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| 1 | Strontium and boron isotopic constraint on the marine origin of the Khammuane potash deposits in southeastern Laos显示文摘Since 2006,we have conducted a geological exploration of the Khammuane area in southeastern Laos.Several thick sequences of potash deposits containing sylvite and carnallite were discovered from drilling Paleocene strata of the Thangon Formation(E1tg).To constrain the origin of the brine that formed thick sequences of salt mineral deposits,we measured the strontium and boron isotope composition of some salt minerals in the potash deposit.Boron isotope composition of halite-and potash-associated minerals in the Khammuane potash deposit varied from 19.91%to 31.01‰,which differs significantly from continental evaporates(-6.83‰--5.79‰)but is very close to that of salts precipitated from evapo-concentrated seawater(10‰-36‰).The 87Sr/86Sr ratios(0.707542 to 0.709461)of salts were also close to the values of Paleocene seawater(0.70772 to 0.707830).The content of Br-(0.01%-0.25%)and Br×103/Cl ratios(0.10-0.52)of halite were>10 times higher than that of common continental salts.These characteristics indicate clearly that the Laos potash deposits were deposited from seawater.The small variation in boron and strontium isotopes in all salt sedimentary sequences(gypsum-halite-potash-halite)also suggests that the recharge source should be stable and the effects of other continental water mixing are negligible.Large-scale potash deposits are commonly precipitated from seawater.Hence,the results of recent regional drilling work and geochemical research suggest extensive potash resources could occur in the Thangon Formation of southeastern Laos. | TAN HongBing MA HaiZhou LI BinKai ZHANG XiYing XIAO YingKai | 2010 | Chinese Science Bulletin2010，55，27： | 37 |
| 2 | Improving water-use efficiency by decreasing stomatal conductance and transpiration rate to maintain higher ear photosynthetic rate in drought-resistant wheat显示文摘In wheat, the ear is one of the main photosynthetic contributors to grain filling under drought stress conditions. In order to determine the relationship between stomatal characteristics and plant drought resistance, photosynthetic and stomatal characteristics and water use efficiency(WUE) were studied in two wheat cultivars: the drought-resistant cultivar ‘Changhan 58' and the drought-sensitive cultivar ‘Xinong 9871'. Plants of both cultivars were grown in pot conditions under well-watered(WW) and water-stressed(WS) conditions. In both water regimes,‘Changhan 58' showed a significantly higher ear photosynthetic rate with a lower rate of variation and a significantly higher percentage variation of transpiration compared to control plants at the heading stage under WS conditions than did ‘Xinong 9871' plants. Moreover,‘Changhan 58' showed lower stomatal density(SD) and higher stomatal area per unit organ area(A) under both water conditions. Water stress decreased SD, A, and stomatal width(SW), and increased stomatal length in flag leaves(upper and lower surfaces) and ear organs(awn, glume,lemma, and palea), with the changes more pronounced in ear organs than in flag leaves.Instantaneous WUE increased slightly, while integral WUE improved significantly in both cultivars. Integral WUE was higher in ‘Changhan 58', and increased by a greater amount, than in‘Xinong 9871'. These results suggest that drought resistance in ‘Changhan 58' is regulated by stomatal characteristics through a decrease in transpiration rate in order to improve integral WUE and photosynthetic performance, and through sustaining a higher ear photosynthetic rate, therefore enhancing overall drought-resistance. | Yuping Li Hongbing Li Yuanyuan Li Suiqi Zhang | 2017 | The Crop Journal2017，5，3： | 18 |
| 3 | PM_(2.5)-bound polycyclic aromatic hydrocarbons(PAHs) in Beijing:Seasonal variations,sources,and risk assessment显示文摘Polycyclic aromatic hydrocarbons(PAHs) have been of health concern due to its carcinogenesis and mutagenesis. In this study, we aimed to assess the variations, sources, and lifetime excessive cancer risk(ECR) attributable to PAHs bound to ambient particulate matters with aerodynamic diameter less than 2.5 μm(PM_(2.5)) in metropolitan Beijing, China. We collected24-hour integrated PM_(2.5) samples on daily basis between November 2014 and June 2015 across both central heating(cold months) and non-heating(warm months) seasons, and further analyzed the PAH components in these daily PM_(2.5) samples. Our results showed that total concentrations of PM_(2.5)-bound PAHs varied between(88.6 ± 75.4) ng/m^3 in the cold months and(11.0 ± 5.9) ng/m^3 in the warm months. Benzo[a]pyrene(Ba P), the carcinogenic marker of PAHs,averaged at 5.7 and 0.4 ng/m^3 in the cold and warm months, respectively. Source apportionment analyses illustrated that gasoline, biomass burning, diesel, coal combustion and cooking were the major contributors, accounting for 12.9%, 17.8%, 24.7%, 24.3% and 6.4% of PM_(2.5)-bound PAHs, respectively. The BaP equivalent lifetime ECR from inhalation of PM_(2.5)-bound PAHs was 16.2 cases per million habitants. Our results suggested that ambient particulate reduction from energy reconstruction and adaption of clean fuels would result in reductions PM_(2.5)-bound PAHs and its associated cancer risks. However, as only particulate phased PAHs was analyzed in the present study, the concentration of ambient PAHs could be underestimated. | Baihuan Feng Lijuan Li Hongbing Xu Tong Wang Rongshan Wu Jie Chen Yi Zhang Shuo Liu Steven Sai Hang Ho Junji Cao Wei Huang | 2019 | Journal of Environmental Sciences2019，31，3： | 17 |
| 4 | Total pollution effect of urban surface runoff显示文摘For pollution research with regard to urban surface runoff,most sampling strategies to date have focused on differences in land usage. With single land-use sampling,total surface runoffpollution effect cannot be evaluated unless every land usage spot is monitored. Through a new sampling strategy known as mixed stormwater sampling for a street community at discharge outlet adjacent to river,this study assessed the total urban surface runoffpollution effect caused by a variety of land uses and the pollutants washed off from the rain pipe system in the Futian River watershed in Shenzhen City of China.The water quality monitoring indices were COD(chemical oxygen demand),TSS(total suspend solid),TP(total phosphorus),TN(total nitrogen)and BOD(biochemical oxygen demand).The sums of total pollution loads discharged into the river for the four indices of COD,TSS,TN,and TP over all seven rainfall events were very different.The mathematical model for simulating total pollution loads was established from discharge outlet mixed stormwater sampling of total pollution loads on the basis of four parameters:rainfall intensity,total land area,impervious land area,and pervious land area.In order to treat surface runoffpollution,the values of MFF30(mass first flush ratio)and FF30(first 30%of runoffvolume) can be considered as split-flow control criteria to obtain more effective and economical design of structural BMPs(best management practices)facilities. | LUO Hongbing LUO Lin HUANG Gu LIU Ping LI Jingxian HU Sheng WANG Fuxiang XU Rui HUANG Xiaoxue | 2009 | Journal of Environmental Sciences2009，21，9： | 13 |
| 5 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 6 | Origin and evolution of oilfield brines from Tertiary strata in western Qaidam Basin:Constraints from ^(87)Sr/^(86)Sr,δD,δ^(18)O,δ^(34)S and water chemistry显示文摘Chemistry of major and minor elements,87Sr/86Sr,δD,δ18O and δ34S of brines were measured from Tertiary strata and Quaternary salt lakes in the western Qaidam Basin.The water chemistry data show that all oilfield brines are CaCl2 type.They were enriched in Ca2+,B3+,Li+,Sr2+,Br-,and were depleted in Mg2+,SO42-,which indicated that these brines had the characteristics of deeply circulated water.The relationship between δD and δ18O shows that all data of these brines decline towards the Global Meteoric Water Line(GWL) and Qaidam Meteoric Water Line(QWL),and that the intersection between oilfield brines and Meteoric Water Lines was close to the local spring and fresh water in the piedmont in the western Qaidam Basin.The results suggest that oilfield brines has initially originated from meteoric water,and then might be affected by water-rock metamorphose,because most oilfield brines distribute in the range of metamorphosing water.The 87Sr/86Sr values of most oilfield brines range from 0.71121 to 0.71194,and was less than that in salt lake water(>0.712),but close to that of halite in the study area.These imply that salt dissolution occurred in the process of migration.In addition,all oilfield brines have obviously much positive δ34S values(ranging from 26.46‰ to 54.57‰) than that of salt lake brines,which was caused by bacterial sulfate reduction resulting in positive shift of δ34S value and depleteed SO42-in oilfield brines.Combined with water chemical data and δD,δ18O,87Sr/86Sr,δ34S values,we concluded that oilfield brines mainly originate from the deeply circulated meteoric waters,and then are affected by salt dissolution,water-rock metamorphose,sulfate reduction and dolomitization during the process of migration.These processes alter the chemical compositions of oilfield brines and accumulate rich elements(such as B,Li,Sr,Br,K and so on) for sustainable utilization of salt lake resources in the Qaidam Basin. | FAN Qishun MA Haizhou LAI Zhongping TAN Hongbing LI Tingwei | 2010 | Chinese Journal Of Geochemistry2010，29，4： | 10 |
| 7 | A highly durable catalyst based on CoxMn3-xO4 nanosheets for low-temperature formaldehyde oxidation显示文摘为不稳定的有机化合物(VOC ) 的氧化的划算的催化剂对精力变换应用和环境保护批评。这个过程的主要瓶颈是能氧化的有效、稳定、划算的催化剂的发展在低温度的 HCHO。这里,一致地由锰钴氧化物 nanosheet 数组组成的先进材料在一件碳纺织品上盖住被与帖子退火相结合的一个简单阳极的电极淀积方法成功地制作处理,和罐头直接为 HCHO 作为高效的催化材料被使用消除。得益于增加的表面氧种类和改进氧化还原作用性质,同样准备的锰钴氧化物 nanosheets 为 HCHO 氧化显示出实质地更高的催化活动。催化剂完全在象 100 一样低的温度把 HCHO 变换成公司 2 | Yongchao Huang Kaihang Ye Haibo Li Wenjie Fan FengyiZhao Yuanming Zhang Hongbing Ji | 2016 | Nano Research2016，9，12： | 10 |
| 8 | Secure Big Data Storage and Sharing Scheme for Cloud Tenants显示文摘The Cloud is increasingly being used to store and process big data for its tenants and classical security mechanisms using encryption are neither sufficiently efficient nor suited to the task of protecting big data in the Cloud.In this paper,we present an alternative approach which divides big data into sequenced parts and stores them among multiple Cloud storage service providers.Instead of protecting the big data itself,the proposed scheme protects the mapping of the various data elements to each provider using a trapdoor function.Analysis,comparison and simulation prove that the proposed scheme is efficient and secure for the big data of Cloud tenants. | CHENG Hongbing RONG Chunming HWANG Kai WANG Weihong LI Yanyan | 2015 | China Communications2015，12，6： | 10 |
| 9 | Prediction of petroleum exploration risk and subterranean spatial distribution of hydrocarbon accumulations显示文摘油和煤气的资源和它的未被发现的资源的地理地点的精确预言的空间分发的调查为减少探索风险和改善探索利益是重要的。为预言油资源的空间分发的一个新方法在这份报纸被讨论。它在石油探索和烃丰富的模拟由风险概率的预言组成。 | Xie Hongbing Guo Qiulin Li Feng Li Jianzhong Wu Na Hu Suyun Liang Kun | 2011 | Petroleum Science2011，8，1： | 10 |
| 10 | Y chromosomal clue successfully facilitated the arrest of Baiyin serial killer显示文摘The Baiyin serial murders,or called Gan-Meng 8.05 serial murders,has been considered to be the most infamous among the major criminal cases since 1949.Between May26,1988 and February 9,2002,11 women including an8-year-old girl were found gagged,raped,and murdered,often by slitting their throats,and some of their bodies were mutilated brutally,resembling the infamous‘‘Jack the Ripper’’killings that occurred in London more than one hundred years ago.Nine of these 11 murders took place | Hongbing Yao Shaoqing Wen Xinzhu Tong Boyan Zhou Panxin Du Meisen Shi Li Jin Hui Li | 2016 | Science Bulletin2016，61，22： | 8 |
| 11 | Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia显示文摘Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations(AVHs) in schizophrenia(SZ) remains unclear. In this study, we used stochastic dynamic causal modeling(s DCM) to quantify connections among the left dorsolateral prefrontal cortex(inner speech monitoring), auditory cortex(auditory processing), hippocampus(memory retrieval), thalamus(information filtering), and Broca's area(language production) in 17 first-episode drug-na?¨ve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging.Finally, we performed receiver operating characteristic(ROC) analysis and correlation analysis between image measures and symptoms. s DCM revealed an increasedsensitivity of auditory cortex to its thalamic afferents and a decrease in hippocampal sensitivity to auditory inputs in SZ patients with AVHs. The area under the ROC curve showed the diagnostic value of these two connections to distinguish SZ patients with AVHs from those without AVHs. Furthermore, we found a positive correlation between the strength of the connectivity from Broca's area to the auditory cortex and the severity of AVHs. These findings demonstrate, for the first time, augmented AVHspecific excitatory afferents from the thalamus to the auditory cortex in SZ patients, resulting in auditory perception without external auditory stimuli. Our results provide insights into the neural mechanisms underlying AVHs in SZ. This thalamic-auditory cortical-hippocampal dysconnectivity may also serve as a diagnostic biomarker of AVHs in SZ and a therapeutic target based on direct in vivo evidence. | Baojuan Li Long-Biao Cui Yi-Bin Xi Karl J.Friston Fan Guo Hua-Ning Wang Lin-Chuan Zhang Yuan-Han Bai Qing-Rong Tan Hong Yin Hongbing Lu | 2017 | Neuroscience Bulletin2017，33，3： | 8 |
| 12 | Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms显示文摘刺激干扰素的基因 56 (ISG56 ) 家庭成员在堵住病毒的复制并且然而,调整细胞的功能起重要作用他们的内在的分子的机制大部分是不清楚的。这里,我们在场 ISG54 的水晶结构,有新奇 RNA 有约束力的结构的 ISG56 家庭蛋白质。结构证明 ISG54 单体有 9 tetratricopeptide 像重复的主题和伙伴到形成交换域的 dimers。C 终端部分合拢进超级螺旋状的结构并且在它的内部表面上有一条广泛地断然控告的核苷酸绑定隧道。EMSA 结果证明 ISG54 明确地绑在一些 RNA,例如 adenylate uridylate (AU ) 富有的 RNA,与或没有 5 ′triphosphorylation。Mutagenesis 和功能的研究证明这个 RNA 有约束力的能力对它的抗病毒的活动重要。我们的结果建议位于这干扰素可诱导的基因的抗病毒的活动下面的新机制 56 家庭成员。 | Zhenlin Yang Huanhuan Liang Qian Zhou Ying Li Haiwei Chen Wen Ye Danying Chen Joy Fleming Hongbing Shu Yingfang Liu | 2012 | Cell Research2012，22，9： | 8 |
| 13 | Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population显示文摘Objective:Recent evidence indicates that dysregulation of microRNA(miRNA)biogenesis is implicated in cancer development and progression.Based on the important role of miRNA biogenesis genes in carcinogenesis,we hypothesized that genetic variations of the miRNA biogenesis genes may modulate susceptibility to cervical cancer.Methods:We identified three single nucleotide polymorphisms(SNPs)located in the 3'-untranslated regions(3'-UTR)of of miRNA biogenesis key genes(rs1057035 in DICER,rs3803012 in RAN and rs10773771 in HIWI)and genotyped these SNPs in a case-control study of 1,486 cervical cancer cases and1,549 cancer-free controls in Chinese women.Results:Logistic regression analyses showed that no significant associations were observed between the three SNPs and cervical cancer risk[rs3803012 in RAN AG/GG vs.AA adjusted OR=1.104,95%confidence interval(CI):0.859-1.419;rs1057035 in DICER CT/CC vs.TT adjusted OR=0.962,95%CI:0.805-1.149;rs10773771 in HIWI CT/CC vs.TT adjusted OR=0.963,95%CI:0.826-1.122].Conclusions:The findings did not suggest that genetic variants in the 3'-UTR of RAN,DICER and HIWI of miRNA biogenesis genes were associated with the risk of cervical cancer in this Chinese population. | Jiaping Chen Zhenzhen Qin Shandong Pan Jie Jiang Li Liu Jibin Liu Xiaojun Chen Zhibin Hu Hongbing Shen | 2013 | Chinese Journal of Cancer Research2013，25，5： | 8 |
| 14 | One-step generation of myostatin gene knockout sheep via the CRISPR/Cas9 system显示文摘The CRISPR/Cas(clustered regularly interspaced short palindromic repeats/CRISPR-associated)adaptive immune system,which was discovered in bacteria and archaea,can specifically degrade invasive viral and plasmid DNA by base pairing between crRNAs(CRISPR RNAs)and the target DNA[1,2].Recently,the Streptococcus pyogenes type II CRISPR system was shown to be able to perform efficient targeted gene disruption by employing three fundamental components:(1)Cas9 endonuclease. | Hongbing HAN Yonghe MA Tao WANG Ling LIAN Xiuzhi TIAN Rui HU Shoulong DENG Kongpan LI Feng WANG Ning LI Guoshi LIU Yaofeng ZHAO Zhengxing LIAN | 2014 | Frontiers of Agricultural Science and Engineering2014，1，1： | 8 |
| 15 | Function of Ca^(2+)-/calmodulin-dependent protein kinase Ⅳ in Ca^(2+)-stimulated neuronal signaling and behavior显示文摘The activity of Ca2+/calmodulin-dependent protein kinase IV(Ca MKIV) is sensitive to activity-dependent changes in the level of intracellular Ca2+.Following neuronal stimulation,the activation of Ca MKIV may trigger synaptic modifications and transcriptional responses,both of which are involved in regulating cognitive and emotional behavior.Here,we used Ca MKIV knockout(KO) neurons and mice to examine the function of Ca MKIV in Ca2+-stimulated intracellular signaling and animal behavior,respectively.Following NMDA receptor activation or membrane depolarization,the up-regulation of CREB(c AMP responsive element binding protein) and its target gene Bdnf(brain-derived neurotrophic factor) was intact in cortical neurons obtained from Ca MKIV KO mice.Ca MKIV KO mice displayed severe impairment in contextual fear memory but normal locomotor activity and anxiety level in the contextual training chamber.Although Ca MKIV KO mice showed normal memory in the standard passive avoidance task,they were defective in learning the temporal dissociative passive avoidance task.As indicated by the light/dark test and marble-burying test data,Ca MKIV KO mice showed less anxiety and normal perseveration.In the voluntary wheel-running test,Ca MKIV KO mice showed normal running time and distance but higher maximal running speed.Our results demonstrate the function of Ca MKIV in regulating different forms of fear memory,anxiety,and certain aspect of motor function. | SONG ZiXiang CHEN Qi DING Qi ZHENG Fei LI ChengWei XU LePing WANG HongBing | 2015 | Science China(Life Sciences)2015，58，1： | 6 |
| 16 | Neurological manifestations of patients with COVID-19:potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has caused a global pandemic in only 3 months.In addition to major respiratory distress,characteristic neurological manifestations are also described,indicating that SARS-CoV-2 may be an underestimated opportunistic pathogen of the brain.Based on previous studies of neuroinvasive human respiratory coronaviruses,it is proposed that after physical contact with the nasal mucosa,laryngopharynx,trachea,lower respiratory tract,alveoli epithelium,or gastrointestinal mucosa,SARS-CoV-2 can induce intrinsic and innate immune responses in the host involving increased cytokine release,tissue damage,and high neurosusceptibility to COVID-19,especially in the hypoxic conditions caused by lung injury.In some immunecompromised individuals,the virus may invade the brain through multiple routes,such as the vasculature and peripheral nerves.Therefore,in addition to drug treatments,such as pharmaceuticals and traditional Chinese medicine,non-pharmaceutical precautions,including facemasks and hand hygiene,are critically important. | Zhengqian Li Taotao Liu Ning Yang Dengyang Han Xinning Mi Yue Li Kaixi Liu Alain Vuylsteke Hongbing Xiang Xiangyang Guo | 2020 | Frontiers of Medicine2020，14，5： | 5 |
| 17 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 18 | The Antitumor Components from Marine-derived Bacterium Streptoverticillium luteoverticillatum 11014 Ⅱ显示文摘Eight known compounds were isolated from a marine-derived bacterium Streptoverticillium luteoverticillatum 11014 using bioassay-guided fractionations. Their structures were identified by spectral analysis as bis (4-hydroxybenzyl) ether (1), p-hydroxyphenylethyl alcohol (2), N-(4-hydroxyphenethyl) acetamide (3), indole-3 carboxylic acid methyl ester (4), dibenzo[b,e] [1,4]dioxine (5), thymine (6), cytosine deoxyribonucleoside (7) and 2, 3-butanediol (8). These compounds were evaluated for their cytotoxic activities against K562 cell line with the SRB method for the first time. Compounds 2 and 4 showed cytotoxcities with IC50 values of 101.1 and 165.3 μmol L-1, respectively. All compounds were isolated from S. luteoverticillatum 11014 for the first time. | LI Dehai ZHU Tianjiao FANG Yuchun LIU Hongbing GU Qianqun ZHU Weiming | 2007 | Journal of Ocean University of China2007，6，2： | 4 |
| 19 | The calcium uniporter regulates the permeability transition pore in isolated cortical mitochondria显示文摘To investigate the influence of the mitochondrial calcium uniporter on the mitochondrial permeability transition pore, the present study observed mitochondrial morphology in cortical neurons isolated from adult rats using transmission electron microscopy, and confirmed the morphology and activity of isolated mitochondria by detecting succinic dehydrogenase and monoamine oxidase, two mitochondrial enzymes. Isolated mitochondria were treated with either ruthenium red, an inhibitor of the uniporter, spermine, an activator of the uniporter, or in combination with cyclosporin A, an inhibitor of the mitochondrial permeability transition pore. Results showed that ruthenium red inhibited CaCl2-induced mitochondrial permeability transition pore opening, spermine enhanced opening, and cyclosporin A attenuated the effects of spermine. Results demonstrated that the mitochondrial calcium uniporter plays a role in regulating the mitochondrial permeability transition pore in mitochondria isolated from the rat brain cortex. | Ning Yu Shilei Wang Peng Wang Yu Li Shuhong Li Li Wang Hongbing Chen Yanting Wang | 2012 | Neural Regeneration Research2012，7，2： | 4 |
| 20 | Preparation of Ni/bentonite catalyst and its applications in the catalytic hydrogenation of nitrobenzene to aniline显示文摘Ni supported on bentonite was prepared by the impregnation method with different nickel contents, applied to the hydrogenation of nitrobenzene to aniline in a fixed-bed reactor, and it was characterized by X-ray diffraction(XRD), H_2-temperature programmed reduction(H_2-TPR), and X-ray photoelectron spectrometry(XPS). The results showed that Ni/bentonite catalyst with 20 wt% nickel content provided a higher conversion of nitrobenzene and selectivity of aniline compared to other catalysts. Ni O was the precursor of the active component of the catalyst, and the small crystallite size as well as the highly dispersed Ni O on the Ni/bentonite-20 catalyst, contributed to the catalytic performance. The hydrogenation of nitrobenzene was carried out at 300 °C with a H_2 gaseous hourly space velocity of 4800 ml·(g cat)^(-1)·h^(-1)and a nitrobenzene liquid hourly space velocity of4.8 ml·(g cat)^(-1)·h^(-1)over Ni/bentonite-20. A 95.7% nitrobenzene conversion and 98.8% aniline selectivity were obtained. While the nitrobenzene liquid hourly space velocity was 4.8 ml·(g cat)^(-1)·h^(-1), the yield of aniline was more than 95.0% during a 10-hour reaction. | Yuexiu Jiang Xiliang Li Zuzeng Qin Hongbing Ji | 2016 | Chinese Journal of Chemical Engineering2016，24，9： | 4 |
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