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| 1 | Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions显示文摘Genotyping and phenotyping large natural populations provide opportunities for population genomic analysis and genome-wide association studies(GWAS). Several rice populations have been re-sequenced in the past decade;however, many major Chinese rice cultivars were not included in these studies. Here, we report large-scale genomic and phenotypic datasets for a collection mainly comprised of 1,275 rice accessions of widely planted cultivars and parental hybrid rice lines from China. The population was divided into three indica/Xian and three japonica/Geng phylogenetic subgroups that correlate strongly with their geographic or breeding origins. We acquired a total of 146 phenotypic datasets for 29 agronomic traits under multi-environments for different subpopulations. With GWAS, we identified a total of 143 significant association loci, including three newly identified candidate genes or alleles that control heading date or amylose content. Our genotypic analysis of agronomically important genes in the population revealed that many favorable alleles are underused in elite accessions, suggesting they may be used to provide improvements in future breeding efforts. Our study provides useful resources for rice genetics research and breeding. | Xiuxiu Li Zhuo Chen Guomin Zhang Hongwei Lu Peng Qin Ming Qi Ying Yu Bingke Jiao Xianfeng Zhao Qiang Gao Hao Wang Yunyu Wu Juntao Ma Liyan Zhang Yongli Wang Lingwei Deng Shanguo Yao Zhukuang Cheng Diqiu Yu Lihuang Zhu Yongbiao Xue Chengcai Chu Aihong Li Shigui Li Chengzhi Liang | 2020 | Science China(Life Sciences)2020，63，11： | 8 |
| 2 | The blooming intersection of transcatheter hepatic artery chemoembolization and nanomedicine显示文摘Transcatheter hepatic artery chemoembolization(TACE)is a universal treatment for patients with hepatocellular carcinoma(HCC)that inhibits tumor growth by cutting off the blood supply and provides chemotherapeutics locally to the tumor.The strategy of combining TACE formulation with image-guided ablation holds tremendous potential,but patient tolerance and undesired toxicity/immunosuppression remains a challenge.The application of nanotechnology in TACE opens new doors for the treatment of HCC.Strikingly,nanomaterials or nano-drugs dispersed in the TACE formulation can effectively improve the delivery efficiency of drugs by achieving both controlled and continuous release.In addition,the utilization of multifunctional nanoparticles can provide guidance and monitoring for various advanced imaging methods for TACE treatment,and can realize the combination therapy of thermal ablation,microwave ablation,in situ radiotherapy,and other therapies,greatly expanding the therapeutic strategies available for HCC treatment.Here,the current exploration of nanotechnology in TACE of HCC is briefly summarized and the challenges of TACE with nanoformulations for clinical translation are comprehensively discussed. | Hu Chen Hongwei Cheng Wenying Wu Dengfeng Li Jingsong Mao Chengchao Chu Gang Liu | 2020 | Chinese Chemical Letters2020，31，6： | 4 |
| 3 | Enhanced perovskite electronic properties via A-site cation engineering显示文摘Organic-inorganic halide perovskites have emerged as excellent candidates for low-cost photovoltaics and optoelectronics.While the predominant recent trend in designing perovskites for efficient and stable solar cells has been to mix different A-site cations,the role of A-site cations is still limited to tune the lattice and bandgap of perovskites.Herein we compare the optoelectronic properties of acetamidinum(Ace)and guanidinium(Gua)mixed methylammonium lead iodide perovskites and shed a light on the hidden role of A-site cation on the carrier mobility of mixed-cation lead iodide perovskites.The cations do not affect the bandgap of the perovskites since the orbitals from Ace and Gua do not contribute to the band edges of the material.However,the mobility of the Ace mixed perovskite is significantly enhanced to be an order of magnitude higher than that of the pristine perovskite.We apply the Ace mixed perovskite in hole-conductor-free printable mesoscopic perovskite solar cells and obtain a stabilized PCE of over 18%(certified 17.7%),which is the highest certified efficiency so far. | Xufeng Xiao Yanmeng Chu Chunyu Zhang Zhihui Zhang Zexiong Qiu Cheng Qiu Huaixing Wang Anyi Mei Yaoguang Rong Gengzhao Xu Yue Hu Hongwei Han | 2021 | Fundamental Research2021，1，4： | 2 |
| 4 | Antibacterial nano-structured titania coating incorporated with silver nanoparticles显示文摘 | Lingzhou Zhao Hairong Wang Kaifu Huo Lingyun Cui Wenrui Zhang Hongwei Ni Yumei Zhang Zhifen Wu Paul K. Chu | 2011 | Biomaterials2011，，24： | 2 |
| 5 | Irradiation effects on multilayered W/ZrO 2 film under 4MeV Au ions显示文摘 | Hongwei Wang Yuan Gao Engang Fu Tengfei Yang Jianming Xue Sha Yan Paul K. Chu Yugang Wang | 2014 | 2014 (1-3)2014，，1： | 1 |
| 6 | Pocket Matte- ring: Indoor Pedestrian Tracking with Commercial Smart- phone 显示文摘 | Feng Hong Hongwei Chu Lijian Wang | 2012 | International Conference on Indoor Position and Indoor Navigation ( IPIN 2012 )2012，26，7： | 1 |
| 7 | Numerical simulation of gas–liquid flow in the bubble column using Wray–Agarwal turbulence model coupled with population balance model显示文摘In this paper,an improved computational fluid dynamic(CFD)model for gas-liquid flow in bubble column was developed using the one-equation Wary-Agarwal(WA)turbulence model coupled with the population balance model(PBM).Through 18 orthogonal test cases,the optimal combination of interfacial force models,including drag force,lift force,turbulent dispersion force.The modified wall lubrication force model was proposed to improve the predictive ability for hydrodynamic behavior near the wall of the bubble column.The values simulated by optimized CFD model were in agreement with experimental data,and the errors were within±20%.In addition,the axial velocity,turbulent kinetic energy,bubble size distribution,and the dynamic characteristic of bubble plume were analyzed at different superficial gas velocities.This research work could provide a theoretical basis for the extension of the CFD-PBM coupled model to other multiphase reactors.. | Hongwei Liang Wenling Li Zisheng Feng Jianming Chen Guangwen Chu Yang Xiang | 2023 | Chinese Journal of Chemical Engineering2023，58，6： | 1 |
| 8 | Antibacterial nano-structured titania coating incorporated with silver nanoparticles显示文摘 | Lingzhou Zhao Hairong Wang Kaifu Huo Lingyun Cui Wenrui Zhang Hongwei Ni Yumei Zhang Zhifen Wu Paul K. Chu | 2011 | Biomaterials2011，，24： | 1 |
| 9 | Enhancement of surfactant production in ironenriched media by Bacillus subtilis ATCC21332显示文摘 | Yu Hongwei Chu I-Ming | | 0，，： | 1 |
| 10 | Airway Inflammation and bronchial hyperresponsiveness after mycoplasma pneumoniae infection in a mu-rinemodel显示文摘 | Richard J Martin HongWei Chu | 2001 | Am Respir Cell Mol Biol2001，24，： | 1 |
| 11 | Enhanced Q-switching performance of magnetite nanoparticle via compositional engineering with Ti_(3)C_(2) MXene in the near infrared region显示文摘In this work,we reported a new strategy to improve the nonlinear saturable absorption performance of magnetite(Fe_(3)O_(4))nanoparticles(FONPs)via the compositional engineering with the Ti_(3)C_(2) MXene in the near-infrared(NIR)region.Based on the DFT simulation,the band structures and work function were significantly modified by the Ti_(3)C_(2) MXene doping.By using the open-aperture Z-scan technology,the nonlinear optical features of the FONPs@Ti_(3)C_(2) nanocomposite were significantly improved,showing the great potential as the saturable absorber in the pulsed laser.With the nanocomposite as the saturable absorber,the passively Q-switched Nd:GdVO4 lasers emitted much shorter pulse durations when compared with the pristine FONP saturable absorber.These findings indicated that FONPs@Ti_(3)C_(2) heterostructure was a promising saturable absorber for the short pulse generation in the NIR region. | Yutao Hu Hongwei Chu Daozhi Li Ying Li Shengzhi Zhao Li Dong Dechun Li | 2021 | Journal of Materials Science & Technology2021，，22： | 1 |
| 12 | Enhancement of surfactant production in ironenriched media by Bacillus subtillus ATCC21332显示文摘 | Yu Hongwei Chu IMing | 1998 | Enzyme Microb Technol1998，22，： | 1 |
| 13 | Transcriptome analysis of salt-stress response in three seedling tissues of common wheat显示文摘Xiaoyan 60(XY60) is a new wheat variety bred in the laboratory of Zhensheng Li.After salt treatment, seedlings of XY60 maintain green leaves and produce longer roots than the high yielding cultivar Zhongmai 175(ZM175).To explain these different phenotypes we carried out an RNA-Seq analysis using 12 samples from three tissues of both varieties subjected to salt and control treatments.By comparing data from the salt treated plants with the control, 703, 979, and 1197 differentially expressed genes(DEGs) were detected in new leaves, old leaves, and roots of XY60, respectively.The corresponding numbers for ZM175 were 613, 1401, and 1301.The most significantly enriched Gene Ontology(GO) terms and KEGG pathways were associated with polyunsaturated fatty acid(PUFA) metabolism in both new and old leaves from XY60.They were associated with photosynthesis and energy metabolism in ZM175.The most significantly enriched KEGG pathway in roots of both varieties was “glucosinolate biosynthesis”.In addition, jasmonic acid(JA) concentration in XY60 was higher than in ZM175, although it increased significantly in both varieties following salt treatment.Trends in relative expression levels of AOS, MYC2, and JAZ revealed by qRT-PCR were concordant with those from RNA-Seq.Our results suggest that PUFAs may contribute to salt tolerance in common wheat by enhancing the photosynthetic system and JA-related pathways. | Qiaoling Luo Wan Teng Shuang Fang Hongwei Li Bin Li Jinfang Chu Zhensheng Li Qi Zheng | 2019 | The Crop Journal2019，7，3： | 1 |
| 14 | Effects of respiratory mycoplasma pneumoniae infection on allergen-induced bronchial hyperresponsiveness and lung inflammation in mice显示文摘 | Chu Hongwei Honour J M Rawlinson C Av er a! | 2003 | Infect Immunol2003，71，3： | 1 |
| 15 | High Level of Notch1 Protein is Associated with Poor Overall Survival in Colorectal Cancer显示文摘 | Dake Chu MD Yunming Li MD Weizhong Wang MM Qingchuan Zhao MD Jipeng Li MD Yuanyuan Lu MD Mengbin Li MD Guanglong Dong MD Hongwei Zhang MD Huahong Xie MD Gang Ji MD | 2010 | Annals of Surgical Oncology2010，，5： | 1 |
| 16 | A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis显示文摘The gut microbiome is recognized as a key modulator of sepsis development.However,the contribution of the gut mycobiome to sepsis development is still not fully understood.Here,we demonstrated that the level of Candida albicans was markedly decreased in patients with bacterial sepsis,and the supernatant of Candida albicans culture significantly decreased the bacterial load and improved sepsis symptoms in both cecum ligation and puncture(CLP)-challenged mice and Escherichia coli-challenged pigs.Integrative metabolomics and the genetic engineering of fungi revealed that Candida albicans-derived phenylpyruvate(PPA)enhanced the bactericidal activity of macrophages and reduced organ damage during sepsis.Mechanistically,PPA directly binds to sirtuin 2(SIRT2)and increases reactive oxygen species(ROS)production for eventual bacterial clearance.Importantly,PPA enhanced the bacterial clearance capacity of macrophages in sepsis patients and was inversely correlated with the severity of sepsis in patients.Our findings highlight the crucial contribution of commensal fungi to bacterial disease modulation and expand our understanding of the host-mycobiome interaction during sepsis development. | Peng Gu Ruofan Liu Qin Yang Li Xie Rongjuan Wei Jiaxin Li Fengyi Mei Tao Chen Zhenhua Zeng Yan He Hongwei Zhou Hongjuan Peng Kutty Selva Nandakumar Huikuan Chu Yong Jiang Wei Gong Ye Chen Bernd Schnabl Peng Chen | 2023 | Cellular & Molecular Immunology2023，20，10： | 0 |
| 17 | Recent Advances in Interventional Fluorescence Imaging: Toward the Precise Visualization of Transarterial Mini-Invasive Delivery Systems显示文摘CONSPECTUS:Interventional fluorescence imaging has gradually developed into a promising imaging strategy for the diagnosis of diseases in clinic.This strategy could benefit interventional targeted treatment because of the clear display of microstructures at the margins and boundaries.There are some stranded crucial issues in clinical application:(i)fast clearance of fluorescence probes;(ii)light instability and photobleaching;and(iii)residual and microsatellite lesions.The development of superstable homoge-neous intermixed formulation technology(SHIFT)can solve the aforementioned clinical problems for precision hepatectomy.Interventional fluorescence imaging based on SHIFT-prepared product has some advantages such as(i)strong stability,(ii)greatly extending imageable time window,and(iii)precisely visualizing microsatellite lesions.In this Account,we overview our current progress in interventional fluorescence imaging based on SHIFT method for surgical resection following long-lasting embolization conversion.To greatly realize interventional fluorescence imaging,we summarize clinical and preclinical application of interventional fluorescence imaging in a transarterial delivery system.Indeed,compared with conventional fluorescence imaging,interventional fluorescence imaging possesses non-negligible strengths on improved intensity in target location and step-down systemic toxicity.Unfortunately,a challenging issue is that immobile fluorescence performance is difficult to maintain after long-time embolization,resulting in a failed hepatectomy.On this basis,associated with our previous research,SHIFT was proposed and developed.Thus,we detailedly introduce and account the development and preponderance of SHIFT on interventional fluorescence imaging.Predictably,after lengthy embolization,its lightful fluorescence was still observable in tumor targets of a clinical trial.To regulate the fluorescence rendering of microsatellite lesion,SHIFT combining with pure nanoprobes(nanoICG)occurs,namely SHIFT nanoICG,and we dwell on its performance in transarterial invasive surgical navigation and its clinical application under interventional fluorescence imaging compared with conventional indocyanine green(ICG)formulations.Amazingly,the SHIFT nanoICG brings us an extraordinary imaging consequence for deep-seated tumor tissues and imperceptible microsatellite lesions.Finally,we offer perspectives on the future tendency of interventional imaging-guided SHIFT products in clinical translation such as chemoembolization,radioembolization,and immunotherapy.Actually,these directions have been underway for some time,and even relative products are already applied for clinical trials,exhibiting effective therapeutic outcomes.Our green high-performance SHIFT products are concentrated on meeting clinical needs and solving clinical problems,breaking through the cure limitations of patients with advanced diseases.Thus,the discovery offers insight into the development and superiority of SHIFT products under interventional fluorescence imaging and simultaneously provides a new view on the development of clinically pragmatic products. | Xiaoxiao Shi Dazhuang Xu Hongwei Cheng Chengchao Chu Gang Liu | 2023 | Accounts of Materials Research2023，4，3： | 0 |
| 18 | Support induced phase engineering toward superior electrocatalyst显示文摘The phase transformation of catalysts has been extensively observed in heterogeneous catalytic reactions that hinder the long cycling catalysis,and it remains a big challenge to precisely control the active phase during the complex conditions in electrochemical catalysis.Here,we theoretically predict that carbon-based support could achieve the phase engineering regulation of catalysts by suppressing specific phase transformation.Taken single-walled carbon nanotube(SWCNT)as typical support,combined with calculated E-pH(Pourbaix)diagram and advanced synchrotron-based characterizations technologies prove there are two different active phases source from cobalt selenide which demonstrate that the feasibility of using support effect regulating the potential advantageous catalysts.Moreover,it is worth noting that the phase engineering derived Co_(3)O_(4)-SWCNT exhibits a low overpotential of 201 mV for delivering the current density of 10 mA/cm^(2)in electrocatalytic oxygen evolution reaction(OER).Also,it reaches a record current density of 529 mA/cm^(2)at 1.63 V(vs.RHE)in the electrocatalytic urea oxidation reaction(UOR),overwhelming most previously reported catalysts. | Beibei Sheng Dengfeng Cao Hongwei Shou Oyawale Adetunji Moses Wenjie Xu Yujian Xia Yuzhu Zhou Huijuan Wang Ping Wan Shuang Zhu Wangsheng Chu Xiaojun Wu Shuangming Chen Li Song | 2022 | Nano Research2022，15，3： | 0 |
| 19 | Fully automated sample treatment method for high throughput proteome analysis显示文摘The bottom-up strategy for proteome analysis typically employs a multistep sample preparation workflow that suffers from being time-consuming and sample loss or contamination caused by the off-line manual operation.Herein,we developed a hollow fibre membrane(HFM)-aided fully automated sample treatment(FAST)method.Due to the confinement effects of HFMs and the immobilized enzymatic reactor,the proteome samples could be denatured,reduced,desalted and digested within 8–20 min via the one-stop service.This method also showed superiority in trace sample analysis.In one and half hours,we could identify about 1,600 protein groups for 500 HeLa cells as the starting materials,1.5–8 times more than those obtained by previously reported methods.Through the on-line combination of FAST with nano-liquid chromatography-electrospray ionization tandem mass spectrometry(nanoLC-ESI-MS/MS),we further established a fully integrated platform for label-free quantification of proteome with high reproducibility and precision.Collectively,FAST presented here represents a major advance in the high throughput sample treatment and quantitative analysis of proteomes. | Huiming Yuan Zhongpeng Dai Xiaodan Zhang Baofeng Zhao Hongwei Chu Lihua Zhang Yukui Zhang | 2021 | Science China Chemistry2021，64，2： | 0 |
| 20 | Zn(Ⅱ) can mediate self-association of the extracellular C-terminal domain of CD147显示文摘 | Shujuan Jin Pengfei Ding Pengxiang Chu Hongwei Li Jianbo Sun Dehai Liang Fei Song Bin Xia | 2018 | Protein & Cell2018，9，3： | 0 |
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