|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | A novel method for purification of recombinant adeno-associated virus vectors on a large scale显示文摘A novel method for recombinant adeno-associ-ated virus (rAAV) purification on large scale is described. The method involves three steps, including chloroform treatment, PEG/NaCl precipitation and chloroform extraction. The whole procedure can be performed in four hours. Using this purification method, we can reproducibly obtain, from 4 × 109 of proviral cells cultured in roller bottles, purified rAAV-GFP stocks with titers of around 5×1013 particles/mL and purity greater than 95%. The infectious titers of the vector stocks were up to 2×1012 TU/mL, thus particle-to-infectivity rate was about 25. Under an electronic microscope, most rAAV particles appeared full and a few were in intermediate form. Empty particles were rarely seen. The purified rAAV-GFP stocks have been successfully used in in vitro and in vivo transfection experiments. Therefore, this new method offers a simple, rapid and cost-effective way for large-scale rAAV purification. | WU Xiaobing DONG Xiaoyan WU Zhijian CAO Hui NIU Dongbin QU Jianguo WANG Hong HOU Yunde | 2001 | Chinese Science Bulletin2001，46，6： | 21 |
| 3 | Evaluation of phytoextracting cadmium and lead by sunflower,ricinus,alfalfa and mustard in hydroponic culture显示文摘与重金属镉(Cd ) 和铅(Pb ) 污染的土壤对难被重新调停。植物救治可以是一个可行方法把有毒的金属从土壤移开,但是有很少合适的植物,罐头亢奋积累金属。在在四的累积包括葵花(向日葵 annuus L.) 种的这研究, Cd 和 Pb,芥末(Brassica juncea L.) ,苜蓿(Medicago sativa L.) ,篦麻毒素我们(Ricinus communis L.) 在水耕法的文化被比较。结果显示出那这些植物能 phytoextract 重金属,累积的能力与重金属的种类,集中和范畴不同。BCF (简历集中因素) 和 TF (translocation 因素) 的价值显示四种有 phytoextraction 的不一样的能力和重金属的交通。在不同处理的植物, pH 和 Eh 的生物资源上的变化表明这四植物在文化有不同回答到 Cd 和 Pb。大小应该被拿改进与重金属污染的地点的植物救治,例如 pH 并且啊规定等等。 | NIU Zhi-xin SUN Li-na SUN Tie-heng LI Yu-shuang WANG Hong | 2007 | Journal of Environmental Sciences2007，19，8： | 18 |
| 4 | A pilot phase Ⅱ study of neoadjuvant triplet chemotherapy regimen in patients with locally advanced resectable colon cancer显示文摘Objective: This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon cancer.Methods: Patients with clinical stage IIIb colon cancer received a perioperative triple chemotherapy regimen(oxaliplatin 85 mg/m2 and irinotecan 150 mg/m2, combined with folinic acid 200 mg, 5-fluorouracil 500 mg bolus and then 2,400 mg/m2 by 44 h infusion or capecitabine 1 g/m2 or S-1 40–60 mg b.i.d orally d 1–10, repeated at 2-week intervals) for 4 cycles. Complete mesocolic excision was scheduled 2–6 weeks after completion of neoadjuvant treatment and followed by a further 6 cycles of FOLFOXIRI or XELOX. Primary outcome measures of this stage II trial were feasibility, safety, tolerance and efficacy of neoadjuvant treatment.Results: All 23 patients received neoadjuvant chemotherapy and underwent surgery. Twenty-one patients(91.3%) had reductions in tumor volume after neoadjuvant treatment, and 13 patients(56.5%) had grade 3–4toxicity. No patients had severe complications from surgery. Preoperative therapy resulted in significant downstaging of T-stage and N-stage compared with the baseline clinical stage including one pathological complete response.Conclusions: Neoadjuvant triple chemotherapy has high activity and acceptable toxicity and perioperative morbidity, and is feasible, tolerable and effective for locally advanced resectable colon cancer. | Haitao Zhou Yan Song Jun Jiang Haitao Niu Hong Zhao Jianwei Liang Hao Su Zheng Wang Zhixiang Zhou Jing Huang | 2016 | Chinese Journal of Cancer Research2016，28，6： | 18 |
| 5 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 6 | Slip rate along the Lijiang-Ninglang fault zone estimated from repeating microearthquakes显示文摘Seismicity 并且沿着在 1999 和 2006 之间的 Lijiang-Ninglang 差错地区滑动率被调查,波形数据由云南数字地震网络记录了。由双差别方法的重定位的 seismicity 清楚地展出在北、南部的片断之间的不同特征。超过 76% 地震在丽江区域附近发生在差错的南部的片断。重定位的 seismicity 看起来反映学习区域的外壳的速度结构。用跨关联的分析,我们识别了显示出高波形类似的 92 件马甲和 70 根多重谱线的一个总数。大多数这些序列是非周期的,复发间隔从一些分钟变化到几百天。用在学习时期上定期发生了的二个序列,我们获得了一个差错在 ∼23 km 滑动约 5 mm/a 的率,在对的好同意地质并且表面 GPS 测量。 | LI Le CHEN QiFu NIU FengLin FU Hong LIU RuiFeng HOU YanYan | 2009 | Chinese Science Bulletin2009，54，3： | 16 |
| 7 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 8 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 9 | Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination显示文摘 | Yiqiang Cui Yuyu Niu Jiankui Zhou Yongchang Chen Yiwei Cheng Shangang Li Zongyong Ai Chu Chu Hong Wang Bo Zheng Xuejin Chen Jiahao Sha Xuejiang Guo Xingxu Huang Weizhi Ji | 2018 | Cell Research2018，28，3： | 13 |
| 10 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 11 | Damage identification method of girder bridges based on finite element model updating and modal strain energy显示文摘A timely and accurate damage identification for bridge structures is essential to prevent sudden failures/collapses and other catastrophic accidents.Based on response surface model(RSM)updating and element modal strain energy(EMSE)damage index,this paper proposes a novel damage identification method for girder bridge structures.The effectiveness of the proposed damage identification method is investigated using experiments on four simply supported steel beams.With Xiabaishi Bridge,a prestressed continuous rigid frame bridge with large span,as the engineering background,the proposed damage identification method is validated by using numerical simulation to generate different bearing damage scenarios.Finally,the efficiency of the method is justified by considering its application to identifying cracking damage for a real continuous beam bridge called Xinyihe Bridge.It is concluded that the EMSE damage index is sensitive to the cracking damage and the bearing damage.The locations and levels of multiple cracking damages and bearing damages can be also identified.The results illuminate a great potential of the proposed method in identifying damages of real bridge structures. | NIU Jie ZONG Zhou Hong CHU Fu Peng | 2015 | Science China(Technological Sciences)2015，58，4： | 12 |
| 12 | Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development显示文摘Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive.Here,we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation)carrying human copies of MCPH1,an important gene for brain development and brain evolution.Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation,resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys,similar to the known evolutionary change of developmental delay(neoteny)in humans.Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes,providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys.More importantly,the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task.The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits. | Lei Shi Xin Luo Jin Jiang Yongchang chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi Shi Martin Styner Jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su | 2019 | National Science Review2019，6，3： | 12 |
| 13 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 14 | Origin of Baotoudong syenites in North China Craton:Petrological, mineralogical and geochemical evidence显示文摘Baotoudong 正长岩 pluton 被定位到 Baotou 城市的东方,内部蒙古,沿着北方中国 Craton (NCC ) 的北边缘的三叠纪的碱的 magmatic 带的最西的部分。锆石 U-Pb 年龄, petrological,矿物学并且 pluton 的 geochemical 数据在这份报纸被获得,抑制它的起源和披风来源特征。pluton 由 nepheline-clinopyroxene 正长岩和碱长石正长岩组成,与 214.7 ? 的锆石 U-Pb 年龄 ?????????? 潡潴摵湯 ????? 甠瑬慲潰慴獳捩 ???????????????????? | NIU Xiao Lu YANG Jing Sui LIU Fei ZHANG Hong Yu YANG Ming Chun | 2016 | Science China Earth Sciences2016，59，1： | 10 |
| 15 | The retromer component SNX6 interacts with dynactin p150Glued and mediates endosome-to-TGN transport显示文摘retromer 是调停的蛋白质建筑群后退到 trans-Golgi 网络(TGN ) 的从内涵体的 transmembrane 货物的运输。它由 Vps26, Vps29 和 Vps35 的货物选择 subcomplex 和排序 nexins (SNX ) 的膜绑定上衣 subcomplex 组成。以前的研究作为第二 SNX 的候选人作为 SNX subcomplex,和 SNX5/6 的部件之一识别了 SNX1/2。联系 retromer 的货物怎么被分子的马达认出并且搬运,大部分是未知的。在这研究,我们发现了一个 SNX1/2 的 dimerization 搭挡, SNX6,与 dynein/dynactin 马达建筑群的 p150Glued 子单元交往。我们 SNX6 是 retromer 的一个部件的现在的证据,和到联系膜的 retromer 的马达建筑群的那招募要求 SNX6-p150Glued 相互作用。在从内涵体在一些 CI-MPR 检索从内涵体和结果排序结构到 TGN 的 tubulovesicular 的形成和分开的 SNX6-p150Glued 相互作用原因失败的混乱。这些观察显示除了 SNX1/2,与 dynein/dynactin 建筑群联合的 SNX6 驾驶形成和运动管状后退中介。 | Zhi Hong Yanrui Yang Cheng Zhang Yang Niu Ke Li Xi Zhao Jia-JiaLiu | 2009 | Cell Research2009，19，12： | 8 |
| 16 | Viral and Bacterial Etiology of Acute Febrile Respiratory Syndrome among Patients in Qinghai, China显示文摘Objective This study was conducted to investigate the viral and bacterial etiology and epidemiology of patients with acute febrile respiratory syndrome(AFRS) in Qinghai using a commercial routine multiplex-ligation-nucleic acid amplification test(NAT)-based assay. Methods A total of 445 nasopharyngeal swabs specimens from patients with AFRS were analyzed using the RespiFinderSmart22 kit(PathoFinder BV, Netherlands) and the LightCycler 480 real-time PCR system. Results Among the 225(225/445, 51%) positive specimens, 329 positive pathogens were detected, including 298(90.58%) viruses and 31(9%) bacteria. The most commonly detected pathogens were influenza virus(IFV;37.39%;123/329), adenovirus(AdV;17.02%;56/329), human coronaviruses(HCoVs;10.94%;36/329), rhinovirus/enterovirus(RV/EV;10.03%;33/329), parainfluenza viruses(PIVs;8.51%;28/329), and Mycoplasma pneumoniae(M. pneu;8.51%;28/329), respectively. Among the co-infected cases(17.53%;78/445), IFV/AdV and IFV/M. pneu were the most common co-infections. Most of the respiratory viruses were detected in summer and fall. Conclusion In our study, IFV-A was the most common respiratory pathogen among 22 detected pathogens, followed by AdV, HCoV, RV/EV, PIV, and M. pneu. Bacteria appeared less frequently than viruses, and co-infection was the most common phenomenon among viral pathogens. Pathogens were distributed among different age groups and respiratory viruses were generally active in July, September, and November. Enhanced surveillance and early detection can be useful in the diagnosis, treatment, and prevention of AFRS, as well as for guiding the development of appropriate public health strategies. | LIU Gao Shan LI Hong ZHAO Sheng Cang LU Rou Jian NIU Pei Hua TAN Wen Jie | 2019 | Biomedical and Environmental Sciences2019，32，6： | 8 |
| 17 | A Novel Surgery Classification for Endoscopic Approaches to Middle Ear Cholesteatoma显示文摘This study aimed to develop a novel surgery classification for an endoscopic approach to middle ear cholesteatoma.We retrospectively analyzed the surgical approaches and outcomes of patients with middle ear cholesteatoma.Middle ear cholesteatoma surgeries were divided into four types and two special types as follows:type I,attic retraction pocket,which only requires tympanostomy tube placement or retraction pocket resection and cartilage reconstruction;typeⅡ,cholesteatoma which is limited to the attic or in which endoscopy can confirm complete removal of mastoid cholesteatoma lesions,including type Ⅱa,requiring only use of a curette,and type Ⅱ b,requiring use of an electric drill or chisel;type Ⅲ,cholesteatoma not limited to the attic,in which endoscopy cannot confirm complete removal of mastoid cholesteatoma lesions,requiring the combined use of endoscope and microscope to perform endoscopic tympanoplasty and'Canal Wall Up'mastoidectomy;type Ⅳ,extensive involvement of mastoid cavity cholesteatoma lesions and/or cases with a potential risk of complications,removal of which can only be performed under a microscope for'Canal Wall Down'mastoidectomy.In addition,there were two special types:'difficult external auditory canal'and congenital cholesteatoma in children.In our system,type I and type U middle ear cholesteatoma surgery was completely performed under an endoscope alone.However,estimating the extent of the lesions,determining the choice of mastoid opening and reestablishing ventilation are the key points for an endoscopic approach to middle ear cholesteatoma.The classification of endoscopic middle ear cholesteatoma surgery may benefit the selection of surgical indications. | Yu SUN En-hao WANG Jin-tao YU Gang ZHONG Li-xin ZHU-Yi WANG Niu XUN Hong YU Wen ZHOU Zhen XIE Kun ZHANG Guo-run FAN Yi ZHONG Hong-jun XIAO Wei-jia KONG | 2020 | Current Medical Science2020，40，1： | 8 |
| 18 | Temperature field reconstruction of 3D luminous flames based on light field tomography theory显示文摘Standard plenoptic camera can be used to capture multi-dimensional radiation information of high temperature luminous flame to reconstruct the temperature distribution. In this study, a novel method for reconstructing three-dimensional temperature field is proposed. This method is based on the optical tomography combined with standard plenoptic camera. The flame projection information from different planes is contained in one radiation image. In this model, we introduced the effective concept of the nearest neighbor method in the frequency domain to strip the interference of redundant information in the projection and to realize three-dimensional deconvolution. The flame emission intensity received by the pixels on the charge-coupled device sensor can be obtained according to the optical tomographic model. The temperature distributions of the axisymmetric and nonaxisymmetric flames can be reconstructed by solving the mathematical model with the nearest neighbor method. The numerical results show that three-dimensional temperature fields of high temperature luminous flames can be retrieved, proving the validity of the proposed method. | NIU ZhiTian QI Hong SHI JingWen ZHANG JuQi REN YaTao | 2021 | Science China(Technological Sciences)2021，64，2： | 6 |
| 19 | Etiology and prevalence of abnormal serum alanine aminotransferase levels in a general population in Northeast China显示文摘背景长期的肝疾病是在 China.Alanine aminotransferase (中高音)的主要负担能被用作 hepatocyte damage.In 的指示物这研究,我们在吉林在一张成年人口决定了提高的中高音的流行和病原学, 4072 个个人的一个总数在 18 和 79 年之间变老的 China.Methods 首先被会见,然后经历提高的中高音的流行是的 ultrasonography 和血 tests.Results 17.53% .The | ZHANG Hong JIANG Yan-fang HE Shu-mei SUN Jie GU Qing FENG Xiang-wei DU Bing WANG Wei SHI Xiao-dong WANG Chun-yan ZHANG Si-qi LI Wan-yu NIU Jun-qi | 2011 | Chinese Medical Journal2011，，17： | 6 |
| 20 | A Novel Green Preparation ofα,α′-Bis(substituted benzylidene)-cycloalkanones Promoted by FeCl3·6H2O in Ionic Liquid显示文摘α, α'-Bis(substituted benzylidene)cycloalkanones were efficiently prepared fromcycloalkanones and benzaldehydes in [bmim][BF4] by using iron(Ⅲ) chloride hexahydrate as acatalyst. It is shown that [bmim][BF4] and iron(Ⅲ) chloride hexahydrate can be quantitativelyrecovered and be reused effectively for many times. Compared with the known methods, thisnovel process has the advantage of being an environmentally benign process together with goodyields and mild reaction conditions. | Xin Ying ZHANG, Xue Sen FAN, Hong Ying NIU, Jian Ji WANGSchool of Chemical and Environmental Sciences, Henan Normal University, Key Laboratory ofEnvironmental Science and Engineering of Henan Education Department,Xinxiang 453002 | 2003 | Chinese Chemical Letters2003，14，10： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员