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| 1 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 2 | Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy显示文摘CD8^+T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1,an interaction acts like brakes to prevent T cell overreaction under normal conditions but is exploited by tumor cells to escape the immune surveillance.Immune checkpoint inhibitors have revolutionized cancer therapeutics by removing such brakes.Unfortunately,only a minority of cancer patients respond to immunotherapies presumably due to inadequate immunity.Antitumor immunity depends on the activation of the cGAS-STING pathway,as STING-deficient mice fail to stimulate tumor-infiltrating dendritic cells(DCs)to activate CD8^+T cells.STING agonists also enhance natural killer(NK)cells to mediate the clearance of CD8^+T cell-resistant tumors.Therefore STING agonists have been intensively sought after.We previously discovered that manganese(Mn)is indispensable for the host defense against cytosolic dsDNA by activating cGAS-STING.Here we report that Mn is also essential in innate immune sensing of tumors and enhances adaptive immune responses against tumors.Mn-insufficient mice had significantly enhanced tumor growth and metastasis,with greatly reduced tumor-infiltrating CD8^+T cells.Mechanically,Mn^2+promoted DC and macrophage maturation and tumor-specific antigen presentation,augmented CD8^+T cell differentiation,activation and NK cell activation,and increased memory CD8^+T cells.Combining Mn^2+with immune checkpoint inhibition synergistically boosted antitumor efficacies and reduced the anti-PD-1 antibody dosage required in mice.Importantly,a completed phase 1 clinical trial with the combined regimen of Mn^2+and anti-PD-1 antibody showed promising efficacy,exhibiting type I IFN induction,manageable safety and revived responses to immunotherapy in most patients with advanced metastatic solid tumors.We propose that this combination strategy warrants further clinical translation. | Mengze Lv Meixia Chen Rui Zhang Wen Zhang Chenguang Wang Yan Zhang Xiaoming Wei Yukun Guan Jiejie Liu Kaichao Feng Miao Jing Xurui Wang Yun-Cai Liu Qian Mei Weidong Han Zhengfan Jiang | 2020 | Cell Research2020，30，11： | 27 |
| 3 | Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017显示文摘Objective: Breast cancer in young females was usually considered more aggressive and requires aggressive therapy. We investigated whether early detection and improved treatments changed the patterns of characteristics,management and outcomes of young breast cancer patients over time.Methods: Females under 40 years of age diagnosed with breast cancer during the periods 1999-2017 and1999-2015 were identified in the Fudan University Shanghai Cancer Center(FUSCC) and the population-based Surveillance, Epidemiology, and End Results(SEER) registry, respectively. Clinicopathologic characteristics and treatment information were collected. Patients diagnosed before 2013 were followed up.Results: The proportions of young breast cancer patients were 15.0% and 5.3% in the FUSCC and SEER cohorts, respectively. In the FUSCC cohort, there was a significant increase in the proportion of ductal carcinoma in situ(DCIS)(from 8.8% to 16.9%;P<0.0001) and it remained stable in SEER cohort. The proportion of T1-stage tumors increased dramatically in the FUSCC cohort(from 35.3% to 41.9%;P=0.008), whereas it decreased in SEER cohort(from 42.4% to 33.0%;P<0.0001). The percentage of estrogen receptor(ER)-positive cancers was consistently increased in both the invasive ductal carcinoma(IDC) and DCIS patients in the two cohorts. Breastconserving surgery and immediate implant reconstruction after mastectomy both exhibited increased use over time in the FUSCC cohort. Both the FUSCC and SEER cohorts showed a significantly better prognosis in the recent time period.Conclusions: With the increased early-stage and ER-positive diseases in young patients as well as better systemic treatment strategies, improved survival has been observed in recent years. There has been a substantial deescalation in surgical therapies in young breast cancer patients. | Rong Guo Jing Si Jingyan Xue Yonghui Su Miao Mo Benlong Yang Qi Zhang Weiru Chi Yayun Chi Jiong Wu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 24 |
| 4 | Human gut microbiota: the links with dementia development显示文摘痴呆是是足够很好的影响工作的一份人日报的大脑疾病的一个全面范畴。痴呆的最普通的类型是 Alzheimers 疾病,它做大多数盒子。新研究显示胃肠的道 microbiota 直接通过触发新陈代谢的疾病和低档发炎进步被连接到痴呆致病。新奇策略通过 ? microbiota 的调整为痴呆和另外的相关疾病的精神病学的治疗为这些混乱并且作为一个助手的管理被建议 ?( 例如与 probiotics 的使用) 。 | Rashad Alkasir Jing Li Xudong Li Miao Jin Baoli Zhu | 2017 | Protein & Cell2017，8，2： | 23 |
| 5 | Research progress on synergistic anti-tumor mechanisms of compounds inTraditional Chinese Medicine显示文摘The curative effects of Chinese herbal compounds result from the coordination of numerous natural compounds.We aimed to review the mechanism of action of Traditional Chinese Medicine(TCM)compounds(TCMC),explore the rationality of formulation theory and synergistic effects in TCM compounds,and analyze the effectiveness of drug compatibility of TCMC in molecular biology.This literature review covers the mechanisms of the anti-tumor effects of compounds,and their synergistic antitumor mechanisms.We aim to provide reference for the effective development and use of natural resources and the organic combination of TCM and modern medicine using molecular biology. | Jing Zhou Tianyao Zhou Meijuan Chen Miao Jiang Xiaoxia Wang Qin Liu Zhen Zhan Xu Zhang | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 15 |
| 6 | Projected drought conditions in Northwest China with CMIP6 models under combined SSPs and RCPs for 2015—2099显示文摘Northwest China is one of the most arid regions in the world and has experienced intriguing climate warming and humidification.Nonetheless,future climate conditions in Northwest China still remain uncertain.In this study,we applied an ensemble of the 12 latest model simulations of the Coupled Model Intercomparison Project Phase 6(CMIP6)to assess future drought conditions until 2099 in Northwest China,as inferred from the Palmer Drought Severity Index(PDSI).Future drought conditions were projected under three climate change scenarios through the combination of shared socioeconomic pathways(SSPs)and representative concentration pathways(RCPs),namely,SSP126(SSP1+RCP2.6,a green development pathway),SSP245(SSP2+RCP4.5,an intermediate development pathway),and SSP585(SSP5+RCP8.5,a high development pathway).For 2015-2099,drought severity showed no trend under SSP126,in contrast,for the SSP245 and SSP585 scenarios,a rapid increase during 2015-2099 was observed,especially under SSP585.We also found that the drought frequency in Northwest China under SSP585 was generally lower than that under SSP126 and SSP245,although the drought duration under SSP585 tended to be longer.These findings suggest the green development pathway in drought mitigation and adaptation strategies in Northwest China,an arid and agricultural region along the Silk Road. | LI Su-Yuan MIAO Li-Juan JIANG Zhi-Hong WANG Guo-Jie GNYAWALI Kaushal Raj ZHANG Jing ZHANG Hui FANG Ke HE Yu LI Chun | 2020 | Advances in Climate Change Research2020，11，3： | 14 |
| 7 | Impact of Cardiovascular Disease Deaths on Life Expectancy in Chinese Population显示文摘Objective We aimed to analyze the impact of cardiovascular disease(CVD) deaths on life expectancy(LE) in Chinese population and estimate the percentage reduction in CVD mortality needed to increase LE by 1 year from the current level, a national target of health improvement. Methods We used life tables, cause-elimination life tables, and age decomposition of LE with corrected mortality data from the National Disease Surveillance System in 2010. Results LE at birth of Chinese people was 73.24 years in 2010. Women had a longer LE than men, and urban population had a longer LE than rural population. CVD deaths resulted in a 4.79-year LE loss and premature deaths in people aged 25 to 64 years were responsible for a substantial part of LE loss from CVD. Death from ischemic heart disease and cerebrovascular diseases accounted for 69.2% of LE loss from CVD deaths and death from cerebrovascular diseases was the largest contributor. In rural men, 51.1% LE loss from CVD deaths was caused by cerebrovascular diseases. If there were no changes in mortality rates for all other diseases, a 27.4% reduction in CVD mortality would increase LE by 1 year in Chinese population. Conclusion There is a considerable impact of CVD deaths on LE. A 1-year LE increase in the future requires at least a 27.4% reduction in CVD mortality from the current level. Targeting the rural population and tackling cerebrovascular diseases are important for reaching the national goal of health improvement. | FAN Jie LI Guo Qi LIU Jing WANG Wei WANG Miao QI Yue XIE Wu Xiang LIU Jun ZHAO Fan LI Yan ZHAO Dong | 2014 | Biomedical and Environmental Sciences2014，27，3： | 13 |
| 8 | Performance of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome显示文摘AIM To investigate the performance of transient elastography(TE) for diagnosis of fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis(AIHPBC) overlap syndrome.METHODS A total of 70 patients with biopsy-proven AIH-PBC overlap syndrome were included. Spearman correlation test was used to analyze the correlation of liver stiffness measurement(LSM) and fibrosis stage. Independent samples Student's t-test or one-way analysis of variance was used to compare quantitative variables. Receiver operating characteristics(ROC) curve was used to calculate the optimal cut-off values of LSM for predicting individual fibrosis stages. A comparison on the diagnostic accuracy for severe fibrosis was made between LSM and other serological scores.RESULTS Patients with AIH-PBC overlap syndrome had higher median LSM than healthy controls(11.3 ± 6.4 k Pa vs 4.3 ± 1.4 k Pa, P < 0.01). LSM was significantly correlated with fibrosis stage(r = 0.756, P < 0.01). LSM values increased gradually with an increased fibrosis stage. The areas under the ROC curves of LSM for stages F ≥ 2, F ≥ 3, and F4 were 0.837(95%CI: 0.729-0.914), 0.910(0.817-0.965), and 0.966(0.893-0.995), respectively. The optimal cut-off values of LSM for fibrosis stages F ≥ 2, F ≥ 3, and F4 were 6.55, 10.50, and 14.45 k Pa, respectively. LSM was significantly superior to fibrosis-4, glutaglumyl-transferase/platelet ratio, and aspartate aminotransferase-to-platelet ratio index scores in detecting severe fibrosis(F ≥ 3)(0.910 vs 0.715, P < 0.01; 0.910 vs 0.649, P < 0.01; 0.910 vs 0.616, P < 0.01, respectively).CONCLUSION TE can accurately detect hepatic fibrosis as a noninvasive method in patients with AIH-PBC overlap syndrome. | Hui-Min Wu Li Sheng Qi Wang Han Bao Qi Miao Xiao Xiao Can-Jie Guo Hai Li Xiong Ma De-Kai Qiu Jing Hua | 2018 | World Journal of Gastroenterology2018，24，6： | 13 |
| 9 | Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population显示文摘 | Xue SUN Feng JIANG Rong ZHANG Shan-shan TANG Miao CHEN Dan-feng PENG Jing YAN Tao WANG Shi-yun WANG Yu-qian BAO Cheng HU Wei-ping JIA | 2014 | Acta Pharmacologica Sinica2014，35，11： | 12 |
| 10 | Multiphasic characterization of a plant growth promoting bacterial strain, Burkholderia sp.7016 and its effect on tomato growth in the field显示文摘Aiming at searching for plant growth promoting rhizobacteria(PGPR), a bacterium strain coded as 7016 was isolated from soybean rhizosphere and was characterized in the present study. It was identified as Burkholderia sp. based on 16 S r DNA sequence analysis, as well as phenotypic and biochemical characterizations. This bacterium presented nitrogenase activity, 1-aminocyclopropane-1-carboxylic acid(ACC) deaminase activity and phosphate solubilizing ability; inhibited the growth of Sclerotinia sclerotiorum, Gibberella zeae and Verticillium dahliae; and produced small quantities of indole acetic acid(IAA). In green house experiments, significant increases in shoot height and weight, root length and weight, and stem diameter were observed on tomato plants in 30 d after inoculation with strain 7016. Result of 16 S r DNA PCR-DGGE showed that 7016 survived in the rhizosphere of tomato seedlings. In the field experiments, Burkholderia sp. 7016 enhanced the tomato yield and significantly promoted activities of soil urease, phosphatase, sucrase, and catalase. All these results demonstrated Burkholderia sp. 7016 as a valuable PGPR and a candidate of biofertilizer. | GAO Miao ZHOU Jian-jiao WANG En-tao CHEN Qian XU Jing SUN Jian-guang | 2015 | Journal of Integrative Agriculture2015，14，9： | 11 |
| 11 | Traditional Chinese medicine for treatment of coronavirus disease 2019:a review显示文摘prevalence.A number of clinical workers and researchers have made great efforts to understand the pathogenesis and clinical characteristics and develop effective drugs for treatment.However,no effective drugs with antiviral effects on severe acute respiratory syndrome coronavirus 2 have been discovered currently.Traditional Chinese medicine(TCM)has gained abundant experience in the treatment of infectious diseases for thousands of years.In this review,the authors summarized the clinical outcome,pathogensis and current application of TCM on coronavirus disease 2019.Further,we discussed the potential mechanisms and the future research directions of TCM against severe acute respiratory syndrome coronavirus 2. | Huan-Tian Cui Yu-Ting Li Li-Ying Guo Xiang-Guo Liu Lu-Shan Wang Jian-Wei Jia Jia-Bao Liao Jing Miao Zhai-Yi Zhang Li Wang Hong-Wu Wang Wei-Bo Wen | 2020 | Traditional Medicine Research2020，5，2： | 11 |
| 12 | Up-regulation of T-lymphoma and metastasis gene 1 in gastric cancer and its involvement in cell invasion and migration显示文摘 | SHI Yu-long MIAO Rui-zheng CHENG Li GUO Xiao-bo YANG Bo JING Chang-qing ZHANG Li JINXing LI Le-ping | 2013 | Chinese Medical Journal2013，，4： | 11 |
| 13 | Review of the fabrication and application of porous materials from silicon-rich industrial solid waste显示文摘Porous materials have promise as sound insulation, heat barrier, vibration attenuation, and catalysts. Most industrial solid wastes, such as tailings, coal gangue, and fly ash are rich in silicon. Additionally, a high silicon content waste is a potential raw material for the syn- thesis of silicon-based, multi-porous materials such as zeolites, mesoporous silica, glass-ceramics, and geopolymer foams. Representative sil- icon-rich industrial solid wastes (SRISWs) are the focus of this mini review of the processing and application of porous silicon materials with respect to the physical and chemical properties of the SRISW. The transformation methods of preparing porous materials from SRISWs are summarized, and their research status in micro-, meso-, and macro-scale porous materials are described. Possible problems in the application of SRISWs and in the preparation of functional porous materials are analyzed, and their development prospects are discussed. This review should provide a typical reference for the recycling and use of industrial solid wastes to develop sustainable “green materials.” | Chao Miao Lixing Liang Fan Zhang Shumei Chen Kaixuan Shang Jinlong Jiang Yi Zhang Jing Ouyang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，3： | 10 |
| 14 | Meta-analysis of the efficacy of probiotics in Helicobacter pylori eradication therapy显示文摘AIM:To evaluate the role of probiotics in the standard triple Helicobacter pylori therapy.METHODS:In this meta-analysis,we investigated the efficacy of probiotics in a standard triple H.pylori therapy in adults.Searches were mainly conducted in MEDLINE/Pub Med,EMBASE,and the Cochrane Central Register of Controlled Trials.Fourteen studies met our criteria,and the quality of these studies was assessedusing the Jadad scale.We used STATA version 12.0to extract data and to calculate the odds ratios(ORs),which are presented with the corresponding 95%confidence intervals(CIs).The data are presented as forest plots.RESULTS:The pooled ORs for the eradication rates calculated by intention-to-treat analysis and perprotocol analysis in the probiotic group vs the control group were 1.67(95%CI:1.38-2.02)and 1.68(95%CI:1.35-2.08),respectively,using the fixed-effects model.The sensitivity of the Asian studies was greater than that of the Caucasian studies(Asian:OR=1.78,95%CI:1.40-2.26;Caucasian:OR=1.48,95%CI:1.06-2.05).The pooled OR for the incidence of total adverse effects was significantly lower in the probiotic group(OR=0.49,95%CI:0.26-0.94),using the random effects model,with significant heterogeneity(I2=85.7%).The incidence of diarrhea was significantly reduced in the probiotic group(OR=0.21,95%CI:0.06-0.74),whereas the incidence of taste disorders,metallic taste,vomiting,nausea,and epigastric pain did not differ significantly between the probiotic group and the control group.CONCLUSION:Supplementary probiotic preparations during standard triple H.pylori therapy may improve the eradication rate,particularly in Asian patients,and the incidence of total adverse effects. | Rong Zhu Kan Chen Yuan-Yuan Zheng Hua-Wei Zhang Jun-Shan Wang Yu-Jing Xia Wei-Qi Dai Fan Wang Miao Shen Ping Cheng Yan Zhang Cheng-Fen Wang Jing Yang Jing-Jing Li Jie Lu Ying-Qun Zhou Chuan-Yong Guo | 2014 | World Journal of Gastroenterology2014，20，47： | 9 |
| 15 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 16 | Three-dimensional-printed individualized porous implants:A new“implant-bone”interface fusion concept for large bone defect treatment显示文摘Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration. | Teng Zhang Qingguang Wei Hua Zhou Zehao Jing Xiaoguang Liu Yufeng Zheng Hong Cai Feng Wei Liang Jiang Miao Yu Yan Cheng Daoyang Fan Wenhao Zhou Xinhong Lin Huijie Leng Jian Li Xinyu Li Caimei Wang Yun Tian Zhongjun Liu | 2021 | Bioactive Materials2021，6，11： | 9 |
| 17 | Architecture of PtFe/C catalyst with high activity and durability for oxygen reduction reaction显示文摘PtFe/C 催化剂被列在后面由的受精和高温度的减小综合了酸沥滤。X 光检查衍射, X 光检查光电子光谱学和在边光谱学描述附近原子的 X 光检查揭示那磅 < 潜水艇 class= “ a-plus-plus ” > 3 Fe 合金形成发生在高温度的减小和那不稳定的 Fe 种期间被溶解进酸溶液。在到表面并且强壮的 O-Fe 结合的从核心区域的 Fe 集中的差别可以驾驶 Fe 的外面的散开到高度弄皱的磅骨骼,并且高度结果驱散表面 FeO <潜水艇class=“ a-plus-plus ”> x 在酸的媒介是稳定的,导致磅的构造<潜水艇class=“ a-plus-plus ”> 3 Fe@Pt-FeO <潜水艇class=“ a-plus-plus ”> x 建筑学。是准备了 PtFe/C 催化剂与 Pt/C 催化剂相比为氧减小反应表明一项更高的活动和可比较的耐久性,它可能在 PtFe/C 催化剂由于表面和表面下的 Fe 种类的合作效果。 | Jiayuan Li Guoxiong Wang Jing Wang Shu Miao Mingming Wei Fan Yang Liang Yu Xinhe Bao | 2014 | Nano Research2014，7，10： | 8 |
| 18 | The effect of a secretion-enhanced heavy chain on improving intein-based dual-vector co-delivery of a full-length factor Ⅷ gene显示文摘Treatment of hemophilia A by gene therapy is adversely affected by inefficient FVIII secretion and the large FVIII gene,which is difficult to package in the promising adeno-associated virus (AAV) vectors.Inhibited secretion of FVIII is caused mainly by inefficient secretion of its heavy chain.Previously,we have employed a protein splicing-based dual-vector to co-transfer a B-domain-deleted FVIII (BDD-FVIII) gene,suggesting that the light chain,covalently ligated to a co-expressed heavy chain can improve the secretion of spliced BDD-FVIII.However,its level of secretion was affected by inefficient secretion the heavy chain.Here,we studied the effect of a mutant heavy chain with L303E/F309S substitutions,which enhance FVIII secretion on the heavy chain itself and spliced FVIII when using a protein splicing-based split-delivery of a full-length FVIII gene.Eukaryotic vectors expressing Ssp DnaB intein-fused mutant heavy and light chains were transiently co-transfected into cultured COS-7 cells.A spliced FVIII protein was seen in co-transfected cells by Western blot analysis.The heavy chain was secreted by cells transfected with the mutant heavy chain gene alone at (39±11) ng/mL and this secretion increased to (123±13) ng/mL when cells were co-transfected with the light chain gene,which was greater than the secretion of wild-type heavy chain.The amount of spliced FVIII in the culture supernatant of co-transfected cells was (86±14) ng/mL,with an activity of (0.61±0.08) IU/mL,which was greater than that of wild-type FVIII co-transfected cells.Spliced FVIII and bioactivity were also detected in the combined culture supernatant of cells individually transfected with mutant heavy and light chain gene at a higher level than that of combined wild-type heavy and light chain transfections.This suggested that the heavy chain with improved secretion markedly increased the efficacy of protein splicing-based split delivery of the full-length FVIII gene using a dual-vector.These results encourage the transfer of this technology to an animal model using a dual-AAV vector. | ZHU FuXiang YANG ShuDe LIU ZeLong MIAO Jing QU HuiGe CHI XiaoYan | 2011 | Chinese Science Bulletin2011，56，2： | 8 |
| 19 | Model-based robust estimation and fault detection for MEMS-INS/GPS integrated navigation systems显示文摘In micro-electro-mechanical system based inertial navigation system(MEMS-INS)/global position system(GPS) integrated navigation systems, there exist unknown disturbances and abnormal measurements. In order to obtain high estimation accuracy and enhance detection sensitivity to faults in measurements, this paper deals with the problem of model-based robust estimation(RE) and fault detection(FD). A filter gain matrix and a post-filter are designed to obtain a RE and FD algorithm with current measurements, which is different from most of the existing priori filters using measurements in one-step delay. With the designed filter gain matrix, the H-infinity norm of the transfer function from noise inputs to estimation error outputs is limited within a certain range; with the designed post-filter, the residual signal is robust to disturbances but sensitive to faults. Therefore, the algorithm can guarantee small estimation errors in the presence of disturbances and have high sensitivity to faults. The proposed method is evaluated in an integrated navigation system, and the simulation results show that it is more effective in position estimation and fault signal detection than priori RE and FD algorithms. | Miao Lingjuan Shi Jing | 2014 | Chinese Journal of Aeronautics2014，27，4： | 8 |
| 20 | A review of high-temperature selective absorbing coatings for solar thermal applications显示文摘Solar selective absorbing coatings directly harvest solar energy in the form of heat.The higher temperatures are required to drive higher power-cycle efficiencies in favor of lower costs of energy.According to different dielectrics,high temperature coatings can mainly be divided to double cermet solar selective coatings,transition metal nitride multilayer coatings and transition metal oxide multilayer coatings.This paper assesses the photothermal conversion efficiency and thermal stability,and discusses the challenges and strategies of improving both thermal and optical properties.Double cermet layers can stabilize nanocrystalline structures by alloying,while transition metal nitride/oxide layers generally choose the reliable materials with superior mechanical properties and thermal stability.The purpose of this review is to get the optimized systems,and propose further research directions at higher temperature,such as all-ceramic absorbing coatings. | Ke Xu Miao Du Lei Hao Jing Mi Qinghe Yu Shijie Li | 2020 | Journal of Materiomics2020，6，1： | 8 |
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