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| 1 | Polarization microwave-induced thermoacoustic imaging for quantitative characterization of deep biological tissue microstructures显示文摘Polarization optical imaging can be used to characterize anisotropy in biological tissue microstructures and has been demonstrated to be a powerful tool for clinical diagnosis. However, the approach is limited by an inability to image targets deeper than ~1 mm due to strong optical scattering in biological tissues. As such, we propose a novel polarization microwave-induced thermoacoustic imaging(P-MTAI) technique to noninvasively detect variations in deep tissue by exploiting the thermoacoustic signals induced by four pulsed microwaves of varying polarization orientations. The proposed P-MTAI method overcomes the penetration limits of conventional polarization optical imaging and provides submillimeter resolution over depths of several centimeters. As part of the paper, the structural characteristics of tissues were quantified using a new parameter, the degree of microwave absorption anisotropy. P-MTAI was also applied to the noninvasive detection of morphological changes in cardiomyocytes as they transitioned from ordered to disordered states, providing a potential indication of myocardial infarction. | YUJING LI SHANXIANG ZHANG LINGHUA WU ZHONGWEN CHENG ZHENHUI ZHANG HAOHAO WANG SHUXIANG ZHAO MINGYANG REN SIHUA YANG DA XING HUAN QIN | 2022 | Photonics Research2022，10，5： | 2 |
| 2 | Natural variations of ZmSRO1d modulate the trade-off between drought resistance and yield by affecting ZmRBOHC-mediated stomatal ROS production in maize显示文摘While crop yields have historically increased,drought resistance has become a major concern in the context of global climate change.The trade-off between crop yield and drought resistance is a common phenomenon;however,the underlying molecular modulators remain undetermined.Through genome-wide association study,we revealed that three non-synonymous variants in a drought-resistant allele of ZmSRO1d-R resulted in plasma membrane localization and enhanced mono-ADP-ribosyltransferase activity of ZmSRO1d toward ZmRBOHC,which increased reactive oxygen species(ROS)levels in guard cells and promoted stomatal closure.ZmSRO1d-R enhanced plant drought resilience and protected grain yields under drought conditions,but it led to yield drag under favorable conditions.In contrast,loss-of-function mutants of ZmRBOHC showed remarkably increased yields under well-watered conditions,whereas they showed compromised drought resistance.Interestingly,by analyzing 189 teosinte accessions,we found that the ZmSRO1d-R allele was present in teosinte but was selected against during maize domestication and modern breeding.Collectively,our work suggests that the allele frequency reduction of ZmSRO1d-R in breeding programs may have compromised maize drought resistance while increased yields.Therefore,introduction of the ZmSRO1d-R allele into modern maize cultivars would contribute to food security under drought stress caused by global climate change. | Huajian Gao Junjun Cui Shengxue Liu Shuhui Wang Yongyan Lian Yunting Bai Tengfei Zhu Haohao Wu Yijie Wang Shiping Yang Xuefeng Li Junhong Zhuang Limei Chen Zhizhong Gong Feng Qin | 2022 | Molecular Plant2022，15，10： | 2 |
| 3 | Enhanced mechanical and thermal properties of γ-allyloxymethyl 18-crown-6 and polyimide composites through hydrosilylation crosslinking显示文摘The complexation of y-allyloxymethyl 18-crown-6(AC6) induced inferior mechanical and thermal properties of polyimide(PI) in spite of lowered dielectric constant(k). To solve this puzzle, tetrakis-(di methylsiloxy)-si lane was employed to crosslink the complex of AC6 and PI(AC6-PI) through hydrosilylation reaction. The crosslinked AC6-PI(SiAC-PI) composites possessed excellent mechanical and thermal properties as well as low k. The tensile strength and fracture energy of SiAC-PI were increased by 87% and 716%, and the glass transition temperature and 5% weight loss temperature elevated 14.5 ℃ and 38.8 ℃, respectively, compared with those of AC6-PI. The structure of SiAC-PI was characterized by FTIR spectra, crosslinked density and XRD diffraction patterns. | Chuqi Shi Shumei Liu Yang Li Jianqing Zhao Haohao Huang | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 4 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 5 | SJES14110700417215显示文摘 | Jiachen Wang Shengli Yang Yang Li Like Wei Haohao Liu | 2014 | International Journal of Rock Mechanics and Mining Sciences2014，，： | 1 |
| 6 | Effects of protein oxidation, cathepsins, and various freezing temperatures on the quality of superchilled sturgeon fillets显示文摘Many aquatic products have been stored using superchilling technology, but rarely used for the storage of sturgeon fillets. In this study, we investigated the effects of protein oxidation, cathepsin, and various freezing temperatures on the quality of superchilled sturgeon fillets. Sensory evaluation results showed that the sensory attributes of superchilled (−3 °C) sturgeon fillets were acceptable three times longer (18 days) than samples stored at refrigeration temperatures (4 °C). The sarcoplasmic protein, carbonyl, myofibrillar protein, total sulfhydryl content and the surface hydrophobicity were determined using fluorescence spectrophotometry and SDS-PAGE. Results showed that superchilling might protect myofibrillar proteins from oxidation compared to refrigeration temperatures. The activity of the three cathepsins (B, L, and H) in terms of myofibrillar, mitochondria, lysosomes, and sarcoplasm demonstrated that superchilling can inhibit cathepsins activity in sturgeon and protect its muscle structure. Microscopic observations showed that as the temperature decreased, the gap area of the muscle fibers decreased, and the deformation of cross-sectional slices was gradually reduced. In addition, the freezing rate of ice crystals produced during the freezing process influenced the muscle structure, texture, and sensory attributes. Superchilled sturgeon fillets showed good hardness, chewiness, and water retention. In conclusion, superchilling technology shows promise for its ability to extend the shelf life while maintaining the texture and sensory attributes of fresh sturgeon fillets. | Nana Zhao Xianqing Yang Yujin Li Haohao Wu Yiping Chen Ruichang Gao Feng Xiao Fan Bai Jinlin Wang Zunying Liu Xin Gao Yuanhui Zhao | 2022 | Marine Life Science & Technology2022，4，1： | 1 |
| 7 | Threshold of Soil pH for Occurrence of Tobacco Bacterial Wilt in Henan Province显示文摘[Objective]The paper was to study the relationship between spatial distribution characteristics of soil p H and bacterial wilt in tobacco-growing area in Henan Province.[Method]The 21 tobacco-growing fields infected by bacterial wilt and 91 tobacco-growing fields with no cases were selected from Henan Province,and the pH of fields was determined.[Result]Bacterial wilt mainly occurred in the tobacco-growing fields in Luoshan,Pingqiao,Queshan,Biyang,Suiping,and Xiping,and the soil pH mainly ranged from 5.5 to 6.5(accounted for 84.75%of total surveyed tobacco fields);bacterial wilt had not been found in tobacco-growing fields in Tanghe,Zhengyang,Shangcai,Sheqi,Wuyang and Chenqu,and the soil pH mainly ranged from 6.5 to 7.0(accounted for 81.25%of total surveyed tobacco fields).There were significant differences in soil pH between the fields with and without bacterial wilt,and soil pH 6.5 could be regarded as the threshold for the occurrence of tobacco bacterial wilt in Henan Province.There was extremely significantly positive linear correlation between soil p H and latitude(y=0.7375 x-17.799,R2=0.386,P<0.01).The geographical boundary of soil pH 6.5 was roughly 33°N,and bacterial wilt was less likely to occur in the north tobacco-growing areas of the boundary.[Conclusion]The study will provide a scientific basis for the prevention and control of tobacco bacterial wilt in Henan. | Haitao Wang Haohao Hao Xiaojing Xu Haitang Huang Xueli Song Lijun Yang | 2021 | Plant Diseases and Pests2021，12，2： | 1 |
| 8 | Chemical characterization of rice straw-derived biochar for soil amendment显示文摘 | Weixiang Wu Min Yang Qibo Feng Kim McGrouther Hailong Wang Haohao Lu Yingxu Chen | 2012 | Biomass and Bioenergy2012，，： | 1 |
| 9 | Intelligent H_(2)S release coating for regulating vascular remodeling显示文摘Coronary atherosclerotic lesions exhibit a low-pH chronic inflammatory response.Due to insufficient drug release control,drug-eluting stent intervention can lead to delayed endothelialization,advanced thrombosis,and unprecise treatment.In this study,hyaluronic acid and chitosan were used to prepare pH-responsive self-assembling films.The hydrogen sulfide(H2S)releasing aspirin derivative ACS14 was used as drug in the film.The film regulates the release of the drug adjusted to the microenvironment of the lesion,and the drug balances the vascular function by releasing the regulating gas H2S,which comparably to NO promotes the self-healing capacity of blood vessels.Drug releasing profiles of the films at different pH,and other biological effects on blood vessels were evaluated through blood compatibility,cellular,and implantation experiments.This novel method of self-assembled films which H2S in an amount,which is adjusted to the condition of the lesion provides a new concept for the treatment of cardiovascular diseases. | Bingyang Lu Xiao Han Ansha Zhao Dan Luo Manfred FMaitz Haohao Wang Ping Yang Nan Huang | 2021 | Bioactive Materials2021，6，4： | 1 |
| 10 | Contourletbased image adaptive watermarking显示文摘 | Song Haohao Yu Songyu Yang Xiaokang | 2008 | Signal Processing:Image Communication2008，23，3： | 1 |
| 11 | Chemical characterization of rice straw-derived biochar for soil amendment显示文摘 | Weixiang Wu Min Yang Qibo Feng Kim McGrouther Hailong Wang Haohao Lu Yingxu Chen | 2012 | Biomass and Bioenergy2012，，： | 1 |
| 12 | Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivo and in vitro显示文摘Peri-implantitis are a major problem causing implant failure these days.Accordingly,anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue.Micro-arc oxidation(MAO)treatment is a way to form an oxidation film on the surface of metallic materials.The method shows good osteogenic properties but weak antibacterial effect.Therefore,we developed combined strategies to combat severe peri-implantitis,which included the use of a novel compound,PD,comprising dendrimers poly(amidoamine)(PAMAM)loading dimethylaminododecyl methacrylate(DMADDM)as well as MAO treatment.Here,we explored the chemical properties of the novel compound PD,and proved that this compound was successfully synthesized,with the loading efficiency and encapsulation efficiency of 23.91%and 31.42%,respectively.We further report the two-stage double benefits capability of PD+MAO:(1)in the first stage,PD+MAO could decrease the adherence and development of biofilms by releasing DMADDM in the highly infected first stage after implant surgery both in vitro and in vivo;(2)in the second stage,PD+MAO indicated mighty anti-infection and osteoconductive characteristics in a rat model of peri-implantitis in vivo.This study first reports the two-staged,double benefits of PD+MAO,and demonstrates its potential in clinical applications for inhibiting peri-implantitis,especially in patients with severe infection risk. | Xiaoyu Huang Yang Ge Bina Yang Qi Han Wen Zhou Jingou Liang Mingyun Li Xian Peng Biao Ren Bangcheng Yang Michael D.Weir Qiang Guo Haohao Wang Xinxuan Zhou Xugang Lu Thomas W.Oates Hockin H.K.Xu Dongmei Deng Xuedong Zhou Lei Cheng | 2021 | Bioactive Materials2021，6，12： | 1 |
| 13 | Regulating f orbital of Tb electronic reservoir to activate stepwise and dual-directional sulfur conversion reaction显示文摘The sluggish kinetics in multistep sulfur redox reaction with different energy requirements for each step,is considered as the crucial handicap of lithium–sulfur(Li–S)batteries.Designing an electron reservoir,which can dynamically release electron to/accept electron from sulfur species during dis-charge/charge,is the ideal strategy for realizing stepwise and dual-directional polysulfide electrocatalysis.Herein,a single Tb^(3+/4+)oxide with moderate unfilled f orbital is synthetized as an electron reservoir to optimize polysulfide adsorption via Tb–S and N…Li bonds,reduce activation energy barrier,expe-dite electron/Li+transport,and selectively catalyze both long-chain and short-chain polysulfide conversions during charge and discharge.As a result,Tb electron reservoir enables stable operation of low-capacity decay(0.087%over 500 cycles at 1 C),high sulfur loading(5.2 mg cm^(2))and electrolyte-starved(7.5μL mg^(-1))Li–S batteries.This work could unlock the potential of f orbital engineering for high-energy battery systems. | Shuang Yu Shuo Yang Dong Cai Huagui Nie Xuemei Zhou Tingting Li Ce Liang Haohao Wang Yangyang Dong Rui Xu Guoyong Fang Jinjie Qian Yongjie Ge Yue Hu Zhi Yang | 2023 | InfoMat2023，5，1： | 0 |
| 14 | Spatio-temporal Variation of Water Heat Flux Using MODIS Land Surface Temperature Product over Hulun Lake,China During 2001–2018显示文摘Heat flux is important for studying interactions between atmosphere and lake.The heat exchange between air-water interfaces is one of the important ways to govern the temperature of the water surface.Heat exchange between the air-water interfaces and the surrounding environment is completed by solar radiation,conduction,and evaporation,and all these processes mainly occur at the air-water interface.Hulun Lake was the biggest lake which is also an important link and an indispensable part of the water cycle in Northeast China.This study mapped surface energy budget to better understand spatial and temporal variations in Hulun Lake in China from 2001 to 2018.Descriptive statistics were computed to build a historical time series of mean monthly heat flux at daytime and nighttime from June to September during 2001–2018.Remote sensing estimation methods we used was suitable for Hulun Lake(R2=0.81).At month scale,shortwave radiation and latent heat flux were decrease from June to September.However,the maximum sensible heat flux appeared in September.Net longwave radiation was the largest in August.The effective heat budget showed that Hulun Lake gained heat in the frost-free season with highest value in June(686.31 W/m2),and then steadily decreased to September(439.76 W/m2).At annual scale,net longwave radiation,sensible heat flux and latent heat flux all show significant growth trend from 2001 to 2018(P<0.01).Wind speed had the well correlation on sensible heat flux and latent heat flux.Water surface temperature showed the highest coefficient in sensitivity analysis. | ZHAO Boyu DU Jia SONG Kaishan Pierre-Andre JACINTHE XIANG Xiaoyun ZHOU Haohao YANG Zhichao ZHANG Liyan GUO Pingping | 2020 | Chinese Geographical Science2020，30，6： | 0 |
| 15 | Unconventional phonon spectra and obstructed edge phonon modes显示文摘Based on the elementary band representations(EBR),many topologically trivial materials are classified as unconventional ones(obstructed atomic limit),where the EBR decomposition for a set of electronic states is not consistent with atomic valenceelectron band representations.In the work,we identify that the unconventional nature can also exist in phonon spectra,where the EBR decomposition for a set of well-separated phonon modes is not consistent with atomic vibration band representations(ABR).The unconventionality has two types:typeⅠis on an empty site;and typeⅡis on an atom site with non-atomic vibration orbitals.The unconventionality is described by the nonzero real-space invariant at the site.Our detailed calculations show that the black phosphorus(BP)has the typeⅠunconventional phonon spectrum,while 1H-Mo Se_(2)has the typeⅡone,although their electronic structures are also unconventional.Accordingly,the obstructed phonon modes are obtained for two types of unconventional phonon spectra. | Ruihan Zhang Haohao Sheng Junze Deng Zhong Fang Zhilong Yang Zhijun Wang | 2024 | Science China(Physics,Mechanics & Astronomy)2024，67，4： | 0 |
| 16 | Superconductivity above 28K in single unit cell FeSe ?lms interfaced with GaO_(2-δ) layer on NdGaO_3(110)显示文摘The discovery of high temperature superconductivity in single unit cell(UC)FeSe on TiO2-δterminated perovskite SrTiO3(001)substrates[1]has attracted intensive attention on searching for new superconducting systems with engineered interfaces as well as understanding the mechanism of interface high temperature superconductivity. | Haohao Yang Guanyu Zhou Yuying Zhu Guan-Ming Gong Qinghua Zhang Menghan Liao Zheng Li Cui Ding Fanqi Meng Mohsin Rafique Heng Wang Lin Gu Ding Zhang Lili Wang Qi-Kun Xue | 2019 | Science Bulletin2019，64，8： | 0 |
| 17 | Study on Reproductive Performance of Improved Hybrid from Chinese Holstein Cattle显示文摘In order to overcome the problems such as decline in adaptability,low fertility and few utilization years due to continuously increasing coefficient of inbreeding of Chinese Holstein cattle,three dairy-beef dual-purpose cattle varieties( purebred Simmental,Montbeliard and Fleckvieh) were introduced as the male parents to be hybridized with Chinese Holstein cattle,so as to study the improvement effect in the reproduction performance and milk production performance of the hybrid cattle. The results showed that the first-filial generation of Montbeliard had a very significant difference in gestation period from Chinese Holstein cattle( P <0. 01). The parity of Fleckvieh's first-filial generation had a very significant effect on 305 d milk yield( P <0. 01); and for the first-filial generation of Montbeliard,mating times and open days significantly affected 305 d milk yield( P < 0. 05),and its total milk yield had a significant difference from Chinese Holstein cattle( P < 0. 05). Comprehensively,the reproduction traits of Montbeliard's first-filial generation are better than other two varieties. | Zhen ZHANG Xinfang ZHAO Xiaoli REN Yakun LI Haohao DENG Lei YAN Yuefei YAN Wenhua YANG Fanjun GENG | 2018 | Agricultural Biotechnology2018，7，5： | 0 |
| 18 | Microbiological safety of expressed breast milk for preterm admitted to neonatal unit in China显示文摘Objective To determine the degrees and types of bacterial contamination in home-expressed mother's milk for preterm admitted to neonatal unit in China. Methods The present paper was a descriptive study enrolled a total of 75 human breast milk samples from February 2nd to March 1st 2015. The primary outcome was microbiological features of breast milk samples collected at home. A sample of more than 104 colony-forming units/mL is considered as the significantly bacterial contaminated breast milk. Results Among the milk samples obtained from the mothers of 75 neonatal babies,69. 3% had substantial bacterial growth. This high contamination rate could be due to the Chinese tradition of avoiding bathing for one month after childbirth.Conclusion Un-processed breast milk expressed by mothers in home was not safe for high risk preterm babies. Health care needs to pay attention to the risk of that in China. Good hygienic practice and strict process control for breast expression,including collection,transportation and storage should be developed for Chinese mothers of hospitalized preterm infants. | YANG Hualu MENG Haohao WU Duanchun | 2017 | 中西医结合护理(中英文)2017，3，5： | 0 |
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