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| 1 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 2 | Assessment of Iron Bioavailability in Ten Kinds of Chinese Wheat Flours Using an in vitro Digestion/Caco-2 cell Model显示文摘Objective To compare iron bioavailability (Fe BV) from ten selected kinds of Chinese wheat flours in order to provide scientific basis for further human trials and enable plant breeding programs to screen biofortified wheat cultivars. Methods An in vitro digestion/Caco-2 cell model was used to assess Fe BV of ten flour samples from six leading Chinese wheat cultivars and the stability of Fe BV in one cultivar was studied across three growing environments. Results Significant differences were observed in both Fe BV and Fe bioavailability per gram of food (Fe BVPG) among cultivars (P<0.01) grown at the same location with the same flour extraction rate. Zhongyou 9507 and Jingdong 8 had Fe BV 37%-54% and Fe BVPG 103%-154% higher than the reference control. In the Anyang environment, Zhongyou 9507 had a higher wheat flour-Fe level and Fe BVPG. Differences in Fe BV were detected in cultivars with different flour extraction rates. Conclusion Zhongyou 9507 and Jingdong 8 were identified as the most promising cultivars for further evaluation of efficacy by using human subjects. The growing environments had no effect on Fe BV, but did have a significant effect on Fe BVPG. Fe bioavailabilities in low-extraction (40%) flours were higher than those in high-extraction (78%) flours. | LEI Ji ZHANG Yong CHEN Xiang Gui ZHANG Ming Qiu BAI Lin HUANG Cheng Yu Ortiz Monasterio IVAN | 2012 | Biomedical and Environmental Sciences2012，25，5： | 5 |
| 3 | Fate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste显示文摘 | Chee-Sanford Joanne C Mackie Roderick I Koike Satoshi Krapac Ivan G Lin Yu-Feng Yannarell Anthony C Maxwell Scott Aminov Rustam I | 2009 | Journal of Environmental Quality2009，，3： | 3 |
| 4 | Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings显示文摘 | Jameson Forster Ivan Damjanov Zhiyue Lin Irene Sarosiek Paul Wetzel Richard W. McCallum | 2005 | Journal of Gastrointestinal Surgery2005，，1： | 2 |
| 5 | Thermophysical propcrties of biporous heat pipe evaporators显示文摘 | TADEJ S LIN Ying-Yu IVAN C | 2008 | Journal of Heat Transfer2008，，： | 1 |
| 6 | Early initiation of eptifibatide in the emergency department before primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Results of the Time to Integrilin Therapy in Acute Myocardial Infarction (TITAN)-TIMI 34 trial显示文摘 | C. Michael Gibson Ajay J. Kirtane Sabina A. Murphy Steve Rohrbeck Venu Menon Jeffrey Lins Samer Kazziha Ivan Rokos Nicolas W. Shammas Theresa M. Palabrica Polly Fish Carolyn H. McCabe Eugene Braunwald | 2006 | American Heart Journal2006，，4： | 1 |
| 7 | Absence of the interstitial cells of cajal in patients with gastroparesis and correlation with clinical findings显示文摘 | Jameson Forster M.D. Ivan Damjanov M.D. Zhiyue Lin M.S. Irene Sarosiek M.D. Paul Wetzel M.D. Richard W. McCallum M.D | 2005 | Journal of Gastrointestinal Surgery2005，，1： | 1 |
| 8 | An ontology-based approach to acquiring domain knowledge for requirement analysis 显示文摘 | qChau-Young Ivan Lin Cheng-Seen HO | 2000 | Proc Natl Sci Count ROC(A)2000，24，1： | 1 |
| 9 | Characterization and functional analysis of the porcine lactoferrin gene promoter显示文摘 | Shih-Rong Jyhshium Lin Ivan Chen Cheng | 1998 | Gene1998，215，： | 1 |
| 10 | Power - aware localized routing in wireless networks 显示文摘 | Ivan Stojmenovic Xu Lin | 2001 | IEEE transactions on parallel and distributed systems2001，12，11： | 1 |
| 11 | Absence of the interstitial cells of cajal in patients with gastroparesis and correlation with clinical findings显示文摘 | Jameson Forster M.D. Ivan Damjanov M.D. Zhiyue Lin M.S. Irene Sarosiek M.D. Paul Wetzel M.D. Richard W. McCallum M.D | 2005 | Journal of Gastrointestinal Surgery2005，，1： | 1 |
| 12 | New Hexatic Liquid Phase Observed in Lyotropic Thin Films 显示文摘 | Chih-Yu Chao Ming-tsong Hsu Wen-Jiunn Hsieh John T Ho and Ivan J B Lin | 2004 | Physical Review Letters2004，，： | 1 |
| 13 | Fate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste显示文摘 | Chee-Sanford Joanne C Mackie Roderick I Koike Satoshi Krapac Ivan G Lin Yu-Feng Yannarell Anthony C Maxwell Scott Aminov Rustam I | 2009 | Journal of Environmental Quality2009，，3： | 1 |
| 14 | Ethanolic Extract of Fructus Alpinia oxyphylla Protects Against 6-Hydroxydopamine-Induced Damage of PC12 Cells In Vitro and Dopaminergic Neurons in Zebrafish显示文摘 | Zai-Jun Zhang Lorita C. V. Cheang Mei-Wei Wang Guo-Hui Li Ivan K. Chu Zhi-Xiu Lin Simon M. Y. Lee | 2012 | Cellular and Molecular Neurobiology2012，，1： | 1 |
| 15 | Use of Bi-Porous Wicks to Remove High Heat Fluxes显示文摘 | Semenic Tadej Lin Yingyu Catton Ivan | 2008 | Applied Thermal Engi- neering2008，28，： | 1 |
| 16 | sopharyngeal carcinoma显示文摘 | Qiu SF Lin SJ Ivan WK et ahIntensity modulated radiation therapy in the salvage of locally recurrent na | 2012 | nt J Radiat Oncol Biol Phys2012，83，2： | 1 |
| 17 | Nonbina- ry LDPO-coded mode-multiplexed coherent optical OFDM 1,28-Tbit/s 16-QAM signal transmission over 2000km of few-mode fibers with mode-dependent Ioss显示文摘 | LIN Chang-yu Ivan B Djordjevic Ding Zou | 2012 | IEEE Pho- tonics Journal2012，4，5： | 1 |
| 18 | Thermo-Physical Properties of Biporous Heat Pipe Evaporators显示文摘 | Semenic Tadej Lin Ying Yu Catton Ivan | 2008 | Journal of Heat Transfer2008，130，： | 1 |
| 19 | Absence of the interstitial cells of cajal in patients with gastroparesis and correlation with clinical findings显示文摘 | Jameson Forster M.D. Ivan Damjanov M.D. Zhiyue Lin M.S. Irene Sarosiek M.D. Paul Wetzel M.D. Richard W. McCallum M.D | 2005 | Journal of Gastrointestinal Surgery2005，，1： | 1 |
| 20 | Metal-containing ionic liquids and ionic liquid crystals based on imidazolium moiety显示文摘 | Ivan J.B. Lin Chandra Sekhar Vasam | 2005 | Journal of Organometallic Chemistry2005，，15： | 1 |
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