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| 1 | Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B显示文摘作为克积极的、形成孢子的厌氧的杆菌, Clostridium 顽固(C。顽固) 为严重、致命的 pseudomembranous 大肠炎负责,并且形成世界范围的最迫切的抗菌素抵抗威胁。流行 C。顽固全球性是联系抗菌素的腹泻的领先的原因,特别由于 hypervirulent 的出现,种类与高死亡和病态联系了的腹泻。TcdB,关键毒力因素之一由这个细菌藏匿了,通过糟糕理解的机制进入主人房间得到它的病原的效果。这里,我们报导 TcdB 细胞的受体的第一鉴定, chondroitin 硫酸盐 proteoglycan 4 (CSPG4 ) 。CSPG4 开始从屏蔽的一个整个染色体的人的 shRNAmir 图书馆被孤立,并且它的角色被证实由调停 TALEN 并且在人的房间的 CRISPR/Cas9-mediated 基因大美人。CSPG4 为对房间表面有约束力的 TcdB 是批评的,导致细胞骨架混乱和房间死亡。在 CSPG4 的 N 终点和 TcdB 的 C 终点之间的一个直接相互作用被证实,并且 CSPG4 的毒素绑定领域的可溶的肽能保护房间免受 TcdB 的行动的伤害。尤其是, CSPG4/NG2 的完全的损失减少了在没有显著地影响动物死亡的老鼠的被触发 TcdB 的 interleukin-8 正式就职。基于两个在里面 vitro 并且在 vivo 研究,我们为 TcdB endocytosis 建议一个双受体的模型。第一 TcdB 受体的发现为 CSPG4 揭示一个以前不受怀疑的角色并且为 C 的处理提供一个新治疗学的目标。顽固感染。 | Pengfei Yuan Hongmin Zhang Changzu Cai Shiyou Zhu Yuexin Zhou Xiaozhou Yang Ruina He Chan Li Shengjie Guo Shan Li Tuxiong Huang Gregorio Perez-Cordon Hanping Feng Wensheng Wei | 2015 | Cell Research2015，25，2： | 6 |
| 2 | Composition and phase structure dependence of mechanical and magnetic properties for AlCoCuFeNi_x high entropy alloys显示文摘In this study, the effects of composition and phase constitution on the mechanical properties and magnetic performance of AlCoCuFeNix(x = 0.5, 0.8, 1.0, 1.5, 2.0, 3.0 in molar ratio) high entropy alloys(HEAs)were investigated. The results show that Ni element could lead to the evolution from face centered cubic(FCC), body centered cubic(BCC) and ordered BCC coexisting phase structure to a single FCC phase. The change of phase constitution enhances the plasticity but reduces the hardness and strength. One of the interesting points is the excellent soft magnetic properties of AlCoCuFeNixHEAs. Soft magnetic performance is dependent on composition and phase transition. AlCoCuFeNi1.5 alloy, achieving a better balance of mechanical and magnetic properties, could be applied as structure materials and soft magnetic materials(SMMs). High Curie temperature(>900 K) and strong phase stability below 1350 K of AlCoCuFeNi0.5 alloy confirm its practicability in a high-temperature environment. Atomic size difference(δ) is utilized as the critical parameter to explain the lattice strain and phase transformation induced by Ni addition. | Cong Liu Wenyi Peng C.S. Jiang Hongmin Guo Jun Tao Xiaohua Deng Zhaoxia Chen | 2019 | Journal of Materials Science & Technology2019，35，6： | 5 |
| 3 | Effect of UTRs from TMV-RNA on the expression of foreign gene in transgenic plants显示文摘To investigate the effects of 5’and 3’ untranslated region (UTR) from tobacco mosaicvirus (TMV) on expression of foreign genes, four plant-expression vectors pBG437, pBG438, pBG440 and pBG440ANOS containing expression cassettes of GUS-NOS; Ω-GUS-NOS, Ω-GUS-3’ UTR-NOS and Ω-GUS-3’ UTR downstream of CaMV 35S promoter with double enhancer sequences respectively have been constructed. Results from a large number of transgenic tobacco plants show that the GUS activity of pBG440 transformed plants is the highest, being 5-fold that of pBG437 and 1.6-fold that of pBG438. Similar results have been obtained in transient expression by injection of Agrobacterium tumefaciens harbouring these constructs into N. benthamiana leaves. These results obtained at the whole plant level confirm the conclusion drawn from the transient expression studies in protoplast system that TMV- Ω fragment can be a translation enhancer and the 3’ UTR has a coordinate effect with ft fragment to enhance foreign gene expression, but | Hongmin Qin Hongnian Guo Yantao Jia Lihong Li Yingchuan Tian | 2000 | Chinese Science Bulletin2000，45，18： | 2 |
| 4 | Energy Management Strategy Considering Multi-time-scale Operational Modes of Batteries for the Grid-connected Microgrids Community显示文摘The advantages and promoting applications of the microgrids community(MGC)allows for a critical step being taken toward a smart grid.An energy management strategy(EMS)is essential to intelligently coordinate the operations of the MGC.This paper presents a multi-time-scale EMS consid-ering battery operational modes for grid-connected MGCs.The proposed strategy consists of two modules:day-ahead integrated optimization and realtime distributed compensation.The first module aims to minimize the operational cost of the MGC considering battery free-overcharging protecting.This problem is solved by the mixed integer linear programming(MILP)sim-ulating two charging/discharging modes:limited-current mode and constant-voltage mode.The second module is installed in local MGs to correct the optimizing deviations of the day-ahead static scheduling,which are caused by predicting errors of renewable energy and loads.The main contribution of this work is integrating the advantages of global optimization of the centralized method and the fast computing speed of the distributed method.Experimental results prove the proposed EMS is feasible and effective.The computing time at each updating step is reduced by 75%on average,which has the potential to be adopted in engineering. | Xiaowen Xing Lili Xie Hongmin Meng Xin Guo Lei Yue Josep M.Guerrero | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 1 |
| 5 | REE bound polysaccharides in leaves of Dicranopteris dichotoma by MAA显示文摘 | Yuqi Wang Jingxin Sun Hongmin Chen Fanqing Guo Lei Xu Guoyin Cao | 1998 | Science in China Series B: Chemistry1998，，3： | 1 |
| 6 | Clinical analysis of the treatment of spinal cord injury with umbilical cord mesenchymal stem cells显示文摘 | Jing Liu Dongmei Han Zhidong Wang Mei Xue Ling Zhu Hongmin Yan Xiaoli Zheng Zikuan Guo Hengxiang Wang | 2013 | Cytotherapy2013，，2： | 1 |
| 7 | Fibroblast growth factor 9 promotes kidney cell proliferation via WNT signaling-mediated activation of ANXA4显示文摘Fibroblast growth factors(FGFs)play pivotal roles in cell migration and proliferation.However,the identity of the FGF that plays a dominant role in kidney cell proliferation remains unclear.Therefore,in this study,we investigated the dominant FGF among all FGFs.To this end,RNA-sequencing,qRT-PCR,western blotting,and ChIP assays were performed.FGF9 showed the highest expression among all FGFs,and its overexpression significantly promoted proliferation in the mouse kidney cell line C57BL/6 and increased JNK and AKT phosphorylation levels.Further,RNA-seq analysis identified 365 upregulated and 276 downregulated genes in FGF9-overexpressed cells.These differentially expressed genes were classified primarily into 20 biological pathways and were enriched in 31 gene ontology terms.qRT-PCR revealed that the expression of WNT and NF-κB signaling genes,as well as ANXA4 expression patterns,correlated with the RNA-seq data,while FGF9-overexpressed cells accumulated moreβ-catenin,a key WNT signaling protein,compared to control cells.Moreover,downregulation of the gene that encodesβ-catenin or ANXA4 inhibited C57BL/6 cell proliferation.Additionally,the expression of ANXA4 was lower in CTNNB1-knockdown cells than in the control group.Additionally,the ChIP assay revealed that a transcription factor complex containing TCF4 andβ-catenin directly binds to the ANXA4 promoter.Taken together,these results suggest a role of FGF9 in the regulation of kidney cell migration.These findings may prove useful in the development of future therapies. | TING LI XINHUI SUN NANNAN LI HONGMIN GUO | 2021 | BIOCELL2021，45，4： | 1 |
| 8 | Clinical analysis of the treatment of spinocerebellar ataxia and multiple system atrophy-cerebellar type with umbilical cord mesenchymal stromal cells显示文摘 | Han Dongmei Liu Jing Xue Mei Zhu Ling Yan Hongmin Wang Zhidong Ding Li Guo Zikuan Wang Hengxiang | 2011 | Cytotherapy2011，，8： | 1 |
| 9 | SO_2-tolerant Pt-MoO_3/C catalyst for oxygen reduction reaction显示文摘A Pt-MoO_3/C catalyst,aimed to eliminate the harmful effect of sulfur dioxide(SCb) on the performance of Pt nanoparticles(NPs) for catalysis of oxygen reduction reaction(ORR) in proton exchange membrane fuel cells(PEMFC),is developed and characterized by TEM,XRD and XPS.The results reveal that Pt-MoO_3/C catalyst exhibits not only a higher catalytic activity,but also a better SO_2 poisoning resistance and a better recovery performance than the commercial Pt/C catalyst does. | Xiao Liu Hongmin Wang Siguo Chen Xueqiang Qi Huiliang Gao Yi Hui Yang Bai Lin Guo Wei Ding Zidong Wei | 2014 | Journal of Energy Chemistry2014，23，3： | 1 |
| 10 | Reconstruction of October Mean Temperature since 1796 in Wuying Based on Tree Ring Data显示文摘在 Heilongjiang 省,为 Wuying 的 Fenglin 国家自然储备地的 10 月的每月吝啬的温度为用物件树戒指年表从 1796 ~ 2004 跑的时期被重建。重建的解释变化是 34.8% 。在过去的 209 年里,有 4 更冷并且 4 个更温暖的时期根据重建的系列。一个时期 3.33 年基于力量光谱方法被发现重要。突然的变化也基于变光滑的 t 测试与 30 年的时间规模在重建的系列被检测,弄平 F-test 和雷·佩奇测试方法。在吝啬的价值的重要突然的变化为约 1871 和 1900 被观察,并且在标准差的一个重要突然的变化为约 1851 被观察。引证殷, H. , H. 刘, L. 黄,等, 2010:10 月的重建自从 1796,基于树戒指数据在 Wuying 意味着温度。副词。Clim。变化物件, 1, doi:10.3724/SP .J.1248.2010.00100。 | Hong Yin Hongbin Liu Lei Huang Hongmin Yu Shiyou Guo Fang Wang Pinwen Guo | 2010 | Advances in Climate Change Research2010，1，2： | 1 |
| 11 | Construction of a new plant expression vector containing two insect resistant genes and its expression in transgenic tobacco plants显示文摘A new plant expression vector (pBS29K-BA) containing two insect resistant genes, a synthetic chimeric gene BtS29K encoding the activated insecticidal protein Cry1Ac and a gene API-BA encoding the arrowhead (Sagittaria sagittifolia L.) proteinase inhibitor (API) A and B, is constructed. Transgenic tobacco plants expressing these two genes are obtained through Agrobacterium-mediated transformation of tobacco leaf discs. The average expression levels of Cry1Ac and API-BA proteins in transgenic plants are of 3.2 μg and 4.9 μg per gram fresh leaf respectively. The results of insecticidal assay of transgenic plants indicate that the pBS29K-BA transformed plants are more resistant to insect damage than the plants expressing the Cry1Ac gene or API-BA gene alone. | GUO Hongnian, QIN Hongmin, CHEN Xiaoying, LI Changqing, LU Rui and TIAN Yingchuan(Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China) | 2002 | Progress in Natural Science:Materials International2002，12，5： | 1 |
| 12 | Representation of Semantic Word Embeddings Based on SLDA and Word2vec Model显示文摘To solve the problem of semantic loss in text representation,this paper proposes a new embedding method of word representation in semantic space called wt2svec based on supervised latent Dirichlet allocation(SLDA)and Word2vec.It generates the global topic embedding word vector utilizing SLDA which can discover the global semantic information through the latent topics on the whole document set.It gets the local semantic embedding word vector based on the Word2vec.The new semantic word vector is obtained by combining the global semantic information with the local semantic information.Additionally,the document semantic vector named doc2svec is generated.The experimental results on different datasets show that wt2svec model can obviously promote the accuracy of the semantic similarity of words,and improve the performance of text categorization compared with Word2vec. | TANG Huanling ZHU Hui WEI Hongmin ZHENG Han MAO Xueli LU Mingyu GUO Jin | 2023 | Chinese Journal of Electronics2023，32，3： | 1 |
| 13 | The grape VvMBF1 gene improves drought stress tolerance in transgenic Arabidopsis thaliana显示文摘 | Qin Yan Hongmin Hou Stacy D. Singer Xiaoxiao Yan Rongrong Guo Xiping Wang | 2014 | Plant Cell, Tissue and Organ Culture (PCTOC)2014，，3： | 1 |
| 14 | Cross-reactivity of anti-programmed death ligand 2 polyclonal antibody in mouse tissues显示文摘The inhibitory co-receptor programmed death 1 (PD-1, encoded by pdcd1) and its two ligands PD-L1 and PD-L2 comprise an important immune inhibitory signaling pathway for defense against microbes and for self-tolerance. Unlike other members of the B7-CD28 family, expression of PD-L1 and PD-L2 is not limited to the immune system. In this study, we determined that a polyclonal antibody (pAb) (R&D Systems) against extracellular domains of mouse PD-L2 (mPD-L2) could recognize anti- gen(s) in diverse mouse tissues, including the anterior and intermediate pituitary gland, olfactory bulbs and olfactory epitheli- um, tongue epithelium, keratinized epithelial cells and skin and whisker hair follicles. These findings differed from previous reports of mPD-L2 localization. Reverse transcription PCR and Western blot analyses, however, were unable to detect any mPD-L2 transcripts or proteins of the 25-kD predicted molecular weight in RNA and protein extracts, respectively, from the above tissues, suggesting that the anti-mPD-L2 pAb cross-reacts with certain novel antigen(s). Developmental studies revealed that the earliest expression of mPD-L2-like antigen was in the olfactory epithelium at embryonic day 12.5 (E12.5). At E14.5, mPD-L2-like antigen was present in the skin, tongue and follicles of the skin and whiskers. The distribution patterns of mPD-L2-like antigen remained similar from E18.5 to adulthood. The results of bioinformatic analysis and other experiments suggested neural cell adhesion molecule and hemicentin-1 as candidate proteins with cross-reactivity to the anti-mPD-L2 pAb. These results demonstrate that care is required in interpreting staining patterns generated when anti-PD-L2 pAb is used to locate PD-L2-expressing cells in the central nervous system and epithelial tissues, such as the olfactory epithelium. In addition, this anti-PD-L2 pAb may be used as an alternative antibody for labeling the olfactory epithelium during embryonic development in mice. | ZHAO Yu BIAN GanLan YU CaiYong LIU Fang-Fang LIU Ling GUO HongMin GUO Jun JU Gong WANG Jian | 2012 | Science China(Life Sciences)2012，55，11： | 0 |
| 15 | Romidepsin(FK228) improves the survival of allogeneic skin grafts through downregulating the production of donor-specific antibody via suppressing the IRE1α-XBP1 pathway显示文摘Antibody-mediated rejection(AMR)is one of the major causes of graft loss after transplantation.Recently,the regulation of B cell differentiation and the prevention of donor-specific antibody(DSA)production have gained increased attention in transplant research.Herein,we established a secondary allogeneic in vivo skin transplant model to study the effects of romidepsin(FK228)on DSA.The survival of grafted skins was monitored daily.The serum levels of DSA and the number of relevant immunocytes in the recipient spleens were evaluated by flow cytometry.Then,we isolated and purified B cells from B6mouse spleens in vitro by magnetic bead sorting.The B cells were cultured with interleukin-4(IL-4)and anti-clusters of differentiation 40(CD40)antibody with or without FK228 treatment.The immunoglobulin G1(IgG1)and IgM levels in the supernatant were evaluated by enzyme-linked immunosorbent assay(ELISA).Quantitative reverse transcription-polymerase chain reaction(RT-q PCR)and western blotting were conducted to determine the corresponding levels of messenger RNA(mRNA)and protein expression in cultured cells and the recipient spleens.The results showed that FK228 significantly improved the survival of allogeneic skin grafts.Moreover,FK228 inhibited DSA production in the serum along with the suppression of histone deacetylase 1(HADC1)and HDAC2 and the upregulation of the acetylation of histones H2A and H3.It also inhibited the differentiation of B cells to plasma cells,decreased the transcription of positive regulatory domain-containing 1(Prdm1)and X-box-binding protein 1(Xbp1),and decreased the expression of phosphorylated inositol-requiring enzyme 1α(p-IRE1α),XBP1,and B lymphocyte-induced maturation protein-1(Blimp-1).In conclusion,FK228 could decrease the production of antibodies by B cells via inhibition of the IRE1α-XBP1 signaling pathway.Thus,FK228 is considered as a promising therapeutic agent for the clinical treatment of AMR. | Yuliang GUO Siyu SONG Xiaoxiao DU Li TIAN Man ZHANG Hongmin ZHOU Zhonghua Klaus CHEN Sheng CHANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，5： | 0 |
| 16 | Identification of prognostic molecular subtypes and model based on CD8+ T cells for lung adenocarcinoma显示文摘Background:Cytotoxic T lymphocytes(CD8+T)cells function critically in mediating anti-tumor immune response in cancer patients.Characterizing the specific functions of CD8+T cells in lung adenocarcinoma(LUAD)could help better understand local anti-tumor immune responses and estimate the effect of immunotherapy.Methods:Gens related to CD8+T cells were identified by cluster analysis based on the single-cell sequencing data of three LUAD tissues and their paired normal tissues.Weighted gene co-expression network analysis(WGCNA),consensus clustering,differential expression analysis,least absolute shrinkage and selection operator(LASSO)and Cox regression analysis were conducted to classify molecular subtypes for LUAD and to develop a risk model using prognostic genes related to CD8+T cells.Expression of the genes in the prognostic model,their effects on tumor cell invasion,and interactions with CD8+T cells were verified by cell experiments.Results:This study defined two LUAD clusters(CD8+0 and CD8+1)based on CD8+T cells,with cluster CD8+0 being significantly associated with the prognosis of LUAD.Three heterogeneous subtypes(clusters 1,2,and 3)differing in prognosis,genome mutation events,and immune status were categorized using 42 prognostic genes.A prognostic model created based on 11 significant genes(including CD200R1,CLEC17A,ZC3H12D,GNG7,SNX30,CDCP1,NEIL3,IGF2BP1,RHOV,ABCC2,and KRT81)was able to independently estimate the death risk for patients in different LUAD cohorts.Moreover,the model also showed general applicability in external validation cohorts.Low-risk patients could benefit more from taking immunotherapy and were significantly related to the resistance to anticancer drugs.The results from cell experiments demonstrated that the expression of CD200R1,CLEC17A,ZC3H12D,GNG7,and SNX30 was significantly downregulated,while that of CDCP1,NEIL3,IGF2BP1,RHOV,ABCC2 and KRT81 was upregulated in LUAD cells.Inhibition of CD200R1 greatly increased the invasiveness of the LUAD cells,but inhibiting CDCP1 expression weakened the invasion ability of LUAD cells.Conclusion:This study defined two prognostic CD8+T cell clusters and classified three heterogeneous molecular subtypes for LUAD.A prognostic model predictive of the potential effects of immunotherapy on LUAD patients was developed. | HONGMIN CAO YING XUE FEI WANG GUANGYAO LI YULAN ZHEN JINGWEN GUO | 2024 | BIOCELL2024，48，3： | 0 |
| 17 | Effects of selective cyclooxygenase-2 inhibitor on C6 glioma cell proliferation and apoptosis显示文摘BACKGROUND:Studies have shown that cyclooxygenase-2 is associated with proliferation and apoptosis of glioma cells. OBJECTIVE:To investigate the effects of selective cyclooxygenase-2 inhibitor celecoxib on proliferation and apoptosis of C6 glioma cells in vitro. DESIGN,TIME AND SETTING:A cellular,molecular,controlled study was performed at the Central Laboratory and Room of Electron Microscope,Medical School,Xi'an Jiaotong University,China from March 2007 to March 2008. MATERIALS:C6 glioma cells during in vitro log phase were assigned to control and experimental groups.Celecoxib(Pfizer,USA),dimethyl sulfoxide(Sigma,USA),and MTT(Sigma,USA) were used for this study. METHODS:The control group was subdivided into blank control and dimethyl sulfoxide control groups.C6 glioma cells in the blank control and dimethyl sulfoxide control groups were incubated in Dulbecco's modified Eagle's medium supplemented with 10%calf serum and 0.3%dimethyl sulfoxide respectively.C6 glioma cells in the experimental group were separately treated with 60,80, and 100μmol/L celecoxib. MAIN OUTCOME MEASURES:Activity of C6 glioma cells was examined by MTT assay.C6 glioma cell cycle and apoptosis were determined by annexin V-fluorescein isothiocyanate/propidium iodide double-staining,followed by flow cytometry.Morphology and ultrastructure of C6 glioma cells were observed with an inverted microscope and a transmission electron microscope,respectively. RESULTS:Compared with the blank control group,cell density was reduced,adherence ability weakened,and irregular nuclei were visible,with the presence of chromatin condensation, margination,and some apoptotic bodies in the experimental group.Activity of C6 glioma cells was significantly decreased(P<0.05),cell number was reduced during S phase,cell number was significantly increased during G_2/M phase(P<0.01),and the apoptotic rate was significantly increased(P<0.05) in the experimental group.These results were displayed in a dose- and time-dependent fashion.The outcomes were obvious in the 100μmol/L celecoxib group following 72 hours of treatment. CONCLUSION:Celecoxib blocked proliferation and induced apoptosis of C6 glioma cells in a dose-and time-dependent fashion. | Shiwen Guo Tao Li Hongmin Che Wenzhi Li Minxue Lian Yuliang Han | 2009 | Neural Regeneration Research2009，4，11： | 0 |
| 18 | Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens显示文摘Microplastics(MPs)have attracted growing attention worldwide as an increasingly prevalent environmental pollutant.In addition,chicken meat is currently the most widely consumed kind of poultry in the global market.Consumer demand for chicken is on the rise both at home and abroad.As a result,the safety of chicken raising has also received significant attention.The lungs play an essential role in the physiological activities of chickens,and they are also the most vulnerable organs.Lung injury is difficult to repair after the accumulation of contaminants,and the mortality rate is high,which brings huge economic losses to farmers.The research on the toxicity of MPs has mainly focused on the marine ecosystem,while the mechanisms of toxicity and lung damage in chickens have been poorly studied.Thus,this study explored the effects of exposure to polystyrene microplastics(PS-MPs)at various concentrations for 42 d on chicken lungs.PS-MPs could cause lung pathologies and ultrastructural abnormalities,such as endoplasmic reticulum(ER)swelling,inflammatory cell infiltration,chromatin agglutination,and plasma membrane rupture.Simultaneously,PS-MPs increased the expression of genes related to the heat shock protein family(Hsp60,Hsp70,and Hsp90),ER stress signaling(activating) transcription factor 6(ATF0),ATF4,protein kinase RNA-like ER kinase(PERK),and eukaryotic translation initiation factor 2 subunitα(eIF2a),pyroptosis-related genes(NOD)-,LRR-and pyrin domain-containing protein 3(NLRP3),apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC),interleukin-1β(IL-1β),cysteinyl aspartate-specific proteinase 1(Caspasel),and gasdermin-D(GSDMD),and the inflammatory signaling pathway(nuclear factor-kB(NF-kB),inducible nitric oxide synthase(iNOS),and cyclooxygenase-2(COX-2).The above results showed that PS-MP exposure could result in lung stress,ER stress,pyroptosis,and inflammation in broilers.Our findings provide new scientific clues for further research on the mechanisms of physical health and toxicology regardingMPs. | Hongmin LU Tiantian GUO Yue ZHANG Dewang LIU Lulu HOU Chengxue MA Mingwei XING | 2024 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2024，25，3： | 0 |
| 19 | The principle,application,and prospect of using the uranium comminution age to indicate the catchment erosion depth显示文摘Catchment erosion not only shapes various landforms of the earth’s surface but also affects the rates of chemical weathering and CO_(2) absorption by controlling the exposure of rock fragments,and thus acts as a regulator of the global climate.Therefore,studying the occurrence and controlling factors of catchment erosion can improve our understanding of topographic evolution and long-term climate change.This paper introduces the“comminution age”method based on (^(234)U/^(238)U) of sediment detrital components and its applications to indicate the catchment erosion depth,which is widely applied to different depositional environments.In tectonically stable regions,where there is shallow erosion,the sediment output from the catchment is usually accompanied by a low (^(234)U/^(238)U).On the other hand,where there is deep erosion,the (^(234)U/^(238)U) of the downstream sediments is usually high.In tectonically active regions,deep erosion is common,and the sediment erosion process is subject to rapid material transport,such as landslide-induced sediment displacement.Since the sediment exposure history is short,the (^(234)U/^(238)U) of the detrital components is close to 1,thus reaching“secular equilibrium”.The comminution age method is promising in terms of tracing catchment erosion depths at the orbital scale.Furthermore,this method is also sensitive to the erosion changes caused by rapid climate changes and human activities. | Hongmin XU Chao LI Zhifei DUAN Yulong GUO Shouye YANG | 2023 | Science China Earth Sciences2023，66，7： | 0 |
| 20 | Finite element simulation of the micromachining of nanosized-silicon-carbide-particle reinforced composite materials based on the cohesive zone model显示文摘A finite element method based on the cohesive zone model was used to study the micromachining process of nanosized silicon-carbide-particle(SiCp) reinforced aluminum matrix composites. As a hierarchical multiscale simulation method, the parameters for the cohesive zone model were obtained from the stress-displacement curves of the molecular dynamics simulation. The model considers the random properties of the siliconcarbide-particle distribution and the interface of bonding between the silicon carbide particles and the matrix.The machining mechanics was analyzed according to the chip morphology, stress distribution, cutting temperature, and cutting force. The simulation results revealed that the random distribution of nanosized SiCp causes non-uniform interaction between the tool and the reinforcement particles. This deformation mechanics leads to inhomogeneous stress distribution and irregular cutting force variation. | Hongmin Pen Jianhua Guo Zizhen Cao Xianchong Wang Zhiguo Wang | 2018 | Nanotechnology and Precision Engineering2018，1，4： | 0 |
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