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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Smoothness for the collision local times of bifractional Brownian motions显示文摘Let BHi,Ki={BtHi,Ki,t≥0},i=1,2 be two independent bifractional Brownian motions with respective indices H i ∈(0,1) and K i ∈(0,1].One of the main motivations of this paper is to investigate the smoothness of the collision local time,introduced by Jiang and Wang in 2009,lT = integral(δ(BsH1,K1-BsH2,K2)ds) from n=0 to T,T > 0,where δ denotes the Dirac delta function.By an elementary method,we show that T is smooth in the sense of the Meyer-Watanabe if and only if min{H1K1,H2K2} <1/3. | SHEN GuangJun 1,2,& YAN LiTan 3 1 Department of Mathematics,East China University of Science and Technology,Shanghai 200237,China 2 Department of Mathematics,Anhui Normal University,Wuhu 241000,China 3 Department of Mathematics,Donghua University,Shanghai 201620,China | 2011 | Science China Mathematics2011，54，9： | 12 |
| 3 | Establishment and Application of a SYBR Green I Real-time Quantitative PCR Assay for the Detection of LAT Gene of Pseudorabies Virus in Bama Miniature Pigs显示文摘[Objective] This study aimed to establish a rapid,sensitive and specific SYBR Green I real-time quantitative PCR assay for the detection of latent pseudorabies virus( PRV) infection. [Method]SYBR Green I real-time quantitative PCR conditions and system for early detection of latent pseudorabies virus infection were optimized and compared with conventional PCR to investigate the sensitivity and specificity. Subsequently,the established assay was applied to detect different clinical samples. [Result]The sensitivity of SYBR Green I real-time quantitative PCR assay( 52 copies / μl) was 1 000 times higher than that of conventional PCR( 5. 2 × 104 copies / μl) and the detection time was shortened by 1 /2. The established assay could be used to detect PRV but could not be used to detect PCV2,PPV,CSFV or PRRSV. Various tissues were collected from Bama miniature pigs with latent PRV infection under sterile conditions for real-time PCR detection. Results showed that viral copy number in the brain,nasal swab,inguinal lymph node,liver,lung and spleen was above 20,while PRV was not detected in the kidney and heart tissues. [Conclusion]The established SYBR Green I real-time quantitative PCR assay for PRV LAT detection was specific,sensitive and rapid,which could be used for pathogen monitoring,epidemiological investigation and quantitative study of PRV. | Sufang LU Guangjun GUO Ling MO Feng WEI Bingmei DONG Wentong ZHANG Zhiqiang SHEN | 2015 | Agricultural Biotechnology2015，4，3： | 2 |
| 4 | Weak convergence to Rosenblatt sheet显示文摘我们在 Rosenblatt 表的法律学习近似的问题。我们在过程的二个家庭的法律证明集中到 Rosenblatt 表:第一在飞机从一个泊松过程被构造,第二基于随机的散步。 | Guangjun SHEN Xiuwei YIN Dongjin ZHU | 2015 | Frontiers of Mathematics in China2015，10，4： | 2 |
| 5 | Expression of Pseudorabies Virus gE Core Epitopes in Escherichia coli Strain BL21 and Utilization of Indirect PRV gE-ELISA显示文摘Pseudorabies virus glycoprotein E( PRV gE) has been recognized as a suitable diagnostic antigen for pseudorabies. In order to produce gE antigen in large quantities and at low cost,a gene fragment encoding PRV gE core epitopes was expressed in E. coli BL21 expression system. SDS-PAGE and Western Blotting revealed that the expression product in culture supernatant of E. coli BL21 was a recombinant protein,approximately 51. 8 Kd. At 5 h post-induction,protein concentration assay showed that the expression product amounted to 1. 65 mg /ml,accounting for 24. 17% of total proteins in the culture supernatant. An indirect PRV gE-ELISA was established by using the recombinant expression product as a coating antigen. Cross-reactivity assay showed that this antigen was PRV specific. In addition,the assay was consistently reproducible. Comparison of detection results of 240 serum samples between PRV gE-ELISA and a commercially available PRV diagnostic kit showed that there was no significant difference between these two methods( P > 0. 05). | Guangjun GUO Sufang LU Guanggang QU Feng LI Lin DONG Yanli BI Jinliang WANG Feng WEI Na TANG Chunling ZHANG Zhuang DING Zhiqiang SHEN | 2014 | Agricultural Biotechnology2014，3，4： | 2 |
| 6 | Berry-Ess6en bounds and amost sure CLT for quadratic variation of weighted frac- tional Brownian motion显示文摘 | SHEN Guangjun AN Litan CUI Jing | 2013 | Journal of Inequalities and Applications2013，2013，： | 1 |
| 7 | Mossbauer effect probe of field-induced magnetic phase transition in LaFe13-xSix intermetallic compounds 显示文摘 | Cheng Zhaohua Di Naili Li Qingan Kou Zhiqi Luo Zhi Ma Xiao Wang Guangjun Hu Fengxia Shen Baogen | 2004 | Applied Physics Letters2004，85，10： | 1 |
| 8 | An approximation of subfrac- tional Brownian motion显示文摘 | Shen Guangjun Yan Litan | 2014 | Communications in Statistics: Theory and Methods2014，43，9： | 1 |
| 9 | 16S rRNA Cloning and Identification of a Strain Isolated from Intestinal Tract of Rex Rabbit显示文摘This study was conducted to identify bacterial strain He Nan-001 isolated from intestinal tract of healthy rex rabbit.The strain was identified by gram staining,and OD_(600) values at different culture time were measured to develop a bacterial growth curve.The metabolic pathways of the bacterium using sugar in fermentation was identified with biochemical tubes.Total RNA of the strain was extracted,and total cDNA was obtained by Oligo(dT) method.Primers were designed using Primer 5.0 bio-software according to the 16S rRNA sequence published in Gen Bank,through cloning,ligation to vector PMD18T,construction of PMD18T/16S rRNA vector and transformation into DH5α,plasmid was extracted and sequenced,and the sequencing result was compared with sequences in NCBI followed by drawing of phylogenetic tree.The strain was verified to be double-stranded gram-positive cocci,which could ferment glucose,mannose,maltose and sorbitol,producing acids production,but failed to ferment sucrose,serum inulin and β-galactosidase.The phylogenetic tree analysis showed that the isolated bacterium shared the highest homology with an India isolate,and belongs to diplostreptococcus.This study provides significance experimental data and theoretical guidance for further development and utilization of the bacterial strain. | Guangjun GUO Yumao WANG Sufang LYU Jing HAN Xinming WU Hanjie ZHANG Qiqi ZOU Qiang FU Zhiqiang SHEN | 2016 | Agricultural Biotechnology2016，5，5： | 1 |
| 10 | Limit theorems for functionals of Gaussian vectors显示文摘作为自我类似的进程的扩展,操作符自我类似的进程广泛地被学习了。在这个工作,我们为 Gaussian 向量的 functionals 学习限制定理。在一些条件下面,我们决定随机的向量的一个静止 Gaussian 序列的 functionals 的部分和的限制是一个操作员自我类似的过程。 | Hongshuai DAI Guangjun SHEN Lingtao KONG | 2017 | Frontiers of Mathematics in China2017，12，4： | 0 |
| 11 | Microstructure Study in Slow Neutron Irradiated Bi-2223显示文摘The effect of slow neutron irradiation at a low Auence of about 10^(8)n/cm^(2) on the microstructures of Bi-2223 polycrystalline samples was observed by transmission electron microscopy.By comparative study of the defect structures in a given area in one sample,we get evidence for the flux pinning enhancement by low Auence slow neutron irradiation. | SHEN Guangjun JI Helin JIN Jirong JIN Xin ZHANG Yitong XU Xiaonong YAO Xixian | 1993 | Chinese Physics Letters1993，10，1： | 0 |
| 12 | A Study of 90°Ferroelectric Domains in Potassium Tantalate Niobate Crystals by Means of Transmission Electron Microscopy显示文摘By flux method,potassium tantalate niobate crystals with 46%Nb contents were prepared.In this material 90°a-type domains with(011)and(01ī)walls were observed by a transmission electron microscope,and the nature of fringe patterns associated with these domain walls was analysed.According to the extinction rules for the domain walls,the displacement vector R along<01ī>direction can be determined.Finally,using a selected area electron diffraction method,we examined the crystallographic character of these 90°domains and defined the ratio of lattice parameters c to a. | XU Huiping LI Qi SHEN Guangjun WANG Luchun SHA Zhenshun ZHU Jianming FENG Duan WANG Jiyang | 1993 | Chinese Physics Letters1993，10，5： | 0 |
| 13 | Formation and Growth of Stacking Fault in YBCO by Electron Irradiation显示文摘This paper studies a new electron irradiation effect of the formation,movement and growth of stacking fault in YBa_(2) Cu_(3) O_(6+x).The energy of electron irradiation is about 160keV.It would be a promising way to enhance the density of pinning centers. | SHEN Guangjun HAN Yongsheng JIN Jirong JIN Xin JI Helin YAO Xixian FAN Zhanguo | 1993 | Chinese Physics Letters1993，10，5： | 0 |
| 14 | Research Progress in Prevention and Treatment of Bacterial Diseases by Traditional Chinese Medicine显示文摘Recently,antibiotics have been widely used to resist various bacterial diseases in livestock breeding,which generated more superbacteria with resistance. Food safety problems,such as animal drug residues are urgent to be solved. Traditional Chinese medicines are traditional treasures of China,which attract more and more attention in the prevention and treatment of bacterial diseases because of their abundant advantages including improving immunologic function of organisms,antibacterial,antivirus,antitumor,anti-inflammatory and improving animal performance. The advantages of traditional Chinese medicines,such as low toxicity,low residual,green and safe,conform to food safety requirements. The using condition of traditional Chinese medicines in main bacterial diseases of animals was reviewed in the paper,thus to provide a reference for livestock production. | Sufang LYU Guangjun GUO Ling MO Feng LI Feng WEI Bingmei DONG Zhiqiang SHEN | 2016 | Agricultural Biotechnology2016，5，4： | 0 |
| 15 | Phase transition, structure and shape memory effect of Ni_(47)Ti43Hf_(10) alloy | LIANG Xuelei, SHEN Huimin, ZHANG Zhifang, WANG Yening and SHEN Guangjun( State Key Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, China . Analysis and Testing Center, Southeast University, Nanjing 210018, China) | 2002 | Progress in Natural Science:Materials International2002，12，1： | 0 |
| 16 | Least squares estimator of Ornstein-Uhlenbeck processes driven by fractional Levy processes with periodic mean显示文摘VVc deal with the least squares estimator for the drift parameters of an Ornstein-Uhlenbeck process with periodic mean function driven by fractional Levy process.For this estimator,we obtain consistency and the asymptotic distribution.Compared with fractional Ornstein-Uhlenbeck and Ornstein-Uhlenbeck driven by Levy process,they can be regarded both as a Levy generalization of fractional Brownian motion and a fractional generalization of Levy process. | Guangjun SHEN Qian YU Yunineng LI | 2019 | Frontiers of Mathematics in China2019，14，6： | 0 |
| 17 | TEM STUDY OF TWINNING ORIENTATION RELATIOSHIP BETWEEN A AND B MARTENSITE VARIANTS IN A CuZnAl SHAPE MEMORY ALLOY显示文摘A secondary twinning orientation relationship between A and B martensite variants in aCuZnAl shape memory alloy was confirmed under TEM observation.The twin plane,(50),is a linear combination of (8)and(1 0 10)planes,which are twin planes ofA:C and A:D type pair respectively. | SHEN Guangjun WANG shidong ZHANG Jinping Lab.of Solid State Microstructure,Nanjing University Analysis and Testing Centre,Southeast University,Nanjing,China Associate Professor,Analysis and Testing Centre,Southeast University,Nanjing,210018,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，6： | 0 |
| 18 | Effects of Microbial Fertilizers in Improving Acidic Tobacco-planting Soil and Tobacco Leaf Quality显示文摘[Objectives]This study was conducted to improve acidic soil and enhance the quality of tobacco leaves.[Methods]The effects of different microbial fertilizers on improving acidic tobacco-planting soil and tobacco leaf quality were investigated through plot experiments.[Results]The application of microbial fertilizers could improve the pH value of acidic soil,and composite microbial agent A showed the best application effect.The application of bio-organic fertilizer was beneficial to improving the contents of available phosphorus and available boron in acidic soil.The application of composite microbial agent A was beneficial to improving the contents of available phosphorus and available potassium in acidic soil,and could promote the growth of tobacco plants and improve the economic traits of flue-cured tobacco and the coordination of chemical components in tobacco leaves.The application of composite microbial agent B led to a downward trend in the content of available boron in acidic soil.The application of composite microbial agent B could promote the absorption of nutrients by tobacco plants,and improve their disease resistance and the quality of tobacco leaves.Due to the differences in functional microorganisms contained,the application effects of different microbial fertilizers in improving acidic tobacco-planting soil and improving tobacco leaf quality varied.Overall,the application of microbial fertilizers could increase soil pH,activate soil nutrients,promote tobacco growth,enhance disease resistance,increase tobacco output value,and improve tobacco quality.Microbial fertilizers have good application prospects in improving acidic soil and improving tobacco quality.[Conclusions]The application of microbial fertilizers to improve acidic tobacco-planting soil can ensure the normal growth and development of tobacco plants and the improvement of tobacco leaf quality,achieving high-quality and sustainable development of Zhaotong tobacco. | Xia NI Shungang SHEN Xianyi ZENG Dewen LI Yeming FU Min CHEN Chaokai YU Libing QI Ying-guo RUAN Changchong ZI Haohan GONG Guangjun HU Mengsheng ZHANG Xu ZHANG Shu PENG Hongbing LI | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
| 19 | Total Factor Productivity in China's Manufacturing Sector in the Aftermath of the Global Financial Crisis显示文摘This paper improves the estimation of firm-level total factor productivity(TFP)by considering energy use and including small-and medium-sized enterprises using data from the Chinese National Tax Survey Database(2008-2011).It analyzes the production efficiency of Chinese manufacturing firms using the improved TFP data and finds that(i)the TFP data frequently used in previous studies overestimated firms'real production efficiency;(i)the TFP of manufacturing firms decreased from 2008 to 2011 due to declines in both technical efficiency and allocation efficiency,(ii)the lower capacity utilization of production factors led to lower technical efficiency;and(iv)allocation efficiency decreased more in provinces and industries with higher shares of state-owned enterprises.The findings have policy implications for enhancing growth potential in the long run. | Guangjun Shen Jingxian Zou | 2023 | China & World Economy2023，31，2： | 0 |
| 20 | Inhibitory Effects of 12 Chemical Agents against Alternaria alternata显示文摘[Objective]The paper was to screen highly efficient fungicides for the prevention and control of tobacco brown spot(Alternaria alternata).[Method]The inhibitory effects of 12 chemical agents against A.alternata were determined indoors by mycelium growth rate method.[Result]Toxicity test showed that 30%kresoxim-methyl·boscalid SC had the best inhibitory effect,with an EC_(50)of 1.05μg/mL,followed by 9%pyraclostrobin CS,with an EC_(50)of 2.09μg/mL.As a broad spectrum protective fungicide,77%copper calcium sulfate WP showed a low sensitivity against A.alternata in the petri dish test since it had a mechanism of action different from that of other chemical agents.[Conclusion]The study lays the foundation for subsequent screening of fungicides for the prevention and control of A.alternata in the field. | Shen Hong Zhang Jiatao Cui Zhiyan Sun Guangjun Li Bin Zhang Yongfeng Xu Chuantao Ai Yongfeng Song Guanglong Ji Xiuting Wang Xiaoqiang | 2020 | Plant Diseases and Pests2020，11，4： | 0 |
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