的首先指向的代理人,指向脉管的 endothelial 生长因素(VEGF ) 小径。如果高血压是有效预兆的 factor.Methods,这研究的目的是在对待变形清楚房间的 RCC 调查 sunitinib 的功效和安全并且证实有变形 RCC 的 36 个病人的一个总数在 2008 年 6 月和 2010 年 12 月之间被注册。在他们之中, 29 个案例是第一线治疗, 7 个案例在首要的 cytokine 或 sorafinib 治疗上的前进。所有病人的病理被证实在清楚的房间类型占优势。Sunitinib 单音治疗在每日的口头的治疗的重复 6 星期的周期被管理 4 个星期,到 2 个星期列在后面离开在 34 个病人;并且 3 个病人连续地与 37.5 mg/d 被管理直到疾病前进或不能接受的毒性发生了。全面反应率和安全被评估。我们根据中部的后续是的血压 level.Results 把病人划分了成组 A 和组 B 15 个月(10 个周期,范围 1.5-30.0 月(1-20 周期)) 。十个病人(29.4 ) 完成了部分回答(PR ) ;23 个病人(67.6 ) 表明了持续 2 个周期的稳定的疾病(SD ) 。十七个病人(50 ) 在后续期间得了进步疾病(PD ) 。中部的没有前进的幸存(PFS ) 是 15 个月(范围 3.0-28.5 ) 月。9 个病人的一个总数死了;全面幸存没被到达;死亡病人的中部的幸存时间是 13 个月(范围 7-24 ) 月。最普通的不利事件是手脚症候群(77.8 ) , thrombocytopenia (75.0 ) ,高血压(61.1 ) 和腹泻(46.0 ) 。最不利的事件由治疗打断是可逆的。22 个病人(61.1 ) 得了高血压;并且高血压与很长时间被联系到疾病前进和长全面的幸存(P=0.004, 0.000,分别地) 这研究的结果表明的 .Conclusions 功效和可管理的不利事件与变形清楚的房间 RCC 为病人在首要或第二线的治疗作为一个单个代理人 sunitinib 介绍。进一步,联系 sunitinib 的高血压可以是为在变形 RCC 的治疗功效的一个强壮的预兆的标记。 | LI Xue-song WU Xiang ZHAO Peng-ju HUANG Li-hua SONG Yi GONG Kan SHEN Cheng YU Wei SONG Gang ZHAO Zheng ZHANG Zheng ZHANG Qian WANG Gang HE Zhi-song ZHOU Li-qun JIN Jie | 2011 | Chinese Medical Journal2011，，18： | 17 |
| 15 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 16 | Correlation of 4-month infant feeding modes with their growth and iron status in Beijing显示文摘背景:婴儿的生长和开发很长时间是在儿科的一个重要话题。婴儿们必须提供包含所有必要营养素的食物。母乳被相信为正常营养是最理想的天赋和最便宜的食物。但是与在在发达国家的代用品食物的发展的进步,公式牛奶能为婴儿生长满足要求,这被认为。在早幼年期期间,作为健康的最敏感的索引,生长因此是在评估母乳喂养的足够的一个批评部件,喂混合并且喂的公式。铁地位是婴儿健康的另一个重要索引。铁营养缺乏性贫血在世界范围的婴儿仍然是最流行的营养的缺乏索引。这研究是在 4 个月在北京比较婴儿在三个不同的喂模式上(用母乳喂,喂混合并且喂的公式) 在物理变化和铁地位。结果可以在喂模式选择向新母亲提供支持,它将也对在喂模式教育的中国营养协会有用。方法:这是队研究。1001 个正常北京婴儿定期被跟随 12 个月。体重和水平长度被测量。血红素,红血房间计数,红细胞平均容量,吝啬的血球的血红素和浆液铁在 4 个月被分析。结果:在开始的 4 个月内的用母乳喂百分比是 47.9% 。喂的模式不是显著地与母亲的交货年龄,教育,劳动小径也不婴儿性别(P>0.05 ) 有关。婴儿男孩和从 0 ~ 4 个月只以母奶抚育的女孩在 0-6 月有最高的重量。在 4 个月的以母奶抚育的婴儿男孩的贫血症率最高。结论:用母乳喂应该被给更多的强调。新母亲如果可能,母乳喂养他们的婴儿是强制的。社会环境应该也为用母乳喂保证要求。而且,血红素,红细胞平均容量和浆液铁的正常价值,它是原来过去常判定孩子的铁营养缺乏性贫血,可能别为评估婴儿最佳。可能有需要为婴儿开发血红素,红细胞平均容量和浆液铁的性特定的截止层次。 | GONG Yu-hua JI Cheng-ye ZHENG Xiu-xia SHAN Jin-ping HOU Rui | 2008 | Chinese Medical Journal2008，，5： | 15 |
| 17 | Comparison of simple discectomy and instrumented posterior lumbar interbody fusion for treatment of lumbar disc herniation combined with Modic endplate changes显示文摘 | Cao Peng Chen Zhe Zheng Yuehuan Wang Yuren Jiang Leisheng Yang Yaoqi Zhuang Chengyu Liang Yu Zheng Tao Gong Yaocheng Zhang Xingkai Wu Wenjian Qiu Shijing | 2014 | Chinese Medical Journal2014，，15： | 15 |
| 18 | Mutational Analysis of Region-cytotoxicity Relationship in Human Transmembrane Tumor Necrosis Factor-alpha显示文摘Objective:To determine the region of human transmembrane tumor necrosis factor-alpha (TM-TNFa), essential for cytotoxic activity a-gainst human breast cancer cell line MCF-7. Methods:Single amino-acid-substituted TM-TNFα mutant proteins (muteins) were produced by in vitro transcription linked translation techniques. The cDNA of TM-TNFα was site-directed mutagenized by recombinant PCR. Results:13 single amino-acid substituted TM-TNFα muteins were generated and assayed for cytotoxic activity. The cytotoxic activities of TM-TNFα muteins, eg, TM-TNFα-71/Lys, -28/Phe and 117/Leu were significantly decreased (P<0.01) compared to that of parent TM-TNFα, 143/Tyr decreased 4-folds, and-17/Thr,-39/Ser,ll9/His,35/Gly,95/Cys and 147/Phe decreased 1.5-2.5-folds, respectively. However, the cytotoxic activities of TM-TNFα-8/Arg, 31/Gly and 87/Phe showed no significant change. Conclusion:These results indicate that the regions associated with cytotoxic-activity of TM-TNFα are different with that of secretory TNF-lpha (S-TNFα). The inner cell region and transmembrane region of TM-TNFα are related to the cytotoxic activity of TM-TNFα. | ZHENG Fang, GONG Feili, LI Zhuoya, JIANG Xiaodan, XIONG Ping, FENG Wei, XU Yong, Institute of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 2002 | The Chinese-German Journal of Clinical Oncology2002，1，1： | 14 |
| 19 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 20 | Municipal wastewater treatment in China:Development history and future perspectives显示文摘China has the world's largest and still growing wastewater sector and water market,thus its future development will have profound influence on the world.The high-speed development of China's wastewater sector over the past 40 years has forged its global leading treatment capacity and innovation ability.However,many problems were left behind,including underdeveloped sewers and sludge disposal facilities,low sustainability of the treatment processes,questionable wastewater treatment plant(WWTP)effluent discharge standards,and lacking global thinking on harmonious development between wastewater management,human society and the nature.Addressing these challenges calls for fundamental changes in target design,policy and technologies.In this mini-review,we revisit the development history of China's municipal wastewater management and identify the remaining challenges.Also,we highlight the future needs of sustainable development and exploring China's own wastewater management path,and outlook the future from several aspects including targets of wastewater management,policies and technologies,especially the new concept WWTP.Furthermore,we envisage the establishment of new-generation WWTPs with the vision of turning WWTP from a site of pollutant removal into a plant of energy,water and fertilizer recovery and an integrated part urban ecology in China. | Jiuhui Qu Hongchen Wang Kaijun Wang Gang Yu Bing Ke Han-Qing Yu Hongqiang Ren Xingcan Zheng Ji Li Wen-Wei Li Song Gao Hui Gong | 2019 | Frontiers of Environmental Science & Engineering2019，13，6： | 13 |
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