|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Combined treatment of vitamin K_2 and angiotensin-converting enzyme inhibitor ameliorates hepatic dysplastic nodule in a patient with liver cirrhosis显示文摘Although it is well known that the hepatocellular carcinoma (HCC) is an ominous complication in patients with liver cirrhosis, there has been no approved drug to prevent the development of HCC to date. We previously reported that the combined treatment of vitamin K2 (VK) and angiotensin-converting enzyme inhibitor (ACE-I) significantly suppressed the experimental hepatocarcinogenesis. A 66-year-old Japanese woman with hepatitis C virus (HCV)-related liver cirrhosis developed a dysplastic nodule in the liver detected by enhanced computed tomography along with elevation of the tumor markers, namely, alpha-fetoprotein (AFP) and lectin-reactive demarcation (AFP-L3), suggesting the presence of latent HCC. After oral administration of VK and ACE-I, the serum levels of both AFP and AFP-L3 gradually decreased without any marked alteration of the serum aminotransferase activity. After one-year treatment, not only the serum levels of AFP and AFP-L3 returned to the normal ranges, but also the dysplastic nodule disappeared. Since both VK and ACE-I are widely used without serious side effects, this combined regimen may become a new strategy for chemoprevention against HCC. | Hitoshi Yoshiji Ryuichi Noguchi Masaharu Yamazaki Yasuhide Ikenaka Masayoshi Sawai Masatoshi Ishikawa Hideto Kawaratani Tsuyoshi Mashitani Mitsuteru Kitade Kosuke Kaji Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara Motoyuki Yoshida Hiroshi Fukui | 2007 | World Journal of Gastroenterology2007，13，23： | 5 |
| 2 | Eosinophilic cholecystitis along with pericarditis caused by Ascaris lumbricoides: A case report显示文摘Although the etiology of eosinophilic cholecystitis is still obscure, the postulated causes include allergies, parasites, hypereosinophilic syndrome, and eosinophilic gastroenteritis. It is sometimes accompanied by several complications, but a simultaneous onset with pericarditis is very rares. A 28-year-old woman complained of acute right hypocondrial pain and dyspnea associated with systemic eruption. Several imaging modalities revealed acute cholecystitis and pericarditis with massive pericardial effusion. A marked peripheral blood eosinophilia was observed, and the eruption was diagnosed as urticaria. Her serum had a high titer of antibody against Ascaris lumbricoides . Treatment with albendazole drastically improved all clinical manifestations along with normalization of the imaging features and eosinophilia. We report herein a rare case of simultaneous onset of acute cholecystitis and pericarditis associated with a marked eosinophilia caused by parasitic infection. | Kosuke Kaji Hitoshi Yoshiji Masahide Yoshikawa Masaharu Yamazaki Yasuhide Ikenaka Ryuichi Noguchi Masayoshi Sawai Masatoshi Ishikawa Tsuyoshi Mashitani Mitsuteru Kitade Hideto Kawaratani Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara Motoyuki Yoshida Hiroshi Fukui | 2007 | World Journal of Gastroenterology2007，13，27： | 3 |
| 3 | 前列腺癌重碳离子放疗计划与调强放疗计划的比较显示文摘目的比较前列腺癌重碳离子放疗(C-ion RT)与调强放疗(IMRT)在剂量学方面的差异。方法随机选取5例前列腺癌患者,分别设计4野共面的C-ion RT计划和7野共面的IMRT计划。剂量均采用百分剂量,95%的等剂量面必须包括100%的计划靶体积(PTV)。比较靶区剂量分布的适形度指数(CI)和异质性指数(IC),根据剂量体积直方图(DVH),比较相同剂量水平下C-ion RT计划与IMRT计划中周围器官及非靶区正常组织的照射体积。结果在C-ion RT计划中,CI_(50%)、CI_(95%)、IC分别为3.36、1.20和0.03,与IMRT计划比较差异有统计学意义(P均<0.01),靶区剂量分布的CI和IC均优于IMRT计划。除了95%的剂量水平外,在10%、30%、50%、70%和90%剂量水平,采用C-ion RT均可明显减少直肠的受照射体积(P均<0.05),同时完全保护直肠的后壁;在任何剂量水平,C-ion RT可明显减少膀胱和非靶区正常组织的受照射体积(P均<0.05);在10%、20%、30%和40%剂量水平,C-ion RT可明显减少双侧股骨头的受照射体积(P均<0.05)。结论在前列腺癌的放射治疗中,与IMRT计划相比,C-ion RT计划在剂量学方面有明显优势,C-ion RT的这些优势将能够进一步提高前列腺癌的局部控制率,减少放疗引起的并发症。 | 王维虎 Hiroshi Tsuji Hitoshi Ishikawa Hirohiko Tsujii Tadashi Kamada Junetsu Mizoe 李晔雄 | 2006 | 中华肿瘤杂志2006，28，11： | 3 |
| 4 | Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis显示文摘 | Mitsuhiro Yokoyama Hideki Origasa Masunori Matsuzaki Yuji Matsuzawa Yasushi Saito Yuichi Ishikawa Shinichi Oikawa Jun Sasaki Hitoshi Hishida Hiroshige Itakura Toru Kita Akira Kitabatake Noriaki Nakaya Toshiie Sakata Kazuyuki Shimada Kunio Shirato | 2007 | The Lancet2007，，9567： | 2 |
| 5 | Thymosin-α1 increases intrahepatic NKT cells and CTLs in patients with chronic hepatitis B显示文摘 | Satoshi Sugahara Takafumi Ichida Satoshi Yamagiwa Toru Ishikawa Kazuhiro Uehara Yuhei Yoshida Xiu-Hua Yang Minoru Nomoto Hisami Watanabe Toru Abo Hitoshi Asakura | 2002 | Hepatology Research2002，，4： | 1 |
| 6 | Evaluation Of a high-velocity flame-spraying technique for hydroxyl apatite显示文摘 | Keiko Ishikawa Satoshi Ojima | 1992 | Biomaterials1992，13，7： | 1 |
| 7 | Expression of Osteopontin in Kupffer Cells and Hepatic Macrophages and Stellate Cells in Rat Liver after Carbon Tetrachloride Intoxication: A Possible Factor for Macrophage Migration into Hepatic Necrotic Areas显示文摘 | Rumiko Kawashima Satoshi Mochida Atsushi Matsui YuSuFu YouLuTuZ Keiko Ishikawa Keiko Toshima Fumio Yamanobe Mie Inao Hitoshi Ikeda Akihiko Ohno Sumiko Nagoshi Toshimitsu Uede Kenji Fujiwara | 1999 | Biochemical and Biophysical Research Communications1999，，3： | 1 |
| 8 | De- m2onst ration of rqeurovascular Compression in TfigeminalNeuralgia and Hemifacial Spasm with Magnetic Resonance Imaging显示文摘 | Hitoshi Fukuda Masat sune Ishikawa Ryosuke Okumum | 2003 | Surg Neurol2003，59，1： | 1 |
| 9 | Evaluation Of a high-velocity flame-spraying technique for hydroxyl apatite显示文摘 | Keiko Ishikawa Satoshi Ojima | 1992 | Biomaterials1992，13，7： | 1 |
| 10 | Forensicmolecular pathology:its impacts on routine work,education and training显示文摘 | Hitoshi Maeda Takaki Ishikawa Tomomi Michiue | 2014 | Legal medicine(Tokyo Japan)2014，16，2： | 1 |
| 11 | Health‐related quality of life after carbon‐ion radiotherapy for prostate cancer: A 3‐year prospective study显示文摘 | Hiroyuki Katoh Hiroshi Tsuji Hitoshi Ishikawa Tadashi Kamada Masaru Wakatsuki Naoki Hirasawa Hiroyoshi Suzuki Koichiro Akakura Takashi Nakano Jun Shimazaki Hirohiko Tsujii | 2014 | Int J Urol2014，，： | 1 |
| 12 | Gastric duplication cyst: Evaluation by endoscopic ultrasonography and magnetic resonance imaging显示文摘 | Takashi Takahara Toshihiko Torigoe Hiromitsu Haga Hitoshi Yoshida Shinji Takeshima Shinji Sano Yoshifumi Ishii Takashi Furuya Eishu Nakamura Masahisa Ishikawa | 1996 | Journal of Gastroenterology1996，，3： | 1 |
| 13 | Characterization of tantalum capacitor fabricated with a conducting polypyrrole as a counter electrode显示文摘 | Satoh Masaharu Ishikawa Hitoshi Amanio Kosuke | 1995 | Synth Met1995，71，： | 1 |
| 14 | Film formation of condcting polypyrrole and its application to tantalum capacitor显示文摘 | Satoh Masaharu Ishikawa Hitoshi Amanio Kosuke | 1997 | NEC Res Dev1997，36，3： | 1 |
| 15 | Film formation of condcting polypyrrole and its application to tantalum capacitor显示文摘 | Satoh Masaharu Ishikawa Hitoshi | 1997 | NEC Res Dev1997，36，3： | 1 |
| 16 | Pegylated Interferon-Associated Retinopathy in Chronic Hepatitis C Patients显示文摘 | Hiroko Ogata Hiromasa Suzuki Kimiya Shimizu Hitoshi Ishikawa Namiki Izumi Masayuki Kurosaki | 2006 | Japanese Journal of Ophthalmology2006，，3： | 1 |
| 17 | Significance of postmortem biochemistry in determining the cause of death显示文摘 | HITOSHI MAEDA BAO-LI ZHU TAKAKI ISHIKAWA | | 0，，01： | 1 |
| 18 | Expressions of Vascular Endothelial Growth Factor in Nonparenchymal as Well as Parenchymal Cells in Rat Liver after Necrosis显示文摘 | Keiko Ishikawa Satoshi Mochida Shoji Mashiba Mie Inao Astushi Matsui Hitoshi Ikeda Akihiko Ohno Masabumi Shibuya Kenji Fujiwara | 1999 | Biochemical and Biophysical Research Communications1999，，3： | 1 |
| 19 | Risk factors of late rectal bleeding after carbon ion therapy for prostate cancer显示文摘 | Hitoshi Ishikawa Hiroshi Tsuji Tadashi Kamada Naoki Hirasawa Takeshi Yanagi Jun-Etsu Mizoe Koichiro Akakura Hiroyoshi Suzuki Jun Shimazaki Hirohiko Tsujii | 2006 | International Journal of Radiation Oncology Biology Physics2006，，4： | 1 |
| 20 | Stability of endogenous reference genes in postmortem human brains for normalization of quantitative real-time PCR data: comprehensive evaluation using geNorm, NormFinder, and BestKeeper显示文摘 | Qi Wang Takaki Ishikawa Tomomi Michiue Bao-Li Zhu Da-Wei Guan Hitoshi Maeda | 2012 | International Journal of Legal Medicine2012，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员