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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Deformation Behavior of Medium-strength TA18 High-pressure Tubes During NC Bending with Different Bending Radii显示文摘To improve the forming quality and forming limit of the numerical control (NC) bending of high-pressure titanium alloy tubes, in this study, using three-dimensional (3D) finite element method, deformation behavior of medium-strength TA18 high-pressure tubes during NC bending with different bending radii is investigated. The results show that the cross-sectional deformation and the wall thickness variation during NC bending of TA18 tubes using a small bending radius (less than 2 times of tube outside diameter) are clearly different from that using a normal bending radius (between 2 and 4 times of tube outside diameter). For bending with a normal bending radius, with or without a mandrel, the distribution of the flattening in the bending area resembles a platform and an asymmetric parabola, respectively. For bending with a small bending radius, with or without a mandrel, the flattening both distributes like a parabola, but the former has a stable peak which deflects toward the initial bending section, and the latter has a more pronounced peak with a bending angle and deflects slightly toward the bending section. The wall thickness variations with a normal bending radius, with and without a mandrel, both resemble a platform when the bending angle exceeds a certain angle. For the bending with a small radius, the distribution of the wall thickness variation without a mandrel follows an approximate parabola which increases in value as the bending angle increases. If a mandrel is used, the thickening ratio increases from the initial bending section to the bending section. | JIANG Zhiqiang ZHAN Mei YANG He XU Xudong LI Guangjun | 2011 | Chinese Journal of Aeronautics2011，24，5： | 16 |
| 3 | Numerically controlled bending performance of medium strength TA18 titanium alloy tubes under different die sets显示文摘The rapid development of aviation and aerospace technologies has led to increased interest in the application of numerically controlled(NC) technology for bending light-weight titanium alloy tubes.In order to study and develop advanced NC bending technology,it is necessary to understand the bending performance of medium strength TA18(Ti-3Al-2.5V,ASTM Gr.9) titanium alloy tubes during NC bending under different die sets.This paper focuses on the bending performance of medium strength TA18 tubes under different NC bending die sets,including the variations in the stress,strain,wall thickness,cross sectional deformation,and defects.The results show that adding a wiper die to the base die set decreases the radial,hoop,and tangential compressive stress and the tangential compressive strain,and adding a mandrel to the base die set also decreases these stresses,but increases the radial and hoop tensile stress and decreases the hoop compressive strain obviously,and brings about a three-dimensional tensile stress concentration where the mandrel provides support.For the NC bending of medium strength TA18 tubes,the flattening of cross section is more sensitive index than the thinning of wall thickness.Introducing a mandrel can improve the flattening of cross section obviously but it has a little worse effect on the thinning of wall thickness,and adding a wiper die to the base die set can inhibit the occurrence of the inside bulge but worsen the flattening of the cross section remarkably.Considering the above effects of the mandrel and wiper die on bending performance,it is reasonable to apply the die set comprising a bending die,clamp die,and pressure die for tubes with a small diameter and the die set including an appropriate mandrel additionally for tubes with a larger diameter,in order to bend the medium strength TA18 tubes with high quality and at low cost. | ZHAN Mei JIANG ZhiQiang YANG He XU XuDong LI GuangJun | 2011 | Science China(Technological Sciences)2011，54，4： | 13 |
| 4 | Wheat straw-derived magnetic carbon foams: In-situ preparation and tunable high-performance microwave absorption显示文摘Recently,biomass-derived three-dimensional (3D) porous carbon materials have been gaining more interest as promising microwave absorbers due to their low cost,vast availability,and sustainability.Here,a novel 3D interconnected porous magnetic carbon foams are in-situ synthesized via a combination of sol-gel and carbonization process with wheat straw as the carbon source and FeCl3·6H2O as the magnetic regulating agent.During the process of foams formation,the lignocelluloses from the steam-exploded wheat straw are converted into interconnected carbon sheet networks with hierarchical porous structures,and the precursor FeCl3·6H2O is converted into magnetic nanoparticles uniformly embedded in the porous carbon foams.The generated magnetic nanoparticles are benefit to enhance the interface polarization and magnetic loss ability to improve the efficient complementarities between the dielectric and magnetic loss,thus increasing the impedance matching.The obtained sample treated at 600 ℃ displays the best microwave absorption (MA) performance.It presents a minimal reflection loss (RL) of-43.6 dB at 7.1 GHz and the effective bandwidth (RL <-10 dB) is 3.3 GHz with the thickness of 4.7 mm.The 3D porous structure,multi-interfaces and the synergy of dielectric loss and magnetic loss make great contribution to the outstanding MA performance. | Guangjun Gou Fanbin Meng Huagao Wang Man Jiang Wei Wei Zuowan Zhou | 2019 | Nano Research2019，12，6： | 9 |
| 5 | Retardant effect of dihydroartemisinin on ulcerative colitis in a JAK2/STAT3-dependent manner显示文摘Dihydroartemisinin(DHA)is a semi-synthetic derivative and the main active metabolite of artemisinin.The purpose of this study was to investigate the effect of DHA on the ulcerative colitis(UC)in both in vivo and in vitro models.Weight,survival rate,colon length,and Disease Activity Index score were used to evaluate the severity of colitis.Reverse transcription quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect the expressions of cytokines interleukin(IL)-1,IL-1β,IL-4,IL-6,IL-10,IL-12,and tumor necrosis factor-α(TNF-α).The expressions of Janus kinase 2(JAK2)and signal transducer and activator of transcription 3(STAT3),and the phosphorylation of JAK2(p-JAK2)and STAT3(p-STAT3),were measured by western blot analysis.Western blot analysis and immunohistochemistry were used to detect the expressions of tight junction proteins.We found that the weights and colon lengths of mice in dextran sodium sulfate(DSS)+DHA group were significantly lower and longer than those in the DSS group,respectively.Compared with those in the DSS group,the expressions of IL-1β,IL-6,IL-17,and TNF-αin the DSS+DHA and DSS+5-aminosalicylic acid(5-ASA)groups were decreased,while the expressions of IL-4 and IL-10 were significantly upregulated.DHA largely increased the expressions of zonula occludens-1 and occludin.Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2,STAT3,p-JAK2,and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.DHA has a specific therapeutic effect on UC.The anti-inflammatory mechanism of DHA is related to the blockage of the JAK2/STAT3 signaling pathway.These findings provide evidence that DHA may be a useful drug and is expected to become a promising new treatment for human UC. | Mingrui Jiang Guangjun Zhong Yichao Zhu Liuhua Wang Yuzhe He Qiannan Sun Xiaoqing Wu Xiaolan You Sujun Gao Dong Tang Daorong Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 6 |
| 6 | Influence of Climatic Conditions on Planting of Hami Melon显示文摘Climate warming has made the planting area of Hami melon expand northward to Barry Bakai Town,Altay City,near 47° N. Climate events often induce the occurrence of pests and diseases in crops,affecting the steady production of Hami melon. In 2013,pests and diseases occurred seriously,resulting in low yield and poor quality of Hami melon. Based on the production survey data of Hami melon in recent20 years,the interaction of various meteorological factors in different time and different intervals of various factors was analyzed in this paper to explore the characteristics of the meteorological factors that cause diseases and influence the quality of Hami melon. | Jiangang WANG Min JIANG Yuchao LI Guangjun LI | 2018 | Asian Agricultural Research2018，10，2： | 2 |
| 7 | Rapid startracking algorithm for star sensor 显示文摘 | Jiang Jie Zhang Guangjun Wei Xinguo | 2009 | IEEE Aerospace andElectronic Systems Magazine2009，24，9： | 1 |
| 8 | Full-sky autonomous star identification based on radial and cyclic features of star pattern显示文摘 | Guangjun Z Wei X Jiang J | 2008 | Image Vision Computer2008，26，7： | 1 |
| 9 | Rapid star tracking algorithm for star sensor显示文摘 | Jiang Jie Zhang Guangjun | 2009 | IEEE Aerospace and Electronic Systems Magazine2009，24，9： | 1 |
| 10 | Colon hydrotherapy plus Traditional Chinese Medicine to treat non-alcoholic fatty liver disease:a pilot study显示文摘OBJECTIVE: To demonstrate the potential to treat non-alcoholic fatty liver disease(NAFLD) with colon hydrotherapy(CHT) plus Traditional Chinese Medicine(TCM).METHODS: A total of 20 patients were enrolled into the study and received CHT with TCM for 2 weeks.Body mass index(BMI) and levels of serum triglycerides(TG) and total cholesterol(TC) were compared between pre-treatment and post-treatment.RESULTS: Two-week treatment with CHT plus TCM significantly lowered BMI and reduced blood lipids.BMI decreased from 29.5 ± 4.3 to 25.4 ± 1.0, while mean TG levels decreased by 0.70 mmol/L on average from baseline and mean TC levels decreased by0.37 mmol/L. Forty-five percent of patients exhibited TC decreasing by more than 10% from baseline and25%ofpatientsexhibited TCdecreasingbymore than 20%. Sixty percent of patients exhibited TG decreasing by more than 20% and 20% of patients exhibited TG decreasing by more than 40%. However,high-density and low-density lipoprotein cholester-ol levels did not change significantly after intervention. No serious adverse events were reported.CONCLUSION: Our findings suggest that CHT plus TCM to treat NAFLD is promising and it might be a new treatment strategy for management of NAFLD. | Xiao Huanming Jiang Junmin Xie Yubao Shi Meijie Tian Guangjun Zhao Pengtao Zhang Chaozhen Chen Huijun Xu Chanyuan Chi Xiaoling | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 1 |
| 11 | Rapid star tracking algorithm for star sensor显示文摘 | Jiang Jie Zhang Guangjun | 2009 | IEEE Aerospace and Electronic Systems Magazine2009，24，9： | 1 |
| 12 | Star Sensor Image Acquisition and Pre-processing Hardware System Based on CMOS Image-sensor and FGPA显示文摘 | Hao Xuetao Jiang Jie Zhang Guangjun | 2003 | SPIE2003，5253，： | 1 |
| 13 | Full-sky autonomous star identification based on radial and cyclic features of star pat- tern 显示文摘 | GUANGJUN Z WEI X JIANG J | 2008 | Image Vision Computing2008，26，7： | 1 |
| 14 | A Comparison between TGT and Cz Grown Nd:YAG显示文摘大大小的做钕的 Y_3Al_5O_(12 )(Nd : 钇铝柘榴石) 激光晶体被温度种了坡度技术(TGT ) 方法并且与 Czochralski (Cz ) 相比方法。这二个晶体成长方法的 Thecomparison 被列出了。结果证明 TGTmethod 比 Cz 方法有许多优点。在晶体的 Nd 离子的集中分发被决定,这些晶体的吸收系列被调查了并且比较。高度种的 TGT 做了 Nd : 钇铝柘榴石水晶比 Czgrown Nd 的有更大的吸收 FWHM : 钇铝柘榴石 crysral。高度做的 Nd : 钇铝柘榴石(约 2.8 在。%) 晶体能被 TGT 获得。 | Benxue JIANG Jun XU Hongjun LI Jingya WANG Guangjun ZHAO | 2006 | Journal of Materials Science & Technology2006，22，5： | 0 |
| 15 | Low-Complexity Adaptive Moving Target Tracking Algorithm over Multipath Fading Channels显示文摘 | DU Jiang SONG Ting LI Guangjun | 2008 | Chinese Journal of Electronics2008，17，4： | 0 |
| 16 | Rolling Bearing Fault Diagnosis Based On Convolutional Capsule Network显示文摘Fault diagnosis technology has been widely applied and is an important part of ensuring the safe operation of mechanical equipment.In response to the problem of frequent faults in rolling bearings,this paper designs a rolling bearing fault diagnosis method based on convolutional capsule network(CCN).More specifically,the original vibration signal is converted into a two-dimensional time–frequency image using continuous wavelet transform(CWT),and the feature extraction is performed on the two-dimensional time–frequency image using the convolution layer at the front end of the network,and the extracted features are input into the capsule network.The capsule network converts the extracted features into vector neurons,and the dynamic routing algorithm is used to achieve feature transfer and output the results of fault diagnosis.Two different datasets are used to compare with other traditional deep learning models to verify the fault diagnosis capability of the method.The results show that the CCN has good diagnostic capability under different working conditions,even in the presence of noise and insufficient samples,compared to other models.This method contributes to the safe and reliable operation of mechanical equipment and is suitable for other rotating scenarios. | Guangjun Jiang Dezhi Li Ke Feng Yongbo Li Jinde Zheng Qing Ni He Li | 2023 | Journal of Dynamics, Monitoring and Diagnostics2023，2，4： | 0 |
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