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| 1 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 2 | The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu | 2018 | Genes & Diseases2018，5，1： | 4 |
| 3 | Coevolution study of mitochondria respiratory chain proteins:Toward the understanding of protein-protein interaction显示文摘Coevolution can be seen as the interdependency between evolutionary histories.In the context of protein evolution,functional correlation proteins are ever-present coordinated evolutionary characters without disruption of organismal integrity.As to complex system,there are two forms of protein—protein interactions in vivo,which refer to inter-complex interaction and intra-complex interaction.In this paper,we studied the difference of coevolution characters between inter-complex interaction and intra-complex interaction using 'Mirror tree' method on the respiratory chain(RC) proteins.We divided the correlation coefficients of every pairwise RC proteins into two groups corresponding to the binary protein—protein interaction in intra-complex and the binary protein—protein interaction in inter-complex,respectively.A dramatical discrepancy is detected between the coevolution characters of the two sets of protein interactions(Wilcoxon test,p-value = 4.4×10^(-6)).Our finding reveals some critical information on coevolutionary study and assists the mechanical investigation of protein—protein interaction. Furthermore,the results also provide some unique clue for supramolecular organization of protein complexes in the mitochondrial inner membrane.More detailed binding sites map and genome information of nuclear encoded RC proteins will be extraordinary valuable for the further mitochondria dynamics study. | Ming Yang Yan Ge Jiayan Wu Jingfa Xiao Jun Yu | 2011 | Journal of Genetics and Genomics2011，38，5： | 3 |
| 4 | Vascular endothelial growth factor induces multidrug resistance-associated protein 1 overexpression through phosphatidylinositol-3-kinase/protein kinase B signaling pathway and transcription factor specificity protein 1 in BGC823 cell line显示文摘Multidrug 抵抗(MDR ) 是化疗失败和癌复发的最重要的原因之一。但是 rolesof 在 MDR 遗体的联系 MDR 的蛋白质 MRP1 糟糕理解。脉管的 endothelial 生长因素(VEGF ) , themost 之一活跃、特定的脉管的生长因素,在增长,区别,和 metastasisof 癌症起一个重要作用。在 MRP1 的表示上探索 VEGF 的效果,我们使用了 recombinant 人 VEGF 刺激 K562 andBGC-823 房间线。量的即时聚合酶链反应和西方的污点分析证明在 mRNA 和蛋白质层次的 expressionof MRP1 被增加。3-(4,5-Dimethylthiazol-2-yl )-2,5-diphenyl tetrazolium 溴化物 resultsalso 证明 VEGF 显著地提高了与 adriamycin 对待的房间的 IC 50 。探索内在的规章的机制,我们构造了 MRP1 倡导者和 theluciferase 记者基因 recombinant 向量。,酶记者基因试金证明 MRP1 倡导者的活动被 VEGF 刺激显著地增加 LY294002, phosphatidylinositol-3-kinase (PI3K ) 的一个禁止者表明小径的 /proteinkinase B (Akt ) ,减少了这效果。抄写因素特性蛋白质 1 (SP1 ) 有约束力的地点 mutationpartially 由 VEGF 堵住了 MRP1 倡导者活动的起来规定。在摘要,我们的结果表明了 MRP1 的那 VEGF enhancedthe 表情,并且表明小径和 SP1 的 PI3K/Akt 可以涉及这调整。 | Juan Li Xiaojun Wu Jinling Gong Jing Yang Jiayan Leng Qiaoyun Chen Wenlin Xu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 2 |
| 5 | The 1 PW/0.1 Hz laser beamline in SULF facility显示文摘In this paper,we report the recent progress on the 1 PW/0.1 Hz laser beamline of Shanghai Superintense Ultrafast Laser Facility(SULF).The SULF-1 PW laser beamline is based on the double chirped pulse amplification(CPA)scheme,which can generate laser pulses of 50.8 J at 0.1 Hz after the final amplifier;the shot-to-shot energy fluctuation of the amplified pulse is as low as 1.2%(std).After compression,the pulse duration of 29.6 fs is achieved,which can support a maximal peak power of 1 PW.The contrast ratio at-80 ps before main pulse is measured to be 2.5×10^-11.The focused peak intensity is improved by optimizing the angular dispersion in the grating compressor.The maximal focused peak intensity can reach 2.7×10^19W/cm2 even with an f/26.5 off-axis parabolic mirror.The horizontal and vertical angular pointing fluctuations in 1 h are measured to be 1.89 and 2.45μrad,respectively.The moderate repetition rate and the good stability are desirable characteristics for lasermatter interactions.The SULF-1 PW laser beamline is now in the phase of commissioning,and preliminary experiments of particle acceleration and secondary radiation under 300–400 TW/0.1 Hz laser condition have been implemented.The progress on the experiments and the daily stable operation of the laser demonstrate the availability of the SULF-1 PW beamline. | Zongxin Zhang Fenxiang Wu Jiabing Hu Xiaojun Yang Jiayan Gui Penghua Ji Xingyan Liu Cheng Wang Yanqi Liu Xiaoming Lu Yi Xu Yuxin Leng Ruxin Li Zhizhan Xu | 2020 | High Power Laser Science and Engineering2020，8，1： | 2 |
| 6 | Photothermal treatment with EGFRmAb-AuNPs induces apoptosis in hypopharyngeal carcinoma cells via PI3K/AKT/mTOR and DNA damage response pathways显示文摘 | Yingying Zhang Linhai Cong Jiayan He Yu Wang Yingying Zou Zhihong Yang Yuexin Hu Shiwen Zhang Xiaoguang He | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 2 |
| 7 | The Kuroshio Extension: a leading mechanism for the seasonal sea-level variability along the west coast of Japan显示文摘 | Chao Ma Jiayan Yang Dexing Wu Xiaopei Lin | 2010 | Ocean Dynamics2010，，3： | 1 |
| 8 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 9 | Synergistic Effects of Salt Concentration and Working Temperature towards Dendrite-Free Lithium Deposition显示文摘The lithium-(Li-)metal anode is crucial for developing high-energy-density batteries,while its dendritic growth and the low charge/discharge Coulombic efficiency in organic electrolytes hinder its practical application.Herein,we employed an in situ optical microscope to investigate the effect of the electrolyte concentration and the working temperature on the Li-plating/-stripping process.It is found that a higher concentration electrolyte can suppress its side reaction to improve the charge/discharge Coulombic efficiency,and a higher temperature can help lithium plate/strip uniformly with less lithium dendritic growth.An average Coulombic efficiency was obtained as high as 99.2%for over 150 cycles with a fixed plating capacity of 2 mAh cm^(-2) on copper foil in a 3 mol/kg ether-based electrolyte under 60℃,which provides an efficient and facile strategy for developing high-performance Li-metal batteries. | Panlong Li Chao Li Yang Yang Chanyuan Zhang Renhe Wang Yao Liu Yonggang Wang Jiayan Luo Xiaoli Dong Yongyao Xia | 2019 | Research2019，，1： | 1 |
| 10 | Research and Practice of Flexibility in Distribution Systems:A Review显示文摘Flexibility in energy systems can support the operation of the electricity grid by providing active and reactive power to avoid voltage limit violations or congestion.Active distribution networks can provide this flexibility by implementing systems to control distributed generators,storage or loads.Additionally,power flow controlling devices can be used to implement operational flexibility in the energy system.This paper presents concepts for planning and forecasting of flexibility,monitoring of energy systems and control of flexibility from active distribution networks(ADNs)to enable the use of flexibility in future power systems. | Stefan Dalhues Yang Zhou Oliver Pohl Florian Rewald Fabian Erlemeyer Dennis Schmid Jannik Zwartscholten Zita Hagemann Christian Wagner Daniel Mayorga Gonzalez Hua Liu Mingmin Zhang Jiayan Liu Christian Rehtanz Yong Li Yijia Cao | 2019 | CSEE Journal of Power and Energy Systems2019，5，3： | 1 |
| 11 | Effect of Different Electron Donating Groups on thePerformance of Dye-Sensitized Solar Cells 显示文摘 | TIAN Haining YANG Xichuan CONG Jiayan | 2010 | Dyes and Pigments2010，84，1： | 1 |
| 12 | Processable Potassium Metal Anode for Stable Batteries显示文摘The future of high-energy density electrochemical energy storage systems relies on the advancement of rechargeable batteries that utilize reactive metals as anodes.In the alkaline metal,secondary battery systems because of abundant resource,high capacity and low redox potential,potassium(K)metal secondary battery(KMB)is expected to replace the existing lithiumion battery as a versatile platform for high-energy density,cost-effective energy storage devices.However,the difficulty in processing metal K results in nonstandard electrodes and hinders the development of KMBs.Furthermore,the mobility of the K metal anode due to its unique lowmelting point character at elevated temperatures in practical conditions leads to severe instability and risks in chemical/electrochemical processes.Herein,we fabricate a processable and moldable composite K metal anode by encapsulating K into reduced graphene oxide(rGO).The composite electrode can be engineered into various shapes discretionarily with precise sizes and stabilize the K metal anode at relatively high temperatures.Remarkably,the composite anode exhibits excellent cycling performance at high current density(8 mA cm^(-2)) with dendrite-free morphology.Paired with a Prussian blue cathode,the rGO-K composite anode shows much improved electrochemical performance and extended lifetime. | Zhenghang Wei Aoxuan Wang Xuze Guan Guojie Li Zhiwei Yang Chengde Huang Jing Zhang Libin Ren Jiayan Luo Xingjiang Liu | 2022 | Energy & Environmental Materials2022，5，4： | 0 |
| 13 | Defect and interface control on graphitic carbon nitrides/upconversion nanocrystals for enhanced solar hydrogen production显示文摘The effective utilization of solar energy for hydrogen production requires an abundant supply of thermodynamically active photo-electrons;however,the photocatalysts are generally impeded by insufficient light absorption and fast photocarrier recombination.Here,we report a multiple-regulated strategy to capture photons and boost photocarrier dynamics by devel-oping a broadband photocatalyst composed of defect engineered g-C_(3)N_(4)(DCN)and upconversion NaYF4:Yb^(3+),Tm^(3+)(NYF)nanocrystals.Through a precise defect engineering,the S dopants and C vacancies jointly render DCN with defect states to effectively extend the visible light absorption to 590 nm and boost photocarrier separation via a moderate electron-trapping ability,thus facilitating the subsequent re-absorption and utilization of upconverted photons/electrons.Importantly,we found a promoted interfacial charge polarization between DCN and NYF has also been achieved mainly due to Y-N interaction,which further favors the upconverted excited energy transfer from NYF onto DCN as verified both theoretically and experimentally.With a 3D architecture,the NYF@DCN catalyst exhibits a superior solar H2 evolution rate among the reported upconversion-based system,which is 19.3 and 1.5 fold higher than bulk material and DCN,respectively.This work provides an innovative strategy to boost solar utilization by using defect engineering and building up interaction between hetero-materials. | Xiaochun Gao Nailiang Yang Jin Feng Jiayan Liao Shaoqi Hou Xiaoguang Ma Dawei Su Xingxing Yu Ziqing Yang Javad Safaei Dan Wang Guoxiu Wang | 2023 | National Science Open2023，2，2： | 0 |
| 14 | A novel MYCN-YTHDF1 cascade contributes to retinoblastoma tumor growth by eliciting m^(6)A-dependent activation of multiple oncogenes显示文摘Retinoblastoma, the most prevalent primary intraocular tumor in children, leads to vision impairment, disability and even death.In addition to RB1 inactivation, MYCN activation has been documented as another common oncogenic alteration in retinoblastoma and represents one of the high-risk molecular subtypes of retinoblastoma. However, how MYCN contributes to the progression of retinoblastoma is still incompletely understood. Here, we report that MYCN upregulates YTHDF1, which encodes one of the reader proteins for N6-methyladenosine(m^(6)A) RNA modification, in retinoblastoma. We further found that this MYCN-upregulated m^(6)A reader functions to promote retinoblastoma cell proliferation and tumor growth in an m^(6)A bindingdependent manner. Mechanistically, YTHDF1 promotes the expression of multiple oncogenes by binding to their m RNAs and enhancing m RNA stability and translation in retinoblastoma cells. Taken together, our findings reveal a novel MYCN-YTHDF1regulatory cascade in controlling retinoblastoma cell proliferation and tumor growth, pinpointing an unprecedented mechanism for MYCN amplification and/or activation to promote retinoblastoma progression. | Yingxiu Luo Mengjia He Jie Yang Feifei Zhang Jie Chen Xuyang Wen Jiayan Fan Xianqun Fan Peiwei Chai Renbing Jia | 2023 | Science China(Life Sciences)2023，66，9： | 0 |
| 15 | Novel insights into histone lysine methyltransferases in cancer therapy:From epigenetic regulation to selective drugs显示文摘The reversible and precise temporal and spatial regulation of histone lysine methyltransferases(KMTs)is essential for epigenome homeostasis.The dysregulation of KMTs is associated with tumor initiation,metastasis,chemoresistance,invasiveness,and the immune microenvironment.Therapeutically,their promising effects are being evaluated in diversified preclinical and clinical trials,demonstrating encouraging outcomes in multiple malignancies.In this review,we have updated recent understandings of KMTs'functions and the development of their targeted inhibitors.First,we provide an updated overview of the regulatory roles of several KMT activities in oncogenesis,tumor suppression,and immune regulation.In addition,we summarize the current targeting strategies in different cancer types and multiple ongoing clinical trials of combination therapies with KMT inhibitors.In summary,we endeavor to depict the regulation of KMT-mediated epigenetic landscape and provide potential epigenetic targets in the treatment of cancers. | Qili Liao Jie Yang Shengfang Ge Peiwei Chai Jiayan Fan Renbing Jia | 2023 | Journal of Pharmaceutical Analysis2023，13，2： | 0 |
| 16 | 共营与共赢·健康社区规划显示文摘Introduction The 2020 Annual Meeting of the Housing and Community Planning Committee of the Urban Planning Society of China(UPSC)was successfully held in Xi’an on Sept.4,2020.Jointly supported by the UPSC,the Housing and Community Planning Committee of the UPSC,the School of Architecture of Tsinghua University,the Beijing Tsinghua Tongheng Urban Planning&Design Institute,and the Xi’an University of Architecture and Technology. | 尹稚 贾强 叶裕民 Liu Dongwei Duan Degang Yang Xiao Mi Weisong Zhou Jingmin Shao Lei Li Min(translated) Liu Jiayan(Proofread) | 2021 | China City Planning Review2021，30，1： | 0 |
| 17 | Chirality of Eruptive Neutral Line Indicated by Bipolar Double Dimmings显示文摘 | Yunchun Jiang Jiayan Yang Jun Zhang Jinxiu Wang | 2011 | Journal of Physical Science and Application2011，1，3： | 0 |
| 18 | PBK/TOPK promotes chemoresistance to oxaliplatin in hepatocellular carcinoma cells by regulating PTEN显示文摘Oxaliplatin(OXA)resistance limits the efficiency of treatment for hepatocellular carcinoma(HCC).Studies have shown that the PDZ-binding kinase(PBK)plays important roles in tumors.However,the role of PBK in HCC is still a problem.In this study,we explored whether PBK is involved in the chemoresistance to OXA in HCC.Expressions of PBK in six HCC cell lines and one human hepatocytes line were determined by real-time quantitative PCR and western blot analysis.SNU-182 and HepG2 cells were chosen to induce OXA resistance.PBK was silenced or overexpressed in OXA-resistant and sensitive cell lines.Then,cell proliferation,migration,and invasion were measured by cholecystokinin-8 assay and Transwell assay,respectively.The Cancer Genome Atlas dataset showed that PBK is highly expressed in HCC and signifies poor prognosis to patient with HCC.Results showed that expression of PBK in HCC cells was significantly higher than that in THLE2 cells,and it was further increased in OXA-resistant HCC cells.Silencing of PBK promoted the sensitivity of drug-resistant HCC cells to OXA.Overexpression of PBK relieved the apoptosis induced by OXA and promoted the migration and invasion of OXA-sensitive HCC cells.Thus,this study revealed that high PBK expression is correlated with OXA resistance in HCC cells,which may provide a promising therapeutic target for treating HCC. | Hongmin Cao Mei Yang Yufeng Yang Jiayan Fang Yejia Cui | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 0 |
| 19 | Corrigendum to “The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs” [Genes & Diseases 5 (2018) 62–74]显示文摘The authors regret having an image assembly error in Figure 5Ca,in which the image for the 'Oh dBiFP-AdRFp'group was erroneously duplicated with an overlapping image from the'36h BiFP dBIFP-AdR-simH19'group.We confirm the error is restricted to the image assembly,and the underlying data and conclusions are correct and unchanged.The authors would like to apologize for any inconvenience caused. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C. Haydon Hue H. Luu Lan Zhou Russell R. Reid Tong-Chuan He Xingye Wu | 2023 | Genes & Diseases2023，10，2： | 0 |
| 20 | Effects of Polysaccharides from Enteromorpha prolifera on Hepatorenal Syndrome in Mice显示文摘[Objectives]This study was conducted to evaluate the protective effect of polysaccharides from Enteromorpha prolifera(PEP)on mice with hepatorenal syndrome induced by carbon tetrachloride.[Methods]A mouse hepatorenal syndrome model was induced by carbon tetrachloride.The serum levels of lipid,total antioxidant capacity,liver and kidney function,pathological changes of liver and kidney were selected to clarity the effectiveness of PEP on hepatorenal syndrome in mice.[Results]PEP effectively lowered the serum levels of lipid,increased total antioxidant capacity,improved liver and kidney injury,and alleviated pathological changes of liver and kidney of mice induced by carbon tetrachloride.[Conclusions]PEP has a potent preventive effect on hepatorenal syndrome induced by carbon tetrachloride in mice,which provides theoretical support for future clinical application of PEP. | Shanshan WANG Jiayan ZHOU Yue HE Yating ZHOU Qiuxi YANG Qianqian YUAN Qingying DU Hanchi CHENG Suduo JIANG Xiaojuan ZHAO | 2023 | Medicinal Plant2023，14，1： | 0 |
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