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| 1 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 2 | Performing optical logic operations by a diffractive neural network显示文摘Optical logic operations lie at the heart of optical computing,and they enable many applications such as ultrahighspeed information processing.However,the reported optical logic gates rely heavily on the precise control of input light signals,including their phase difference,polarization,and intensity and the size of the incident beams.Due to the complexity and difficulty in these precise controls,the two output optical logic states may suffer from an inherent instability and a low contrast ratio of intensity.Moreover,the miniaturization of optical logic gates becomes difficult if the extra bulky apparatus for these controls is considered.As such,it is desirable to get rid of these complicated controls and to achieve full logic functionality in a compact photonic system.Such a goal remains challenging.Here,we introduce a simple yet universal design strategy,capable of using plane waves as the incident signal,to perform optical logic operations via a diffractive neural network.Physically,the incident plane wave is first spatially encoded by a specific logic operation at the input layer and further decoded through the hidden layers,namely,a compound Huygens’metasurface.That is,the judiciously designed metasurface scatters the encoded light into one of two small designated areas at the output layer,which provides the information of output logic states.Importantly,after training of the diffractive neural network,all seven basic types of optical logic operations can be realized by the same metasurface.As a conceptual illustration,three logic operations(NOT,OR,and AND)are experimentally demonstrated at microwave frequencies. | Chao Qian Xiao Lin Xiaobin Lin Jian Xu Yang Sun Erping Li Baile Zhang Hongsheng Chen | 2020 | Light(Science & Applications)2020，9，1： | 8 |
| 3 | Breast cancer stem-like cells can promote metastasis by activating platelets and down-regulating antitumor activity of natural killer cells显示文摘OBJECTIVE:To investigate whether cancer stem cells(CSCs) more efficiently activating platelets and evading immune surveillance than non-CSCs thus promoting metastasis.METHODS:We enriched and identified sphereforming cells(SFCs) and coincubated washed platelets with several platelet activators including collagen,4T1 and SFCs.Platelet-coating tumor cells,platelet activation and TGF-β1 release were analyzed.Then natural kell cells(NK) were incubated with supernatants of different activated platelet samples what we called sample release(SR).The degranulation assay and NKG2 D expression on NK cells were conducted by flow cytometry.Finally tissue factor(TF) expression of SFCs or 4T1 were evaluated by western blot.RESULTS:Breast cancer cell line 4T1 could form spheres in serum-free medium at low adherence.Sphere-forming cells expressed high levels of the CD24-/lowCD44 + stem cell phenotype.Both sphere-forming cells or 4T1 were coated with abundant platelets while sphere-forming cells induced significantly higher expression of platelet activating receptor CD62 p than 4T1 did(P < 0.01).And sphere-forming cells induced platelets to produce more TGF-β1 than 4T1 did(P < 0.01).Furthermore,sample releases induced by sphere-forming cells caused more vigorous inhibition of NK cells antitumor reactivity(P < 0.05) and reduced NKG2 D expression(P < 0.01).The final results showed that sphere-forming cells expressed higher levels of TF than 4T1(P < 0.05).CONCLUSION:Our findings indicate that CSCs could efficiently activate platelets,induce platelets to secrete more TGF-β1,decrease NKG2 D expression and inhibit antitumor activity of NK cell,compared with 4T1.And higher levels of TF expression of CSCs may account for this correlation of CSCs and platelets. | Wang Shuo Zhang Ying Cong Weihong Liu Jie Zhang Yuren Fan Huiting XuYonggang Lin Hongsheng | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 5 |
| 4 | Spiral Field Generation in Smith-Purcell Radiation by Helical Metagratings显示文摘Moving electrons interacting with media can give rise to electromagnetic radiations and has been emerged as a promising platform for particle detection,spectroscopies,and free-electron lasers.In this letter,we investigate the Smith-Purcell radiation from helical metagratings,chiral structures similar to deoxyribonucleic acid(DNA),in order to understand the interplay between electrons,photons,and object chirality.Spiral feld patterns can be generated while introducing a gradient azimuthal phase distribution to the induced electric dipole array at the cylindrical interface.Experimental measurements show efcient control over angular momentum of the radiated feld at microwave regime,utilizing a phased electromagnetic dipole array to mimic moving charged particles.Te angular momentum of the radiated wave is determined solely by the handedness of the helical structure,and it thus serves as a potential candidate for the detection of chiral objects.Our fndings not only pave a way for design of orbital angular momentum free-electron lasers but also provide a platform to study the interplay between swif electrons with chiral objects. | Liqiao Jing Zuojia Wang Xiao Lin Bin Zheng Su Xu Lian Shen Yihao Yang Fei Gao Min Chen Hongsheng Chen | 2019 | Research2019，，1： | 4 |
| 5 | Mea6 controls VLDL transport through the coordinated regulation of COPil assembly显示文摘 | Yaqing Wang Liang Liu Hongsheng Zhang Junwan Fan FengZhang Mei Yu Lei Shi Lin Yang Sin Man Lam Huimin Wang Xiaowei Chen Yingchun Wang Fei Gao Guanghou Shui Zhiheng Xu | 2016 | Cell Research2016，26，7： | 4 |
| 6 | A novel inhibitor of N^(6)-methyladenosine demethylase FTO induces m RNA methylation and shows anti-cancer activities显示文摘N^(6)-methyladenosine(m^(6)A)modification is critical for m RNA splicing,nuclear export,stability and translation.Fat mass and obesity-associated protein(FTO),the first identified m^(6)A demethylase,is critical for cancer progression.Herein,we developed small-molecule inhibitors of FTO by virtual screening,structural optimization,and bioassay.As a result,two FTO inhibitors namely 18077 and 18097 were identified,which can selectively inhibit demethylase activity of FTO.Specifically,18097 bound to the active site of FTO and then inhibited cell cycle process and migration of cancer cells.In addition,18097 reprogrammed the epi-transcriptome of breast cancer cells,particularly for genes related to P53 pathway.18097 increased the abundance of m^(6)A modification of suppressor of cytokine signaling1(SOCS1)m RNA,which recruited IGF2 BP1 to increase m RNA stability of SOCS1 and subsequently activated the P53 signaling pathway.Further,18097 suppressed cellular lipogenesis via downregulation of peroxisome proliferator-activated receptor gamma(PPARγ),CCAAT/enhancer-binding protein alpha(C/EBPa),and C/EBPβ.Animal studies confirmed that 18097 can significantly suppress in vivo growth and lung colonization of breast cancer cells.Collectively,we identified that FTO can work as a potential drug target and the small-molecule inhibitor 18097 can serve as a potential agent against breast cancer. | Guoyou Xie Xu-Nian Wu Yuyi Ling Yalan Rui Deyan Wu Jiawang Zhou Jiexin Li Shuibin Lin Qin Peng Zigang Li Hongsheng Wang Hai-Bin Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 7 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 8 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 9 | Distributed Consensus-Based K-Means Algorithm in Switching Multi-Agent Networks显示文摘 | LIN Peng WANG Yinghui QI Hongsheng HONG Yiguang | 2018 | Journal of Systems Science & Complexity2018，31，5： | 3 |
| 10 | Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice显示文摘亲爱的编辑, | Dekun Wang Qingwen Meng Lihong Huo Meng Yang Lingling Wang Xinyu Chen JianchaoWang Zhiguo Li Xiaoying Ye Na Liu Qiuyan Li Zhen Dai Hongsheng Ouyang Ning Li Jun Zhou Lingyi Chen Lin Liu | 2015 | Protein & Cell2015，6，2： | 3 |
| 11 | Two singlemutations commonly cause qualitative change of nonspecificcarboxylesterases in insects显示文摘 | Cui Feng Lin Zhe Wang Hongsheng | 2011 | Insect Biochem Mol Biol2011，41，1： | 1 |
| 12 | Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population显示文摘 | Jixia Liu Yongyong Shi Wei Tang Tingwei Guo Dawei Li Yifeng Yang Xinzhi Zhao Hongsheng Wang Xingwang Li Guoyin Feng Niufan Gu Shaomin Zhu Huijun Liu Yangling Guo Jianguo Shi Hong Sang Lijuan Yan Lin He | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 1 |
| 13 | Flow stress of carbon steel 08F in temperature range of warm-forging 显示文摘 | Lin Xinbo Xiao Hongsheng Zhang Zhiliang | 2003 | Journal of Materials Processing Technology2003，139，： | 1 |
| 14 | Systematic screening for polymorphisms in the CYP3A4 gene in the Chinese population显示文摘 | Jing Du Qinghe Xing Lingyun Xu Mingsheng Xu Anli Shu Yongyong Shi Lan Yu Aiping Zhang Lei Wang Hongsheng Wang Xingwang Li Guoyin Feng Lin He | 2006 | Pharmacogenomics2006，，6： | 1 |
| 15 | Fenton oxidation and sequencing batch reactor (SBR) treatments of highstrength semiconductor 显示文摘 | Lin Hongsheng Jiang Dechang | 2003 | Wastewater Desalination2003，154，3： | 1 |
| 16 | 查看详情显示文摘 | Zhang Hongsheng Zhang Yuanzhi Lin Hui | | 0，，： | 1 |
| 17 | Production of cloned transgenic cow expressing omega-3 fatty acids显示文摘 | Xia Wu Hongsheng Ouyang Biao Duan Daxin Pang Li Zhang Ting Yuan Lian Xue Daibang Ni Lei Cheng Shuhua Dong Zhuying Wei Lin Li Ming Yu Qing-Yuan Sun Da-Yuan Chen Liangxue Lai Yifan Dai Guang-Peng Li | 2012 | Transgenic Research2012，，3： | 1 |
| 18 | Light - induced degradation in undoped hydrogenated amorphous silicon films studied by the surface photovoltage:a comparison of lifetime versus space - charge effects 显示文摘 | Hegedus S Lin Hongsheng Moore A | 1988 | J Appl Phys1988，64，3： | 1 |
| 19 | Impacts of feature normalization on optical and SAR data fusion for land use/land cover classification显示文摘 | ZHANG Hongsheng LIN Hui and LI Yu | 2015 | IEEE Geoscience and Remote Sensing Letters2015，12，5： | 1 |
| 20 | 浅谈中美两国口腔颌面外科研究生培养模式的差异显示文摘本文结合中美两国口腔颌面外科研究生教育发展状况,通过对美国口腔颌面外科研究生培养模式的考察,分析两国在生源、学制、教学方法及就业等方面的差异,希望为我国口腔颌面外科研究生教育提供参考。 | 冯杭 段瑶 陈犹白 邢在臣 HongSheng Lin 张海钟 步荣发 | 2015 | 中国口腔颌面外科杂志2015，13，6： | 1 |
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