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| 1 | Relationship of human leukocyte antigen class II genes with the susceptibility to hepatitis B virus infection and the response to interferon in HBV-infected patients显示文摘AIM: To study the relationship of human leukocyte antigen (HLA)-DRB1 and -DQB1 alleles with the genetic susceptibility to HBV infection and the response to interferon (IFN) in HBV-infected patients.METHODS: Low-resolution DNA typing kit was used to determine HLA-DR-1 and -DQB1 genes in 72 patients with chronic hepatitis B (CHB) and HLA-DRB1 in 200 healthy people ready to donate their bone marrow in Shanghai.Among CHB patients, 35 were treated with IFNα-1b for 24 wk.RESULTS: The frequencies of HLA-DRB1*06, DRB1*08and DRB1*16 alleles in 72 patients were higher than in 200 healthy people (2.08% vs0%, OR = 3.837, P= 0.018;11.11% vs5.50%, OR = 2.148, P= 0.034; and 6.94% vs 3.00%, OR = 0.625, P = 0.049, respectively); whereas that of DRB1*07 allele was lower (2.78% vs 7.75%,OR = 0.340, P = 0.046). The frequency of HLA-DRB1* 14allele was higher in 11 responders to IFN compared with 24 non-responders (18.18% vs2.08%, OR = 10.444,P = 0.031), whereas that of DQB1*07 allele was inverse (9.09% vs 37.50%, OR = 0.167, P= 0.021).CONCLUSION: The polymorphism of HLA class Ⅱ may influence the susceptibility to HBV infection and the response to IFN in studied CHB patients. Compared with other HLA-DRB1 alleles, HLA-DRB1*06, DRB1*08, and DRB1*16 may be associated with chronicity of HBV infection, HLA-DRB1*07 with protection against HBV infection, and HLA-DRB1*14 allele may be associated with a high rate of the response of CHB patients to IFN treatment.Compared with other HLA-DQB1 alleles, HLA-DQB1*07 may be associated with low response rate to IFN. | Yong-Nian Han Jin-Long Yang Shui-Gen Zheng Qun Tang Wei Zhu | 2005 | World Journal of Gastroenterology2005，11，36： | 28 |
| 2 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 3 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 4 | Bisoprolol reverses down-regulation of potassium channel proteins in ventricular tissues of rabbits with heart failure显示文摘Remodeling of ion channels is an important mechanism of arrhythmia induced by heart failure (HF).We investigated the expression of potassium channel encoding genes in the ventricles of rabbit established by volumeoverload operation followed with pressure-overload.The reversible effect of these changes with bisoprolol was also evaluated.The HF group exhibited left ventricular enlargement,systolic dysfunction,prolongation of corrected QT interval (QTc),and increased plasma brain natriuretic peptide levels in the HF rabbits.Several potassium channel subunit encoding genes were consistently down-regulated in the HF rabbits.After bisoprolol treatment,heart function was improved significantly and QTc was shortened.Additionally,the mRNA expression of potassium channel subunit genes could be partially reversed.The down-regulated expression of potassium channel subunits Kv4.3,Kv1.4,KvLQT1,minK and Kir 2.1 may contribute to the prolongation of action potential duration in the heart of rabbits induced by volume combined with pressure overload HF.Bisoprolol could partially reverse these down-regulations and improve heart function. | Xi Li Tingzhong Wang Ke Han Xiaozhen Zhuo Qun Lu Aiqun Ma | 2011 | The Journal of Biomedical Research2011，25，4： | 6 |
| 5 | Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages显示文摘发炎是到损害和感染的身体纸巾的回答。能禁止发炎的混合物被显示了有潜在的治疗学的临床的申请。Gambogenic 酸(GEA ) 有有势力 antitumor 和反煽动性的活动。此处, GEA 反煽动性的效果的分子的机制在刺激的 lipopolysaccharide (LPS ) 被调查巨噬细胞房间。结果证明有 GEA 的那个预告的处理能显著地禁止 interleukin (IL )-1, IL-1,肿瘤坏死因素 -- ,以在导致 LPS 的模型的一种剂量依赖者方式的 IFN- , IL-12b,和 IL-23a 生产。而且,这药显著地减少了氮的氧化物的版本(没有) ,并且损害了蛋白质水平可诱导没有 synthase 和 cyclooxygenase 2。发现也证明 GEA 的效果可能与原子 factor-B (NF-B ) 和表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 GEA 能由 attenuating 部分压制模仿 LPS 的煽动性的反应没有合成和 NF-B 和 MAPK 激活,建议它可以成为一个有势力为煽动性的疾病的处理的治疗学的代理人。 | Xianjun Yu Qun Zhao Haiwei Zhang Cunxian Fan Xixi Zhang Qun Xie Chengxian Xu Yongbo Liu Xiaoxia Wu Quanbin Han Haibing Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 6 | Recent progress in organic solar cells(PartⅠmaterial science)显示文摘During past several years,the photovoltaic performances of organic solar cells(OSCs)have achieved rapid progress with power conversion efficiencies(PCEs)over 18%,demonstrating a great practical application prospect.The development of material science including conjugated polymer donors,oligomer-like organic molecule donors,fused and nonfused ring acceptors,polymer acceptors,single-component organic solar cells and water/alcohol soluble interface materials are the key research topics in OSC field.Herein,the recent progress of these aspects is systematically summarized.Meanwhile,the current problems and future development are also discussed. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，2： | 5 |
| 7 | Estimating biological reference points for Largehead hairtail(Trichiurus lepturus) fishery in the Yellow Sea and Bohai Sea显示文摘It is important to find a reliable method to estimate maximum sustainable yield(MSY)or total allowable catch(TAC)for fishery management,especially when the data availability is limited which is a case in China.A recently developed method(CMSY)is a data-poor method,which requires only catch data,resilience and exploitation history at the first and final years of the catch data.CMSY was used in this study to estimate the biological reference points for Largehead hairtail(Trichiurus lepturus,Temminck and Schlegel)in the Yellow Sea and Bohai Sea,based on the fishery data from China Fishery Statistical Year Books during 1986 to 2012.Additionally,Bayesian state-space Schaefer surplus production model(BSM)and the classical surplus production models(Schaefer and Fox)performed by software CEDA and ASPIC,were also projected in this study to compare with the performance of CMSY.The estimated MSYs from all models are about 19.7×104–27.0×104 t,while CMSY and BSM yielded more reasonable population parameter estimates(the intrinsic population growth rate and the carrying capacity).The biological reference points of B/BMSY smaller than 1.0,while F/FMSY higher than 1.0 revealed an over-exploitation of the fishery,indicating that more conservative management strategies are required for Largehead hairtail fishery. | Yupeng Ji Qun Liu Baochao Liao Qingqing Zhang Ya’nan Han | 2019 | Acta Oceanologica Sinica2019，38，10： | 5 |
| 8 | Association between Polymorphism of Interleukin-23 Receptor and Hashimoto's Thyroiditis in Chinese Han Population of Shandong显示文摘 | Zhi-Hua Li Jie Han Yu-Fei Wang Jun Dai Hui Zhang Chun-Xia Li Qun Ma | 2015 | Chinese Medical Journal2015，，15： | 5 |
| 9 | Role of miR-124 in the regulation of retinoic acid-induced Neuro-2A cell differentiation显示文摘Retinoic acid can cause many types of cells,including mouse neuroblastoma Neuro-2 A cells,to differentiate into neurons.However,it is still unknown whether microRNAs(miRNAs)play a role in this neuronal differentiation.To address this issue,real-time polymerase chain reaction assays were used to detect the expression of several differentiation-related miRNAs during the differentiation of retinoic acid-treated Neuro-2 A cells.The results revealed that miR-124 and miR-9 were upregulated,while miR-125 b was downregulated in retinoic acid-treated Neuro-2 A cells.To identify the miRNA that may play a key role,miR-124 expression was regulated by transfection of miRNA mimics or inhibitors.Morphological analysis results showed that inhibition of miR-124 expression reversed the effects of retinoic acid on neurite outgrowth.Moreover,miR-124 overexpression alone caused Neuro-2 A cells to differentiate into neurons,and its inhibitor could block this effect.These results suggest that miR-124 plays an important role in retinoic acid-induced differentiation of Neuro-2 A cells. | Qun You Qiang Gong Yu-Qiao Han Rou Pi Yi-Jie Du Su-Zhen Dong | 2020 | Neural Regeneration Research2020，15，6： | 4 |
| 10 | Optimal design of Er/Yb co-doped fiber amplifiers with an Yb-band fiber Bragg grating显示文摘In this paper, Er/Yb co-doped fiber amplifiers(EYDFAs) with an Yb-band fiber Bragg grating(FBG) at the pump end to improve the performance of the amplifier is systematically studied. The influence of the reflectivity and center wavelength of the FBG along with the gain-fiber length on the performance of an EYDFA are numerically analyzed. The results show that the wavelength of the FBG has critical influence on the efficiency of the EYDFA,whereas the requirement to its reflectivity is relaxed. It is an effective and promising way to improve the efficiency of a high-power pumped EYDFA by introducing a suitable Yb-band FBG at the pump end. Based on the analysis of the underlying principles, suggestions for the practical design and possible further improvement strategies are also proposed. | Qun Han Wenchuan Yan Yunzhi Yao Yaofei Chen Tiegen Liu | 2016 | Photonics Research2016，4，2： | 3 |
| 11 | Recent progress in organic solar cells(PartⅡdevice engineering)显示文摘1 Introduction Organic solar cells(OSCs)belong to a multidisciplinary field composed of chemistry,materials science,physics,engineering,etc.For a better reviewing of this field,we briefly divide the research field of OSCs into two parts:material science and device engineering.In our previous review,the material science part of OSCs,including conjugated polymer donors and acceptors,small molecular donors and acceptors. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yuqiang Liu Lei Meng Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，8： | 3 |
| 12 | Hierarchical Bayesian Estimation of the Products Reliability Based on Zero-Failure Data | HAN Ming 1,\ LI Yi\|qun 21.Department of Mathematics, Ningbo University, Ningbo, China, 315211 2.Shanghai Sauer Hydrostatic Transmission Co. Ltd. Shanghai, China, 201206 | 1999 | Systems Science and Systems Engineering1999，9，4： | 3 |
| 13 | Fiber loop ring-down cavity integrated U-bent single-mode-fiber for magnetic field sensing显示文摘A novel magnetic field sensing system based on the fiber loop ring-down technique is proposed in this paper. In the fiber loop, a U-bent single-mode-fiber structure coated with magnetic fluid(MF) serves as the sensing head, and an erbium-doped fiber amplifier(EDFA) is introduced to compensate for the intrinsic loss of the cavity. The ring-down time of the system varies with the change of applied magnetic field due to the tunable absorption coefficient and refractive index of the MF. Therefore, measurement of the magnetic field can be realized by monitoring the ringdown time. The experimental results show that the performance of the system is extremely dependent on the interrogation wavelength, because both the gain of the EDFA and the loss of the sensing head are wavelength dependent.We found that at the optimal wavelength, the ratio of the gain to loss attained its maximum. The sensing system was experimentally demonstrated and a sensitivity of-0.5951 μs∕Oe was achieved. | Yaofei Chen Tiegen Liu Qun Han Wenchuan Yan Lin Yu | 2016 | Photonics Research2016，4，6： | 3 |
| 14 | Consideration of Monkeypox Surveillance in China,2022显示文摘Since the first monkeypox cases were confirmed in England in May 2022(1),100 countries worldwide have reported 53,027 confirmed cases and 15 deaths as of September 2(2).This is the largest and most widespread monkeypox epidemic in the world since monkeypox virus was discovered and identified in 1958,involving the largest number of countries and transmitting primarily in non-endemic countries(3).Moreover,the currently ongoing monkeypox epidemic also has some characteristics that are different from previous outbreaks(4).For example,most cases have a history of sexual contact,with an overwhelming majority of men who have sex with men(MSM)(5).On July 23,the WHO declared the global monkeypox outbreak a Public Health Emergency of International Concern(PHEIC)in order to address the ongoing outbreak with the required urgency(6). | Lei Zhou Yali Wang Dan Li Mengjie Han Guoqing Shi Qun Li | 2022 | China CDC weekly2022，4，41： | 2 |
| 15 | Variations in OsSPL10 confer drought tolerance by directly regulating OsNAC2 expression and ROS production in rice显示文摘Drought is a major factor restricting the production of rice(Oryza sativa L.).The identification of natural variants for drought stress-related genes is an important step toward developing genetically improved rice varieties.Here,we characterized a member of the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE(SPL)family,OsSPL10,as a transcription factor involved in the regulation of drought tolerance in rice.OsSPL10 appears to play a vital role in drought tolerance by controlling reactive oxygen species(ROS)production and stomatal movements.Haplotype and allele frequency analyses of OsSPL10 indicated that most upland rice and improved lowland rice varieties harbor the OsSPL10Hap1allele,whereas the OsSPL10Hap2allele was mainly present in lowland and landrace rice varieties.Importantly,we demonstrated that the varieties with the OsSPL10Hap1allele showed low expression levels of OsSPL10 and its downstream gene,OsNAC2,which decreases the expression of OsAP37 and increases the expression of OsCOX11,thus preventing ROS accumulation and programmed cell death(PCD).Furthermore,the knockdown or knockout of OsSPL10 induced fast stomatal closure and prevented water loss,thereby improving drought tolerance in rice.Based on these observations,we propose that OsSPL10 confers drought tolerance by regulating OsNAC2 expression and that OsSPL10Hap1could be a valuable haplotype for the genetic improvement of drought tolerance in rice. | Yingxiu Li Shichen Han Xingming Sun Najeeb Ullah Khan Qun Zhong Zhanying Zhang Hongliang Zhang Feng Ming Zichao Li Jinjie Li | 2023 | Journal of Integrative Plant Biology2023，65，4： | 2 |
| 16 | 老年患者经皮冠状动脉介入术后急性肾损伤的早期诊断的研究(英文)显示文摘目的:探索老年患者尿液中肝型脂肪酸结合蛋白(L-FABP)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)及肾损伤分子1(KIM-1)三种新型肾损伤标志物对经皮冠状动脉介入(PCI)术后急性肾损伤(AKI)的早期预测作用。创新点:本研究主要评估PCI术后肾损伤标志物的上升倍数对AKI早期诊断的价值,对基线标志物水平不同的患者而言,具有一定意义。方法:采用巢式病例对照研究的方法来比较PCI术后AKI患者和对照组患者围手术期肾损伤标志物的变化。结论:老年患者PCI术后6小时尿L-FABP和NGAL的上升倍数对AKI具有一定的预测价值。二者联合检验预测价值更高。而尿KIM-1的早期预测价值较低。 | Hong-hua YE Gen SHEN Qun LUO Fang-fang ZHOU Xiao-ling XIE Chun-yan WANG Li-na HAN | 2018 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2018，19，5： | 2 |
| 17 | A multi-paradigm decision modeling framework for combat system effectiveness measurement based on domain-specific modeling显示文摘Decision modeling is an essential part of the combat system effectiveness simulation (CoSES), which needs to cope with the cognitive quality, diversity, flexibility, and higher abstraction of decision making. In this paper, a multi-paradigm decision modeling framework is proposed to support decision modeling at three levels of abstraction based on domain-specific modeling (DSM). This framework designs a domain-specific modeling language (DSML) for decision modeling to raise the abstraction level of modeling, transforms the domain-specific models to formalism-based models to enable formal analysis and early verification and validation, and implements the semantics of the DSML based on a Python scripts framework which incorporates the decision model into the whole simulation system. The case study shows that the proposed approach incorporates domain expertise and facilitates domain modeler's participation in CoSES to formulate the problem using DSML in the problem domain, and enables formal analysis and automatic implementation of the decision model in the solution domain. | Xiao-bo LI Yong-lin LEI Hans VANGHELUWE Wei-ping WANG Qun LI | 2013 | Journal of Zhejiang University-Science C(Computers and Electronics)2013，14，5： | 2 |
| 18 | Stimulation and experiment of erbium/yt terbium co-doped double-clad fiber amplifier显示文摘 | ZHANG Wei-yi NING Ji-ping HAN Qun | 2012 | Microwave and Optical Techno logy Letters2012，54，5： | 1 |
| 19 | Multiwavelet Frames from Refinable Function Vectors显示文摘 | Bin Han Qun Mo | 2003 | Advances in Computational Mathematics (-)2003，，2： | 1 |
| 20 | Identification of a novel thrombin-like phospholipase A2 from Gloydius ussuriensis snake venom显示文摘 | Qiuyan Zhang Jingyun Wang Ying Han Qun Xie Lijia An Yongming Bao | 2007 | Blood Coagulation & Fibrinolysis2007，，8： | 1 |
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