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| 1 | Characterization of char from high temperature fluidized bed coal pyrolysis in complex atmospheres显示文摘 | Mei Zhong Shiqiu Gao Qi Zhou Junrong Yue Fengyun Ma Guangwen Xu | 2016 | Particuology2016，14，2： | 5 |
| 2 | Development of highly active coated monolith SCR catalyst with strong abrasion resistance for low-temperature application显示文摘与 V 2 O 5-WO3/TiO2 被改变文件夹和涂层厚度准备。与独块巨石作比较与 100% V 2 O 5-WO3/TiO2 粉末,有 260 的催化剂涂层层的涂的独块巨石吗? | Lina GAN Shan LEI Jian YU Hongtao MA Yo YAMAMOTO Yoshizo SUZUKI Guangwen XU Zhanguo ZHANG | 2015 | Frontiers of Environmental Science & Engineering2015，9，6： | 4 |
| 3 | TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2显示文摘Tripartite motif(TRIM)family proteins are important effectors of innate immunity against viral infections.Here we identified TRIM35 as a regulator of TRAF3 activation.Deficiency in or inhibition of TRIM35 suppressed the production of type I interferon(IFN)in response to viral infection.777m35-deficient mice were more susceptible to influenza A virus(IAV)infection than were wild-type mice.TRIM35 promoted the RIG-Imediated signaling by catalyzing Lys63-linked polyubiquitination of TRAF3 and the subsequent formation of a signaling complex with VISA and TBK1.IAV PB2 polymerase countered the innate antiviral immune response by impeding the Lys63-linked polyubiquitination and activation of TRAF3.TRIM35 mediated Lys48-linked polyubiquitination and proteasomal degradation of IAV PB2,thereby antagonizing its suppression of TRAF3 activation.Our in vitro and in vivo findings thus reveal novel roles of TRIM35,through catalyzing Lys63-or Lys48-linked polyubiquitination,in RIG-I antiviral immunity and mechanism of defense against IAV infection. | Nan Sun Li Jiang Miaomiao Ye Yihan Wang Guangwen Wang Xiaopeng Wan Yuhui Zhao Xia Wen Libin Liang Shujie Ma Liling Liu Zhigao Bu Hualan Chen Chengjun Li | 2020 | Protein & Cell2020，11，12： | 4 |
| 4 | Secondary cracking of volatile and its avoidance in infrared-heating pyrolysis reactor显示文摘This study aims to compare the pyrolysis behavior of Huadian oil shale in two infrared heating fixed bed reactors with different directions of infrared beam.Our previous work has shown that fast pyrolysis of oil shale conducted in the shallow fixed bed infrared heating reactor(co-current)presented the massive secondary reactions,which lowered the shale oil production(Siramard et al.,2017).Conversely,the cross-current infrared achieved shale oil yields higher than the Fischer Assay oil yield(13.07 wt%of dry basis),such as 117.7%of the Fischer Assay yield at our realized highest heating rate of 7℃/s under a specified pyrolysis temperature of 550℃.The shale oil from the cross-current infrared heating reactor was obviously heavier than the oil obtained from the cocurrent heating reactor.Thus,the infrared cross heating evidently suppressed the secondary reactions toward volatile.Our realized shale oil yield could reach 13.67 wt%or 122.5%of the Fischer Assay yield under reducing pyrolysis pressure of 0.6 atm,indicating that lower pressure is also beneficial to the release of volatile and reduction of the secondary cracking reactions.This work shows essentially that the infrared cross heating provides an effective merge of the advantages from quick heating and minimization of secondary cracking reactions to enable the shale oil yields being higher than the Fischer Assay oil yield. | Somprasong Siramard Jin-Hui Zhan Zhennan Han Shipei Xu Ondřej Mašek Guangwen Xu | 2018 | Carbon Resources Conversion2018，1，3： | 3 |
| 5 | Pyrolysis characteristics of waste tire particles in fixed-bed reactor with internals显示文摘This study investigated the characteristics of pyrolysis for waste tire particles in the newly developed fixed-bed reactor with internals that are a central gas collection channel mounted inside reactor.And a few metallic plates vertically welded on the internal wall of the reactors and extending to the region closing their central gas collection pipe walls.Experiments were conducted in two laboratory fixed bed reactors with or without the internals.The results shown that employing internals produced more light oil at externally heating temperatures above 700℃due to the inhibited secondary reactions in the reactor.The oil from the reactor with internals contained more aliphatic hydrocarbons and fewer aromatic hydrocarbons,leading to its higher H/C atomic ratios as for crude petroleum oil.The char yield was relatively stable for two beds and showed the higher heating values(HHVs)of about 23 MJ/kg.The gaseous product of pyrolysis mainly consisted of H2 and CH4,but the use of internals led to less pyrolysis gas through its promotion of oil production. | Shipei Xu Dengguo Lai Xi Zeng Lijuan Zhang Zhennan Han Jiguang Cheng Rongcheng Wu Ondřej Mašek Guangwen Xu | 2018 | Carbon Resources Conversion2018，1，3： | 3 |
| 6 | Expression of orphan nuclear receptor NR4A2 in gastric cancer cells confers chemoresistance and predicts an unfavorable postoperative survival of gastric cancer patients with chemotherapy显示文摘 | Yifang Han Hui Cai Liye Ma Yibo Ding Xiaojie Tan Wenjun Chang Wei Guan Yan Liu Qiuxia Shen Yongwei Yu Hongwei Zhang Guangwen Cao | 2013 | Cancer2013，，19： | 2 |
| 7 | Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection显示文摘The COVID-19 response strategies in Chinese mainland were recently adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants.In Chengdu,China,an infection wave was predominantly induced by the BA.5 subvariant.It is crucial to determine whether the hybrid anti-SARS-CoV-2 immunity following BA.5 infection. | Jingyun Yang Weiqi Hong Hong Lei Cai He Wenwen Lei Yanan Zhou Tingmei Zhao Aqu Alu Xuelei Ma Jiong Li Li Yang Zhenling Wang Wei Wang Guangwen Lu Guobo Shen Shuaiyao Lu Guizhen Wu Huashan Shi Xiawei Wei | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 1 |
| 8 | Process characteristics of hydrothermal treatment of antibiotic residue for solid biofuel显示文摘 | Guangyi Zhang Dachao Ma Cuina Peng Xiaoxing Liu Guangwen Xu | 2014 | Chemical Engineering Journal2014，，： | 1 |
| 9 | Structure and Cleavage Specificity of the Chymotrypsin-Like Serine Protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)显示文摘 | Xinsheng Tian Guangwen Lu Feng Gao Hao Peng Youjun Feng Guangpeng Ma Mark Bartlam Kegong Tian Jinghua Yan Rolf Hilgenfeld George F. Gao | 2009 | Journal of Molecular Biology2009，，4： | 1 |
| 10 | Direct synthesis of diphenyl carbonate over heterogeneous catalyst: effects of structure of substituted perovskite carrier on the catalyst activities显示文摘The perovskite-type compound LaMnO_(3) was substituted for the part of La in position A and for the part of Mn in position B by citrate method.The phases were detected by X-ray diffraction.Powder morphologies were scanned by scanning electron microscopy.The valence of atoms was determined by X-ray photoelectron spectroscopy.It was found that the perovskite can form crystal defect and increase the proportion of high valence B element by doping.Active component Pd was loaded on various perovskite supports for synthesis of diphenyl carbonate.The results showed that the activities of catalysts in which supports have crystal defect by substitution were higher.It can be concluded that perovskite with defect structure by doping could lead to the formation of oxygen vacancy where the lattice oxygen became exchangeable with the oxygen gas.Also,this improved the redox process of the carrier by transferring electrons and activities of catalysts. | WU Guangwen WU Yuxin MA Peisheng JIN Fang ZHANG Guangxu LI Dinghuo WANG Cunwen | 2007 | Frontiers of Chemical Science and Engineering2007，1，1： | 1 |
| 11 | In vitro Transcriptome Analysis of Two Chinese Isolates of Streptococcus suis Serotype 2显示文摘The Streptococcus suis serotype 2(S. suis 2) isolates 05ZYH33 and 98HAH33 have caused severe human infections in China. Using a strand-specific RNA-seq analysis, we compared the in vitro transcriptomes of these two Chinese isolates with that of a reference strain(P1/7). In the89 K genomic island that is specific to these Chinese isolates, a toxin–antitoxin system showed relatively high levels of transcription among the S. suis. The known virulence factors with high transcriptional activity in these two highly-pathogenic strains are mainly involved in adhesion, biofilm formation, hemolysis and the synthesis and transport of the outer membrane protein. Furthermore,our analysis of novel transcripts identified over 50 protein-coding genes with one of them encoding a toxin protein. We also predicted over 30 small RNAs(s RNAs) in each strain, and most of them are involved in riboswitches. We found that six s RNA candidates that are related to bacterial virulence, including csp A and rli38, are specific to Chinese isolates. These results provide insight into the factors responsible for the difference in virulence among the different S. suis 2 isolates. | Dake Zhang Nan Du Sufang Ma Qingtao Hu Guangwen Lu Wei Chen Changqing Zeng | 2014 | Genomics, Proteomics & Bioinformatics2014，12，6： | 1 |
| 12 | Parameter identification and calibration of the Xin'anjiang model using the surrogate modeling approach显示文摘实际经验证明了那个单个目的工作,不管怎么小心地选择,证明在观察数据的特征为所有提供合适的大小不适当。避免这个问题的一策略是定义,并且使用多标准优化识别非统治的最佳的解决方案多重的适合测量系统行为的不同方面的标准。不幸地,这些分析要求跑的原来的模拟模型几千次。因此,他们要求禁止地大的计算预算。作为结果,代理人模型与许多多客观的优化算法在联合被使用了接近在内的真 Pareto 前面为原来的模型限制了评估。在这研究,多客观的优化基于代理人建模(multivariate 适应回归花键,火星) 为一个概念的降雨流量模型(Xin'anjiang 模型, XAJ ) 被建议。拿三的 Yanduhe 盆作为案例研究在中国在长江的上面的溪流塞满,三个评估标准被选择确定对从模拟模型的计算价值的观察的 goodness-of-fit。选择的三个标准是 Nash-Sutcliffe 效率系数,山峰流动的相对错误,和流量体积(REPF 和 RERV ) 。这个方法的功效在 XAJ 模型的刻度上被表明。比作单个客观优化结果,多客观的优化方法能推断最可能的参数集合,这被显示。结果也证明使用建模代理人启用更有效的优化;并且全部的计算费用被大约 92.5% 减少,与没有使用代理人建模的优化相比。与建议方法获得的结果支持把参数优化用于计算地集中的模拟模型的可行性,经由减少更加在数字模型要求的模拟跑的数字[出版摘要] | Yan YE Xiaomeng SONG Jianyun ZHANG Fanzhe KONG Guangwen MA | 2014 | Frontiers of Earth Science2014，8，2： | 1 |
| 13 | Generation and application of replication-competent Venus-expressing H5N1,H7N9,and H9N2 influenza A viruses显示文摘The generation and application of replication-competent influenza A virus(IAV) expressing a reporter gene represent a valuable tool to elucidate the mechanism of viral pathogenesis and establish new countermeasures to combat the threat of influenza. Here, replication-competent IAVs with a neuraminidase(NA) segment harboring a fluorescent reporter protein, Venus, were generated in the background of H5N1, H7N9, and H9N2 influenza viruses, the three subtypes of viruses with imminent pandemic potential. All three reporter viruses maintained virion morphology, replicated with similar or slightly reduced titers relative to their parental viruses, and stably expressed the fluorescent signal for at least two passages in embryonated chicken eggs. As a proof of concept, we demonstrated that these reporter viruses,used in combination with a high-content imaging system, can serve as a convenient and rapid tool for the screening of antivirals and host factors involved in the virus life cycle. Moreover, the reporter viruses demonstrated similar growth properties and tissue tropism as their parental viruses in mice, among which the H7N9 NA-Venus virus could potentially be used in ex vivo studies to better understand H7N9 pathogenesis or to develop novel therapeutics. | guangwen wang jie zhang fandi kong qibing li jinliang wang shujie ma yuhui zhao libin liang junping li nan sun lizheng guan yuan zhou chenchen zhou shanyu huang zhigao bu li jiang hualan chen chengjun li | 2018 | Science Bulletin2018，63，3： | 1 |
| 14 | circGLS2 inhibits hepatocellular carcinoma recurrence via regulating hsa-miR-222-3p–PTEN–AKT signaling显示文摘Dear Editor,Growing evidences indicate that circRNAs affect hepatocellular carcinoma(HCC)progression.1,2,3,4 Understanding the roles of circRNAs in HCC recurrence helps develop innovated therapies.To identify novel HCC recurrence-related circRNA,thirteen HCC patients were subjected to a multi-omics analysis of mRNA,circRNA. | Xi Chen Ting Wu Linfeng Xian Longteng Ma Nan Li Wenbin Liu Peng Cai Xiaojie Tan Jianhua Yin Guangwen Cao | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
| 15 | Roles of a metastasis-associated molecule, RTVP-1, in cancer immunosurveillance显示文摘Objective: To elucidate distinct functions of a recently identified cancer metastasis-associated molecule, related to testes-specific, vespid, and pathogenesis protein-1 (RTVP-1) in the mammalian immune system. Methods: Immunohistochemical assays and functional analysis on the immune system were performed on RTVP-/- mice and RTVP-1+/+ mice. Protein-protein interaction (PPI) was used to predict the functions of RTVP-1. Results: Abnormal lymphocyte growth kinetics and reduced numbers of CD8+ T cells were revealed in lymph nodes of RTVP-1-/- mice. Expression of phenotypic markers of maturation in bone marrow-derived dendritic cells (DC) was impaired in RTVP-1-/- DC following antigenic stimulation in vitro and RTVP-1-/- DC failed to provide normal CD4+ T cell stimulatory activities in vivo. RTVP-1-/- mice failed to generate normal CTL or antibody responses in vivo after vaccination. In vivo tumor challenge experiments using a mouse cancer cell line demonstrated that the growth rate of subcutaneous tumors in RTVP-1-/- mice was significantly increased and CD8+ T cell infiltration significantly reduced compared to RTVP-1+/+ mice. PPI showed that RTVP-1 protein closely interacted with molecules associated with immune response and cancer metastasis. Conclusion: RTVP-1 might function as a tumor metastasis suppressor and immunosurveillance molecule in cancer. | Sun Junwen Chang Wenjun Yang Guang Hou Jianguo Ma Liye Zhang Hongwei Tan Xiaojie He Xiang Timothy C. Thompson Cao Guangwen | 2008 | Journal of Medical Colleges of PLA(China)2008，23，4： | 0 |
| 16 | Strategic Bidding Model for Power Generation Company Based on Repast Platform显示文摘 | Zhigang Zhang Guangwen Ma | 2008 | Journal of Systems Science and Information2008，6，4： | 0 |
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