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| 1 | Genome Editing Enables Next-Generation Hybrid Seed Production Technology显示文摘The next-generation hybrid seed technology enables the successful production of sortable hybrid seeds from genic male sterile(GMS)lines and maintainers;however,it requires multiple laborious and complicated steps.Here,we designed a simple next-generation hybrid seed production strategy that takes advantage of the CRISPR/Cas9 technology to create a Manipulated GMS Maintainer(MGM)system via a single transformation.Under this schema,the maize male fertility gene ZmMS26 was nullified by removal of its fifth exon using the CRISPR/Cas9 system on a vector,and a second vector carrying a functional ZmMS26 cDNA was co-transformed to restore fertility.The second vector also contains a male gametophyte inactivation gene(ZmAA1)encoding maizeα-amylase driven by the pollen-specific promoter PG47 and an endosperm fluorescent marker(DsRED)driven by the barley endosperm aleurone-specific promoter Ltp2.The derived single-copy hemizygous MGM lines bore a mutated MS26 gene,leading to complete male sterility but normal vegetative growth and grain yield.The MGM system could prevent genetic transmission of the MGM elements via male gametophytes,providing an efficient method for sorting maintainer seeds labeled by DsRED.This strategy can be extended to any GMS gene and to hybrid crops other than maize. | Xiantao Qi Congsheng Zhang Jinjie Zhu Changlin Liu Changling Huang Xinhai Li Chuanxiao Xie | 2020 | Molecular Plant2020，13，9： | 18 |
| 2 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 3 | Experimental Investigation on Vibration Control of Rotor-bearing System with Active Magnetic Exciter显示文摘Vibration control is an efficient way to minimize a rotating machine's vibration level so that its vibration fault-free can be realized.While,several factors,such as unbalance,misalignment and instability,contribute to the serious vibration of rotating machines.It is necessary that one apparatus can depress vibration caused by two or more reasons.The fault self-recovery(FSR) mechanism is introduced and investigated.Strategies of vibration control are investigated theoretically using numerical method firstly.Active magneticelectric exciter(AME) are selected as the actuator of a FSR device because it can provide suitable force by varying the control current in the exciters depending upon a proportional and derivative control law.By numerical study,it is indicate that only a small control force is needed to improve stability margins of the compressor and prevent subsynchronous vibration fault efficiently.About synchronous vibration,three control strategies,searching in whole circle,fast optimizing control(FOC),and none mistaking control,are investigated to show which of the control strategy can realize the fault self-recovery in the shortest time.Experimental study is conducted on a test rig with variable rotating speed.Results of the test indicate that the non-mistake control strategy can minimize synchronous vibration in less than three seconds.The proposed research can provide a new insight for subsynchronous and synchronous vibration restraining about centrifugal compressor. | WANG Weimin GAO Jinji HUANG Liquan XIN Zhengqiu | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 11 |
| 4 | Precise base editing of non-allelic acetolactate synthase genes confers sulfonylurea herbicide resistance in maize显示文摘Single-nucleotide polymorphisms contribute to phenotypic diversity in maize. Creation and functional annotation of point mutations has been limited by the low efficiency of conventional methods based on random mutation. An efficient tool for generating targeted single-base mutations is desirable for both functional genomics and precise genetic improvement. The objective of this study was to test the efficiency of targeted C-to-T base editing of two non-allelic acetolactate synthase(ALS) in generating sulfonylurea herbicide-resistant mutants. A CRISPR/Cas9 nickase-cytidine deaminase fused with uracil DNA glycosylase inhibitor(UGI) was employed to achieve targeted conversion of cytosine to thymine in ZmALS1 and ZmALS2. Both protoplasts and recovered mutant plants showed the activity of the cytosine base editor, with an in vivo efficiency of up to 13.8%. Transgene-free edited plants harboring a homozygous ZmALS1 mutation or a ZmALS1 and ZmALS2 double mutation were tested for their resistance at a dose of up to 15-fold the recommended limit of chlorsulfuron, a sulfonylurea herbicide widely used in agriculture. Targeted base editing of C-to-T per se and a phenotype verified in the generated mutants demonstrates the power of base editing in precise maize breeding. | Yanmin Li Jinjie Zhu Hao Wu Changlin Liu Changling Huang Jinhao Lan Yanming Zhao Chuanxiao Xie | 2020 | The Crop Journal2020，8，3： | 9 |
| 5 | Conversion of a normal maize hybrid into a waxy version using in vivo CRISPR/Cas9 targeted mutation activity显示文摘Waxy maize is a specialty maize that produces mainly amylopectin starch with special food or industrial values. The objective of this study was to overcome the limitations of wx mutant allele acquisition and breeding efficiency by conversion of parental lines from normal to waxy maize. The intended mutation activity was achieved by in vivo CRISPR/Cas9 machinery involving desired-target mutation of the Wx locus in the ZC01 background,abbreviated as ZC01-DTM^(wx). Triple selection was applied to segregants to obtain high genome background recovery with transgene-free wx mutations. The targeted mutation was identified, yielding six types of mutations among progeny crossed with ZC01-DTM^(wx).The amylopectin contents of the endosperm starch in mutant lines and hybrids averaged94.9%, while those of the wild-type controls were significantly(P < 0.01) lower, with an average of 76.9%. Double selection in transgene-free lines was applied using the Bar strip test and Cas9 PCR screening. The genome background recovery ratios of the lines were determined using genome-wide SNP data. That of lines used as male parents was as high as98.19% and that of lines used as female parents was as high as 86.78%. Conversion hybrids and both parental lines showed agronomic performance similar to that of their wild-type counterparts. This study provides a practical example of the efficient extension of CRISPR/Cas9 targeted mutation to industrial hybrids for transformation of a recalcitrant species. | Xiantao Qi Hao Wu Haiyang Jiang Jinjie Zhu Changling Huang Xin Zhang Changlin Liu Beijiu Cheng | 2020 | The Crop Journal2020，8，3： | 4 |
| 6 | One Dictionary vs. Two Dictionaries in Sparse Coding Based Denoising显示文摘As a promising technique,sparse coding can be widely used for representation,compression,denoising and separation of signals.This technique has been introduced into noisy speech processing,where enhancing speech itself or speech feature remains a challenge.Unlike other fields where noises are dense,the noises in speech are often sparse or partly sparse over the speech dictionary,resulting in performance degradation.It is necessary to understand the noise conditions of speech environments and the applied range of sparse coding.This paper analyzes the assumptions of sparse coding and provides the bounds of reconstruction error for two sparse coding methods which are widely used.Based on this analysis,the performance of the two methods under different conditions are compared.The results show that the performance of sparse coding can be improved by a well-prepared noise dictionary.Experiments on speech enhancement and recognition are conducted,and the results coincide with the theoretical analysis well. | XIE Yining HUANG Jinjie HE Yongjun | 2017 | Chinese Journal of Electronics2017，26，2： | 3 |
| 7 | OS1 functions in the allocation of nutrients between the endosperm and embryo in maize seeds显示文摘Uncovering the genetic basis of seed develop-ment will provide useful tools for improving both crop yield and nutritional value, However, the genetic regulatory networks of maize (Zea mays) seed development remain largely unknown. The maize opaque endosperm and small germ 1 (osl) mutant has opaque endosperm and a small embryo,Here, we cloned OSi1 and show that it encodes a putative transcription factor containing an RWP-RK domain-Transcriptional analysis indicated that OSi1 expression is elevated in early endosperm development, especially in the basal endosperm transfer layer (BETL), conducting zone (CZ), and central starch endospcrm (CSE) cells. RNA sequencing (RNA-Seq) analysis of the osi mutant revealed sharp downregulation of certain genes in specific cell types, including ZmMRP-1 and Megl in BETL cells and a majority of zein-and starch-related genes in CSE cells. Using a haploid induction system, we show that wild-type endosperm could rescue the smaller size of osi embryo, which suggests that nutrients are allocated by tho wild type endosperm. Therefore, our dsta imply that the network regulated by 051 accomplishes a key step in nutrient allocation between endosperm and embryo within maize seeds. Identification of this network will help uncover the mechanisms regulating the nutritional balance between endosperm and embryo. | Weibin Song Jinjie Zhu Haiming Zhao Yingnan Li Jiangtao Liu Xiangbo Zhang Liangliang Huang Jinsheng Lai | 2019 | Journal of Integrative Plant Biology2019，61，6： | 3 |
| 8 | A hierarchical multicast protocol in mobile IPv6 networks显示文摘 | Ping Wang Yunze Cai Jinjie Huang Xiaoming Xu | 2006 | Computer Communications2006，30，1： | 1 |
| 9 | Study on the COVID-19 epidemic in China's Mainland between November 2022 and January 2023,with prediction of its tendency显示文摘The prediction system EpiSIX was used to study the COVID-19 epidemic in China's Mainland between November 2022 and January 2023,based on reported data from December 9,2022,to January 30,2023,released by The Chinese Center for Disease Control and Prevention on February 1,2023.Three kinds of reported data were used for model fitting:the daily numbers of positive nucleic acid tests and deaths,and the daily number of hospital beds taken by COVID-19 patients.It was estimated that the overall infection rate was 87.54%and the overall case fatality rate was 0.078%–0.116%(median 0.100%).Assuming that a new COVID-19 epidemic outbreak would start in March or April of 2023,induced by a slightly more infectious mutant strain,we predicted a possible large rebound between September and October 2023,with a peak demand of between 800,000 and 900,000 inpatient beds.If no such new outbreak was induced by other variants,then the current COVID-19 epidemic course in China's Mainland would remain under control until the end of 2023.However,it is suggested that the necessary medical resources be prepared to manage possible COVID-19 epidemic emergencies in the near future,especially for the period between September and October 2023. | Yao Bai Zhihang Peng Fengying Wei Zhen Jin Jinjie Wang Ximing Xu Xinyan Zhang Jun Xu Zixiong Ren Bulai Lu Zhaojun Wang Jianguo Xu Senzhong Huang | 2023 | Journal of Biosafety and Biosecurity2023，5，1： | 1 |
| 10 | Few-layer Ti3C2Tx MXene delaminated via flash freezing for high-rate electrochemical capacitive energy storage显示文摘Few-layer Ti3C2Tx MXene is synthesized from multi-layered Ti3C2Tx via a flash freezing-assisted delamination process.During the flash freezing process,the water molecules in the interlayers of multi-layered MXene are induced to rearrange and produce volume expansion,thus notably expand the MXenes’interlayer distance to form few-layer MXene.The synthesized few-layer Ti3C2Tx MXene nanosheets display a very small thickness(less than 5 Ti3C2 atom-layers)and expanded interlayer spacing.Consequently,the few-layer Ti3C2Tx exhibits enhanced capacitance(255 F g^-1 vs.177 F g^-1 for the multi-layered Ti3C2Tx)and significantly optimized rate capability(150 F g^-1 at 200 mV s^-1 vs.25 F g^-1 for the multi-layered Ti3C2Tx),because redox-active sites in the few-layer MXene are easily accessible to electrolyte ions.Moreover,an asymmetric supercapacitor is constructed using the few-layer Ti3C2Tx negative electrode and an activated carbon fiber positive electrode.The asymmetric supercapacitor presents a high energy density of 17.9 Wh kg^-1 and a high power density of 14 kW kg^-1,which is inseparable from its wide voltage window of 1.4 V and the good rate performance of the few-layer Ti3C2Tx MXene electrode.Overall,the flash freezing-assist delamination provides an effective and environmental-friendly strategy to synthesize few-layer MXene materials for high-rate electrochemical energy storage. | Xianli Wang Liubing Dong Wenbao Liu Yongfeng Huang Xuechao Pu Jinjie Wang Feiyu Kang Jia Lia Chengjun Xu | 2020 | Journal of Energy Chemistry2020，29，9： | 1 |
| 11 | Molecular and Pathogenic Variation Identified Among Isolates of Corynespora cassiicola显示文摘 | Yanxiang Qi Yixian Xie Xin Zhang Jinji Pu Huiqiang Zhang Siliang Huang He Zhang | 2009 | Molecular Biotechnology2009，，2： | 1 |
| 12 | Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their high stability,easy preparation,and tunable catalytic properties,especially in the field of cancer therapy.However,the unfavorable catalytic effects of nanozymes in the acidic tumor microenvironment have limited their applications.Herein,we developed a biomimetic erythrocyte membrane-camouflaged ultrasmall black phosphorus quantum dots(BPQDs)nanozymes that simultaneously exhibited an exceptional near-infrared(NIR)photothermal property and dramatically photothermal-enhanced glucose oxidase(GOx)-like activity in the acidic tumor microenvironment.We demonstrated the engineered BPQDs gave a photothermal conversion efficiency of 28.9%that could rapidly heat the tumor up to 50℃ while effectively localized into tumors via homing peptide iRGD leading after intravenously injection.Meanwhile,the significantly enhanced GOx-like activity of BPQDs under NIR irradiation was capable of catalytical generating massive toxic reactive oxygen species via using cellular glucose.By combining the intrinsic photothermal property and the unique photothermal-enhanced GOx-like catalytic activity,the developed BPQDs were demonstrated to be an effective therapeutic strategy for inhibiting tumor growth in vivo.We believe that this work will provide a novel perspective for the development of nanozymes in tumor catalytic therapy. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2022 | Nano Research2022，15，2： | 1 |
| 13 | A hybrid genetic algorithm for feature selection wrapper based on mutual information显示文摘 | Huang Jinjie Cai Yunze Xu Xiaoming | 2007 | Pattern Recognition Letters2007，28，13： | 1 |
| 14 | 晚期非小细胞肺癌化疗和靶向治疗失败后的挽救性化疗(英文)显示文摘Objective: We conducted a prospective phase II trial of single-agent salvage chemotherapy with docetaxel in patients with advanced non-small cell lung cancer (NSCLC) after failure of chemotherapy and gefitinib to assess the efficacy and toxicity of docetaxel in this setting. Methods: Patients with histologically confirmed NSCLC who were failure of chemotherapy and gefitinib were given docetaxel 75 mg/m2 intravenously for 30 min every 3 weeks until the toxicity was unacceptable or disease progressed. The response evaluation criteria in solid tumors (RECIST) guidelines were used for the evaluation of antitumor activity. Toxicity was graded according to the National Cancer Institute Common Toxicity Criteria version 2.0. Results: In total, 31 patients were enrolled in this phase II trial between February 2004 and December 2006, and 84 cycles (average 2.7 cycles) were given. We observed 4 partial responses (PRs) and 10 stable disease (SD) states in 31 eligible patients. The objective response rate was 12.9%, and the disease control rate was 45.2%. The median survival time (MST) was 10 months (95% CI, 5.05-15.08 months). The 1-year survival rate was 40.6%. The most common toxicities were neutropenia, anemia, and peripheral neuropathy that occurred as follows: 45% of the patients experienced grade 3 or 4 neutropenia, 29% experienced grade 3 anemia, and 25.8% had grade 3 peripheral neuropathy. No patient terminated docetaxel chemotherapy due to toxicity. Conclusion: Docetaxel is beneficial as salvage chemotherapy in patients with advanced NSCLC after failure of cytotoxic agents and gefitinib. | Yilong Wu Jinji Yang Yujuan Huang Qin Zhou Yisheng Huang Chongrui Xu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，9： | 1 |
| 15 | Theoretical investigation on self-recovery regulation method for diesel engine misalignment through co-simulation显示文摘Misalignment is one of the most common faults for the diesel engine.In order to eliminate the misalignment fault of the diesel engine in the process of operation,a targeting self-recovery regulation system is constructed by using a movable base and displacement sensors.Misalignment is monitored and detected in real time,the value of misalignment is calculated rapidly and accurately,andintelligent decision is made.Then,the base is moved reversely with a definite target to drive the shaft to translate or rotate,so that the shafts can be recovered to alignment online.A co-simulation model for the self-recovery system is established which consists of a dynamic model of the crankshaft system and control model.The self-recovery regulation process of misalignment is simulated.The simulation results show that the system can accurately calculate the misalignment values,with an error of less than 5%,and can automatically eliminate the misalignment fault of the diesel engine online.The research results provide theoretical support for the self-recovery regulation of misalignment fault,and due to the universality of structure and principle,the self-recovery system is not only suitable for diesel engine,but also for other rotating machineries. | 江志农 Wang Zijia Mao Zhiwei Zhang Jinjie Wang Chenguang Huang Yifei | 2021 | High Technology Letters2021，27，3： | 0 |
| 16 | Erratum to:Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Erratum to Nano Research 2022,15(2):1554–1563 http://gffzzd3cc09b8251d45dfs5ppvp5q9npfp6nc5.ffgz.tsg.suse.edu.cn/10.1007/s12274-021-3701-8 Figure 3(d)in the original paper contained duplicated micrographs(BPQDs+NIR)for different xenografts(B16 vs.CNE-2).This error did not affect any of the conclusions from the published paper. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2023 | Nano Research2023，16，1： | 0 |
| 17 | Enhanced Differentiable Architecture Search Based on Asymptotic Regularization显示文摘In differentiable search architecture search methods,a more efficient search space design can significantly improve the performance of the searched architecture,thus requiring people to carefully define the search space with different complexity according to various operations.Meanwhile rationalizing the search strategies to explore the well-defined search space will further improve the speed and efficiency of architecture search.With this in mind,we propose a faster and more efficient differentiable architecture search method,AllegroNAS.Firstly,we introduce a more efficient search space enriched by the introduction of two redefined convolution modules.Secondly,we utilize a more efficient architectural parameter regularization method,mitigating the overfitting problem during the search process and reducing the error brought about by gradient approximation.Meanwhile,we introduce a natural exponential cosine annealing method to make the learning rate of the neural network training process more suitable for the search procedure.Moreover,group convolution and data augmentation are employed to reduce the computational cost.Finally,through extensive experiments on several public datasets,we demonstrate that our method can more swiftly search for better-performing neural network architectures in a more efficient search space,thus validating the effectiveness of our approach. | Cong Jin Jinjie Huang Yuanjian Chen Yuqing Gong | 2024 | Computers, Materials & Continua2024，78，2： | 0 |
| 18 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 19 | Spin-Enhanced C-C Coupling in CO_(2)Electroreduction with Oxide-Derived Copper显示文摘Electrocatalytic reduction of carbon dioxide(CO_(2))to multicarbon(C2+)products involves intricate multiple protons and electron transfer of C-C coupling,which is dictated by not only the intrinsic reactivity but also the spin states of electrons in the catalyst.Here,we observe spin-enhanced CO_(2)reduction(CO_(2)RR)electrocatalytic activity on an oxidederived copper(OD-Cu)catalyst due to the existence of a specific Cu*site that carried the magnetic moments.Due to the correlation of magnetic and catalytic properties in OD-Cu,the current density through the OD-Cu electrode increases by nearly 10%at 350 mT.The field strength and angle dependence of such magnetic field effect(MFE),together with the time-resolved measurements proved that it originated from the alignment of magnetic moments on Cu*sites.The MFE on the electrocatalytic process enabled an enhancement(up to 15%)of the CO_(2)RR Faradaic efficiency using the OD-Cu catalyst.Importantly,the enhancement was attributed to the spinantiparallel alignment of electrons to promote C-C coupling on asymmetric Cu*-Cu sites;consequently,the optimal bias was reduced by∼0.2 V under the magnetic field for C2 products with Faradaic efficiency>30%and selectivity>75%.Our work uncovers a new paradigmfor spin-enhanced catalysis applicable to a broad range of chemical reactions involving spin singlet products. | Jinjie Hao Shijie Xie Qing Huang Zijing Ding Hua Sheng Chuang Zhang Jiannian Yao | 2023 | CCS Chemistry2023，5，9： | 0 |
| 20 | Simulation analysis of wear characteristics of connecting rod bearing bush based on improved mixed lubrication model显示文摘The failure rate of crankpin bearing bush of diesel engine under complex working conditions such as high temperature,dynamic load and variable speed is high.After serious wear,it is easy to deteriorate the stress state of connecting rod body and connecting rod bolt,resulting in serious accidents such as connecting rod fracture and body damage.Based on the mixed lubrication characteristics of connecting rod big endbearing shell of diesel engine under high explosion pressure impact load,an improved mixed lubrication mechanism model is established,which considers the influence of viscoelastic micro deformation of bearing bush material,integrates the full film lubrication model and dry friction model,couples dynamic equation of connecting rod.Then the actual lubrication state of big end bearing shell is simulated numerically.Further,the correctness of the theoretical research results is verified by fault simulation experiments.The results show that the high-frequency impact signal with fixed angle domain characteristics will be generated after the serious wear of bearing bush and the deterioration of lubrication state.The fault feature capture and alarm can be realized through the condition monitoring system,which can be applied to the fault monitoring of connecting rod bearing bush of diesel engine in the future. | 高云端 WANG Zijia TIAN Ye HUANG Yan ZHANG Jinjie | 2023 | High Technology Letters2023，29，1： | 0 |
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