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| 1 | 一体化PET/CT与3.0 T全身MRI对非小细胞肺癌分期的对照研究显示文摘目的前瞻性对照一体化PET/CT和3.0T全身MRI确定非小细胞肺癌(NSCLC)TMN分期的诊断效用。方法本研究经伦理委员会批准.所有受试者均签署知情同意书。本研究包括了病理证实的165例NSCLC病人(男125例,女40例,平均年龄61岁),均进行了PET/CT平扫和全身MRI检查。病理结果作为T(n=123)和N(n=150)的分期参考标准,病理结果或随访的影像结果作为M(n=54)的分期参考标准。采用McNemas检验对PET/CT和全身MR成像对NSCLC的分期诊断作用进行对照检验。结果123例原发肺癌中,PET/CT正确分期101例(82%), | C.A.Yi K.M. Shin K.S. Lee B.T. Kim H. Kim O.J. Kwon 高莉(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 25 |
| 2 | A model to predict survival in patients with end-stage liver disease显示文摘 | Patrick S. Kamath Russell H. Wiesner Michael Malinchoc Walter Kremers Terry M. Therneau Catherine L. Kosberg Gennaro D’Amico E.Rolland Dickson W.Ray Kim | 2001 | Hepatology2001，，2： | 10 |
| 3 | The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting显示文摘Background Vascular smooth muscle cells (VSMCs) can express heme-oxygenase (HO), a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO). VSMC-derived CO can suppress VSMC proliferation and may serve as an antiproliferation factor. The promoter region of HO-1 shows a polymorphism with different (GT)_n repeats that has been reported to differently induce gene expression. The objective of this study was to examine the effect of this variation on the occurrence of restenosis after in-stent treatment in patients with coronary artery disease. Methods Candidates who underwent coronary stent implantation were genotyped for the HO-1 promoter polymorphism using polymerase chain reaction (PCR) and automated DNA capillary sequencer. Serum levels of IL-6 and C-reactive protein (CRP) were obtained at baseline, 24 hours and 48 hours after stenting. The primary end point for the study was angiographic evidence of in-stent restenosis at 6 months. All parameters for evaluation of restenosis were analysed by quantitatve computer-assisted angiographic analysis (QCA). Results One hundred and eighty-seven patients who underwent coronary stent implantation were studied of whom 27.8% showed ≥50% restenosis after 6 months. The distribution of (GT)_n repeats of all patients in the promoter region of HO-1 genotype ranged from 22 to 42, with (GT)_ 25 and (GT)_ 32 being the two most common alleles. The allelic repeats were divided into the short class (S) with 29 (GT)_n, the middle class (M) with 30-37 (GT)_n and the long class (L) with 38 (GT)_n. There was no significant difference in the restenosis between the genotype groups or between post operation levels of inflammation markers, but carriers of the S allele (n=120) had 33.3% lower baseline IL-6 compared with non-S carriers (n=67, P=0.0008). Conclusions Although no association was observed between the HO-1 promoter polymorphism aod coronary in-stent restenosis following the stent procedure, the association with plasma IL-6 levels suggests that HO-1 S allele might protect from the atherosclerotic inflammatory process. | LI Ping Mohamed A. Elrayess Abuzeid H. Gomma Jutta Palmen Emma Hawe Kim M. Fox Steve E. Humphries | 2005 | Chinese Medical Journal2005，，18： | 6 |
| 4 | The Level of Expression of Thioredoxin is Linked to Fundamental Properties and Applications of Wheat Seeds显示文摘有谷物(大麦和小麦) 和荚(Medicago truncatula ) 的工作作为种子的中央规章的蛋白质建立了 thioredoxin h (Trx h ) 。Trx h 由减少二硫化物(SS ) 扮演一些多样的种子蛋白质(存储蛋白质,酶,和酶禁止者) ,从而便于萌芽。早,在 vitro,蛋白质研究与有在内乳的 Trx h overexpressed 的大麦种子在显示出加速的萌芽和联系的酶(淀粉酶和 pullulanase ) 的早或提高的表示的实验被补充。当前的学习扩大转基因的工作到小麦。二条途径被跟随在内乳改变 Trx h 基因的表示:(1 ) 一个大麦蛋白倡导者和它指向顺序的蛋白质身体导致了 Trx h5 的 overexpression,并且(2 ) Trx h9 的 antisense 构造导致了那基因(Arabidopsis 指明) 的 cytosolic underexpression。Trx h9 的 Underexpression 导致了对在萌芽的 barleyretardation 为 overexpression Trx h5 观察并且推迟了或减少联系的酶的表示的那些相反的效果。类似的酶变化在开发种子被观察。有 underexpressed Trx 的小麦线看了发芽的推迟的 preharvest 没有减少,什么时候在最后的产量在温室或领域成长。有 overexpressed Trx h5 的小麦显示出与同量的变化在 vitro 工作更早:二硫化物蛋白质的增加的溶解度和麦胶蛋白质部分的更低的 allergenicity。结果是在谷物内乳的 Trx h 的水平决定基本性质以及种子的潜在的应用程序的进一步的证据。 | Yong-Chun Li Jiang-Ping Ren Myeong-Je Cho Su-Mei Zhou Yong-Bum Kim Hong-Xiang Guo Joshua H. Wong Hong-Bin Niu Hyun-Kyung Kim Susumu Morigasaki Peggy G. Lemaux Oscar L. Frick Jun Yin Bob B. Buchanan | 2009 | Molecular Plant2009，2，3： | 5 |
| 5 | Endoscopic submucosal dissection with sentinel node navigation surgery for early gastric cancer显示文摘 | G. Bok Y. Kim S. Jin C. Chun T. Lee H. Kim S. Jeon J. Cho | 2012 | Endoscopy2012，，10： | 5 |
| 6 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 4 |
| 7 | Combinations of eight key mutations in the X /pre C region and genomic activity of hepatitis B virus are associated with hepatocellular carcinoma显示文摘 | Y. M. Park J. W. Jang S. H. Yoo S. H. Kim I. M. Oh S. J. Park Y. S. Jang S. J. Lee | 2014 | J Viral Hepat2014，，3： | 4 |
| 8 | Predictive factors for lymph node metastasis in patients with poorly differentiated early gastric cancer显示文摘 | J. H. Lee M.‐G. Choi B.‐H. Min J. H. Noh T. S. Sohn J. M. Bae S. Kim | 2012 | Br J Surg2012，，12： | 4 |
| 9 | Synergistic Effects of A1896, T1653 and T1762/A1764 Mutations in Genotype C2 Hepatitis B Virus on Development of Hepatocellular Carcinoma显示文摘 | H. Lyu D. Lee Y.‐H. Chung J. A. Kim J.‐H. Lee Y.‐J. Jin W. Park P. Mathews E. Jaffee L. Zheng E. Yu Y. J. Lee | 2012 | J Viral Hepat2012，，3： | 3 |
| 10 | Serial diffusion-weighted MRI in patients with hepatocellular carcinoma: Prediction and assessment of response to transarterial chemoembolization. Preliminary experience显示文摘 | Lorenzo Mannelli Sooah Kim Cristina H. Hajdu James S. Babb Bachir Taouli | 2012 | European Journal of Radiology2012，，： | 3 |
| 11 | Randomised clinical trial: the effects of H elicobacter pylori eradication on glandular atrophy and intestinal metaplasia after subtotal gastrectomy for gastric cancer显示文摘 | S.‐J. Cho I. J. Choi M.‐C. Kook H. Yoon S. Park C. G. Kim J. Y. Lee J. H. Lee K. W. Ryu Y.‐W. Kim | 2013 | Aliment Pharmacol Ther2013，，5： | 3 |
| 12 | Prediction of response to entecavir therapy in patients with HBeAg‐positive chronic hepatitis B based on on‐treatment HBsAg, HBeAg and HBV DNA levels显示文摘 | J. W. Shin S. W. Jung B. R. Park C. J. Kim J. B. Eum B. G. Kim I. D. Jeong S.‐J. Bang S.‐H. Lee S. R. Kim N. H. Park | 2012 | Journal of Viral Hepatitis2012，，10： | 3 |
| 13 | The rationale behind complete mesocolic excision (CME) and a central vascular ligation for colon cancer in open and laparoscopic surgery显示文摘 | K. S?ndenaa P. Quirke W. Hohenberger K. Sugihara H. Kobayashi H. Kessler G. Brown V. Tudyka A. D’Hoore R. H. Kennedy N. P. West S. H. Kim R. Heald K. E. Storli A. Nesbakken B. Moran | 2014 | International Journal of Colorectal Disease2014，，4： | 3 |
| 14 | Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial显示文摘 | Paul Moayyedi Michael G. Surette Peter T. Kim Josie Libertucci Melanie Wolfe Catherine Onischi David Armstrong John K. Marshall Zain Kassam Walter Reinisch Christine H. Lee | 2015 | Gastroenterology2015，，： | 3 |
| 15 | Aspirin use and bleeding risk after endoscopic submucosal dissection in patients with gastric neoplasms显示文摘 | S-J. Cho I. Choi C. Kim J. Lee B.-H. Nam M. Kwak H. Kim K. Ryu J. Lee Y.-W. Kim | 2012 | Endoscopy2012，，02： | 3 |
| 16 | Diagnostic yield and safety of jumbo biopsy forceps in patients with subepithelial lesions of the upper and lower GI tract显示文摘 | Jonathan M. Buscaglia Satish Nagula Vijay Jayaraman David H. Robbins Deepak Vadada Seth A. Gross Christopher J. DiMaio Shireen Pais Kal Patel Divyesh V. Sejpal Michelle K. Kim | 2012 | Gastrointestinal Endoscopy2012，，6： | 3 |
| 17 | Extracellular quality control in the epididymis显示文摘因为发生在它的范围以内的活跃精子成熟过程,附睾腔代表唯一的细胞外的环境。尽管大部分集中在腔放在和精子的附睾的能分泌的蛋白质的相互作用上的过时的人或物,很,很少关于整个的复杂附睾周围怎么被维持被知道,包括阻止或控制不能呆在他们合拢的土著人的蛋白质州的列在后面的机制分泌物。因为一些错误褶层蛋白质能形成作为淀粉知道的细胞毒素的总数结构,控制 / 监视机制在附睾以内存在免于这进程并且允许精子成熟发生,是可能的。学习蛋白质聚集并且在附睾识别细胞外的质量控制机制,因为两蛋白质有固有的性质聚集并且形成 amyloid,我们把半胱氨酸朊酶禁止者,包括的 cystatin 相关的附睾精子发生的和 cystatin C 的 cystatin 家庭用作分子的模型。在这章,我们在场由淀粉的小径的蛋白质聚集的一篇简短摘要基于从另外的机关系统被知道并且描述细胞内部地存在到的质量控制机制的控制蛋白质错误褶层和聚集。我们然后介绍我们的研究的一篇摘要在附睾腔以内的 ofcystatin 相关的附睾精子发生的(CRES ) oligomerization,包括建议那 transglutaminase cross-linking 的研究可以是在附睾以内的细胞外的质量控制的一机制。 | Gail A. Cornwall H. Henning von Horsten Douglas Swartz Seethal Johnson Kim Chau Sandra Whelly | 2007 | Asian Journal of Andrology2007，9，4： | 3 |
| 18 | Symptom Management for Irritable Bowel Syndrome: A Pilot Randomized Controlled Trial of Acupuncture/Moxibustion显示文摘 | Joyce K. Anastasi Donald J. McMahon Gee H. Kim | 2009 | Gastroenterology Nursing2009，，4： | 3 |
| 19 | Systematic review and meta‐analysis of robotic surgery compared with conventional laparoscopic and open resections for gastric carcinoma显示文摘 | M.‐H. Hyun C.‐H. Lee H.‐J. Kim Y. Tong S.‐S. Park | 2013 | Br J Surg2013，，12： | 3 |
| 20 | Thermostable and alkalophilic maltogenic amylase of Bacillus thermoalkalophilus ET2 in monomer-dimer equilibrium显示文摘 | Cheong, K. A. Tang, S. Y. Cheong, T. K. Cha, H Kim, J. W. Park, K. H. | 2007 | 中国生物学文摘2007，21，1： | 3 |
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