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| 1 | Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells显示文摘目的: 间充质的干细胞(MSC ) 是心脏的代替治疗的一个有希望的候选人。然而,因为差的血供给, ischemia-reperfusion,和煽动性的因素,移植 MSC 的多数乐意地在移植以后被失去。我们试图在 MSC.Methods 的 hypoxia/reoxygenation-induced apoptosis 上学习组织缺氧 preconditioning ( HPC )的效果: MSC 的三代被划分成 6 个组包括正常的组, hypoxia-reoxygenation ( H/R )组, cyclosporine A ( CsA ),和 HPC 10 min , 20 min ,并且 30 min 组织。 apoptotic 索引,房间生存能力, mitochondrial 膜电位, Bcl-2 和 bax 的易位,细胞外的调整激酶(英皇家空军之阶级最低之兵), Akt ,组织缺氧可诱导的因素 1-alpha ,并且脉管的内皮生长因素( VEGF )在 H/R treatment.Results 以后被测试: HPC 减少了 apoptotic 索引并且增加了 H/R.Moreover 导致的生存能力, HPC 显著地稳定了 mitochondrial 膜电位在调整 Bcl-2 和 VEGF 表达式上面,并且增加了英皇家空军之阶级最低之兵和 Akt.As 的磷酸化积极控制, CsA 有象 HPC 的一样的函数,除了支持英皇家空军之阶级最低之兵和 Akt 磷酸化并且在调整 VEGF.Conclusion 上面: HPC 对 H/R 经由稳定 mitochondrial 膜电位导致的 MSC apoptosis 有保护的效果在调整 Bcl-2 和 VEGF 上面,并且支持英皇家空军之阶级最低之兵和 Akt phosphorylation.HPC 为新奇干细胞protective 策略的开发有含意。 | Jian-an WANG Tie-long CHEN Jun JIANG Heng SHI Chun GUI Rong-hua LUO Xiao-jie XIE Mei-xiang XIANG Xing ZHANG | 2008 | Acta Pharmacologica Sinica2008，29，1： | 25 |
| 2 | Inherent mechanism of breakdown in laminar-turbulent transition of plane channel flows显示文摘Laminar-turbulent transition is an old yet unsolved problem. Notwithstanding the great effort made, there is an important question that seems not to have been addressed yet, that is, what is the inherent mechanism of breakdown that eventually leads to transition? The conventional idea is that the transition starts from the amplification of disturbances, and when the disturbances become larger, higher harmonics will be generated due to nonlinear effect, making the flow more and more complicated, and finally turbulent. Though the scenario seems clear, yet there is a missing link, that is, what happens in the breakdown process. Here we show by analyzing the results from direct numerical simulations that the change of stability characteristics of the mean flow profile plays a key role in the breakdown process. | LUO Jisheng, WANG Xinjun & ZHOU Heng Department of Mechanics, Tianjin University Liu-Hui Center of Mathematics, Nankai and Tianjin University, Tianjin 300071, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，2： | 14 |
| 3 | Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice显示文摘瞄准:最近的研究证明中国植物 Polygalae 根值的摘录在老鼠和人施加提高认知的行动。这研究的目的是描绘从 Polygalae Radix.Methods 提取的活跃混合物的药理学侧面:二部分 P3 和 P6 和二混合物 PTM-15 和 polygalasaponin XXXII (PGS32 ) 被准备。Neuroprotective 效果在暴露于高集中 glutamate,浆液缺乏或 H 2 O 2 。反痴呆行动用走彻底地回避测试和隧道水迷宫测试在老鼠在导致莨菪胺的健忘被估计。在进行隧道水迷宫测试以后,在老鼠马头鱼尾的怪兽的 TrkB phosphorylation 用西方的弄污被检测。长期的 potentiation (LTP ) 在成年老鼠在有牙齿的回转被导致;PGS32 (5 μ L 400 μ mol/L ) 被注入侧面的服的室在高频率刺激(HFS ) 以后的 20 min .Results:在老鼠在导致莨菪胺的健忘比作部分 P6,显示出的更突出的 neuroprotective 在 vitro 完成的部分 P3 和提高认知的效果。在部分 P3 的一活跃复合 PGS32 施加了有势力提高认知的行动:PGS32 的口头的管理(0.125 mg·为 19 天的 kg −1·d−1) 在老鼠废除了导致莨菪胺的记忆缺陷。而且, PGS32 (0.5 和 2 mg· kg −1·d−1) 显著地在马头鱼尾的怪兽刺激了 TrkB 的 phosphorylation。PGS32 的 Intracerebroventricular 注射显著地在 rats.Conclusion 的有牙齿的回转提高了导致 HFS 的 LTP:PGS32 在老鼠稀释导致莨菪胺的认知缺陷,建议它有为认知机能障碍和痴呆的处理的一个潜力。 | Heng ZHOU Wei XUE Shi-feng CHU Zhen-zhen WANG Chuang-jun LI Yi-na JIANG Lin-ming LUO Piao LUO Gang LI Dong-ming ZHANG Nai-hong CHEN | 2016 | Acta Pharmacologica Sinica2016，37，8： | 12 |
| 4 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 5 | Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota显示文摘Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota. | Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-Bo Zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li Yan Wang Jian-Dong Jiang Wu Zhong | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 12 |
| 6 | The investigation of coherent structures in the wall region of a supersonic turbulent boundary layer based on DNS database显示文摘Through temporal mode direct numerical simulation, flow field database of a fully developed turbulent boundary layer on a flat plate with Mach number 4.5 and Reynolds number Reθ =1094 has been obtained. Commonly used detection meth- ods in experiments are applied to detecting coherent structures in the flow field, and it is found that coherent structures do exist in the wall region of a supersonic turbulent boundary layer. The detected results show that a low-speed streak is de- tected by using the Mu-level method, the rising parts of this streak are detected by using the second quadrant method, and the crossing regions from a low-speed streak to the high-speed one are detected by using the VITA method respectively. Notwithstanding that different regions are detected by different methods, they are all accompanied by quasi-stream-wise vortex structures. | HUANG ZhangFeng ZHOU Heng LUO JiSheng | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，3： | 8 |
| 7 | A cohort autopsy study defines COVID-19 systemic pathogenesis显示文摘Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs.However,the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown.We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan,China,and determined the systemic distribution of SARS-CoV-2. | Xiao-Hong Yao Tao Luo Yu Shi Zhi-Cheng He Rui Tang Pei-Pei Zhang Jun Cai Xiang-Dong Zhou Dong-Po Jiang Xiao-Chun Fei Xue-Quan Huang Lei Zhao Heng Zhang Hai-Bo Wu Yong Ren Zhen-Hua Liu Hua-Rong Zhang Cong Chen Wen-Juan Fu Heng Li Xin-Yi Xia Rong Chen Yan Wang Xin-Dong Liu Chang-Lin Yin Ze-Xuan Yan Juan Wang Rui Jing Tai-Sheng Li Wei-Qin Li Chao-Fu Wang Yan-Qing Ding Qing Mao Ding-Yu Zhang Shu-Yang Zhang Yi-Fang Ping Xiu-Wu Bian | 2021 | Cell Research2021，31，8： | 7 |
| 8 | Sonic hedgehog protein promotes bone marrow-derived endothelial pro-genitor cell proliferation,migration and VEGF production via PI 3-kinase/Akt signaling pathways显示文摘瞄准:调查声音的刺猬(嘘) 的效果骨髓上的蛋白质 -- 表明小径的导出的内皮祖先房间(BM-EPC ) 增长,迁居和脉管的内皮生长因素(VEGF ) 生产,和潜力在这些包含了效果。方法:骨头导出髓的 Flk-1 (+) 房间从成年 Kunming 鼠标用 MACS 系统被充实然后 BM-EPC 在明胶涂的培养皿是有教养的。BM-EPC 增长上的嘘 N 终端肽的效果用 MTT 比色测定被评估。细胞移行是用一种修改 Boyden 房间技术的 assayed。VEGF 的生产被 ELISA 和免疫萤光分析决定。表明小径的 PKC 和 PI3K 的潜在的参与用选择禁止者或西方的污点被探索。结果:在 BM-EPC 的增长,迁居和 VEGF 生产能被内长的嘘 N 终端肽在 0.1 microg/mL 的集中提升到 10 microg/mL,并且能被反嘘抗体禁止。在 BM-EPC 的调停嘘的增长和移植能被 anti-VEGF 部分稀释。在最新分开的 BM-EPC 的 Phospho-PI3-kinase 表示是低的,并且外长的嘘 N 终端肽什么时候被增加,但是能被 anti-human/mouse 嘘 N 终端肽抗体稀释,显著地增加了。而且, PI3-kinase 的禁止者,然而并非 PKC 的禁止者,显著地禁止了调停嘘的增长,迁居和 VEGF 生产。结论:嘘蛋白质罐头 stimulate 骨头导出髓的 BM-EPC 增长,移植和 VEGF 生产,它可以把 neovascularization 提升到是化学家纸巾。这也结果建议表明小径的 PI3-kinase/Akt 涉及嘘的 angiogenic 效果。 | Jin-rong FU Wen-li LIU Jian-feng ZHOU Han-ying SUN Hui-zhen XU Li LUO Heng ZHANG Yu-feng ZHOU | 2006 | Acta Pharmacologica Sinica2006，27，6： | 7 |
| 9 | 雷帕霉素对小鼠百草枯中毒导致肺纤维化的治疗作用(英文)显示文摘目的:评估雷帕霉素(RAPA)对小鼠百草枯(PQ)中毒导致肺纤维化的治疗作用,并初步探讨其作用机制。创新点:首次在小鼠PQ中毒的模型中证明RAPA可明显抑制肺纤维化,且此作用与转化生长因子-β1(TGF-β1)的抑制相关。方法:将C57BL/6J雄鼠分为对照组(腹腔注射生理盐水)和实验组(腹腔注射10 mg/kg PQ)。实验组根据采用的治疗不同,可分为以下四组:PQ组、PQ+RAPA组、PQ+MP(甲强龙)组和PQ+MP+RAPA组。用苏木精-伊红染色法(H&E)和马松(Masson)三色染色法观察肺组织病理结构变化,用酶联免疫吸附测定(ELISA)试剂盒检测肺组织中的羟脯氨酸(HYP)含量,用免疫组化和免疫印迹的方法检测TGF-β1和α-平滑肌肌动蛋白(α-SMA)的表达水平。结论:本实验中小鼠的肺组织病理染色结果显示,RAPA治疗能缓解肺纤维化导致的病理改变(图3)。ELISA实验结果显示,RAPA治疗28天后可显著降低肺组织中HYP的含量(图4)。免疫组化和免疫印迹实验结果显示,RAPA治疗能明显下调肺组织中TGF-β1和α-SMA的高表达(图5和6)。综上所述,RAPA在治疗PQ中毒导致的肺纤维化中有重要价值。 | Xue SHAO Meng LI Chong LUO Ying-ying WANG Ying-ying LU Shi FENG Heng LI Xia-bing LANG Yu-cheng WANG Chuan LIN Xiu-jin SHEN Qin ZHOU Hong JIANG Jiang-hua CHEN | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，1： | 7 |
| 10 | Effects of Mercury on the Structure and Activity of BLM642-1290 Recombinant Helicase显示文摘Objective Bloom's syndrome is an autosomal recessive disorder characterized by genomic instability and a predisposition to many cancers. Mutations of the BLM gene (encoding a BLM helicase) may form a structure of the etiology of this disease. As a global pollutant, mercury poses a major threat to human health. The current study was conducted to elucidate the effects of Hg 2+ on the structure and activity of BLM642‐1290 recombinant helicase, and to further explore the molecular mechanisms of mercury toxicity to the DNA helicase. Methods The effects of Hg 2+ on biological activity and structure of BLM642‐1290 recombinant helicase were determined by fluorescence polarized, ultraviolet spectroscopic, and free‐phosphorus assay technologies, respectively. Results The helicase activity, the DNA‐binding activity, and the ATPase activity of BLM642‐1290 recombinant helicase were inhibited by Hg 2+ treatment. The LMCT (ligand‐to‐metal charge transition) peaks of the helicase were enhanced with the increase of the Hg 2+ level. The LMCT peaks of the same concentration of helicase gradually increased over time. Conclusions The biological activity of BLM642‐1290 recombinant helicase is inhibited by Hg 2+ treatment. The conformation of the helicase is significantly altered by Hg 2+ . There exist two binding sites between Hg 2+ and the helicase, which are located in the amino acid residues 1063‐1066 and 940‐944 of the helicase, respectively. | CHEN Xiang LUO Heng DUAN LiXia XU QingHe ZHANG Yong XU HouQiang | 2011 | Biomedical and Environmental Sciences2011，24，1： | 7 |
| 11 | Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China显示文摘 | Xu-Ying Luo Ying-Hong Hu Xiang-Yuan Cao Yan Kang Li-Ping Liu Shou-Hong Wang Rong-Guo Yu Xiang-You Yu Xia Zhang Bao-Shan Li Zeng-Xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-Li Duan Jin Hu Yun-Feng Hoang Gui-Jun Jia Li-Hong Li Yu-Min Liang Bing-Yu Qin Xian-Dong Wang Jian Xiong Li-Mei Yan Zheng-Ping Yang Chen-Ming Dong Dong-Xin Wang Qing-Yuan Zhan Shuang-Lin FU Lin Zhao Qi-Bing Huang Ying-Guang Xie Xiao-Bo Huang Guo-Bin Zhang Wang-Bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu Xiao-Feng Yang Ming Xu Zhong-Hua Shi Han Chen Xuan He Yan-Lin Yang Guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou | 2016 | Chinese Medical Journal2016，，14： | 6 |
| 12 | Atomic Fe-Zn dual-metal sites for high-efficiency pH-universal oxygen reduction catalysis显示文摘An effective electrocatalyst being highly active in all pH range for oxygen reduction reaction(ORR)is crucial for energy conversion and storage devices.However,most of the high-efficiency ORR catalysis was reported in alkaline conditions.Herein,we demonstrated the preparation of atomically dispersed Fe-Zn pairs anchored on porous N-doped carbon frameworks(Fe-Zn-SA/NC),which works efficiently as ORR catalyst in the whole pH range.It achieves high half-wave potentials of 0.78,0.85 and 0.72 V in 0.1 M HClO4,0.1 M KOH and 0.1 M phosphate buffer saline(PBS)solutions,respectively,as well as respectable stability.The performances are even comparable to Pt/C.Furthermore,when assembled into a Zn-air battery,the high power density of 167.2 mWcm−2 and 120 h durability reveal the feasibility of Fe-Zn-SA/NC in real energy-related devices.Theoretical calculations demonstrate that the superior catalytic activity of Fe-Zn-SA/NC can be contributed to the lower energy barriers of ORR at the Fe-Zn-N6 centers.This work demonstrates the potential of Fe-Zn pairs as alternatives to the Pt catalysts for efficient catalytic ORR and provides new insights of dual-atom catalysts for other energy conversion related catalytic reactions. | Jie Xu Shuhua Lai Defeng Qi Min Hu Xianyun Peng Yifan Liu Wei Liu Guangzhi Hu Heng Xu Fan Li Chao Li Jia He Longchao Zhuo Jiaqiang Sun Yuan Qiu Shusheng Zhang Jun Luo Xijun Liu | 2021 | Nano Research2021，14，5： | 6 |
| 13 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 14 | Three Cases of COVID-19 Variant Delta With and Without Vaccination——Chengdu City,Sichuan Province,April-May,2021显示文摘On April 26,2021,a 33-year-old male Chinese sailor returning from India via Kathmandu,Nepal,tested positive for the coronavirus disease 2019(COVID-19)by Chengdu Customs and was confirmed positive by Chengdu CDC(Case A).On May 2,2021,a housewife in the same flight tested positive for COVID-19 by Pengzhou CDC in Sichuan Province during her quarantine period and was confirmed positive by Chengdu CDC the next day(Case B). | Heng Chen Yi Mao Zhenhua Duan Liang Wang Yue Cheng Yingxue Dai Haixia Luo Wenjun Xie Shuangfeng Fan Yuzhen Zhou Jingpei Xu Lan Feng Liwen Hu Zhu Liu Xian Liang Liangshuang Jiang Xiaoli Tuo | 2021 | China CDC weekly2021，3，25： | 5 |
| 15 | Carbamylated erythropoietin regulates immune responses and promotes long-term kidney allograft survival through activation of PI3K/AKT signaling显示文摘Modulation of alloimmune responses is critical to improving transplant outcome and promoting long-term graft survival.To determine mechanisms by which a nonhematopoietic erythropoietin(EPO)derivative,carbamylated EPO(CEPO),regulates innate and adaptive immune cells and affects renal allograft survival,we utilized a rat model of fully MHC-mismatched kidney transplantation.CEPO administration markedly extended the survival time of kidney allografts compared with the transplant alone control group.This therapeutic effect was inhibited when the recipients were given LY294002,a selective inhibitor of the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway or anti-EPO receptor(EPOR)antibody,in addition to CEPO.In vitro,CEPO inhibited the differentiation and function of dendritic cells and modulated their production of proinflammatory and anti-inflammatory cytokines,along with activating the PI3K/AKT signaling pathway and increasing EPOR mRNA and protein expression by these innate immune cells.Moreover,after CD4^(+)T cells were exposed to CEPO the Th1/Th2 ratio decreased and the regulatory T cell(Treg)/Th17 ratio increased.These effects were abolished by LY294002 or anti-EPOR antibody,suggesting that CEPO regulates immune responses and promotes kidney allograft survival by activating the PI3K/AKT signaling pathway in an EPOR-dependent manner.The immunomodulatory and specific signaling pathway effects of CEPO identified in this study suggest a potential therapeutic approach to promoting kidney transplant survival. | Ning Na Daqiang Zhao Jinhua Zhang Jiaqing Wu Bin Miao Heng Li Yingxun Luo Zuofu Tang Wensheng Zhang Joseph A.Bellanti Song Guo Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 16 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 17 | Effect of cerium on wettability of mechanically milled Cu-based brazing alloy powder显示文摘CuSn powders and TiH_2 powders were milled using high energy mechanical milling to prepare Cu-based alloy powders for brazing diamond. And Ce was added to the milled Cu-based alloy powders to improve the wettability. It is found that the wetting angle reaches the minimum value 13.2° and the maximum spreading area 178 mm^2 is achieved when the amount of Ce is 0.75 wt%. And Ce remarkably reduces the surface tension of liquid alloy, which improves the climbing height along the diamond and forms a massive support profile. And the results show that Ce can effectively improve the transverse rupture strength(TRS) due to high wettability. The wear characteristics of the diamonds brazed with Cu-based alloy containing 0.75 wt% Ce mainly consist of integrity, micro-fracture, fracture and rubdown, diamonds pull-out can not easily happen. | Qiaoping Wu Zhou Luo Yu Wang Heng Zhao Weijia Zheng | 2018 | Journal of Rare Earths2018，36，11： | 4 |
| 18 | First total synthesis of(±)-sepicanin A显示文摘为自然地发生的 geranylated flavanoids sepicanin A 的第一全部的合成的一条灵巧的途径与 16% 在四以后从 2,4,6-trihydroxyacetophenone 开始走的全部的产量被获得了。关键步是催化的 protic 酸(HCl 或 p-TsOH ) 在 protic 的 benzopyrone 形成由在一步的 chalcone 的 deprotection 和环合的极的溶剂。 | Jin Hui Yang Wen Qian Huang Jun Shan Luo Dong Dong Guo Yu Heng Zhang Hong Jun Li | 2012 | Chinese Chemical Letters2012，23，2： | 4 |
| 19 | Targeting folate receptorβpositive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex显示文摘Tumor-associated macrophages(TAMs)facilitate cancer progression by promoting tumor invasion,angiogenesis,metastasis,inflammatory responses,and immunosuppression.Folate receptorβ(FRβ)is overexpressed in TAMs.However,the clinical significance of FRβ-positive macrophages in lung cancer remains poorly understood.In this study,we verified that FRβoverexpression in lung cancer TAMs was associated with poor prognosis.We utilized a folate-modified lipoplex comprising a folatemodified liposome(F-PLP)delivering a BIM-S plasmid to target both lung cancer cells and FRβ-positive macrophages in the tumor microenvironment.Transfection of LL/2 cells and MH-S cells with F-PLP/pBIM induced cell apoptosis.Injection of F-PLP/pBIM into LL/2 and A549 lung cancer models significantly depleted FRβ-positive macrophages and reduced tumor growth.Treatment of tumor-bearing mice with F-PLP/pBIM significantly inhibited tumor growth in vivo by inducing tumor cell and macrophage apoptosis,reducing tumor proliferation,and inhibiting tumor angiogenesis.In addition,a preliminary safety evaluation demonstrated a good safety profile of F-PLP/pBIM as a gene therapy administered intravenously.This work describes a novel application of lipoplexes in lung cancer targeted therapy that influences the tumor microenvironment by targeting TAMs. | Yan Tie Heng Zheng Zhiyao He Jingyun Yang Bin Shao Li Liu Min Luo Xia Yuan Yu Liu Xiangxian Zhang Hongyi Li Min Wu Xiawei Wei | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 20 | Cratering process and morphological features of the Xiuyan impact crater in Northeast China显示文摘By using crater impact morphological theory and mathematics modeling,the paper studies the cratering process and morphological features of the Xiuyan Crater in Northeast China based on remote sensing imagery,digital elevation model(DEM)and drilling and measuring data.The results show that:1)Simulated calculation indicates the diameter of the transient crater was1406±12 m and the depth was 497±4 m.The diameter of the final crater was 1758±15 m and the depth was 374.5±3.5 m;the thickness of the breccia lens was 188.5±0.5 m.The data is basically the same as previous drilling data.2)Preliminary determination of the size of Xiuyan impactor:The diameter at about 55 m for an iron meteorite,and about 115 m for a stony meteorite.3)The depth-to-diameter ratio is 0.143,similar to the typical simple crater.The circularity index of the Xiuyan Crater is0.884,indicating erosion and degradation.4)The distribution pattern of radial fractures has priority in NW-SE and WNW-ESE and these fractures control the development and evolution of drainage inside the crater. | WANG XinYuan LUO Lei GUO HuaDong MU LingLi LI Chao JI Wei CAI Heng | 2013 | Science China Earth Sciences2013，56，10： | 4 |
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