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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Explicit diagnosis of the local ozone production rate and the ozone-NOx-VOC sensitivities显示文摘In the troposphere, ozone is a harmful gas compound to both human health and vegetation. Ozone is produced from the reaction of NO_x(@NO + NO_2) and VOCs(volatile organic compounds) with light. Due to the highly nonlinear relationships between ozone and its precursors, proper ozone mitigation relies on the knowledge of chemical mechanisms. In this study, an observation-based method is used to simulate ozone formation and elucidate its controlling factors for a rural site on the North China Plain. The instantaneous ozone production rate is calculated utilizing a box model using the dataset obtained from the Wangdu campaign. First, the model was operated in a time-dependent mode to calculate the ozone production rate at each time stamp. The calculated ozone formation rate showed a diurnal average maximum value of 17 ppbv/h(1-h diurnal averaged). The contribution of individual peroxy radicals to ozone production was analyzed. In addition, the functional dependence of calculated P(O_3) reveals that ozone production was in a NO_x-limited regime during the campaign. Furthermore, the missing peroxy radical source will further extend NO_x-limited conditions to earlier in the day, making NO_xlimitation dominate more of a day than the current chemical model predicts. Finally, a multiple scenarios mode,also known as EKMA(empirical kinetic modeling approach), was used to simulate the response of P(O_3) to the imaginary change in precursor concentrations. We found that ozone production was in the NO_x-limited region. However, the use of NO_2 measured by the molybdenum converter and/or the absence of a peroxy radical source in the current chemical model could over-emphasize the VOC-limited effect on ozone production. | Zhaofeng Tan Keding Lu Huabin Dong Min Hu Xin Li Yuhan Liu Sihua Lu Min Shao Rong Su Haichao Wang Yusheng Wu Andreas Wahner Yuanhang Zhang | 2018 | Science Bulletin2018，63，16： | 25 |
| 3 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 4 | Formation law and criterion of nebulous macroscopic segregation in ZL205A alloy castings显示文摘The appearance of macroscopic segregation in ZL205A alloy castings bears a super resemblance to theappearance of shrinkage porosity, and the chemical composition of the segregation is Al2Cu whose microstructure isin the form of dentrite or skeleton crystal. According to the characteristic of nebulous segregation, the formationprocess could be divided into two steps by the eutectic temperature of Al2Cu. Then a criterion for each of the twosteps is brought forward on the basis of the shrinkage porosity criterion of low pressure casting. | Li Yusheng Zhai Hu Feng Zhijun Qu Xuahui | 2008 | China Foundry2008，5，1： | 11 |
| 5 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update on organizational stroke management显示文摘Aim Stroke is characterised by high morbidity,mortality and disability,which seriously affects the health and safety of the people.Stroke has become a serious public health problem in China.Organisational stroke management can significantly reduce the mortality and disability rates of patients with stroke.We provide this evidence-based guideline to present current and comprehensive recommendations for organisational stroke management.Methods A formal literature search of MEDLINE(1 January 1997 through 30 September 2019)was performed.Data were synthesised with the use of evidence tables.Writing group members met by teleconference to discuss data-derived recommendations.The Chinese Stroke Association’s Levels of Evidence grading algorithm was used to grade each recommendation.results Evidence-based guidelines are presented for the organisational management of patients presenting with stroke.The focus of the guideline was subdivided into prehospital first aid system of stroke,rapid diagnosis and treatment of emergency in stroke centre,organisational management of stroke unit and stroke clinic,construction of regional collaborative network among stroke centres and evaluation and continuous improvement of stroke medical quality.Conclusions The guidelines offer an organisational stroke management model for patients with stroke which might help dramatically. | Min Lou Jing Ding Bo Hu Yusheng Zhang Hao Li ZeFeng Tan Yan Wan An-Ding Xu Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 7 |
| 6 | 噪声异常压缩机的声诊断分析显示文摘通过声品质评价方法分析了噪声异常转子压缩机试验样机,并计算出A声级、响度、粗糙度和尖锐度作为声品质的客观评价指标,结果表明与正常压缩机相比,该噪声异常压缩机具有较差的声品质。声阵列技术能够精确定位复杂形状的目标声源,与传统采用声级计测试相比,能够获得更加丰富的声场信息。为了诊断出压缩机的异常噪声,通过声阵列技术在全频段对该异常压缩机进行了声源识别定位分析,找到了影响压缩机噪声的关键频率点及相应的噪声源,从而为压缩机噪声的改善提供了有力证据。 | 张金圈 张荣婷 胡余生 HU Yusheng | 2013 | 制冷2013，32，3： | 6 |
| 7 | Single-nucleus transcriptomic landscape of primate hippocampal aging显示文摘The hippocampus plays a crucial role in learning and memory,and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases.Yet a systematic profiling of the aging effects on various hippocampal cell types in primates is still missing.Here,we reported a variety of new aging-associated phenotypic changes of the primate hippocampus.These include,in particular,increased DNA damage and heterochromatin erosion with time,alongside loss of proteostasis and elevated inflammation.To understand their cellular and molecular causes,we established the first single-nucleus transcriptomic atlas of primate hippocampal aging.Among the 12 identified cell types,neural transiently amplifying progenitor cell(TAPC)and microglia were most affected by aging.In-depth dissection of gene-expression dynamics revealed impaired TAPC division and compromised neuronal function along the neurogenesis trajectory;additionally elevated pro-inflammatory responses in the aged microglia and oligodendrocyte,as well as dysregulated coagulation pathways in the aged endothelial cells may contribute to a hostile microenvironment for neurogenesis.This rich resource for understanding primate hippocampal aging may provide potential diagnostic biomarkers and therapeutic interventions against age-related neurodegenerative diseases. | Hui Zhang Jiaming Li Jie Ren Shuhui Sun Shuai Ma Weiqi Zhang Yang Yu Yusheng Cai Kaowen Yan Wei Li Baoyang Hu Piu Chan Guo-Guang Zhao Juan Carlos Izpisua Belmonte Qi Zhou Jing Qu Si Wang Guang-Hui Liu | 2021 | Protein & Cell2021，12，9： | 5 |
| 8 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 9 | Strengthening and ductilization of laminate dual-phase steels with high martensite content显示文摘The steels with excellent strength and ductility are expected to be achieved by tailoring the microstructural features.In this work,laminate dual-phase(DP)steels with high martensite content(laminate HMDP steels)were produced by a combination of warm rolling and intercritical annealing.Influence of rolling strain and annealing temperature on the microstructural evolution and mechanical properties of laminate HMDP steels were systematically studied.The strength of HMDP steels was significantly improved to~1.6 GPa associated with a high uniform elongation of 7%,as long as the laminate structure is maintained.The strengthening and ductilizing mechanisms of laminate HMDP steels are discussed based on the influence of laminate structure and the high martensite content,which promote the development of internal stresses and can be correlated to the Bauschinger effect as measured by the cyclic loadingunloading-reloading experiments.Detailed transmission electron microscopy(TEM)observation was applied to characterize the dislocation structure in the deformed ferrite. | Bo Gao Rong Hu Zhiyi Pan Xuefei Chen Yi Liu Lirong Xiao Yang Cao Yusheng Li Qingquan Lai Hao Zhou | 2021 | Journal of Materials Science & Technology2021，，6： | 4 |
| 10 | LSTM-based Energy Management for Electric Vehicle Charging in Commercial-building Prosumers显示文摘As typical prosumers,commercial buildings equipped with electric vehicle(EV)charging piles and solar photovoltaic panels require an effective energy management method.However,the conventional optimization-model-based building energy management system faces significant challenges regarding prediction and calculation in online execution.To address this issue,a long short-term memory(LSTM)recurrent neural network(RNN)based machine learning algorithm is proposed in this paper to schedule the charging and discharging of numerous EVs in commercial-building prosumers.Under the proposed system control structure,the LSTM algorithm can be separated into offline and online stages.At the offline stage,the LSTM is used to map states(inputs)to decisions(outputs)based on the network training.At the online stage,once the current state is input,the LSTM can quickly generate a solution without any additional prediction.A preliminary data processing rule and an additional output filtering procedure are designed to improve the decision performance of LSTM network.The simulation results demonstrate that the LSTM algorithm can generate near-optimal solutions in milliseconds and significantly reduce the prediction and calculation pressures compared with the conventional optimization algorithm. | Huayanran Zhou Yihong Zhou Junjie Hu Guangya Yang Dongliang Xie Yusheng Xue Lars Nordström | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，5： | 3 |
| 11 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 12 | Genome-wide prediction for hybrids between parents with distinguished difference on exotic introgressions in Brassica napus显示文摘Extensive exotic introgression could significantly enlarge the genetic distance of hybrid parental populations to promote strong heterosis.The goal of this study was to investigate whether genome-wide prediction can support pre-breeding in populations with exotic introgressions.We evaluated seed yield,seed yield related traits and seed quality traits of 363 hybrids of Brassica napus (AACC) derived from two parental populations divergent on massive exotic introgression of related species in three environments.The hybrids presented strong heterosis on seed yield,which was much higher than other investigated traits.Five genomic best linear unbiased prediction models considering the exotic introgression and different marker effects (additive,dominance,and epistatic effects) were constructed to test the prediction ability for different traits of the hybrids.The analysis showed that the trait complexity,exotic introgression,genetic relationship between the training set and testing set,training set size,and environments affected the prediction ability.The models with best prediction ability for different traits varied.However,relatively high prediction ability (e.g.,0.728 for seed yield) was also observed when the simplest models were used,excluding the effects of the special exotic introgression and epistasis effect by5-fold cross validation,which would simplify the prediction for the trait with complex architecture for hybrids with exotic introgression.The results provide novel insights and strategies for genome-wide prediction of hybrids between genetically distinct parent groups with exotic introgressions. | Dandan Hu Yusheng Zhao Jinxiong Shen Xiangxiang He Yikai Zhang Yong Jiang Rod Snowdon Jinling Meng Jochen C.Reif Jun Zou | 2021 | The Crop Journal2021，9，5： | 2 |
| 13 | Size-resolved effective density of submicron particles during summertime in the rural atmosphere of Beijing, China显示文摘Particle density is an important physical property of atmospheric particles.The information on high time-resolution size-resolved particle density is essential for understanding the atmospheric physical and chemical aging processes of aerosols particles.In the present study,a centrifugal particle mass analyzer(CPMA) combined with a differential mobility analyzer(DMA) was deployed to determine the size-resolved effective density of 50 to 350 nm particles at a rural site of Beijing during summer 2016.The measured particle effective densities decreased with increasing particle sizes and ranged from 1.43 to 1.55 g/cm^3,on average.The effective particle density distributions were dominated by a mode peaked at around 1.5 g/cm^3 for 50 to350 nm particles.Extra modes with peaks at 1.0,0.8,and 0.6 g/cm3 for 150,240,and 350 nm particles,which might be freshly emitted soot particles,were observed during intensive primary emissions episodes.The particle effective densities showed a diurnal variation pattern,with higher values during daytime.A case study showed that the effective density of Aitken mode particles during the new particle formation(NPF) event decreased considerably,indicating the significant contribution of organics to new particle growth. | Kai Qiao Zhijun Wu Xiangyu Pei Qianyun Liu Dongjie Shang Jing Zheng Zhuofei Du Wenfei Zhu Yusheng Wu Shengrong Lou Song Guo Chak K.Chan Ravi Kant Pathak Mattias Hallquist Min Hu | 2018 | Journal of Environmental Sciences2018，30，11： | 2 |
| 14 | Accumulation of freshwater in the permanent ice zone of the Canada Basin during summer 2008显示文摘A combination of δ^(18)O and salinity data was employed to explore the freshwater balance in the Canada Basin in summer 2008.The Arctic river water and Pacific river water were quantitatively distinguished by using different saline end-members.The fractions of total river water,including the Arctic and Pacific river water,were high in the upper 50 m and decreased with depth as well as increasing latitude.In contrast,the fraction of Pacific river water increased gradually with depth but decreased toward north.The inventory of total river water in the Canada Basin was higher than other arctic seas,indicating that Canada Basin was a main storage region for river water in the Arctic Ocean.The fraction of Arctic river water was higher than Pacific river water in the upper 50 m while the opposite was true below 50 m.As a result,the inventories of Pacific river water were higher than those of Arctic river water,demonstrating that the Pacific inflow through the Bering Strait is the main source of freshwater in the Canada Basin.Both the river water and sea-ice melted water in the permanent ice zone were more abundant than those in the region with sea-ice just melted.The fractions of total river water,Arctic river water,Pacific river water increased northward to the north of 82°N,indicating an additional source of river water in the permanent ice zone of the northern Canada Basin.A possible reason for the extra river water in the permanent ice zone is the lateral advection of shelf waters by the Trans-Polar Drift.The penetration depth of sea-ice melted waters was less than 30 m in the southern Canada Basin,while it extended to 125 m in the northern Canada Basin.The inventory of seaice melted water suggested that sea-ice melted waters were also accumulated in the permanent ice zone,attributing to the trap of earlier melted waters in the permanent ice zone via the Beaufort Gyre. | TONG Jinlu CHEN Min1 YANG Weifeng ZHANG Run PAN Hong ZHENG Minfang QIU Yusheng HU Wangjiang ZENG Jian | 2017 | Acta Oceanologica Sinica2017，36，8： | 1 |
| 15 | Ambient photolysis frequency of NO2 determined using chemical actinometer and spectroradiometer at an urban site in Beijing显示文摘 | Qi Zou Keding Lu Yusheng Wu Yudong Yang Zhuofei Du Min Hu | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 1 |
| 16 | China Foundry显示文摘 | Li Yusheng Zhai Hu Qu Xuanhui | 2008 | 5(1):202008，5，1： | 1 |
| 17 | Impact of interlayer on moisture characteristics of reclaimed soil backfilled with Yellow River sediments显示文摘Underground coal mining causes land subsidence,and backfilling with Yellow River sediment is an effective reclamation technology to restore farmland in China.To date,two-layer soil reconstructed(TSR)for subsided land reclamation resulted in poor capacity to retain water.To solve this problem,multi-layered soil reconstructed(MSR),sandwiching soil interlayers between sediment,was developed as a new reclamation strategy with Yellow River sediment.In order to evaluate the impact of soil interlayer on moisture characteristics,laboratory experiments of infiltration and evaporation were conducted.Two control treatments(CK1,CK2)and four experimental treatments(T1-T4)were designed.CK1 was undamaged farmland,CK2 was conventional reconstructed two-layers soil profile(filled sediment with 40 cm soil cover).T1-T4 were multiple-layers soil profiles sandwiching different structures of soil interlayers between sediment layers.The results indicated that putting interlayers into sediment reduced water leakage and water evaporation,improved the water-holding capacity of conventional two-layer soil profiles.The total thickness of soil interlayers of 30 cm(T3 and T4)was better than 20 cm(T1 and T2)and two soil interlayers(T2)were better than one(T1)on water-holding capacity.Furthermore,the best reconstructed soil profile was T3,sandwiched two soil interlayer and the first thickness was 20 cm.This treatment had the greatest improvement on soil water holding capacity with an increase of 49.14%compared to CK2 at the end of the evaporation and was closest to CK1(402.31 mm).This study provided experimental evidence that compares with TSR,MRS improved the moisture characteristics of backfilling with Yellow River sediment. | Xiaotong Wang Zhenqi Hu Yusheng Liang | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 1 |
| 18 | Triple-functional bone adhesive with enhanced internal fixation,bacteriostasis and osteoinductive properties for open fracture repair显示文摘At present,effective fixation and anti-infection implant materials represent the mainstay for the treatment of open fractures.However,external fixation can cause nail tract infections and is ineffective for fixing small fracture fragments.Moreover,closed reduction and internal fixation during the early stage of injury can lead to potential bone infection,conducive to bone nonunion and delayed healing.Herein,we designed a bone adhesive with anti-infection,osteogenic and bone adhesion fixation properties to promote reduction and fixation of open fractures and subsequent soft tissue repair.It was prepared by the reaction of gelatin(Gel)and oxidized starch(OS)with vancomycin(VAN)-loaded mesoporous bioactive glass nanoparticles(MBGNs)covalently cross-linked with Schiff bases.Characterization and adhesion experiments were conducted to validate the successful preparation of the Gel-OS/VAN@MBGNs(GOVM-gel)adhesive.Meanwhile,in vitro cell experiments demonstrated its good antibacterial effects with the ability to stimulate bone marrow mesenchymal stem cell(BMSCs)proliferation,upregulate the expression of alkaline phosphatase(ALP)and osteogenic proteins(RunX2 and OPN)and enhance the deposition of calcium nodules.Additionally,we established a rat skull fracture model and a subcutaneous infection model.The histological analysis showed that bone adhesive enhanced osteogenesis,and in vivo experiments demonstrated that the number of inflammatory cells and bacteria was significantly reduced.Overall,the adhesive could promote early reduction of fractures and antibacterial and osteogenic effects,providing the foothold for treatment of this patient population. | Yusheng Yang Shenghui Su Shencai Liu Weilu Liu Qinfeng Yang Liangjie Tian Zilin Tan Lei Fan Bin Yu Jian Wang Yanjun Hu | 2023 | Bioactive Materials2023，，7： | 1 |
| 19 | MECHANISM MAP OF TORSIONAL FATIGUE FRACTURE显示文摘Studies have been made of the torsional fatigue fracture life of notched specimens,themacroscopic fractography and microscopic fracture mechanism of steel 40Cr after varioustempering treatments under different stresses,With the increase of stress,the fracture modelchanges from normal stress fracture to longitudinal shear one,and then transversal shear one.Under same stress,with the increase of strength,the fracture mode transfers from shear tonormal stress fracture.The mechanism of normal stress fracture may be:transgranular frac-ture→striation+intergranular fracture→dimple+intergranular fracture,and of shear fracturemay be:transgranular fracture→shear trace→dimple.Based on the experimental results,afracture mechanism map of torsional fatigue has been drawn up. | HU Zhizhong WU Yusheng CAI Heping MA Lihua Xi′an jiaotong University,Xi′an,China Senior Engineer,Res.Inst.for Strength of Metals,Xi′an jiaotong University,Xi′an 710049,China | 1991 | Acta Metallurgica Sinica(English Letters)1991，4，2： | 1 |
| 20 | Analysis on the effectiveness of decoupling capacitor on mitigating radiated emission from power ground planes by BEM显示文摘The radiation emission(RE) of multilayer printed circuit board(PCB) will cause electromagnetic compatibility problem. An efficient numerical method for evaluating the effectiveness of decoupling capacitors in reducing RE from power ground(P/G) planes in PCB was presented. A two-dimensional boundary-element method(BEM) was used to establish the radiation model. Then, the RE was calculated by equivalent magnetic current of edge field around P/G planes. Furthermore, the radiation and input impedance of P/G planes mounted decoupling capacitors were calculated for frequency up to 5 GHz. The results were compared to those of the case without decoupling capacitors. It shows that the decoupling capacitors can effectively decrease RE except for anti-resonant frequency. At higher frequencies, the decoupling effectiveness mainly depends on the parasitic inductance of capacitor pin rather than the value. | Wen Shuhua Zhang Jinling Hu Yusheng | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，1： | 1 |
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