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| 1 | Efficient visible light photo-Fenton-like degradation of organic pollutants using in situ surface-modified BiFeO_3 as a catalyst显示文摘The visible light photo-Fenton-like catalytic performance of BiFeO3 nanoparticles was investigated using Methyl Violet(MV),Rhodamine B(RhB) and phenol as probes.Under optimum conditions,the pseudo first-order rate constant(k) was determined to be 2.21 × 102,5.56 × 102 and 2.01 × 102 min 1 for the degradation of MV(30 μmol/L),RhB(10 μmol/L) and phenol(3 mmol/L),respectively,in the BiFeO3-H2O2-visible light(Vis) system.The introduction of visible light irradiation increased the k values of MV,RhB and phenol degradation 3.47,1.95 and 2.07 times in comparison with those in dark.Generally,the k values in the BiFeO3H2O2-Vis system were accelerated by increasing BiFeO3 load and H2O2 concentration,but decreased with increasing initial pollutant concentration.To further enhance the degradation of pollutants at high concentrations,BiFeO3 was modified with the addition of surface modifiers.The addition of ethylenediamineteraacetic acid(EDTA,0.4 mmol/L) increased the k value of MV degradation(60 μmol/L) from 1.01 × 102 min-1 in the BiFeO 3-H2O2-Vis system to 1.30 min-1 in the EDTA-BiFeO3-H2O2-Vis system by a factor of 128.This suggests that in situ surface modification can enable BiFeO3 nano-particles to be a promising visible light photo-Fenton-like catalyst for the degradation of organic pollutants. | Junjian An Lihua Zhu Yingying Zhang Heqing Tang | 2013 | Journal of Environmental Sciences2013，25，6： | 10 |
| 2 | Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism显示文摘The obstruction of post-insulin receptor signaling is the main mechanism of insulin-resistant diabetes.Progestin and adipoQ receptor 3(PAQR3),a key regulator of inflammation and metabolism,can negatively regulate the PI3 K/AKT signaling pathway.Here,we report that gentiopicroside(GPS),the main bioactive secoiridoid glycoside of Gentiana manshurica Kitagawa,decreased lipid synthesis and increased glucose utilization in palmitic acid(PA) treated HepG2 cells.Additionally,GPS improved glycolipid metabolism in streptozotocin(STZ) treated high-fat diet(HFD)-induced diabetic mice.Our findings revealed that GPS promoted the activation of the PI3 K/AKT axis by facilitating DNA-binding protein 2(DDB2)-mediated PAQR3 ubiquitinated degradation.Moreover,results of surface plasmon resonance(SPR),microscale thermophoresis(MST) and thermal shift assay(TSA) indicated that GPS directly binds to PAQR3.Results of molecular docking and cellular thermal shift assay(CETSA) revealed that GPS directly bound to the amino acids of the PAQR3 NH2-terminus including Leu40,Asp42,Glu69,Tyr125 and Ser129,and spatially inhibited the interaction between PAQR3 and the PI3 K catalytic subunit(P110α) to restore the PI3 K/AKT signaling pathway.In summary,our study identified GPS,which inhibits PAQR3 expression and directly targets PAQR3 to restore insulin signaling pathway,as a potential drug candidate for the treatment of diabetes. | Haiming Xiao Xiaohong Sun Zeyuan Lin Yan Yang Meng Zhang Zhanchi Xu Peiqing Liu Zhongqiu Liu Heqing Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 7 |
| 3 | Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material显示文摘Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.However,optimal cell types and transplantation methods remain unclear.This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells.We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet.Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system.Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet.Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular remodelling.Results:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell suspension.At the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute injury.Moreover,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for revascularsation.These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.Conclusions:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart.Translational perspective:Due to its excellent availability as well as superior local cellular retention and survival,allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs,such as modulating inflammation and enhancing angiogenesis.Moreover,the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial,further improving its clinical applicability. | Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang Hongjia Zhang Yunpeng Ling Feng Lan | 2021 | Bioactive Materials2021，6，9： | 6 |
| 4 | Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models显示文摘In this work, the biodegradable and histocompatibility properties of pure Mg and ZK60 alloy wereinvestigated as new temporary implants for urinary applications. The corrosion mechanism in artificialurine was proposed using electrochemical impedance spectroscopy and potentiodynamic polarizationtests. The corrosion potential of pure magnesium and ZK60 alloy were -1820 and -1561 mV, respectively,and the corrosion current densities were 59.66 ± 6.41 and 41.94 ± 0.53 μA cm^-2, respectively. Thein vitro degradation rates for pure Mg and ZK60 alloy in artificial urine were 0.382 and 1.023 mm/y,respectively, determined from immersion tests. The ZK60 alloy degraded faster than the pure Mg in bothartificial urine and in rat bladders (the implants of both samples are ø 3 mm × 5 mm). Histocompatibilityevaluations showed good histocompatibility for the pure Mg and ZK60 alloy during the 3 weeks postimplantationin rat bladders, and no harm was observed in the bladder, liver and kidney tissues. Theresults provide key information on the degradation properties and corrosion mechanism of pure Mg andZK60 alloy in the urinary system. | Shiying Zhang Yanze Bi Jianye Li Zhenguo Wang Jingmin Yan Jiawang Song Haibo Sheng Heqing Guo Yan Li | 2017 | Bioactive Materials2017，2，2： | 4 |
| 5 | Electro-Fenton treatment of concentrates generated in nanofiltration of biologically pretreated landfill leachate显示文摘 | Yujue Wang Xinyang Li Limin Zhen Heqing Zhang Ying Zhang Chengwen Wang | 2012 | Journal of Hazardous Materials2012，，： | 3 |
| 6 | Water quality and light absorption attributes of glacial lakes in Mount Qomolangma region显示文摘因为他们是冰河运动的产品,冰川的湖的水身体作文和水质量属性与内陆湖相比有不同特征。尽管卫星遥感提供一条有效途径监视水质量,缺乏在原处,包围冰川的湖的地位和环境上的测量数据在联系卫星数据浇优秀指示物介绍主要限制。这研究在山 Qomolangma 区域介绍初步的调查的调查结果进 3 个冰川的湖的水质量属性。推迟的微粒物质(SPM ) ,浮游植物的轻吸收属性, nonalgal 粒子(小睡) ,和有颜色的溶解有机物(CDOM ) 被测量。推迟的物质集中从 0320 mg/L 显著地变化。这被认为反映湖开发的不同舞台。叶绿素集中比作出对内陆湖有利的裁决的低得多,作为包围这些高高度湖的风景几乎不有植被生长。浮游植物和 CDOM 集中取决于湖斜坡的长期的稳定性。在 Qomolangma 区域给外长、内长的输入的缺乏,在冰川的湖的 CDOM 比在内陆湖显著地低。这些初步的调查结果能支持努力用遥远地察觉到的图象估价水质量参数的估计。 | YAN Huimin YAO Zhijun HUANG Heqing JIANG Dong DONG Xiaohui DUAN Rui ZHANG Yili | 2013 | Journal of Geographical Sciences2013，23，5： | 2 |
| 7 | Engineering core–shell Co_(9)S_(8)/Co nanoparticles on reduced graphene oxide: Efficient bifunctional Mott–Schottky electrocatalysts in neutral rechargeable Zn–Air batteries显示文摘It is significant for the rational construction of the high–efficient bifunctional electrocatalysts for in–depth understandings of how to improve the electron transfer and ion/oxygen transport in catalyzing oxygen reduction reaction and oxygen evolution reaction(ORR and OER),but still full of vital challenges.Herein,we synthesize the novel“three–in–one”catalyst that engineers core–shell Mott–Schottky Co_(9)S_(8)/Co heterostructure on the defective reduced graphene oxide(Co_(9)S_(8)/Co–rGO).The Co_(9)S_(8)/Co–rGO catalyst exhibits abundant Mott–Schottky heterogeneous–interfaces,the well–defined core–shell nanostructure as well as the defective carbon architecture,which provide the multiple guarantees for enhancing the electron transfer and ion/oxygen transport,thus boosting the catalytic ORR and OER activities in neutral electrolyte.As expected,the integrated core–shell Mott–Schottky Co_(9)S_(8)/Co–rGO catalyst delivers the most robust and efficient rechargeable ZABs performance in neutral solution electrolytes accompanied with a power density of 59.5 mW cm^(-2) and superior cycling stability at 5 mA cm^(-2) over 200 h.This work not only emphasizes the rational designing of the high–efficient bifunctional oxygen catalysts from the fundamental understanding of accelerating the electron transfer and ion/oxygen transport,but also sheds light on the practical application prospects in more friendly environmentally neutral rechargeable ZABs. | Xingkun Wang Guangming Zhan Yurou Wang Yan Zhang Jian Zhou Ren Xu Huiyu Gai Huanlei Wang Heqing Jiang Minghua Huang | 2022 | Journal of Energy Chemistry2022，31，5： | 2 |
| 8 | Efficient degradation of drug ibuprofen through catalytic activation of peroxymonosulfate by Fe_3C embedded on carbon显示文摘Ibuprofen(IBU),a nonsteroidal anti-inflammatory drug,is becoming an important member of pharmaceuticals and personal care products(PPCPs)as emerging pollutants.To degrade IBU,magnetic Fe_3C nanoparticles embedded on N-doped carbon(Fe_3C/NC)were prepared as a catalyst by a sol–gel combustion method.As characterized,the Fe_3C/NC nanoparticles were composed of a NC nano-sheet and capsulated Fe_3C particles on the sheet.The Fe_3C/NC nanoparticles were confirmed an efficient catalyst for peroxymonosulfate(PMS)activation to generate sulfate radicals(SO_4^(·-)),single oxygen(~1O_2)and hydroxyl radicals(·OH)toward the degradation of IBU.The added IBU(10 mg/L)was almost completely removed in 30 min by using 0.1 g/L Fe_3C/NC and 2 g/L PMS.The catalyst was confirmed to have good ability and excellent reusability through leaching measurements and cycle experiments.A catalytic mechanism was proposed for the catalytic activation of PMS on Fe_3C/NC,which involves both Fe_3C reactive sites and N-doped carbon matrix as reactive sites in Fe_3C/NC.Moreover,the degradation pathway of IBU in the Fe_3C/NC-PMS system was proposed according to the detections of degradation intermediates. | Guangli Zhang Yaobin Ding Wenshan Nie Heqing Tang | 2019 | Journal of Environmental Sciences2019，31，4： | 2 |
| 9 | Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children:A Repeated-Measure Panel Study显示文摘Ozone is one of the major gaseous pollutants associated with short-term adverse cardiopulmonary effects,even at concentrations below the current indoor air quality limits.However,the underlying biological mechanisms of cardiorespiratory changes with exposure to ozone remain unclear.To further explore molecular linkages between indoor ozone exposure and relevant cardiorespiratory effects,a repeated-measure panel study including 46 schoolchildren was conducted and real-time exposure measurements including ozone were performed inside classrooms every weekday during the study period.Repeated health measurements and urine sample collection were conducted in each participant.Ultra-high-performance liquid chromatography/tandem mass spectrometry and meet-in-metabolite approach were used in metabolomics analysis.Methods including mixed-effect models were adopted to identify metabolites associated with ozone exposure or health indices.Nine metabolites were found to be associated with ozone after mixed-effect model analysis,which are mainly involved in amino acid and bile acid metabolism.Boys may have a greater decrease in bile acid and RNA related metabolites.Four of the nine ozone-related metabolites were also associated with cardiorespiratory function indices.Furthermore,26.67%of the positive association between ozone and heart rate was mediated by cholestane-3,7,12,25-tetrol-3-glucuronide.Exposure to ozone below the current indoor standards was associated with the deteriorated cardiovascular function by disturbing bile acid and endogenous nitric oxide-related oxidation and inflammation,and associated with the exacerbated airway inflammation by reducing GPx-related anti-oxidation.The results provide metabolic evidence of the cardiorespiratory effects of indoor ozone exposure.Indoor ozone pollution should be controlled further,and more attention should be paid to preventing its adverse health effects,especially in children. | Shan Liu Qingyu Huang Xi Zhang Wei Dong Wenlou Zhang Shaowei Wu Di Yang Bingru Nan Jie Zhang Heqing Shen Xinbiao Guo Furong Deng | 2021 | The Innovation2021，2，1： | 1 |
| 10 | A 16 MJ compact pulsed power system for electromagnetic launch显示文摘 | Dai Ling Zhang Qin Zhong Heqing | 2015 | Review of scientific instruments2015，86，7： | 1 |
| 11 | The Distribution of Sandstorms in Tallimakan Desert显示文摘 | Heqing Zhang Jingfen Nagashima Hedeki | 1996 | J Arid Land Studies1996，5，： | 1 |
| 12 | In Situ Growth of Self-Assembled and Single In203 Nanosheets on the Surface of Indium Grains显示文摘 | YANG Heqing ZhANG Ruigang DONG Hongxing | 2008 | Cryst Growth Des2008，8，9： | 1 |
| 13 | A Three-level Induction Motors DTC Algorithm Basedon Fixed Synthesizing Vectors with Reduced Flux and Torque Ripples显示文摘 | Lei Lin Heqing Zhong Jie Zhang Yu Deng Yunping Zou | 2008 | IEEE Conferences2008，，10： | 1 |
| 14 | Kinetics for chlorination of maleic anhydride grafted polypropylene显示文摘 | Fu Heqing Huang Hong Zhang Xinya | 2007 | Journal of Appied Polymer Science2007，106，1： | 1 |
| 15 | Levels of polychlorinated biphenyls and organochlorine pesticides in edible shellfish from Xiamen (China) and estimation of human dietary intake显示文摘 | Jie Zhang Feng Liu Rongbin Chen Tao Feng Sijun Dong Heqing Shen | 2012 | Food and Chemical Toxicology2012，，12： | 1 |
| 16 | Synthesis of 5-(5-nitro-2-pyridylazo)-2,4-diaminotoluene and its application to spectrophotometric determination of microamounts of palladium显示文摘 | Heqing Yang Guang Zhang Linlin Zhang Genqi Liu Xinhuai Zhang | 1996 | Talanta1996，，5： | 1 |
| 17 | Influence of carboxyl groups on the particle size and rheological properties of polyacrylate latices显示文摘 | Xinya Zhang Heqing Fu Hong Huang Huanqin Chen | 2010 | Journal of Wuhan University of Technology - Mater Sci Ed2010，，3： | 1 |
| 18 | Electrochemical sensoring of 2,4-dinitrophenol by using composites of graphene oxide with surface molecular imprinted polymer显示文摘 | Yun Liu Lihua Zhu Yingying Zhang Heqing Tang | 2012 | Sensors & Actuators: B Chemical2012，，： | 1 |
| 19 | 显示文摘 | Jing Li Heqing Tang Aiqing Zhang | 2007 | Macromol Rapid Commun2007，28，： | 1 |
| 20 | Synthesis of 5-(5-nitro-2-pyridyaz)-2,4-diaminotoluene and its applica-tion to spectrephotometric determination of microamounts of palladium显示文摘 | Heqing Yang Guang Zhang Linlin Zhang | 1996 | Taltanta1996，43，： | 1 |
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