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| 1 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 2 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 3 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 4 | Comparative Study between Robotic Total Thyroidectomy with Central Lymph Node Dissection via Bilateral Axillo-breast Approach and Conventional Open Procedure for Papillary Thyroid Microcarcinoma显示文摘 | Qing-Qing He Jian Zhu Da-Yong Zhuang Zi-Yi Fan Lu-Ming Zheng Peng Zhou Lei Hou Fang Yu Yan-Ning Li Lei Xiao Xue-Feng Dong Gao-Feng Ni | 2016 | Chinese Medical Journal2016，，18： | 42 |
| 5 | Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction显示文摘证据建议 exosomes 能转移在房间之间的基因材料。然而,他们在肝炎 B 的角色病毒(HBV ) 感染遗体不清楚。这里,我们报导在长期的肝炎 B (CHB ) 病人的 sera 在场的 exosomes 包含了两 HBV nucleic 酸和 HBV 蛋白质,并且以一种活跃方式把 HBV 转移了到 hepatocytes。尤其是, HBV nucleic 酸在生来的杀手(NK ) 被检测从在到 HBV 积极的 exosomes 的暴露以后的 CHB 病人和健康施主的房间。通过即时荧光显微镜学和流动 cytometry, 1,1-dioctadecyl-3,3,3,3, -tetramethylindodicarbocyanine, 4-chlorobenzenesulfnate 盐() 标记的 exosomes 被观察与 NK 房间交往并且被 NK 房间收起,它被转变生长因素提高 -- 治疗。而且, HBV 积极的 exosomes 损害了 NK 房间功能,包括干扰素(IFN )- 生产, cytolytic 活动, NK 房间增长和幸存,以及房间到的应答 poly (我: C ) 刺激。HBV 感染压制了模式识别受体的表示,特别 retinoic 酸可诱导的基因我(RIG-I ) 在 NK 房间上,导致原子因素 B (NF-B ) 和 p38 阻抑激活 mitogen 的蛋白质 kinase 小径。我们的结果在 CHB 感染期间在 HBV 传播和 NK 房间机能障碍加亮 exosomes 的一个以前未得到欣赏的角色。 | Yinli Yang Qiuju Han Zhaohua Hou Cai Zhang Zhigang Tian Jian Zhang | 2017 | Cellular & Molecular Immunology2017，14，5： | 47 |
| 6 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 7 | Different dose combinations of bortezomib and dexamethasone in the treatment of relapsed or refractory myeloma: an open-label,observational, multi-center study in China显示文摘背景尽管以前的临床的学习表明与 dexamethasone 相结合的 bortezomib 改进了 relapsed 或倔强的多重骨髓瘤(RRMM ) 的结果, bortezomib 和 dexamethasone 的最佳的剂量联合仍然保持未知。这试用试图与 relapsed 在 168 个病人全部的 China.Methods A 在 RRMM 病人的治疗观察 bortezomib 和 dexamethasone 的不同剂量联合的功效和安全多重骨髓瘤(公里)对倔强在以免二优先的治疗在这 multicenter 被注册,开标签,非使随机化,未来的临床的试用。二十个病人为多达 8 个周期和口头或静脉内的 dexamethasone 收到了为 2 星期一个 3 星期的周期两次每周的 bortezomib 的 1.3 mg/m2 在日子并且在每 bortezomib 剂量(组 1 ) 以后的 20 mg;66 个病人收到了 bortezomib 和 dexamethasone 的不到 1.3 mg/m2 (0.7-1.0 mg/m2 ) 一样的时间表(组 2 ) 上的 20 mg;37 个病人收到了 40 mg (组 3 ) 和 45 个病人收到了的 bortezomib 和 dexamethasone 的 1.3 mg/m2 bortezomib 和 dexamethasone 的不到 1.3 mg/m2 (0.7-1.0 mg/m2 ) 40 mg (组 4 ) 。反应为血和髓移植根据欧洲组的标准被评估并且由一个独立评论委员会证实了。不利事件根据国家癌症研究所被分级普通毒性标准,版本 3.0。结果组的中部的年龄 1 ~ 4 分别地是 61,62, 56,和 60 年。大多数病人在公里的阶段/,最普通的子类型是对组 1~4 的 bortezomib 和 dexamethasone 的全面反应的率是的 IgG 72.2 ( 13/18 ), 73.8 ( 48/65 ), 78.8 ( 26/33 )并且 78.0 ( 32/41 )( P=0.91 ),包括 22.2 的完全的反应率( 4/18 ), 20.0 ( 13/65 ), 33.3 ( 11/33 )并且 29.3 ( 12/41 )( P=0.67 )分别地。在这 4 个组(P 0.05 ) 之中及时没有统计意义到前进和全面幸存。在全部 4 个组的任何等级的最通常不利的事件是疲劳,胃肠的效果,外部神经病和 thrombocytopenia ,并且除了外部神经病在组 3 更经常被报导之外,在在 4 个组( P 0.05 )之中的不利事件的数字没有意义( 36.3 )比在组 2 ( 13.8 , P 0.05 )并且组织 4 ( 14.6 , PO.05 ) .Conclusions bortezomib 和 dexamethasone 的联合在中国 RRMM 病人与高回答被联系。功效的重要差别都没在 bortezomib 和 dexamethasone 的不同剂量联合被检测。而且,没有在中国与 RRMM 在病人的治疗影响结果, bortezomib 的低剂量减少了外部神经病的发生。 | YUAN Zhen-gang JIN Jie HUANG Xiao-jun LI Yan CHEN Wen-ming LIU Zhuo-gang CHEN Xie-qun SHEN Zhi-xiang HOU Jian | 2011 | Chinese Medical Journal2011，，19： | 24 |
| 8 | Number concentration and size distributions of submicron particles in Jinan urban area:Characteristics in summer and winter显示文摘喷雾器数字集中和尺寸分发在 Jinan 城市的城市的地点在 2006 的夏天和冬季与最新发达的宽范围的粒子分光计被测量。这里报导了不同观察季节的好粒子的特征。为在 10 500 nm 的直径范围的粒子的相对高数字集中在两个季节被观察。比在所有空气粒子的数字集中上的 100 nm 和百分比比在世界上在另外的城市的地点被测量的高是大部分,主导的数字才在小的颗粒直径散布了。在夏天的数字平均数直径比在冬季小得多,强烈在不同季节建议极其细小的粒子的不同起源。也就是说,在极其细小的模式的粒子主要在夏天来自成核和新粒子形成当时从在冬季的交通排放。日报变化也支持了这个点。在 10 200 nm 的直径范围的数字集中在中午得到了他们的山峰价值,很好在夏天与 SO2 的混合比率和太阳辐射的紧张相关。当时在冬季,那些在交通小时期间在一样的直径范围显示出主要山峰发生在早上和晚上。 | GAO Jian WANG Jin CHENG Shu-hui XUE Li-kun YAN Huai-zhong HOU Lu-jian JIANG Yu-quan WANG Wen-xing | 2007 | Journal of Environmental Sciences2007，19，12： | 21 |
| 9 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 10 | Genome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in cirrhotic patients显示文摘Dear Editor,Hepatocellular carcinoma(HCC)is the second most deadly cancer worldwide.1 Cirrhosis of different causes predisposes patients to HCC,increasing the annual HCC incidence by 2%–4%.1 The development of cirrhosis facilitates a series of genetic or epigenetic changes,resulting in the formation of dysplastic nodules,a premalignant stage in HCC.1 HCC diagnosis at an early stage contributes to an improved prognosis with the possibility of curative treatment.Due to the low accuracy of current diagnostic methods,it is urgently needed to explore new non-invasive strategies for early HCC diagnosis in cirrhotic patients. | Lei Chen Ghassan K.Abou-Alfa Bo Zheng Jing-Feng Liu Jian Bai Lu-Tao Du Yun-Song Qian Rong Fan Xiao-Long Liu Lin Wu Jin-Lin Hou Hong-Yang Wang The PreCar Team | 2021 | Cell Research2021，31，5： | 20 |
| 11 | Analytical model and application of stress distribution on mining coal floor显示文摘Given the analysis of underground pressure, a stress calculation model of coal floor stress has been established based on a theory of elasticity. The model presents the law of stress distribution on the relatively fixed position of the mining coal floor: the extent of stress variation in a fixed floor position decreases gradually along with depth, the decreasing rate of the vertical stress is clearly larger than that of the horizontal stress at a specific depth. The direction of the maximum principal stress changes gradually from a vertical direction to a horizontal direction with the advance of the working face. The deformation and permeability of the rock mass of the coal floor are obtained by contrasting the difference of the principal stress established from theoretical calculations with curves of stress-strain and permeability-strain from tests, which is an important mechanical basis for preventing water inrush from confined aquifers. | ZHU Shu-yun JIAN Zhen-quan HOU Hong-liang XIAO Wei-guo YAO Pu | 2008 | Journal of China University of Mining and Technology2008，18，1： | 19 |
| 12 | Modified constraint-induced movement therapy alters synaptic plasticity of rat contralateral hippocampus following middle cerebral artery occlusion显示文摘Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.However,the molecular mechanism underlying its efficacy remains unclear.In this study,a middle cerebral artery occlusion(MCAO)rat model was produced by the suture method.Rats received modified constraint-induced movement therapy 1 hour a day for 14 consecutive days,starting from the 7^th day after middle cerebral artery occlusion.Day 1 of treatment lasted for 10 minutes at 2r/min,day 2 for 20 minutes at 2 r/min,and from day 3 onward for 20 minutes at 4 r/min.CatWalk gait analysis,adhesive removal test,and Y-maze test were used to investigate motor function,sensory function as well as cognitive function in rodent animals from the 1st day before MCAO to the 21^st day after MCAO.On the 21^st day after MCAO,the neurotransmitter receptor-related genes from both contralateral and ipsilateral hippocampi were tested by micro-array and then verified by western blot assay.The glutamate related receptor was shown by transmission electron microscopy and the glutamate content was determined by high-performance liquid chromatography.The results of behavior tests showed that modified constraint-induced movement therapy promoted motor and sensory functional recovery in the middle cerebral artery-occluded rats,but had no effect on cognitive function.The modified constraint-induced movement therapy upregulated the expression of glutamate ionotropic receptor AMPA type subunit 3(Gria3)in the hippocampus and downregulated the expression of the beta3-adrenergic receptor gene Adrb3 and arginine vasopressin receptor 1 A,Avprla in the middle cerebral artery-occluded rats.In the ipsilateral hippocampus,only Adra2 a was downregulated,and there was no significant change in Gria3.Transmission electron microscopy revealed a denser distribution the more distribution of postsynaptic glutamate receptor 2/3,which is an a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor,within 240 nm of the postsynaptic density in the contralateral cornu ammonis 3 region.The size and distribution of the synaptic vesicles within 100 nm of the presynaptic active zone were unchanged.Western blot analysis showed that modified constraint-induced movement therapy also increased the expression of glutamate receptor 2/3 and brain-derived neurotrophic factor in the hippocampus of rats with middle cerebral artery occlusion,but had no effect on Synapsin I levels.Besides,we also found modified constraint-induced movement therapy effectively reduced glutamate content in the contralateral hippocampus.This study demonstrated that modified constraint-induced movement therapy is an effective rehabilitation therapy in middle cerebral artery-occluded rats,and suggests that these positive effects occur via the upregulation of the postsynaptic membrane a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor expression.This study was approved by the Institutional Animal Care and Use Committee of Fudan University,China(approval No.201802173 S)on March 3,2018. | Bei-Yao Gao Dong-Sheng Xu Pei-Le Liu Ce Li Liang Du Yan Hua Jian Hu Jia-Yun Hou Yu-Long Bai | 2020 | Neural Regeneration Research2020，15，6： | 19 |
| 13 | FUSAR-Ship:building a high-resolution SAR-AIS matchup dataset of Gaofen-3 for ship detection and recognition显示文摘Gaofen-3 (GF-3) is China's first civil C-band fully polarimetric spaceborne synthetic aperture radar (SAR) primarily missioned for ocean remote sensing and marine monitoring. This paper proposes an automatic sea segmentation, ship detection, and SAR-AIS matchup procedure and an extensible marine target taxonomy of 15 primary ship categories, 98 sub-categories, and many non-ship targets. The FUSAR-Ship high-resolution GF-3 SAR dataset is constructed by running the procedure on a total of 126 GF-3 scenes covering a large variety of sea, land, coast, river and island scenarios. It includes more than 5000 ship chips with AIS messages as well as samples of strong scatterer, bridge, coastal land, islands, sea and land clutter. FUSAR-Ship is intended as an open benchmark dataset for ship and marine target detection and recognition. A preliminary 8-type ship classification experiment based on convolutional neural networks demonstrated that an average of 79% test accuracy can be achieved. | Xiyue HOU Wei AO Qian SONG Jian LAI Haipeng WANG Feng XU | 2020 | Science China(Information Sciences)2020，63，4： | 19 |
| 14 | First experimental demonstration of coherent beam combining of more than 100 beams显示文摘Coherent beam combining of 107 beams has been demonstrated for the first time to the best of our knowledge.When the system was in closed loop,the pattern in far-field was stable and the fringe contrast was>96%.The impact of the dynamic tilt error,the piston error,and power inconsistency was theoretically analyzed.Meanwhile,the distribution law of dynamic tilt error was estimated and the correlation of the tilt dithering of different axis was analyzed statistically.The ratio of power in the central lobe was^22.5%.The phase residue error in the closed loop was~λ∕22,which was evaluated by the root-mean-square error of the signal generated from the photoelectric detector. | HONGXIANG CHANG QI CHANG JIACHAO XI TIANYUE HOU RONGTAO SU PENGFEI MA JIAN WUCAN LI MAN JIANG YANXING MA PU ZHOU | 2020 | Photonics Research2020，8，12： | 17 |
| 15 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 16 | Survivin mRNA expression in urine as a biomarker for patients with transitional cell carcinoma of bladder显示文摘膀胱的过渡房间癌(TCC ) 是在 uropoiesis 系统的最普通的恶意的肿瘤。最新,除了 CT 和 MRI 成像和 cystoscopy,仍然有为诊断 ofTCC 的一个理想的标记的缺乏。Cystoscopy 是侵略考试,它增加尿道感染的可能性。尿细胞学有低敏感(21%—40%) 在膀胱癌症的诊断,特别为那些与中等或高的区别。Thespecificity 被象标本收集那样的因素经常影响,尿道感染,等等。由真实 time-PCR 在尿检测 survivin mRNA 的表示在标本收集简单并且敏感、相对特定,它为 TCC 提供一个简单、非侵略的诊断方法。而且它允许比较,基因表示在不同阶段和等级 ofTCC 铺平,它能帮助定义 TCC 的恶意度。 | HOU Jian-quan HE Jun WEN Duan-gai CHEN Zi-xing ZENG Jian | 2006 | Chinese Medical Journal2006，，13： | 15 |
| 17 | GIS-Based and Data-Driven Bivariate Landslide-Susceptibility Mapping in the Three Gorges Area, China显示文摘A detailed landslide-susceptibility map was produced using a data-driven objective bivariate analysis method with datasets developed for a geographic information system (GIS). Known as one of the most landslide-prone areas in China, the Zhongxian-Shizhu Segment in the Three Gorges Reservoir region of China was selected as a suitable case because of the frequency and distribution of landslides. The site covered an area of 260.93 km2 with a landslide area of 5.32 km2. Four data domains were used in this study, including remote sensing products, thematic maps, geological maps, and topographical maps, all with 25 m × 25 m pixels. Statistical relationships for landslide susceptibility were developed using landslide and landslide causative factor databases. All continuous variables were converted to categorical variables according to the percentile divisions of seed cells, and the corresponding class weight values were calculated and summed to create the susceptibility map. According to the map, 3.6% of the study area was identified as high-susceptibility. Extremely low-, very low-, low-, and medium-susceptibility zones covered 19.66%, 31.69%, 27.95%, and 17.1% of the area, respectively. The high- and medium-hazardous zones are along both sides of the Yangtze River, being in agreement with the actual distribution of landslides. | BAI Shi-Biao WANG Jian LU Guo-Nian ZHOU Ping-Gen HOU Sheng-Shan XU Su-Ning | 2009 | Pedosphere2009，19，1： | 15 |
| 18 | TCM-based new drug discovery and development in China显示文摘Over the past 30 years, China has significantly improved the drug development environment by establishing a series of policies for the regulation of new drug approval. The regulatory system for new drug evaluation and registration in China was gradually developed in accordance with international standards. The approval and registration of TCM in China became as strict as those of chemical drugs and biological products. In this review, TCM-based new drug discovery and development are introduced according to the TCM classification of nine categories. | WU Wan-Ying HOU Jin-Jun LONG Hua-Li YANG Wen-Zhi LIANG Jian GUO De-An | 2014 | Chinese Journal of Natural Medicines2014，12，4： | 15 |
| 19 | Evaluation of solar aided biomass power generation systems with parabolic trough field显示文摘Solar and biomass are both renewable energy resources.Using biomass as fuel is becoming more and more attractive after governments increase the tariff for the electricity from the renewable sources.However the costs of power from a biomass power generation plant depend greatly on the availability and quality of the biomass resource.The commercialization of solar alone thermal power generation is hindered by its high initial investment and low thermal efficiency.In this paper,a concept of integrating solar into a biomass power generation system is put forward.In the system the oil heated by a parabolic trough solar field is used to replace the extraction steam to preheat the feed water(entering a biomass boiler) and the previous extraction steam thus saved can continue to do work in the lower stages of turbine.The performance of the hybrid system with different replacements is analyzed and compared through two typical solar aided biomass generating units.The results show that the integration not only reduces the consumption of biomass fuel(at the same generation capacity) but is also proved to be an efficient way to convert solar thermal energy into power.The results also show that with the same solar aperture area,the higher the grade of the replaced extraction steam,the better the thermal performance and economy. | HOU HongJuan YANG YongPing HU Eric SONG JiFeng DONG ChangQing MAO Jian | 2011 | Science China(Technological Sciences)2011，54，6： | 15 |
| 20 | Liver Enzymes Concentrations Are Closely Related to Pre-diabetes:Findings of the Shanghai Diabetes Study Ⅱ (SHDS Ⅱ)显示文摘Objective To investigate the relationship of liver enzymes with hyperglycemia in a large population in Shanghai and identify the association between liver enzymes and insulin resistance.Methods A total of 3 756 participants were enrolled.Each participant underwent an oral glucose tolerance test and completed a questionnaire.Anthropometric indices were recorded and serum samples were collected for measurement.Results Liver enzymes concentrations were independently associated with i-IGT,IFG+IGT,and diabetes.With the increase of ALT and GGT concentrations,ORs for i-IGT,IFG+IGT,and diabetes increased gradually.By comparing patients in the highest quartile of GGT concentrations or ALT concentrations with those in the lowest quartile (Q1),ORs for i-IGT,IFG+IGT,or diabetes was significant after adjustment.Both ALT and GGT concentrations were linearly correlated with HOMA-IR and independently associated with HOMA-IR [ALT OR (95% CI):2.56 (1.51-4.34) P=0.00;GGT OR (95% CI):2.66 (1.53-4.65) P=0.00].Conclusion Serum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance. | GAO Fei PAN Jie Min HOU Xu Hong FANG Qi Chen LU Hui Juan TANG Jun Ling GU Hui Lin PAN Zhi Jian YAO You Hua SHEN Wei Zhen JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 15 |
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