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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 3 | Mn–Co–Ni–O thin films prepared by sputtering with alloy target显示文摘The thin film of heat-sensitive materials has been widely concerned with the current trend of miniaturization and integration of sensors.In this work,Mn1.56 Co0.96 Ni0.48 O4(MCNO)thin films were prepared on Si O2/Si substrates by sputtering with Mn–Co–Ni alloy target and then annealing in air at different temperatures(650–900℃).The X-ray diffraction(XRD)and field emission scanning electron microscopy(FE-SEM)analysis indicated that the main crystalline phase of MCNO thin films was spinel crystal structure;the surface of the thin films was very dense and uniform.The electrical properties of the thin films were studied in the temperature range of–5–50℃.The MCNO thin film with a low room temperature resistance R25 of 71.1 kΩand a high thermosensitive constant B value of 3305 K was obtained at 750℃.X-ray photoelectron spectroscopy(XPS)analysis showed that the concentration of Mn3+and Mn4+cations in MCNO thin films is the highest when annealing temperature is 750℃.The complex impedance analysis revealed internal conduction mechanism of the MCNO thin film and the resistance of the thin film was dominated by grain boundary resistance. | Ruifeng LI Qiuyun FU Xiaohua ZOU Zhiping ZHENG Wei LUO Liang YAN | 2020 | Journal of Advanced Ceramics2020，9，1： | 3 |
| 4 | Exceptional co-catalyst free photocatalytic activities of B and Fe co-doped SrTiO3 for CO2 conversion and H2 evolution显示文摘CO2 should be converted into chemical-fuels,and to reduce H2O to H2 over SrTiO3 (STO) owing to its negative conduction band position vs.NHE.Herein a novel B and Fe co-doped SrTiO3 (B,F-STO) photocatalyst was successfully fabricated via a single-step sol-hydrothermal process.Various experiments confirmed that B and Fe are effectively doped into the STO matrix.Boron substituted oxygen anions,while Fe substituted Ti cations.UV-visible diffuse reflectance spectra (UV-vis DRS) and valence-band X-ray photoelectron spectroscopy (XPS) spectra confirmed that the band gap of STO significantly reduced from 3.4 to 1.9 eV upon co-doping with B and Fe.Hence,the B,F-STO photocatalyst exhibits more absorption (λ ≤ 650 nm) compared to pure STO (λ ≤ 360 nm).Further,from photoluminescence spectra,fluorescence spectra,and photoelectrochemical measurements,charge separation in STO is considerably enhanced by co-doping B and Fe.This resulted in the improved UV-vis light catalytic activities for CO2 conversion to CH4 and CO and H2O splitting to evolve H2.The amounts of CH4 and CO produced over B,F-STO are ~ 17.2 and 21 μmol,respectively,about 5-fold enhanced compared to that of STO (~ 3.4 μmol CH4 and 5.2 μmol CO),and the calculated quantum efficiency at λ =420 run is ~ 2.16%.Similarly,the amount of H2 produced over B,F-STO is ~ 61 μmol,about 6.7-fold enhanced compared to that over STO (9 μmol),and the calculated quantum efficiency at λ =420 nm is ~ 2.12%.This work provides feasible routes to fabricate highly efficient SrTiO3-based nanophotocatalysts for solar-fuel production. | Muhammad Humayun Lei Xu Ling Zhou Zhiping Zheng Qiuyun Fu Wei Luo | 2018 | Nano Research2018，11，12： | 3 |
| 5 | A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis显示文摘The complex pathogenesis of osteoporosis includes excessive bone resorption,insufficient bone formation and inadequate vascularization,a combination which is difficult to completely address with conventional therapies.Engineered exosomes carrying curative molecules show promise as alternative osteoporosis therapies,but depend on specifically-functionalized vesicles and appropriate engineering strategies.Here,we developed an exosome delivery system based on exosomes secreted by mesenchymal stem cells(MSCs)derived from human induced pluripotent stem cells(iPSCs).The engineered exosomes BT-Exo-siShn3,took advantage of the intrinsic anti-osteoporosis function of these special MSC-derived exosomes and collaborated with the loaded siRNA of the Shn3 gene to enhance the therapeutic effects.Modification of a bone-targeting peptide endowed the BT-Exo-siShn3 an ability to deliver siRNA to osteoblasts specifically.Silencing of the osteoblastic Shn3 gene enhanced osteogenic differentiation,decreased autologous RANKL expression and thereby inhibited osteoclast formation.Furthermore,Shn3 gene silencing increased production of SLIT3 and consequently facilitated vascularization,especially formation of type H vessels.Our study demonstrated that BT-Exo-siShn3 could serve as a promising therapy to kill three birds with one stone and implement comprehensive anti-osteoporosis effects. | Yongzhi Cui Yuanyuan Guo Li Kong Jingyu Shi Ping Liu Rui Li Yongtao Geng Weihang Gao Zhiping Zhang Dehao Fu | 2022 | Bioactive Materials2022，7，4： | 3 |
| 6 | Mineralogy of Chang’e-4 landing site:preliminary results of visible and near-infrared imaging spectrometer显示文摘The exploration of mafic anomaly in South Pole-Aitken(SPA,the largest confirmed)basin on the Moon provides important insights into lunar interior.The landing of Chang’e-4(CE-4)and deployment of Yutu-2 rover on the discontinuous ejecta from Finsen crater enabled in-situ measurements of the unusual mineralogy in the central portion of SPA basin with visible and near-infrared imaging spectrometer(VNIS).Here we present detailed processing procedures based on the level 2B data of CE-4 VNIS and preliminary mineralogical results at the exploration area of Yutu-2 rover.A systematic processing pipeline is developed to derive credible reflectance spectra,based on which several spectral and mineral indices are calculated to constrain the mafic mineralogy.The mafic components in the soils and boulder around CE-4 landing site are concluded as clinopyroxene-bearing with intermediate composition and probably dominated by pigeonite although the possibility of mixing orthopyroxen(OPX)and calcic clinopyroxene(CPX)also exists.These mineralogical results are more consistent with a petrogenesis that the CE-4 regolith and rock fragment are derived from rapid-cooling magmatic systems and we interpret that the materials at the CE-4 landing site ejected from Finsen crater are probably recrystallized from impact melt settings. | Jian CHEN Zongcheng LING Le QIAO Zhiping HE Rui XU Lingzhi SUN Jiang ZHANG Bo LI Xiaohui FU Changqing LIU Xiaobin QI | 2020 | Science China(Information Sciences)2020，63，4： | 2 |
| 7 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 8 | Visible Raman and Brillouin lasers from a microresonator/ZBLAN-fiber hybrid system显示文摘Raman and Brillouin lasers based on a high-quality(high-Q) whispering gallery mode microresonator(WGMR)are usually achieved by employing a tunable single-frequency laser as a pump source. Here, we experimentally demonstrate visible Raman and Brillouin lasers using a compact microresonator/ZrF4-BaF2-LaF3-AlF3-NaF(ZBLAN)-fiber hybrid system by incorporating a WGMR with a fiber-compatible distributed Bragg reflector/fiber Bragg grating to form a Fabry–Perot(F-P) fiber cavity and using a piece of Pr:ZBLAN fiber as gain medium.The high-Q silica-microsphere not only offers a Rayleigh-scattering-induced backreflection to form the ~635 nm red laser oscillation in the F-P fiber cavity, but also provides a nonlinear gain in the WGMR itself to generate either stimulated Raman scattering or stimulated Brillouin scattering. Up to six-order cascaded Raman lasers at0.65 μm, 0.67 μm, 0.69 μm, 0.71 μm, 0.73 μm, and 0.76 μm are achieved, respectively. Moreover, a Brillouin laser at 635.54 nm is clearly observed. This is, to the best of our knowledge, the first demonstration of visible microresonator-based lasers created by combining a Pr:ZBLAN fiber. This structure can effectively extend the laser wavelength in the WGMR to the visible waveband and may find potential applications in underwater communication, biomedical diagnosis, microwave generation, and spectroscopy. | SHUISEN JIANG CHANGLEI GUO KAIJUN CHE ZHENGQIAN LUO TUANJIE DU HONGYAN FU HUIYING XU ZHIPING CAI | 2019 | Photonics Research2019，7，5： | 1 |
| 9 | Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex显示文摘 | Huang Ying Wu Zhiping Riwanto Meliana Gao Shengqiang Levison Bruce S Gu Xiaodong Fu Xiaoming Wagner Matthew A Besler Christian Gerstenecker Gary Zhang Renliang Li Xin-Min DiDonato Anthony J Gogonea Valentin Tang W H Wilson Smith Jonathan D | 2013 | Journal of Clinical Investigation2013，，9： | 1 |
| 10 | Test study on coal body's moisture absorption speed 显示文摘 | Fu Gui Chen Xuexi and Lei Zhiping | 1998 | Journal of Coal (in Chinese)1998，，6： | 1 |
| 11 | CyclinD1: normal and abnormal functions显示文摘 | Maofu Fu Chenguang Wang Zhiping Li | 2004 | Endocrinology2004，145，12： | 1 |
| 12 | Luminescent characteristics of LiSrBO 3 :M (M显示文摘 | Panlai Li Zhijun Wang Zhiping Yang Qinglin Guo Guangsheng Fu | 2009 | Materials Research Bulletin2009，，11： | 1 |
| 13 | Cyclin D1: normal and abnormal functions 显示文摘 | Maofu Fu Chenguang Wang Zhiping Li | 2004 | Endocrinology2004，145，12： | 1 |
| 14 | Stent graft-induced new entry after endovascular repair for Stanford type B aortic dissection显示文摘 | Zhihui Dong Weiguo Fu Yuqi Wang Chunsheng Wang Zhiping Yan Daqiao Guo Xin Xu Bin Chen | 2010 | Journal of Vascular Surgery2010，，6： | 1 |
| 15 | Sm3+-dopedBa3Bi(PO4)3orange reddish emitting phosphor显示文摘 | YANG Fu YANG Zhiping YU Quanmao | 2013 | Spectrochim ActaPart A: Mol Biomol Spectrosc2013，105，62： | 1 |
| 16 | Cyclin D1: Normal and Abnormal Functions 显示文摘 | Maofu Fu Chenguang Wang Zhiping Li | 2004 | Endocrinology2004，145，12： | 1 |
| 17 | Comparison of the Effects of the Different Methods for Computing the Slope Length Factor at a Watershed Scale显示文摘The slope length factor is one of the parameters of the Universal Soil Loss Equation(USLE)and the Revised Universal Soil Loss Equation(RUSLE)and is sometimes calculated based on a digital elevation model(DEM).The methods for calculating the slope length factor are important because the values obtained may depend on the methods used for calculation.The purpose of this study was to compare the difference in spatial distribution of the slope length factor between the different methods at a watershed scale.One method used the uniform slope length factor equation(USLFE)where the effects of slope irregularities(such as slope gradient,etc.)on soil erosion by water were not considered.The other method used segmented slope length factor equation(SSLFE)which considered the effects of slope irregularities on soil erosion by water.The Arc Macro Language(AML)Version 4 program for the revised universal soil loss equation(RUSLE).which uses the USLFE,was chosen to calculate the slope length factor.In a parallel analysis,the AML code of RUSLE Version 4 was modified according to the SSLFE to calculate the slope length factor.Two watersheds with different slope and gully densities were chosen.The results show that the slope length factor and soil loss using the USLFE method were lower than those using the SSLFE method,especially on downslopes watershed with more frequent steep slopes and higher gully densities.In addition,the slope length factor and soil loss calculated by the USLFE showed less spatial variation. | Fu Suhua Wu Zhiping Liu Baoyuan Cao Longxi | 2013 | International Soil and Water Conservation Research2013，1，2： | 1 |
| 18 | Development and application of knowledge-based subject group integration platforms:A case study of Shanghai Institute of Ceramics,CAS显示文摘Purpose:According to the different requirements of research group users,we established the knowledge-based subject group integration platforms of Shanghai Institute of Ceramics,the Chinese Academy of Sciences(abbreviated as SIC CAS hereinafter),which were designed and constructed to better meet the needs of CAS research groups for their development,collaboration and communication.Design/methodology/approach:We first identified the requirements of users via preliminary investigation,and then chose CASI1 P,iLibrary and XKE technology,respectively as the building tools compatible with the major demands of users.These steps helped us complete the layout design of SIC CAS integration platforms,as well as its knowledge organization and integration.Findings:According to the need of users,we applied three types of platform construction technologies to five SIC integration platforms,and formulated standard norms for the further construction process,which could provide useful reference for a sustainable development for the extensive construction in CAS institutes.Research limitations:In order to make the SIC integration platforms more intelligent and have more functions,we need to enlarge the scale of the Platforms and upgrade the building tools for the platform construction.Practical implications:The nature of SIC sub-project integration platforms is to construct a content-sensitive environment which can embed knowledge services and knowledge applications seamlessly into scientific activities,so the Platform is expected to be a useful tool to help researchers better understand the recent development of the research field and form collaborations with their peers.Originality/value:SIC integration platforms are the only pilot construction that used 3different platform technologies in the first batch of knowledge-based subject group integration platforms of the Chinese Academy of Sciences.The construction is user-centered throughout the whole process,namely,from the technology selection,content construction to the sustainable development of the platforms,which are all based on user requirements.During this process,we have not only established sustainable mechanisms for both the personalized feedback and security management of the institutional knowledge of SIC CAS,but also formed a service team for the sustainable development of SIC integration platforms. | Yu LIU Jian FU Huijun ZHENG Hao CHEN Zhiping YANG | 2014 | Chinese Journal of Library and Information Science2014，，2： | 1 |
| 19 | Experimental and DFT Studies of Au Deposition Over WO_(3)/g-C_(3)N_(4) Z-Scheme Heterojunction显示文摘A typical Z-scheme system is composed of two photocatalysts which generate two sets of charge carriers and split water into H2 and O2 at different locations.Scientists are struggling to enhance the efficiencies of these systems by maximizing their light absorption,engineering more stable redox couples,and discovering new O2 and H2 evolutions co-catalysts.In this work,Au decorated WO3/g-C3N4 Z-scheme nanocomposites are fabricated via wet-chemical and photo-deposition methods.The nanocomposites are utilized in photocatalysis for H2 production and 2,4-dichlorophenol(2,4-DCP)degradation.It is investigated that the optimized 4Au/6%WO3/CN nanocomposite is highly efficient for production of 69.9 and 307.3μmol h−1 g−1 H2 gas,respectively,under visible-light(λ>420 nm)and UV–visible illumination.Further,the fabricated 4Au/6%WO3/CN nanocomposite is significant(i.e.,100%degradation in 2 h)for 2,4-DCP degradation under visible light and highly stable in photocatalysis.A significant 4.17%quantum efficiency is recorded for H2 production at wavelength 420 nm.This enhanced performance is attributed to the improved charge separation and the surface plasmon resonance effect of Au nanoparticles.Solid-state density functional theory simulations are performed to countercheck and validate our experimental data.Positive surface formation energy,high charge transfer,and strong non-bonding interaction via electrostatic forces confirm the stability of 4Au/6%WO3/CN interface. | Muhammad Humayun Habib Ullah Junhao Cao Wenbo Pi Yang Yuan Sher Ali Asif Ali Tahir Pang Yue Abbas Khan Zhiping Zheng Qiuyun Fu Wei Luo | 2020 | Nano-Micro Letters2020，12，1： | 1 |
| 20 | Cascading dam breach process simulation using a coupled modeling platform显示文摘This study evaluates the possibility of a cascade failure by developing a coupled breach-modeling platform based on onedimensional flow modeling of the river channel, flood propagation, regulation process of reservoir fluctuation, overtopping with breaching, and wave damping downstream. A hyperbolic model of the DB-IWHR was embedded into the platform to simulate the dam breaching process. Five breach models and software were used to calculate the Tangjiashan barrier lake breaching. The results of a sensitivity study were then compared with the measured data. The peak flow and the time of occurrence were confirmed to be predictable with a reasonable accuracy if the input values were within ranges appropriate for the model. The approach was applied to a case involving two layout planning schemes for a cascade of rock-filled dams under extreme operating conditions. The probability of the failure of a key control cascade downstream caused by a continuous cascade breach upstream was simulated. Moreover, measures to prevent the transmission of risk by advance warnings were investigated. The proposed methodology and the discharge capacity measures provide guidelines to assess the risk to a cascade of dams under extreme operating conditions and offer support for the design criteria of unusual discharge structures for very large dams. | LIU ZhiPing GUO XinLei ZHOU XingBo FU Hui XIA QingFu LI ShaoJun | 2019 | Science China(Technological Sciences)2019，62，8： | 1 |
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