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| 1 | High precision landing site mapping and rover localization for Chang'e-3 mission显示文摘This paper presents the comprehensive results of landing site topographic mapping and rover localization in Chang’e-3 mission.High-precision topographic products of the landing site with extremely high resolutions(up to 0.05 m)were generated from descent images and registered to CE-2 DOM.Local DEM and DOM with 0.02 m resolution were produced routinely at each waypoint along the rover traverse.The lander location was determined to be(19.51256°W,44.11884°N,-2615.451 m)using a method of DOM matching.In order to reduce error accumulation caused by wheel slippage and IMU drift in dead reckoning,cross-site visual localization and DOM matching localization methods were developed to localize the rover at waypoints;the overall traveled distance from the lander is 114.8 m from cross-site visual localization and 111.2 m from DOM matching localization.The latter is of highest accuracy and has been verified using a LRO NAC image where the rover trajeactory is directly identifiable.During CE-3 mission operations,landing site mapping and rover localization products including DEMs and DOMs,traverse maps,vertical traverse profiles were generated timely to support teleoperation tasks such as obstacle avoidance and rover path planning. | LIU ZhaoQin DI KaiChang PENG Man WAN WenHui LIU Bin LI LiChun YU TianYi WANG BaoFeng ZHOU JianLiang CHEN HongMin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，1： | 15 |
| 2 | Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer显示文摘Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation,thus stimulating ferroptosis may be a potential strategy for treating gastric cancer,therapeutic agents against which are urgently required.Jiyuan oridonin A(JDA) is a natural compound isolated from Jiyuan Rabdosia rubescens with anti-tumor activity,unclear anti-tumor mechanisms and limited water solubility hamper its clinical application.Here,we showed a2,a new JDA derivative,inhibited the growth of gastric cancer cells.Subsequently,we discovered for the first time that a2 induced ferroptosis.Importantly,compound a2 decreased GPX4 expression and overexpressing GPX4 antagonized the anti-proliferative activity of a2.Furthermore,we demonstrated that a2 caused ferrous iron accumulation through the autophagy pathway,prevention of which rescued a2 induced ferrous iron elevation and cell growth inhibition.Moreover,a2 exhibited more potent anti-cancer activity than 5-fluorouracil in gastric canc er cell line-derived xenograft mice models.Patient-derived tumor xenograft models from different patients displayed varied sensitivity to a2,and GPX4 downregulation indicated the sensitivity of tumors to a2.Finally,a2 exhibited well pharmacokinetic characteristic s.Overall,our data suggest that inducing ferroptosis is the major mechanism mediating anti-tumor activity of a2,and a2 will hopefully serve as a promising compound for gastric cancer treatment. | Ying Liu Zan Song Yajie Liu Xubin Ma Wang Wang Yu Ke Yichao Xu Dequan Yu Hongmin Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 10 |
| 3 | Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase1(LSD1/KDM1A)显示文摘Histone lysine specific demethylase 1(LSD1) has been recognized as an important modulator in post-translational process in epigenetics. Dysregulation of LSD1 has been implicated in the development of various cancers. Herein, we report the discovery of the hit compound 8 a(IC50=3.93 μmol/L) and further medicinal chemistry efforts, leading to the generation of compound 15 u(IC50=49 nmol/L, and Ki= 16 nmol/L), which inhibited LSD1 reversibly and competitively with H3 K4 me2, and was selective to LSD1 over MAO-A/B. Docking studies were performed to rationalize the potency ofcompound 15 u. Compound 15 u also showed strong antiproliferative activity against four leukemia cell lines(OCL-AML3, K562, THP-1 and U937) as well as the lymphoma cell line Raji with the IC50 values of 1.79, 1.30, 0.45, 1.22 and 1.40 μmol/L, respectively. In THP-1 cell line, 15 u significantly inhibited colony formation and caused remarkable morphological changes. Compound 15 u induced expression of CD86 and CD11 b in THP-1 cells, confirming its cellular activity and ability of inducing differentiation.The findings further indicate that targeting LSD1 is a promising strategy for AML treatment, the triazolefused pyrimidine derivatives are new scaffolds for the development of LSD1/KDM1 A inhibitors. | Zhonghua Li Lina Ding Zhongrui Li Zhizheng Wang Fengzhi Suo Dandan Shen Taoqian Zhao Xudong Sun Junwei Wang Ying Liu Liying Ma Bing Zhao Pengfei Geng Bin Yu Yichao Zheng Hongmin Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 6 |
| 4 | Effects of L-lysine·H2SO4 product on the intestinal morphology and liver pathology using broiler model显示文摘Background: Lysine is used widely in livestock production due to the shortage of feed protein resources.Llysine·H2SO4 contains L-lysine sulphate as well as fermentation co-products which contain other amino acids and phosphorus.However,there are few articles about L-lysine·H2SO4 product regarding intestinal morphology and liver pathology of broiler chickens.In this article,we focus on the absorption and metabolism of L-lysine·H2SO4 revealed in the variation of intestinal morphology and liver pathology to determine the tolerance of chicks for L-lysine·H2SO4.Methods: To evaluate the tolerance of broilers for L-lysine·H2SO4,240 one day old broilers were allocated randomly to one of five dietary treatments which included corn-soybean diets containing 0,1%,4%,7% or 10% L-lysine·H2SO4(L-lysine content = 55%).Results: Supplementation of 1% L-lysine·H2SO4 in the diet had no negative effects.However,4%,7% or 10% Llysine·H2SO4 supplementation produced negative responses on broiler performance,carcass characteristics,blood biochemistry,and particularly on intestinal morphology and liver pathology compared with broilers fed the control diet.Conclusion: Our results show that supplementation with 1% L-lysine·H2SO4 had no negative effects on performance,carcass characteristics,blood biochemistry,intestinal morphology and liver pathology in broilers,but supplementation with 4%,7% or 10% L-lysine·H2SO4 produced a negative response,particularly with respect to intestinal morphology and liver pathology. | Hongmin Jia Ting He Haitao Yu Xiangfang Zeng Shihai Zhang Wenfeng Ma Jie Zhang Shiyan Qiao Xi Ma | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 3 |
| 5 | Extraction mechanism of rare earths from chloride acidic solution with ammonium-bifunctionalized ionic liquid extractants显示文摘A series of ammonium-bifunctionalized ionic liquid extractants(ammonium-Bif-ILEs) combined with a number of anions, including carboxylic acids and 1,3-diketonates, have been prepared and studied in this report. Their extraction behavior and properties toward rare earth ions(REs(Ⅲ)) are systematically investigated in chloride media as a function of important parameters such as aqueous phase p H, salting-out agent concentrations, and extraction temperature. The separation performance of ammonium-Bif-ILEs toward REs(Ⅲ) are systematically discussed. The results demonstrate that ammonium-Bif-ILEs have a synergistic effect between the cation and anions in separation of REs(Ⅲ). The influences of different anions on separation factor(b) values are further studied. By comparison, ammonium-Bif-ILEs containing 1,3-diketonates have more potential applications in La(Ⅲ)/RE(Ⅲ) separation than those containing carboxylic acids. | Hualing Yang Ji Chen Wei Wang Hongmin Cui Wengang Liu Yu Liu | 2016 | Science China Chemistry2016，59，5： | 2 |
| 6 | A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer显示文摘Protein neddylation is catalyzed by a neddylation activating enzyme(NAE,E1),an E2 conjugating enzyme,and an E3 ligase.In various types of human cancers,the neddylation pathway is abnormally activated.Our previous study validated that the neddylation E2 UBE2F is a promising therapeutic target in lung cancer.Although the NAE inhibitor MLN4924/pevonedistat is currently under clinical investigation as an anti-cancer agent,there are no small molecules available that selectively target UBE2F.Here,we report,for the first time,the discovery,via structure-based virtual screen and chemical optimization,of such a small molecule,designated as HA-9104.HA-9104 binds to UBE2F,reduces its protein levels,and consequently inhibits cullin-5 neddylation.Blockage of cullin-5 neddylation inactivates cullin-RING ligase-5(CRL5)activity,leading to accumulation of the CRL5 substrate,NOXA,to induce apoptosis.Moreover,HA-9104 appears to form the DNA adduct via its 7-azaindole group to induce DNA damage and G2/M arrest.Biologically,HA-9104 effectively suppresses the growth and survival of lung cancer cells and confers radiosensitization in both in vitro cell culture and in vivo xenograft tumor models.In summary,we discovered a small molecule,designated HA-9104,that targets the UBE2F-CRL5 axis with anti-cancer activity alone or in combination with radiation. | Tiantian Xu Qisheng Ma Yanan Li Qing Yu Peichen Pan Yawen Zheng Zhijian Li Xiufang Xiong Tingjun Hou Bin Yu Hongmin Liu Yi Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 2 |
| 7 | Decrease in Apoptosis and Increase in Polyploidization of Megakaryocytes by Stem Cell Factor During Ex Vivo Expansion of Human Cord Blood CD34<sup>+</sup> Cells Using Thrombopoietin显示文摘 | Jeong‐HaeKie Woo‐IckYang Mi‐KyungLee Tae‐JungKwon Yoo‐HongMin Hyun‐OkKim Hyo‐SeopAhn Seock‐AhIm Hyung‐LaeKim Hae‐YoungPark Kyung‐HaRyu Wha‐SoonChung Myeong‐HeonShin Yu‐JinJung So‐YounWoo Hae‐KyungPark Ju‐YoungSeoh | 2009 | STEM CELLS2009，，1： | 1 |
| 8 | Air foam injec- tion for IOR:from laboratory to field implementation in Zhongyuan oilfield China显示文摘 | Hongmin Yu Baoquan Yang Guorui Xu | 2008 | SPE/DOE improved oil recovery symposium Oklahoma2008，，： | 1 |
| 9 | Label-free electrochemical immunosensor for prostate-specific antigen based on silver hybridized mesoporous silica nanoparticles显示文摘 | Huan Wang Yong Zhang Haiqin Yu Dan Wu Hongmin Ma He Li Bin Du Qin Wei | 2012 | Analytical Biochemistry2012，，： | 1 |
| 10 | Solid phase extraction of trace copper in water samples via modified corn silk as a novel hiosorhent with detection by flame atomic ab- sorption spectrometr显示文摘 | Zhou Xiuhui Yu Hongmei Jia Hongmin | 2013 | Anal Methods2013，5，： | 1 |
| 11 | Well-constructed cellulose acetate membranes for forward osmosis: Minimized internal concentration polarization with an ultra-thin selective layer显示文摘 | Sui Zhang Kai Yu Wang Tai-Shung Chung Hongmin Chen Y.C. Jean Gary Amy | 2010 | Journal of Membrane Science2010，，1： | 1 |
| 12 | BrΦnsted acid-promoted ‘on-water’ C(sp^3)-H functionalization fot the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction显示文摘The isoindolinone and biaryl scaffolds are prevalent in natural products and drug molecules,which have showed broad and interesting biological activities.The efficient construction of such hybridized molecules and biological evaluation are of great interest to medicinal chemistry community.In this communication,we report an efficient BrΦnsted acid-promoted C(sp^3)-H functionalization approach that enables the rapid construction of biologically important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine,2-formylbenzoic acid and various anilines.The title compounds were generated in high to excellent yields(up to 96%)regardless of the electronic nature and steric effects of the substituents.In this reaction,an isoindolinone scaffold,one C-C single bond,and two C-N bonds were formed simultaneously with high atom economy.In this work,we have envisioned that the methyl group linked to the electron-deficient Nheterocycles could be used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chemistry.Besides,the title compounds have exhibited promising activity against the SKP2-CKS1 interaction. | Shuo Yuan Sixi Wang Min Zhao Danqing Zhang Jinjie Chen Jian-Xin Li Jingya Zhang Yihui Song Jinyi Wang Bin Yu Hongmin Liu | 2020 | Chinese Chemical Letters2020，31，2： | 1 |
| 13 | Reconstruction of October Mean Temperature since 1796 in Wuying Based on Tree Ring Data显示文摘在 Heilongjiang 省,为 Wuying 的 Fenglin 国家自然储备地的 10 月的每月吝啬的温度为用物件树戒指年表从 1796 ~ 2004 跑的时期被重建。重建的解释变化是 34.8% 。在过去的 209 年里,有 4 更冷并且 4 个更温暖的时期根据重建的系列。一个时期 3.33 年基于力量光谱方法被发现重要。突然的变化也基于变光滑的 t 测试与 30 年的时间规模在重建的系列被检测,弄平 F-test 和雷·佩奇测试方法。在吝啬的价值的重要突然的变化为约 1871 和 1900 被观察,并且在标准差的一个重要突然的变化为约 1851 被观察。引证殷, H. , H. 刘, L. 黄,等, 2010:10 月的重建自从 1796,基于树戒指数据在 Wuying 意味着温度。副词。Clim。变化物件, 1, doi:10.3724/SP .J.1248.2010.00100。 | Hong Yin Hongbin Liu Lei Huang Hongmin Yu Shiyou Guo Fang Wang Pinwen Guo | 2010 | Advances in Climate Change Research2010，1，2： | 1 |
| 14 | Air foam injection for IOR:From laboratory to field implementation in Zhongyuan Oilfield China显示文摘 | Yu Hongmin Yang Baoquan Xu Guorui | 2008 | SPE 1139132008，，： | 1 |
| 15 | Synthesis, Cytotoxic Activity Evaluation of Novel 1,2,3-Triazole Linked Quinazoline Derivatives显示文摘一系列新奇 1,2,3-triazole-quinazoline 衍生物在由常规方法从 anthranilamide 开始的五步被综合。所有标题混合物 10a10r 在 vitro 用 MTT 试金与四根人的癌症房间线(MGC-803, EC-109, MCF-7 和 HGC-27 ) 为细胞毒素的活动被作比较。一些对对测试癌症房间线的有势力活动中等的展出的综合混合物。在他们之中,加重 10 h 和 10q 对 HGC-27 展出了优秀生长抑制,化合物 10 m 也对 MCF-7 拥有了优秀活动,与 IC 50 价值不到 1 慥敳漠 ? 桰瑯 ' 仪G矛棖 P 湥牥瑡潩 ? 桴湡 ?? 湚 ? 潭楤楦摥朠慲桰湥 ? 浳潯桴映汩 ?爠獥数瑣癩汥y ??? 幐吗?? | Panpan Song Fei Cui Na Li Jingchao Xin Qisheng Ma Xiangchuan Meng Chaojie Wang Qinpo Cao Yifei Gu Yu Ke Qiurong Zhang Hongmin Liu | 2017 | Chinese Journal of Chemistry2017，35，10： | 1 |
| 16 | THE DIELECTRIC PROPERTIES OF HUMAN FETAL ORGAN TISSUES AT RADIO AND MICROWAVE FREQUENCISE显示文摘THEDIELECTRICPROPERTIESOFHUMANFETALORGANTISSUESATRADIOANDMICROWAVEFREQUENCISETHEDIELECTRICPROPERTIESOFHUMANFETALORGANTISSUESA... | Yongjun Lu Hongmin Cui Jue Yu(Department of Biomedical Engineering,Peking Union Medical College,Beijing 10005,China) | 1996 | Chinese Journal of Biomedical Engineering(English Edition)1996，5，2： | 1 |
| 17 | Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death显示文摘 | Hongmin W Seong-Woon Yu David W Koh | 2004 | J Neurosci2004，24，10： | 1 |
| 18 | Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp.1647:Pseudo-Tetrapeptides Active Against Influenza A Viruses and Coronavirus HCoV-229E显示文摘Many microorganisms have mechanisms that protect cells against attack from viruses.The fermentation components of Streptomyces sp.1647 exhibit potent anti-influenza A virus(IAV)activity.This strain was isolated from soil in southern China in the 1970s,but the chemical nature of its antiviral substance(s)has remained unknown until now.We used an integrated multi-omics strategy to identify the antiviral agents from this streptomycete.The antibiotics and Secondary Metabolite Analysis Shell(antiSMASH)analysis of its genome sequence revealed 38 biosynthetic gene clusters(BGCs)for secondary metabolites,and the target BGCs possibly responsible for the production of antiviral components were narrowed down to three BGCs by bioactivity-guided comparative transcriptomics analysis.Through bioinformatics analysis and genetic manipulation of the regulators and a biosynthetic gene,cluster 36 was identified as the BGC responsible for the biosynthesis of the antiviral compounds.Bioactivity-based molecular networking analysis of mass spectrometric data from different recombinant strains illustrated that the antiviral compounds were a class of structural analogues.Finally,18 pseudo-tetrapeptides with an internal ureido linkage,omicsynins A1–A6,B1–B6,and C1–C6,were identified and/or isolated from fermentation broth.Among them,11 compounds(omicsynins A1,A2,A6,B1–B3,B5,B6,C1,C2,and C6)are new compounds.Omicsynins B1–B4 exhibited potent antiviral activity against IAV with the 50%inhibitory concentration(IC_(50))of approximately 1μmol·L^(-1)and a selectivity index(SI)ranging from 100 to 300.Omicsynins B1–B4 also showed significant antiviral activity against human coronavirus HCoV-229E.By integrating multi-omics data,we discovered a number of novel antiviral pseudo-tetrapeptides produced by Streptomyces sp.1647,indicating that the secondary metabolites of microorganisms are a valuable source of novel antivirals. | Hongmin Sun Xingxing Li Minghua Chen Ming Zhong Yihua Li Kun Wang Yu Du Xin Zhen Rongmei Gao Yexiang Wu Yuanyuan Shi Liyan Yu Yongsheng Che Yuhuan Li Jian-Dong Jiang Bin Hong Shuyi Si | 2022 | Engineering2022，，9： | 0 |
| 19 | MICROPROCESSOR-BASED SYSTEM FOR MEASUREMENT OF BIOELECTRICAL IMPEDANCE DURING HEMODIALYSIS显示文摘MICROPROCESSOR-BASEDSYSTEMFORMEASUREMENTOFBIOELECTRICALIMPEDANCEDURINGHEMODIALYSISMICROPROCESSOR-BASEDSYSTEMFORMEASUREMENTOFB... | Hongmin Cul Yongjun Lu and Jue Yu(Department of Biomedical Engineering,Peking Union Medical College,Beijing 100005,China)The tumor diagnosis and treatment with the techniques applying electromagnetic energy require dielectric properties (permittivity | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，4： | 0 |
| 20 | Cross-reactivity of anti-programmed death ligand 2 polyclonal antibody in mouse tissues显示文摘The inhibitory co-receptor programmed death 1 (PD-1, encoded by pdcd1) and its two ligands PD-L1 and PD-L2 comprise an important immune inhibitory signaling pathway for defense against microbes and for self-tolerance. Unlike other members of the B7-CD28 family, expression of PD-L1 and PD-L2 is not limited to the immune system. In this study, we determined that a polyclonal antibody (pAb) (R&D Systems) against extracellular domains of mouse PD-L2 (mPD-L2) could recognize anti- gen(s) in diverse mouse tissues, including the anterior and intermediate pituitary gland, olfactory bulbs and olfactory epitheli- um, tongue epithelium, keratinized epithelial cells and skin and whisker hair follicles. These findings differed from previous reports of mPD-L2 localization. Reverse transcription PCR and Western blot analyses, however, were unable to detect any mPD-L2 transcripts or proteins of the 25-kD predicted molecular weight in RNA and protein extracts, respectively, from the above tissues, suggesting that the anti-mPD-L2 pAb cross-reacts with certain novel antigen(s). Developmental studies revealed that the earliest expression of mPD-L2-like antigen was in the olfactory epithelium at embryonic day 12.5 (E12.5). At E14.5, mPD-L2-like antigen was present in the skin, tongue and follicles of the skin and whiskers. The distribution patterns of mPD-L2-like antigen remained similar from E18.5 to adulthood. The results of bioinformatic analysis and other experiments suggested neural cell adhesion molecule and hemicentin-1 as candidate proteins with cross-reactivity to the anti-mPD-L2 pAb. These results demonstrate that care is required in interpreting staining patterns generated when anti-PD-L2 pAb is used to locate PD-L2-expressing cells in the central nervous system and epithelial tissues, such as the olfactory epithelium. In addition, this anti-PD-L2 pAb may be used as an alternative antibody for labeling the olfactory epithelium during embryonic development in mice. | ZHAO Yu BIAN GanLan YU CaiYong LIU Fang-Fang LIU Ling GUO HongMin GUO Jun JU Gong WANG Jian | 2012 | Science China(Life Sciences)2012，55，11： | 0 |
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