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| 1 | Photoexcited CRYPTOCHROME 1 Interacts Directly with G-Protein 13 Subunit AGB1 to Regulate the DNA-Binding Activity of HY5 and Photomorphogenesis in Arabidopsis显示文摘 | Hongli Lian Pengbo Xu Shengbo He Jun Wu Jian Pan Wenxiu Wang Feng Xu Sheng Wang Junsong Pan Jirong Huang Hong-Quan Yang | 2018 | Molecular Plant2018，11，10： | 10 |
| 2 | Two-dimensional ultrathin MoS2-modified black Ti^3+-TiO2 nanotubes for enhanced photocatalytic water splitting hydrogen production显示文摘Two-dimensional (2D) ultrathin MoS2-modified black Ti^3+-TiO2 nanotubes were fabricated using an electrospinning-hydrothermal treatment-reduction method.Bare TiO2 nanotubes were fabricated via electrospinning.Then,2D MoS2 lamellae were grown on the surface of the nanotubes and Ti^3+/Ov ions were introduced by reduction.The photocatalytic performance of the 2D MoS2/Ti^3+-TiO2 nanotubes was^15 times better than that of TiO2.The HER enhancement of the MoS2/Ti^3+-TiO2 nanotubes can be attributed to the Pt-like behavior of 2D MoS2 and the presence of Ti^3+-ions,which facilitated the quick diffusion of the photogenerated electrons to water,reducing the H2 activation barrier.The presence of Ov ions in the nanotubes and their hollow structure increased their solar utilization. | Wei Ou Jiaqi Pan Yanyan Liu Shi Li Hongli Li Weijie Zhao Jingjing Wang Changsheng Song Yingying Zheng Chaorong Li | 2020 | Journal of Energy Chemistry2020，29，4： | 7 |
| 3 | Scientific literature addressing brain glioma in the Web of Science A 10-year bibliometric analysis显示文摘Brain glioma is a hot topic in recent years; however, brain glioma remains poorly understood. A bibliometric analysis based on the Science Citation Index (SCI) published by the Institute of Scientific Information (ISI) was performed to identify the global research and to improve the understanding of research trends in the brain glioma field from 2001 to 2010. During 2001 to 2010, there were 8 413 papers addressing brain glioma added to the SCI, and this trend is increasing annually. Of these reports, 6 945 papers are written in English. Journals published in the United States had the most papers, including ten core source titles. The Journal of Neuro-Oncology published the most articles followed by Cancer Research. Furthermore, the University of California, San Francisco, is the most productive institution for publishing articles in the brain glioma field. Finally, this study highlights the topics in brain glioma research that are being published around the world. | Zaihua Xu Tao Tang Dongsheng Pan Di Fan Zhenquan Song Hongli Xue | 2011 | Neural Regeneration Research2011，6，32： | 3 |
| 4 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 5 | MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway显示文摘 | Zhenwei Pan Xuelin Sun Hongli Shan Ning Wang Jinghao Wang Jinshuai Ren Shuya Feng Liangjun Xie Chunying Lu Ye Yuan Yang Zhang Ying Wang Yanjie Lu Baofeng Yang | 2012 | Circulation2012，，7： | 2 |
| 6 | The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes显示文摘 | Chaoqian Xu Yanjie Lu Zhenwei Pan Wenfeng Chu Xiaobin Luo Huixian Lin Jiening Xiao Hongli Shan Zhiguo Wang and Baofeng Yang | | Journal of Cell Science0，120，17： | 1 |
| 7 | New Gene Variants Associated with the Risk of Chronic HBV Infection显示文摘Some patients with chronic hepatitis B virus(HBV)infection failed to clear HBV,even persistently continue to produce antibodies to HBV.Here we performed a two stage genome wide association study in a cohort of Chinese patients designed to discover single nucleotide variants that associate with HBV infection and clearance of HBV.The first stage involved genome wide exome sequencing of 101 cases(HBsAg plus anti-HBs positive)compared with 102 control patients(antiHBs positive,HBsAg negative).Over 80%of individual sequences displayed 209 sequence coverage.Adapters,uncertain bases[10%or low-quality base calls([50%)were filtered and compared to the human reference genome hg19.In the second stage,579 chronic HBV infected cases and 439 HBV clearance controls were sequenced with selected genes from the first stage.Although there were no significant associated gene variants in the first stage,two significant gene associations were discovered when the two stages were assessed in a combined analysis.One association showed rs506121-“T”allele[within the dedicator of cytokinesis 8(DOCK8)gene]was higher in chronic HBV infection group than that in clearance group(P=0.002,OR=0.77,95%CI[0.65,0.91]).The second association involved rs2071676—A allele within the Carbonic anhydrase(CA9)gene that was significantly elevated in chronic HBV infection group compared to the clearance group(P=0.0003,OR=1.35,95%CI[1.15,1.58]).Upon replication these gene associations would suggest the influence of DOCK8 and CA9 as potential risk genetic factors in the persistence of HBV infection. | Mengjie Fan Jing Wang Sa Wang Tengyan Li Hong Pan Hankui Liu Huifang Xu Daria V.Zhernakova Stephen J.O’Brien Zhenru Feng Le Chang Erhei Dai Jianhua Lu Hongli Xi Yanyan Yu Jianguo Zhang Binbin Wang Zheng Zeng | 2020 | Virologica Sinica2020，35，4： | 1 |
| 8 | Gut Bacterial Translocation Contributes to Microinflammation in Experimental Uremia显示文摘 | Feiqian Wang Pan Zhang Hongli Jiang Shaoli Cheng | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 9 | Tanshinone H Aprotects against sudden cardiac death induced by lethal arrhyth-mias via repression of microRNA - 1 显示文摘 | Hongli Shan Xuelian Li Zhenwei Pan | 2009 | Br J Pharmacol2009，158，5： | 1 |
| 10 | Study of micro-trichome (mict) reveals novel connections between transcriptional regulation of multicellular trichome development and specific metabolism in cucumber显示文摘Trichomes that cover the epidermis of aerial plant organs play multiple roles in plant protection.Compared with a unicellular trichome in model plants,the development mechanism of the multicellular trichome is largely unclear.Notably,variations in trichome development are often accompanied by defects in the biosynthesis of cuticle and secondary metabolites;however,major questions about the interactions between developmental differences in trichomes and defects in metabolic pathways remain unanswered.Here,we characterized the glabrous mutant mict/csgl1/cstbh via combined metabolomic and transcriptomic analyses to extend our limited knowledge regarding multicellular trichome development and metabolism in cucumber.Mict was found to be explicitly expressed within trichome cells.Transcriptomic analysis indicated that genes involved in flavonoid and cuticle metabolism are significantly downregulated in mict mutants.Further metabolomic analysis confirmed that flavonoids,lipids,and cuticle compositions are dramatically altered in mict mutants.Additional studies revealed that Mict regulates flavonoid,lipid,and cuticle biosynthesis by likely directly binding to downstream functional genes,such as CsTT4,CsFLS1,CsCER26,and CsMYB36.These findings suggest that specific metabolic pathways(e.g.,flavonoids and cuticle components)are co-regulated by Mict and provide insights into transcriptional regulation mechanisms of multicellular trichome development and its specific metabolism in cucumber. | Jian Pan Leyu Zhang Guanqun Chen Haifan Wen Yue Chen Hui Du Junlong Zhao Huanle He Hongli Lian Huiming Chen Jianxin Shi Run Cai Gang Wang Junsong Pan | 2021 | Horticulture Research2021，8，1： | 1 |
| 11 | Energy-Efficient Multi-Trip Routing for Municipal Solid Waste Collection by Contribution-Based Adaptive Particle Swarm Optimization显示文摘Waste collection is an important part of waste management system.Transportation costs and carbon emissions can be greatly reduced by proper vehicle routing.Meanwhile,each vehicle can work again after achieving its capacity limit and unloading the waste.For this,an energy-efficient multi-trip vehicle routing model is established for municipal solid waste collection,which incorporates practical factors like the limited capacity,maximum working hours,and multiple trips of each vehicle.Considering both economy and environment,fixed costs,fuel costs,and carbon emission costs are minimized together.To solve the formulated model effectively,contribution-based adaptive particle swarm optimization is proposed.Four strategies named greedy learning,multi-operator learning,exploring learning,and exploiting learning are specifically designed with their own searching priorities.By assessing the contribution of each learning strategy during the process of evolution,an appropriate one is selected and assigned to each individual adaptively to improve the searching efficiency of the algorithm.Moreover,an improved local search operator is performed on the trips with the largest number of waste sites so that both the exploiting ability and the convergence accuracy of the algorithm are improved.Performance of the proposed algorithm is tested on ten waste collection instances,which include one real-world case derived from the Green Ring Company of Jiangbei New District,Nanjing,China,and nine synthetic instances with increasing scales generated from the commonly-used capacitated vehicle routing problem benchmark datasets.Comparisons with five state-of-the-art algorithms show that the proposed algorithm can obtain a solution with a higher accuracy for the constructed model. | Xiaoning Shen Hongli Pan Zhongpei Ge Wenyan Chen Liyan Song Shuo Wang | 2023 | Complex System Modeling and Simulation2023，3，3： | 0 |
| 12 | YBX1 inhibits mitochondrial-mediated apoptosis in ischemic heart through the PI3K/AKT signaling pathway显示文摘Background:Myocardial infarction(MI)is associated with higher morbidity and mortality in the world,especially in cold weather.YBX1 is an RNA-binding protein that is required for pathological growth of cardiomyocyte by regulating cell growth and protein synthesis.But YBX1,as an individual RNA-binding protein,regulates cardiomyocytes through signaling cascades during myocardial infarction remain largely unexplored.Methods:In vivo,the mouse MI model was induced by ligating the left anterior descending coronary artery(LAD),and randomly divided into sham operation group,MI group,MI+YBX1 knockdown/overexpression group and MI+negative control(NC)group.The protective effect of YBX1 was verified by echocardiography and triphenyltetrazolium chloride staining.In vitro,mitochondrial-dependent apoptosis was investigated by using CCK8,TUNEL staining,reactive oxygen species(ROS)staining and JC-1 staining in hypoxic neonatal mouse cardiomyocytes(NMCMs).Results:YBX1 expression of cardiomyocytes was downregulated in a mouse model and a cellular model on the ischemic condition.Compared to mice induced by MI,YBX1 overexpression mediated by adeno-associated virus serotype 9(AAV9)vector reduced the infarcted size and improved cardiac function.Knockdown of endogenous YBX1 by shRNA partially aggravated ischemia-induced cardiac dysfunction.In hypoxic cardiomyocytes,YBX1 overexpression decreased lactic dehydrogenase(LDH)release,increased cell viability,and inhibited apoptosis by affecting the expression of apoptosis related proteins,while knockdown of endogenous YBX1 by siRNA had the opposite effect.Overexpression of YBX1 restored mitochondrial dysfunction in hypoxic NMCMs by increasing mitochondrial membrane potential and ATP content and decreasing ROS.In hypoxic NMCMs,YBX1 overexpression increased the expression of phosphorylated phosphatidylinositol 3 kinase(PI3K)/AKT,and the anti-apoptosis effect of YBX1 was eliminated t by LY294002,PI3K/AKT inhibitor.Conclusion:YBX1 protected the heart from ischemic damage by inhibiting the mitochondrial-dependent apoptosis through PI3K/AKT pathway.It is anticipated that YBX1 may serve as a novel therapeutic target for MI. | Fangfang Bi Miao Cao Yuquan Wang Qingming Pan Zehong Jing Danyang Bing Lifang Lyu Tong Yu Tianyu Li Xuelian Li Haihai Liang Hongli Shan Yuhong Zhou | 2024 | Frigid Zone Medicine2024，4，1： | 0 |
| 13 | Enhanced magnetic anisotropy and high hole mobility in magnetic semiconductor Ga_(1-x-y)Fe_(x)Ni_(y)Sb显示文摘(Ga,Fe)Sb is a promising magnetic semiconductor(MS)for spintronic applications because its Curie temperature(T_(C))is above 300 K when the Fe concentration is higher than 20%.However,the anisotropy constant Ku of(Ga,Fe)Sb is below 7.6×10^(3)erg/cm^(3)when Fe concentration is lower than 30%,which is one order of magnitude lower than that of(Ga,Mn)As.To address this issue,we grew Ga_(1-x-y)Fe_(x)Ni_(y)Sb films with almost the same x(≈24%)and different y to characterize their magnetic and electrical transport properties.We found that the magnetic anisotropy of Ga_(0.76-y)Fe_(0.24)Ni_(y)Sb can be enhanced by increasing y,in which Ku is negligible at y=1.7%but increases to 3.8×10^(5)erg/cm^(3)at y=6.1%(T_(C)=354 K).In addition,the hole mobility(μ)of Ga_(1-x-y)Fe_(x)Ni_(y)Sb reaches 31.3 cm^(2)/(V∙s)at x=23.7%,y=1.7%(T_(C)=319 K),which is much higher than the mobility of Ga_(1-x)Fe_(x)Sb at x=25.2%(μ=6.2 cm^(2)/(V∙s)).Our results provide useful information for enhancing the magnetic anisotropy and hole mobility of(Ga,Fe)Sb by using Ni co-doping. | Zhi Deng Hailong Wang Qiqi Wei Lei Liu Hongli Sun Dong Pan Dahai Wei Jianhua Zhao | 2024 | Journal of Semiconductors2024，45，1： | 0 |
| 14 | A Study of the Artificial Vegetation Restoration Technology in the Wenchuan Earthquake Area显示文摘The situation of plants on the slope can reflect the effect of vegetation restoration during the process of artificial vegetation recovery.Taking the typical damaged slope of Wenchuan earthquake area as the research object,through observing the vegetation situation of deserted slope,the results show that compositae plants and gramineous plants are suitable for being pioneer plants and dominant in community; during the vegetation succession,many compositae and gramineous species invade,but there is no magaphanerophytes invading; as time goes by,the herbaceous species and diversity increase gradually,so the ecosystem becomes more stable and the gradient is important for the vegetation restoration. | Yu WANG Xingliang LIU Anmin MIN Li WANG Wenbao MA Hongli PAN Hongxia LI Li ZHANG | 2014 | Asian Agricultural Research2014，6，9： | 0 |
| 15 | MouseVenue3D:A Markerless Three-Dimension Behavioral Tracking System for Matching Two-Photon Brain Imaging in Free-Moving Mice显示文摘Understanding the connection between brain and behavior in animals requires precise monitoring of their behaviors in three-dimensional(3-D)space.However,there is no available three-dimensional behavior capture system that focuses on rodents.Here,we present MouseVenue3D,an automated and low-cost system for the efficient capture of 3-D skeleton trajectories in markerless rodents.We improved the most time-consuming step in 3-D behavior capturing by developing an automatic calibration module.Then,we validated this process in behavior recognition tasks,and showed that 3-D behavioral data achieved higher accuracy than 2-D data.Subsequently,MouseVenue3D was combined with fast high-resolution miniature two-photon microscopy for synchronous neural recording and behavioral tracking in the freely-moving mouse.Finally,we successfully decoded spontaneous neuronal activity from the 3-D behavior of mice.Our findings reveal that subtle,spontaneous behavior modules are strongly correlated with spontaneous neuronal activity patterns. | Yaning Han Kang Huang Ke Chen Hongli Pan Furong Ju Yueyue Long Gao Gao Runlong Wu Aimin Wang Liping Wang Pengfei Wei | 2022 | Neuroscience Bulletin2022，38，3： | 0 |
| 16 | Pyrophosphate-Mediated On-Off-On Oxidase-Like Activity Switching of Nanosized MnFe_(2)O_(4) for Alkaline Phosphatase Sensing显示文摘Developing reliable and facile approaches for alkaline phosphatase(ALP)sensing is important due to its role as a clinical biomarker for many diseases.In this study,we proposed a new and convenient colorimetric assay based on the pyrophosphate(PPi)-mediated oxidase-mimicking activity switching of nanosized MnFe_(2)O_(4) for the detection of ALP.The synthesized MnFe_(2)O_(4) exhibited high oxidase-like activity to catalyze the oxidation of colorless 3,3′,5,5′-tetramethylbenzidine(TMB)to its blue product TMBox in the presence of dissolved O2,leading to a color reaction rapidly and remarkably;PPi could significantly inhibit the activity of the MnFe_(2)O_(4) nanozyme via the strong interaction between PPi and the Fe(III)species in MnFe_(2)O_(4),resulting in the suppression of the TMB color reaction;when ALP was added,it hydrolyzed the PPi substrate to phosphate(Pi)that had no obvious effect on the MnFe_(2)O_(4) activity,and such that the TMB color reaction catalyzed by the nanozyme could be observed again.With the above principle,linear colorimetric determination of ALP in the scope of 0.6-55 U L−1 was achieved,giving the limit of detection down to 0.27 U L−1.Besides,the developed assay could provide selective response toward ALP against other co-existing biological species.Furthermore,reliable detection of ALP in human serum samples was verified by our assay,revealing its great promise as an effective and facile tool for ALP monitoring in clinical practice. | Xiangheng Niu Kun Ye Zhibo Li Hongli Zhao Linjie Wang Jianming Pan Hongwei Song Minbo Lan | 2019 | Journal of Analysis and Testing2019，3，3： | 0 |
| 17 | Tanshinone IIA Protects against Sudden Cardiac Death Induced by Lethal Arrhythmias via Repression of microRNA-1显示文摘 | Xuelian Li Hongli Shan Li Zhang Zhenwei Pan Yanjie Lv Baofeng Yang | 2008 | 中国药理通讯2008，25，2： | 0 |
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