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| 1 | Resistin mediates the hepatic stellate cell phenotype显示文摘AIM: To describe the role of resistin in liver fibrosis. METHODS: For the in vivo animal study, Sprague Dawley rats were subjected to bile duct ligation (BDL) for 4 wk. Rat liver, adipose tissue (epididymal fat) and serum were analyzed for resistin expression. For the in vitro experiment, rat primary hepatic stellate cells (HSCs) and Kupffer cells (KCs) were used. HSCs were exposed to recombinant resistin, and collagenⅠ, transforming growth factor β1, α smooth muscle actin, tissue inhibitor of metalloproteinase 1 and connective tissue growth factor expression were analyzed. Resistin gene and protein expression was quantified as was the expression of pro-inflammatory cytokines including tumor necrosis factor α (TNFα), interleukin (IL)-1, IL-6, IL-8 and monocyte chemotactic protein-1 (MCP-1). The effects of resistin on HSC proliferation, migration and apoptosis were determined. The effects of resistin on KCs were also investigated. RESULTS: Following BDL, rat epididymal fat and serum rather than liver showed higher resistin expression compared to control rats. In liver, resistin was expressed in quiescent HSCs and KCs. Resistin treatment resulted in enhancement of TNFα , IL-6 , IL-8 and MCP-1 gene expression and increased IL-6 and MCP-1 protein in HSCs. Resistin activated HSC phospho-MAPK/p38, and p38 inhibition diminished IL-6 and MCP-1 expression. Furthermore, resistin facilitated HSC proliferation and migration, but decreased apoptosis which was via an IL-6 and MCP-1 mechanism. Finally, resistin-induced transforming growth factor β1 from KCs enhanced HSC collagenⅠexpression. CONCLUSION: Resistin directly and indirectly modulates HSC behavior towards a more pro-fibrogenic phenotype. | Zhi-Xia Dong Lin Su Joanne Brymora Claire Bird Qing Xie Jacob George Jian-Hua Wang | 2013 | World Journal of Gastroenterology2013，19，28： | 4 |
| 2 | The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study显示文摘 | Neeraj Bhala Paul Angulo David van der Poorten Eric Lee Jason M. Hui Giorgio Saracco Leon A. Adams Phunchai Charatcharoenwitthaya Joanne H. Topping Elisabetta Bugianesi Christopher P. Day Jacob George | 2011 | Hepatology2011，，4： | 2 |
| 3 | Newly designed CRRT membranes for sepsis and SIRS - - a pragmatic approach for bedside intensivists summarizing the more recent advances: a sys- tematic structured review显示文摘 | Honore PM Jacobs R Joannes - Boyau O | 2013 | ASAIO J2013，59，2： | 1 |
| 4 | Newly designed CRRT membranes for sepsis and SIRS--a pragmatic approach for bedside intensivists summarizing the more recent advances: a systematic structured review显示文摘 | Honore PM Jacobs R Joannes Boyau O | 2013 | Asaio J2013，59，2： | 1 |
| 5 | Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration显示文摘 | A. C. Inge Boullart Erik H. J. G. Aarntzen Pauline Verdijk Joannes F. M. Jacobs Danita H. Schuurhuis Daniel Benitez-Ribas Gerty Schreibelt Mandy W. M. M. Rakt Nicole M. Scharenborg Annemiek Boer Matthijs Kramer Carl G. Figdor Cornelis J. A. Punt Gosse J. | 2008 | Cancer Immunology Immunotherapy2008，，11： | 1 |
| 6 | Clinical outcomes of patients with duodenal adenocarcinoma and intestinal-type papilla of Vater adenocarcinoma显示文摘BACKGROUND Duodenal adenocarcinoma(DA)and intestinal-type papilla of Vater adenocarcinoma(it-PVA)are rare malignancies of the gastrointestinal tract.Current therapeutic options are translated nowadays from treatment strategies for patients with colorectal cancer due to histopathological similarities.AIM To retrospectively investigate the clinical outcome of patients with DA and it-PVA.METHODS All patients with DA and it-PVA diagnosed between 2000 and 2017 were included at two academic centers in the Netherlands.All patients with histopathologically-confirmed DA or it-PVA were eligible for inclusion.Clinical outcome was compared between DA and it-PVA per disease stage.In the subgroup of stage IV disease,survival after local treatment of oligometastases was compared with systemic therapy or supportive care.RESULTS In total,155 patients with DA and it-PVA were included.Patients with it-PVA more often presented with stage I disease,while DA was more often diagnosed at stage IV(P<0.001).Of all patients,79%were treated with curative intent.The median survival was 39 mo,and no difference in survival was found for patients with DA and it-PVA after stratification for disease stage.Seven(23%)of 31 patients with synchronous stage IV disease underwent resection of the primary tumor,combined with local treatment of oligometastases.Local treatment of metastases was associated with an overall survival of 37 mo,compared to 14 and 6 mo for systemic therapy and supportive care,respectively.CONCLUSION Survival of patients with DA and it-PVA is comparable per disease stage.These results suggest a potential benefit for local treatment strategies in selected patients with oligometastases,although additional prospective studies are needed. | Laura L Meijer Marin Strijker Jacob K de Bakker Jurgen GJ Toennaer Barbara M Zonderhuis Hans J van der Vliet Hanneke Wilmink Joanne Verheij Freek Daams Olivier R Busch Nicole CT van Grieken Marc G Besselink Geert Kazemier | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 1 |
| 7 | Kupffer Cells Mediate Leptin-Induced Liver Fibrosis显示文摘 | Jianhua Wang Isabelle Leclercq Joanne M. Brymora Ning Xu Mehdi Ramezani–Moghadam Roslyn M. London David Brigstock Jacob George | 2009 | Gastroenterology2009，，2： | 1 |
| 8 | Diagnostic Accuracy of 64-Slice Computed Tomography Coronary Angiography显示文摘 | W. Bob Meijboom Matthijs F.L. Meijs Joanne D. Schuijf Maarten J. Cramer Nico R. Mollet Carlos A.G. van Mieghem Koen Nieman Jacob M. van Werkhoven Gabija Pundziute Annick C. Weustink Alexander M. de Vos Francesca Pugliese Benno Rensing J. Wouter Jukema Jer | 2008 | Journal of the American College of Cardiology2008，，25： | 1 |
| 9 | Exploring the use of blogs as learning spaces in the higher education sector显示文摘 | Jeremy B Williams Joanne Jacobs | 2004 | Australasian Journal of Educational Technology2004，20，2： | 1 |
| 10 | Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?显示文摘 | Joannes FM Jacobs Stefan Nierkens Carl G Figdor I Jolanda M de Vries Gosse J Adema | 2012 | Lancet Oncology2012，，1： | 1 |
| 11 | Novel mutation in the TOR1A (DYT1) gene in atypical, early onset dystonia and polymorphisms in dystonia and early onset parkinsonism显示文摘 | Joanne Leung Christine Klein Jennifer Friedman Peter Vieregge Helfried Jacobs Dana Doheny Christoph Kamm Deborah DeLeon Peter P. Pramstaller John B. Penney Marvin Eisengart Joseph Jankovic Thomas Gasser Susan B. Bressman David P. Corey Patricia Kramer Mit | 2001 | Neurogenetics2001，，3： | 1 |
| 12 | Prognostic Value of Multislice Computed Tomography and Gated Single-Photon Emission Computed Tomography in Patients With Suspected Coronary Artery Disease显示文摘 | Jacob M. van Werkhoven Joanne D. Schuijf Oliver Gaemperli J. Wouter Jukema Eric Boersma William Wijns Paul Stolzmann Hatem Alkadhi Ines Valenta Marcel P.M. Stokkel Lucia J. Kroft Albert de Roos Gabija Pundziute Arthur Scholte Ernst E. van der Wall Philipp | 2009 | Journal of the American College of Cardiology2009，，7： | 1 |
| 13 | Diagnostic Accuracy of 64-Slice Computed Tomography Coronary Angiography显示文摘 | W. Bob Meijboom Matthijs F.L. Meijs Joanne D. Schuijf Maarten J. Cramer Nico R. Mollet Carlos A.G. van Mieghem Koen Nieman Jacob M. van Werkhoven Gabija Pundziute Annick C. Weustink Alexander M. de Vos Francesca Pugliese Benno Rensing J. Wouter Jukema Jer | 2008 | Journal of the American College of Cardiology2008，，25： | 1 |
| 14 | Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium显示文摘 | Joanne W. Elena Emily Steplowski Kai Yu Patricia Hartge Geoffrey S. Tobias Michelle J. Brotzman Stephen J. Chanock Rachael Z. Stolzenberg-Solomon Alan A. Arslan H. Bas Bueno-de-Mesquita Kathy Helzlsouer Eric J. Jacobs Andrea LaCroix Gloria Petersen Wei Zh | 2013 | Cancer Causes & Control2013，，1： | 1 |
| 15 | Septic acute kidney injury:the culprit is inflammatory apoptosis rather than ischemic necrosis显示文摘 | Jacobs R Honore PM Joannes'Boyau O | 2011 | Blood Purif2011，32，4： | 1 |
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