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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Improving the stability and bioavailability of tea polyphenols by encapsulations:a review显示文摘Tea polyphenols(TPPs)have attracted significant research interest due to their health benefits.However,TPPs are sensitive to certain environmental and gastrointestinal conditions and their oral bioavailability was found to be very low.Delivery systems made of food-grade materials have been reported to improve the shelf-life,bioavailability and bioefficacy of TPPs.This review discusses the chemistry of TPPs;the setbacks of TPPs for application;and the strategies to counteract application limitations by rationally designing delivery systems.An overview of different formulations used to encapsulate TPPs is provided in this study,such as emulsion-based systems(liposome,nanoemulsion,double emulsion,and Pickering emulsion)and nano/microparticles-based systems(protein-based,carbohydrate-based,and bi-polymer based).In addition,the stability,bioavailability and bioactivities of encapsulated TPPs are evaluated by various in vitro and in vivo models.The current findings provide scientific insights in encapsulation approaches for the delivery of TPPs,which can be of great value to TPPs-fortified food products.Further explorations are needed for the encapsulated TPPs in terms of their applications in the real food industry as well as their biological fate and functional pathways in vivo. | Zhiya Yin Ting Zheng Chi-Tang Ho Qingrong Huang Qingli Wu Man Zhang | 2022 | Food Science and Human Wellness2022，11，3： | 7 |
| 3 | Determination of spatial resolution of plastic scintillation fiber array with a simple method显示文摘The spatial resolution of a position sensitive gamma-ray detector configuration based on plastic scintillation fiber array was measured using a Monte Carlo simulation method. Both point spread function and modulation transfer function (MTF) were presented. The factors that influence the spatial resolution were also discussed. The results of the simulation showed that the intrinsic spatial resolution was consistent with the size of the physical pixels and a few centimeters spatial resolution could be obtained under certain circumstances. | TANG Shibiao MA Qingli YIN Zejie HUANG Huan | 2007 | Nuclear Science and Techniques2007，18，2： | 3 |
| 4 | Linear goal programming approach to obtaining the weights of intuitionistic fuzzy ordered weighted averaging operator显示文摘The multiple attribute decision making problems are studied, in which the information about attribute weights is partly known and the attribute values take the form of intuitionistic fuzzy numbers. The operational laws of intuitionistic fuzzy numbers are introduced, and the score function and accuracy function are presented to compare the intuitionistic fuzzy numbers. The intuitionistic fuzzy ordered weighted averaging (IFOWA) operator which is an extension of the well-known ordered weighted averaging (OWA) operator is investigated to aggregate the intuitionistic fuzzy information. In order to determine the weights of intuitionistic fuzzy ordered weighted averaging operator, a linear goal programming procedure is proposed for learning the weights from data. Finally, an example is illustrated to verify the effectiveness and practicability of the developed method. | Yejun Xu Chao Huang Qingli Da Xinwang Liu | 2010 | Journal of Systems Engineering and Electronics2010，21，6： | 3 |
| 5 | Development and validation of a TaqMan^(TM) fluorescent quantitative real-time PCR assay for the rapid detection of Edwardsiella tarda显示文摘Edwardsiella tarda is one of the most important emerging pathogens in the global aquaculture industries. As such, an accurate diagnosis and quantitative analytical methods are urgently needed for this bacterium. In this study, primers and a TaqMan probe specific to the conservative sequences of the 16S rRNA gene of E. tarda were designed. The concentration of primers and TaqMan probe were optimized to 200 nmol/L and 120 nmol/L, respectively. The detection sensitivity of the FQ-PCR assay was determined to be as low as five copies of the target sequence per reaction using the pGEM-16S rDNA recombinant plasmid as a template, which was 100 times more sensitive than conventional PCR. A standard curve by plotting the threshold cycle values (y) against the common logarithmic copies (log_10 n_c as x; n_c is copy number) of pGEM-16S rDNA was generated. The results of intra-and inter-assay variability tests demonstrate that the established FQ-PCR method was highly reproducible. The assay was specific for E. tarda as it showed that there was no cross-reactivity to eight additional bacterial pathogen strains in aquaculture. Thus, the FQ-PCR assay has the potential for diagnostic purposes and for other applications, especially for the rapid detection and quantification of low-grade E. tarda infections. | XIE Guosi HUANG Jie ZHANG Qingli HAN Nana SHI Chengyin WANG Xiuhua | 2012 | Acta Oceanologica Sinica2012，31，4： | 2 |
| 6 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 7 | Surface water quality of factory-based and vegetable-based peri-urban areas in the Yangtze River Delta region, China显示文摘 | ZHANG QingLi SHI Xuezheng HUANG Biao | 2007 | Catena2007，69，1： | 1 |
| 8 | ControUed synthesis of different morphological YF3 crystalline particles at room temperature 显示文摘 | Wang Miao Huang Qingli Hong Jianming | 2007 | Materials Letters2007，61，10： | 1 |
| 9 | Research on image denoising based on space fractional partial differential equations显示文摘 | HUANG Guo XU Li CHEN Qingli | 2012 | Journal of Sichuan University(Engineering Science Edition)2012，44，2： | 1 |
| 10 | Specific and rapid diagnosis of Edwardsiella tarda by a novel loop-mediated isothermal amplification targeting the upstream region of hlyb gene显示文摘 | XIE Guosi HUANG Jie ZHANG Qingli | 2013 | Journal of Aquatic Animal Health2013，25，2： | 1 |
| 11 | Simulation study of BGO array for characteristic gamma rays from neutron-stimulated elements显示文摘Characteristic gamma rays of 100 keV to about 6 MeV from different elements stimulated by neutrons have been applied to diagnosis biological imaging.In this paper,BGO detectors are used for the spectrum simulation. Signals from a single crystal and after correction are both obtained,and the energy spectrum summing adjacent signals seems possible to achieve excellent energy resolution for such high-energy photons.Some ideal suppositions are in- troduced and some other information,such as spatial resolution and difficult electronics,should be considered after this correction. | TANG Shibiao MA Qingli YIN Zejie HUANG Huan | 2007 | Nuclear Science and Techniques2007，18，6： | 1 |
| 12 | Some characteristics of X-ray imaging for energy region of over 100 keV using plastic scintillation fiber array显示文摘In this work, characteristics of using PSFs (plastic scintillation fibers) coupled with CCD (charge-coupled devices ) to build area detectors for high energy X-ray imaging are studied with a Monte Carlo simulation, which cover an energy range of a few hundred keV to about 20 MeV. It was found that the efficiency of PSF in detecting X-ray with energy above a few hundred keV is low. We can use large incident flux to increase the output signal to noise ratio (SNR). The performance can also be improved by coating PSF with X-ray absorption layers and the MTF of the system is presented. By optimizing the absorption layer thickness, the crosstalk of the area detector built with PSF decreases. | TANG Shibiao MA Qingli YIN Zejie HUANG Huan | 2007 | Nuclear Science and Techniques2007，18，3： | 0 |
| 13 | TUNNEL INTERFERENCE IN UNSTEADY POST-STALL EXPERIMENTS显示文摘TUNNELINTERFERENCEINUNSTEADYPOST┐STALLEXPERIMENTSZhangWenhua,DingKewen,HuangDa,LiZhiqiang,ZhangQingli(6thDept.NanjingUniversi... | Zhang Wenhua, Ding Kewen, Huang Da, Li Zhiqiang, Zhang Qingli (6th Dept. Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China) | 1997 | Chinese Journal of Aeronautics1997，10，4： | 0 |
| 14 | Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis(CHESS1904):An international multicenter study显示文摘Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver cirrhosis.Methods:This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June 2020.Data related to the tolerance and acceptance of HVPG measurements were collected using descriptive questionnaires.Results:HVPG measurements were technically successful in all 271 patients,with 141(52.0%)undergoing HVPG measurement alone.The complication rate was 0.4%.Postoperative pain was significantly lower than preoperative expected pain(p<0.001)and intraoperative pain(p<0.001),and intraoperative pain was also significantly lower than preoperative expected pain(p=0.036).No,mild,moderate,severe,and intolerable discomfort scores were reported by 36.9%,44.6%,11.1%,6.3%,and 0.4%of these patients,respectively,during HVPG measurement and by 54.6%32.5%,11.4%,1.5%,and 0%,respectively,after HVPG measurement.Of these patients,39.5%had little understanding and 10%had no understanding of the value of HVPG measurement,with 35.1%and 4.1%regarding HVPG measurements as being of little or no help,respectively.Most patients reported that they would definitely(15.5%),probably(46.9%),or possibly(29.9%)choose to undergo additional HVPG measurements again,and 62.7%regarded the cost of the procedure as acceptable.Conclusion:HVPG measurement was safe and well‐tolerated in patients with cirrhosis,but patient education and communication are warranted to improve the acceptance of this procedure. | Jun‐Hui Sun He Zhao Haijun Zhang Lei Li NecatiÖrmeci Zi‐Niu Yu Xun Li Shuangxi Li Xujun Yang Huaping Wei Xiaoliang Zhu Zhengcong Zhang Yajin Wang Zhongwei Zhao Jianting Mao Qiaohong Wu Xiaole Sun Huiling Xiang Kefeng Jia Chao Yang Wei Wu Xiuqing Lin Haixin Yao Changzeng Zuo Jitao Wang Bo Zhang Chunqing Zhang Xiaoling Wu Guangchuan Wang Shengjuan Yao Ruihang Wang Li Zhou Hui Huan Qingli Tu Xue Pu Feng Zhang Qin Yin Linpeng Zhang Ying Guo Jian Wang Kohei Kotani Sawako Uchida‐Kobayashi Norifumi Kawada He Zhu Li Li Wei Wang Guo Zhang Lei Yu Xudong Cui Qingliang Zhu Hailong Zhang Xiaoli Hu Rafael OXimenes Adriano Gonçalves de Araújo Giulliano Gardenghi Yubao Zheng Zebin Wu Mingsheng Huang Xiaoyong Chen Jun Wu Feng Xie Yang Bo Shengjuan Hu Linke Ma Xiao Li Xiaolong Qi | 2022 | Portal Hypertension & Cirrhosis2022，1，1： | 0 |
| 15 | BRIEF COMMUNICATION ARISING Geng et al.reply显示文摘The accompanying comment by Dr.Rao,suggests that there is an omission of citation of 12 previous publications in our Wang et al.paper.1 We disagree with the suggestion for the following reasons.We believe that the 12 publications cited by Dr.Rao do not have sufficient relevance to the Wang et al.paper.1 The past decades have witnessed an explosive growth in our understanding of the pathogenesis of Alzheimer's disease(AD),which is a very complicated process.The Wang et al. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2020 | Cell Research2020，30，9： | 0 |
| 16 | Facile synthesis of polypyrrole nanowires for high-performance supercapacitor electrode materials显示文摘Polypyrrole nanowires are facile synthesized under a mild condition with FeCl_3 as an oxidant. Polypyrrole nanowires with the width of 120 nm form many nanogaps or pores due to the intertwined nanostructures. More importantly, PPy nanowires were further applied for supercapacitor electrode materials.After electrochemical testing, it was observed that the PPy nanowire based electrode showed a large specific capacitance(420 Fg^(-1), 1.5 Ag^(-1)) and good rate capability(272 Fg^(-1), 18.0 Ag^(-1)), which is larger than that of most of published results. The as-prepared electrode can work well even after 8000 cycles at 1.5 Ag^(-1). | Junhong Zhao Jinping Wu Bing Li Weimin Du Qingli Huang Mingbo Zheng Huaiguo Xue Huan Pang | 2016 | Progress in Natural Science:Materials International2016，26，3： | 0 |
| 17 | Carbon-Nitride-Based Materials for Advanced Lithium-Sulfur Batteries显示文摘Lithium-sulfur(Li-S)batteries are promising candidates for next-generation energy storage systems owing to their high energy density and low cost.However,critical challenges including severe shuttling of lithium polysulfides(LiPSs)and sluggish redox kinetics limit the practical application of Li-S batteries.Carbon nitrides(C_(x)N_(y)),represented by graphitic carbon nitride(g-C_(3)N_(4)),provide new opportunities for overcoming these challenges.With a graphene-like structure and high pyridinic-N content,g-C_(3)N_(4) can effectively immobilize LiPSs and enhance the redox kinetics of S species.In addition,its structure and properties including electronic conductivity and catalytic activity can be regulated by simple methods that facilitate its application in Li-S batteries.Here,the recent progress of applying C_(x)N_(y)-based materials including the optimized g-C_(3)N_(4),g-C_(3)N_(4)-based composites,and other novel C_(x)N_(y) materials is systematically reviewed in Li-S batteries,with a focus on the structure-activity relationship.The limitations of existing C_(x)N_(y)-based materials are identified,and the perspectives on the rational design of advanced C_(x)N_(y)-based materials are provided for high-performance Li-S batteries. | Wenhao Sun Zihao Song Zhenxing Feng Yaqin Huang Zhichuan J.Xu Yi-Chun Lu Qingli Zou | 2022 | Nano-Micro Letters2022，14，12： | 0 |
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