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| 1 | Diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction显示文摘To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction,23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction.The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days.The diffusion coefficient remained unchanged.Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction. | Ruiman Xie Min Fang Linjiang Zhou Shanghua Fan Jianying Liu Hongbo Quan Man Luo Dongying Qiu | 2012 | Neural Regeneration Research2012，7，12： | 20 |
| 2 | Allowance and allocation of industrial volatile organic compounds emission in China for year 2020 and 2030显示文摘As an effective pollution control method, emission allowance and allocation just implemented in volatile organic compounds(VOCs) control strategy of China in 2016. This article presents a possible way to set the emission allowance targets and establishes an allowance allocation model for the object year, 2020 and 2030, using 2010 as the reference year. On the basis of regression and scenario analysis method, the emission allowance targets were designed,which were 17.902 Tg and 18.224 Tg for 2020 and 2030, with an increasing rate of 28.75% and31.06% compared to 2010. From the perspective of industries, processes using VOCscontaining products, like machinery and equipment manufacturing, would continue to be the most significant industrial VOCs emission sources in the future of China. Four allocation indicators were selected, which are per capita GDP of each province, per capita industrial VOCs emission of each province, the economic contribution of industrial sector to regional economy of each province, and the emission intensity per land area of each province, respectively.Based on information entropy, the weights of the indicators were calculated and an emission allocation model was established, and the results showed that provinces like Shandong,Jiangsu, Guangdong, Zhejiang and Fujian were calculated to obtain more emission allowance while burden more reduction responsibility. Meanwhile, provinces like Guizhou, Ningxia,Hainan, Qinghai and Xizang were on the contrary. This paper suggests governments to enhance or ease to industrial VOCs reduction burden of each province in order to stimulate its economy or change its way of economy development. | Jiani Zhang Jingfang Xiao Xiaofang Chen Xiaoming Liang Liya Fan Daiqi Ye | 2018 | Journal of Environmental Sciences2018，30，7： | 13 |
| 3 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 4 | Transgenic breeding of anti-Bombyx mori L. nuclear polyhedrosis virus silkworm Bombyx mori显示文摘对 Bombyx 粗腐殖质 i L 抵抗的蚕紧张。原子 polyhedrosis 病毒通过转基因的实验被获得。与一个 A3 倡导者一起的小猪用绳子拖的平底渡船 transposon 随机被插入到蚕,驾驶进蚕染色体的提高的绿荧光灯的蛋白质(EGFP ) 记者基因。聚合酶链反应结果证实体外的 EGFP 基因的插入,和荧光显微镜学证明 EGFP 在中间的内脏织物被表示。原子 polyhedrosis 的病态比率在转基因的蚕紧张在原来的蚕紧张从 90% 减少了到 66.7% 。与到 Bombyx 粗腐殖质 i L 的抵抗相比。在 Qiufeng 紧张的原子 polyhedrosis 病毒,通常在生产被使用,有在转基因的蚕的 33 个百分的点的增加。在 ChunhuaxQiuyue 紧张的 antivirotic 特性,从一个不同转基因的家庭被引起,比在 QiufengxBaiyu,另一个生气品种在生产使用了高是大约 10 个百分的点。我们的结果在繁殖 anti-BmNPV 蚕紧张显示了插入 transposon 的变化的好申请价值。 | Huijuan Yang Wei Fan Hao Wei Jinwei Zhang Zhonghua Zhou Jianying Li Jianrong Lin Nong Ding Boxiong Zhong | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 6 |
| 5 | Dose-dense paclitaxel plus carboplatin vs.epirubicin and cyclophosphamide with paclitaxel as adjuvant chemotherapy for high-risk triple-negative breast cancer显示文摘Objective:The objective of this open-label,randomized study was to compare dose-dense paclitaxel plus carboplatin(PCdd)with dose-dense epirubicin and cyclophosphamide followed by paclitaxel(ECdd-P)as an adjuvant chemotherapy for early triple-negative breast cancer(TNBC).Methods:We included Chinese patients with high recurrence risk TNBC who underwent primary breast cancer surgery.They were randomly assigned to receive PCdd[paclitaxel 150 mg/m2 on d 1 and carboplatin,the area under the curve,(AUC)=3 on d 2]or ECdd-P(epirubicin 80 mg/m2 divided in 2 d and cyclophosphamide 600 mg/m2 on d 1 for 4 cycles followed by paclitaxel 175 mg/m2 on d 1 for 4 cycles)every 2 weeks with granulocyte colony-stimulating factor(G-CSF)support.The primary endpoint was 3-year disease-free survival(DFS);the secondary endpoints were overall survival(OS)and safety.Results:The intent-to-treat population included 143 patients(70 in the PCdd arm and 73 in the ECdd-P arm).Compared with the ECdd-P arm,the PCdd arm had significantly higher 3-year DFS[93.9%vs.79.1%;hazard ratio(HR)=0.310;95%confidence interval(95%CI),0.137-0.704;log-rank,P=0.005]and OS(98.5%vs.92.9%;HR=0.142;95%CI,0.060-0.825;log-rank,P=0.028).Worse neutropenia(grade 3/4)was found in the ECdd-P than the PCdd arm(47.9%V5.21.4%,P=0.001).Conclusions:PCdd was superior to ECdd-P as an adjuvant chemotherapy for early TNBC with respect to improving the 3-year DFS and OS.PCdd also yielded lower hematological toxicity.Thus,PCdd might be a preferred regimen for early TNBC patients with a high recurrence risk. | Qing Li Jiani Wang Yuxin Mu Tongtong Zhang Ying Han Jiayu Wang Qiao Li Yang Luo Fei Ma Ying Fan Pin Zhang Binghe Xulj | 2020 | Chinese Journal of Cancer Research2020，32，4： | 4 |
| 6 | A novel glasses-free virtual reality rehabilitation system on improving upper limb motor function among patients with stroke:A feasibility pilot study显示文摘Background:Virtual reality(VR)technology is increasingly used in stroke rehabilitation.This study aimed to investigate the effectiveness of using the glasses-free VR training to improve motor function of upper limb in patients with stroke.Methods:Twelve patients with stroke were recruited to participate in the intervention of 3 weeks.At the baseline and post intervention,two times of evaluation including Fugl-Meyer upper-extremity scale(FMS-UE),transcranial magnetic stimulation(TMS)measurement and motion evaluation were performed.Results:No significant difference was observed between two groups at baseline evaluation.After the intervention,the FMS-UE scores presented a greater improvement in the VR group compared with the control group.TMS measurement showed that there was significant difference in cortex latency and central motor conduction time between two groups after the intervention,but no significant difference in the amplitude of motor event potential was observed.In addition,there was a significant correlation between game scores and FMS-UE scores.Conclusions:The novel glasses-free VR training was at least as effective as conventional occupational therapy in upper limb motor function,improving nerve conduction time and corticospinal excitability in patient with stroke. | Haoyu Xie Hantao Zhang Haowen Liang Hang Fan Jianying Zhou Wai Leung Ambrose Lo Le Li | 2021 | Medicine in Novel Technology and Devices2021，，3： | 2 |
| 7 | Ag/AgBr/Co–Ni–NO<sub>3</sub> Layered Double Hydroxide Nanocomposites with Highly Adsorptive and Photocatalytic Properties显示文摘 | Hai Fan Jianying Zhu Jianchao Sun Shenxiang Zhang Shiyun Ai | 2012 | Chem Eur J2012，，7： | 1 |
| 8 | Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non-small-cell lung cancer characterizes the features of response to PD-1 blockade plus chemotherapy显示文摘Background:Although programmed cell death 1(PD-1)blockade plus chemotherapy can significantly prolong the progression-free survival(PFS)and overall survival(OS)in first-line settings in patients with driver-negative advanced non-small-cell lung cancer(NSCLC),the predictive biomarkers remain undetermined.Here,we investigated the predictive value of tumor immune microenvironmental marker expression to characterize the response features to PD-1 blockade plus chemotherapy.Methods:Tumor tissue samples at baseline were prospectively collected from 144 locally advanced or metastatic NSCLC patients without driver gene alterations who received camrelizumab plus chemotherapy or chemotherapy alone.Tumor immune microenvironmental markers,including PD-1 ligand(PDL1),CD8,CD68,CD4 and forkhead box P3,were assessed using multiplex immunofluorescence(mIF)assays.Kaplan-Meier curveswere used to determine treatment outcome differences according to their expression status.Mutational profiles were compared between tumors with distinct expression levels of these markers and their combinations.Results:Responders had significantly higher CD8/PD-L1(P=0.015)or CD68/PD-L1 co-expression levels(P=0.021)than non-responders in the camrelizumab plus chemotherapy group,while no difference was observed in the chemotherapy group.Patients with high CD8/PD-L1 or CD68/PD-L1 co-expression level was associated with significantly longer PFS(P=0.002,P=0.024;respectively)and OS(P=0.006,P=0.026;respectively)than those with low co-expression in camrelizumab plus chemotherapy group.When comparing survival in the camrelizumab plus chemotherapy with chemotherapy by CD8/PD-L1 co-expression stratification,significantly better PFS(P=0.003)and OS(P=0.032)were observed in high co-expression subgroups.The predictive value of CD8/PD-L1 and CD68/PD-L1 co-expression remained statistically significant for PFS and OS when adjusting clinicopathological features.Although the prevalence of TP53 or KRAS mutations was similar between patients with and without CD8/PD-L1 or CD68/PD-L1 co-expression,the positive groups had a significantly higher proportion of TP53/KRAS co-mutations than the negative groups(both 13.0%vs.0.0%,P=0.023).Notably,enriched PI3K(P=0.012)and cell cycle pathway(P=0.021)were found in the CD8/PD-L1 co-expression group.Conclusion:Tumor immune microenvironmental marker expression,especially CD8/PD-L1 or CD68/PD-L1 co-expression,was associated with the efficacy of PD-1 blockade plus chemotherapy as first-line treatment in patients with advanced NSCLC. | Fengying Wu Tao Jiang Gongyan Chen Yunchao Huang Jianying Zhou Lizhu Lin Jifeng Feng Zhehai Wang Yongqian Shu Jianhua Shi Yi Hu Qiming Wang Ying Cheng Jianhua Chen Xiaoyan Lin Yongsheng Wang Jianan Huang Jiuwei Cui Lejie Cao Yunpeng Liu Yiping Zhang Yueyin Pan Jun Zhao LiPing Wang Jianhua Chang Qun Chen Xiubao Ren Wei Zhang Yun Fan Zhiyong He Jian Fang Kangsheng Gu Xiaorong Dong Tao Zhang Wei Shi Jianjun Zou Xuejuan Bai Shengxiang Ren Caicun Zhou | 2022 | Cancer Communications2022，42，12： | 1 |
| 9 | Expression of p73, ER and PR in esophageal carcinoma and precancerous lesions显示文摘Objective:To test the expression of mutant p73,p53,ER and PR proteins in the esophageal normal mucosa,hyperplasia,dysplasia and squamous cell carcinoma,and research the clinically pathological significance and the correlation,for the early diagnosis,prognostic measure and therapy in clinic.Methods:With Immunohistochemistry,it was examined to show these tumor markers’ expression in different epithelial lesions of 40 esophageal squamous cell carcinomas,14 dyspla-sias,14 hyperplasias and 14 normal mucosas.Results:The expression of p73 was 55%,21%,0% and 0% in the esophageal carcinoma,dysplasia,hyperplasia and normal mucosa,respectively.The significant difference in expression of p73(P<0.001)was observed between the esophageal normal mucosia,hyperplasia,dysplasia and esophageal squamous cell carcinoma with Fisher’s exact test.Difference in expression of p73(P<0.05)was observed between the esophageal squamous cell carcinoma and dysplasia with χ2 test.The expression of p73 showed non-correlation with the patient’s age,sex,tumor’s grade,lymph-node metastasis and invasive depth(P>0.05);Similarly,the expression of mutant p53 was 67.5%,35.7%,7% and 0%,respectively;In like manner,the expression of ER was 55%,21.4%,14.2% and 0%,respectively;The expression of PR was 57.5%,14.28%,0% and 0%,respectively.The significant difference in expression of PR(P<0.001)was observed with Fisher’s exact test.Difference in expression of PR(P<0.05)was observed between the esophageal squamous cell carcinoma and dysplasia with χ2 test.The expression of PR(P<0.05)was correlated with lymph-node metastasis,and showed non-correlation with the patient’s age,sex,tumor’s grade,and invasive depth(P>0.05).Moreover,over-expression of mutant p53 and p73 showed significant correlation with ER and PR protein’s positive expression(P<0.05).Conclusion:P73 protein may become a new tumor’s marker to diag-nose esophageal squamous cell carcinoma.Because the expression of p73 protein was closely correlated with ER and PR,they could be simultaneously examined to help to early diagnose,prognosticate and cure esophageal carcinoma. | Sheng Fan Jie Ai Jun Wang Jiani Fan Xiaoguang Guo Suping Guo Xiaofeng Liu Jianping Wei | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，6： | 1 |
| 10 | Prevalence and characteristics of macrosomia in the first and subsequent pregnancy: a multi-center retrospective study显示文摘To the Editor:Macrosomia is of growing prevalence and concern worldwide.In China,there has been a marked increase in the prevalence of macrosomia over the past few decades as a result of economic development and improvements in living standards. | Juan Juan Huixia Yang Yumei Wei Geng Song Rina Su Xu Chen Ruiqin Shan Jianying Yan Mei Xiao Ying Li Shihong Cui Xianlan Zhao Shangrong Fan Ling Feng Meihua Zhang Yuyan Ma Zishan You Haixia Mengn Haiwei Liu Jingxia Sun Yan Cai Kejia Hu | 2022 | Chinese Medical Journal2022，，12： | 1 |
| 11 | Large-area ultracompact pixelated aluminumwire-grid-based metamaterials for Vis-NIR full-Stokes polarization imaging显示文摘The study of pixelated metamaterials that integrate both the functions of linear and circular polarization filters is rapidly growing due to the need for full-Stokes polarization imaging. However, there is a lack of large-area, ultracompact pixelated full-Stokes metamaterials with excellent performance, especially circular polarization filters with a high extinction ratio, a broad operating bandwidth, and a low-cost, high-quality, efficient manufacturing process, which limits the practical applications of pixelated full-Stokes metamaterials. In this study, we propose a universal design and fabrication scheme for large-area, ultracompact pixelated aluminum wire-grid-based metamaterials used in Vis-NIR full-Stokes polarization imaging. The aluminum wire-grid was designed as a linear polarization filter with an average linear polarization extinction ratio of 36,000 and a circular polarization filter with an average circular polarization extinction ratio of 110 in Vis-NIR. A large-area, ultracompact 320 × 320pixelated aluminum wire-grid-based full-Stokes metamaterial was fabricated using nanoimprint lithography and nano transfer printing with the advantages of low cost and high efficiency. This metamaterial was used to achieve full-Stokes polarization imaging with errors within 8.77%, 12.58%, 14.04%, and 25.96% for Stokes parameters S_(0), S_(1), S_(2), and S_(3), respectively. The inversion errors of the compensated Stokes parameters can be reduced to0.21%, 0.21%, 0.42%, and 1.96%, respectively. | YUANYI FAN JINKUI CHU RAN ZHANG CHUANLONG GUAN JIANYING LIU | 2023 | Photonics Research2023，11，11： | 0 |
| 12 | Formation mechanism of tight sandstone gas in areas of low hydrocarbon generation intensity: A case study of the Upper Paleozoic in north Tianhuan depression in Ordos Basin, NW China显示文摘The Upper Paleozoic in the north part of Tianhuan depression in the Ordos Basin,NW China has lower hydrocarbon generation intensity and complex gas-water relationship,the main factors controlling the formation of tight sandstone gas and the distribution of tight sandstone gas in the low hydrocarbon generation intensity area are studied.Through two-dimensional physical simulation experiment of hydrocarbon accumulation,analysis of reservoir micro-pore-throat hydrocarbon system and dissection of typical gas reservoirs,the evaluation models of gas injection pressure,reservoir physical property,and gas generation threshold were established to determine the features of tight gas reservoirs in low hydrocarbon intensity area:(1)at the burial depth of less than 3 000 m,the hydrocarbon generation intensity ofis high enough to maintain effective charging;(2)tight sandstone in large scale occurrence is conducive to accumulation of tight gas;(3)differences in reservoir physical property control the distribution of gas pool,for the channel sandstone reservoirs,ones with better physical properties generally concentrate in the middle of sandstone zone and local structural highs;ones with poor physical properties have low gas content generally.Based on the dissection of the gas reservoir in the north Tianhuan depression,the formation of tight gas reservoirs in low hydrocarbon generating intensity area are characterized by'long term continuous charging under hydrocarbon generation pressure,gas accumulation in large scale tight sandstone,pool control by difference in reservoir physical property,and local sweet spot',and the tight gas pools are distributed in discontinuous'sheets'on the plane.This understanding has been proved by expanding exploration of tight sandstone gas in the north Tianhuan depression. | ZHANG Fudong LI Jun WEI Guoqi LIU Xinshe GUO Jianying LI Jian FAN Liyong SHE Yuanqi GUAN Hui YANG Shen SHAO Liyan | 2018 | Petroleum Exploration and Development2018，45，1： | 0 |
| 13 | Study on Extraction and Properties of Gelatin from Squid Skin显示文摘A kind of aquatic gelatin was prepared from squid skin. The technological parameters for extracting gelatin were optimized by the method of orthogonal design. The fundamental properties of the raw material and gelatin were analyzed. The results showed that the optimal extraction conditions were as follows: pH value of 8,temperature at 70 ℃,material-to-liquid ratio at 1∶ 4,and extraction time of 1. 5 h. under such conditions,the highest yield of gelatin and the purity were 5. 94% and 96. 73%,respectively. The physicochemical properties of squid skin gelatin were coincided with standards of edible gelatin. In addition,the contents of amino acids were similar to many kinds of aquatic gelatin. | Feng ZHU Lin ZHU Mei ZHU Xiaomei ZHU Jun GUO Xuiling FAN Cuiping XIE Min ZHAO Rui WANG Hairong LUO Jianying WANG Yuxi LI Wenfeng SONG Ningning XIE | 2017 | Agricultural Biotechnology2017，6，3： | 0 |
| 14 | Transcriptome Analysis and Morphological Changes in Response to Waterlogging in Iris pseudacorus显示文摘Iris pseudacorus is a widely cultivated and studied ornamental plant with a large biomass,strong adaptability and extensive management.Moreover,it has the ability to decontaminate and enrich heavy metals.However,few studies have been conducted on its submergence tolerance with little known about the molecular response of I.pseudacorus to flooding.Morphologically,I.pseudacorus had strong adaptability to waterlogging,the aerenchyma was gradually enlarged and adventitious roots developed between 0 and 14 d.The transcriptome data showed that the differentially expressed genes counts in plants flooded for 2 h,4 h,12 h and 24 h compared with the unflooded controls were 3555,9439,10734,and 4997,respectively.For GO term entries enriched by different genes,many biological processes,cell components and molecular processes in the I.pseudacorus roots were affected by flooding stress.Pathways enrichment analysis showed DEGs involved in hormone signal transduction pathways,glucose metabolism,glycolysis,and fermentation.The quantitative real-time PCR analysis of DEGs was basically consistent with the trend of transcriptome data,indicating reliability of the transcriptome data.The transcriptome analysis showed that formation of aerenchyma and adventitious roots was mainly induced by IAA(auxin)and accompanied by other hormone signals.Energy production was the primary coping mechanism of I.pseudacorus when aerenchyma was not sufficiently enlarged under water flooding.These results laid a foundation for further study on the mechanism of submerging-tolerance of I.pseudacorus and other aquatic plants. | Xiaofang Yu Linjie Yue Qing Wu Liu Yang Chunyu Fan Zhiwen Wang Jiani Hu | 2022 | Phyton-International Journal of Experimental Botany2022，91，10： | 0 |
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