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| 1 | Soluble Mouse B7-H3 Down-Regulates Dendritic Cell Stimulatory Capacity to Allogenic T Cell Proliferation and Production of IL-2 and IFN-γ显示文摘B7-H3 是 B7 基因家庭的一个最近识别的成员。它的无所不在的表示在淋巴并且 nonlymphoid 纸巾建议它能在自我忍耐的维护起一个重要作用。然而, B7-H3 的准确功能仍然是逃犯的。当前的学习的目的是为调停 DC 的 T 房间激活的预防表明可溶的老鼠 B7-H3 的可能的功能。为这个目的,我们建立了可溶的老鼠 B7-H3 熔化蛋白质(mB7h3-hIg ) 有 C 终端人的 IgG1 Fc 的真核细胞的表示向量(pmB7h3-hIg ) 。C57BL/6 (B6 ) 导出树枝状的房间线(DC2.4 房间) 为可溶的 mB7h3-hIg 的产生被用于稳定的 transfectants 的建立。宫外的 mB7h3-hIg 表示被 RT-PCR,西方的污点和 ELISA 分析证实。49.7 kD 蛋白质被西方的污点与 pmB7h3-hIg 从 DC2.4 房间 transfected 检测。可溶的 mB7h3-hIg 表示没在房间骑车和 apoptosis 和 CD80 的表示和 DC2.4 房间的 CD86 上有效果,这被发现。然而,宫外的可溶的 mB7h3-hIg 表示被发现显著地为 DC2.4 房间影响 allo-stimulatory 能力。当与 MLC.Further 决定的控制相比研究表明可溶的 mB7h3-hIg 能也禁止 IL-2 和建议的 allogenic T cells.These 结果的 IFN- 生产,表示可溶的 mB7h3-hIg 的 DC2.4 房间显示出一个重要减少的 allo-stimulatory 能力为接枝拒绝和 autoimmume 疾病的治疗的可溶的 B7-H3 的一个大潜力。 | Junfa Xu Baojun Huang Ping Xiong Wei Feng Yong Xu Min Fang Fang Zheng Feili Gong | 2006 | Cellular & Molecular Immunology2006，3，3： | 8 |
| 2 | Elevated 8-oxo-7,8-dihydro-2'-deoxyguanosine in genome of T24 bladder cancer cells induced by halobenzoquinones显示文摘Halobenzoquinones(HBQs) are an emerging class of halogenated disinfection byproducts(DBPs) in drinking water, which raised public concerns due to potential carcinogenic effects to human bladder. Our previous work demonstrated that HBQs and hydrogen peroxide(H_2O_2)together generated oxidative DNA damage via a metal-independent and intercalationenhanced oxidation mechanism in vitro. This study further investigated the efficiency of various HBQs to induce oxidative DNA damage in T24 bladder cancer cells. Compared with T24 cells without treatment(3.1 lesions per 10~6 d G), the level of 8-oxo-7,8-dihydro-2′-deoxyguanosine(8-oxod G) significantly increased by 1.4, 3.2, 8.8, and 9.2 times after treatment with tetrabromo-1,4-benzoquinone(TBBQ), terachloro-1,4-benzoquinone(TCBQ),2,6-dichloro-1,4-benzoquinone(2,6-DCBQ) and 2,5-dichloro-1,4-benzoquinone(2,5-DCBQ) for24 hr, respectively. Interestingly, we found that the oxidative potency of HBQs in T24 cells(2,5-DCBQ ≈ 2,6-DCBQ > TCBQ > TBBQ) is inconsistent with that of in vitro ds DNA oxidation(TCBQ > TBBQ > 2,5-DCBQ > 2,6-DCBQ), suggesting HBQs induce oxidative lesions in cellular genomic DNA probably involved with a complex mechanism. | Tian Xu Junfa Yin Shaokun Chen Dapeng Zhang Hailin Wang | 2018 | Journal of Environmental Sciences2018，30，1： | 5 |
| 3 | Towards full-spectrum photocatalysis: Achieving a Z-scheme between Ag2S and TiO2 by engineering energy band alignment with interfacial Ag显示文摘Z 计划是一条有希望的途径完成用途广泛的光催化。有有 1.0 eV 的乐队差距的另一个半导体的 TiO 2 的集成将对紫外的收获和在可见附近理想为光催化的红外线的光;然而,大多数 narrow-bandgap 半导体让与组成一个障碍到为 photocatalytic 氢生产形成 Z 计划的 TiO 2, 跨骑乐队结构排列。在这通讯,我们表明 Ag 2 是的 S 在哪儿的一个模型系统精力乐队分享一个接口,一个金属罐头克服的 narrow-bandgap 半导体换高速档这限制。制作设计,我们开发了一条唯一的途径综合 Ag 2 SAgTiO 2 混血儿结构。戏剧性地展出的获得的第三的混合结构在完整光谱的轻照明下面在 photocatalytic 氢生产提高了性能。这些活动比 Ag 2 SAgTiO 2 结构在下面 < 400 nm 并且 > 他们在任何轻照明下面的对应物的象那些一样的 400 nm 照耀调节。 | Yanrui Li Leilei Li Yunqi Gong Song Bai Huanxin Ju Chengming Wang Qian Xu Junfa Zhu Jun Jiang Yujie Xiong | 2015 | Nano Research2015，8，11： | 5 |
| 4 | Engineering the morphology and electronic structure of atomic cobalt-nitrogen-carbon catalyst with highly accessible active sites for enhanced oxygen reduction显示文摘The stabilization of non-precious metals as isolated active sites with high loading density over nitrogendoped carbon materials is essential for realizing the industrial application of single atom catalysts.However,achieving high loading of single cobalt active sites with greatly enhanced oxygen reduction reaction(ORR)activity and stability remains challenging.Here,an efficient approach was described to create a single atom cobalt electrocatalyst(Co SAs/NC)which possesses enhanced mesoporosity and specific surface area that greatly favor the mass transportation and exposure of accessible active sites.The electronic structure of the catalyst by the strong metal-support interaction has been elucidated through experimental characterizations and theoretical calculations.Due to dramatically enhanced mass transport and electron transfer endowed by morphology and electronic structure engineering,Co SAs/NC exhibits remarkable ORR performance with excellent activity(onset and half-wave potentials of 1.04 V(RHE)and 0.90 V(RHE),Tafel slope of 69.8 mV dec^(-1)and J_(k) of 18.8 mA cm^(-2)at 0.85 V)and stability(7 mV activity decay after 10,000 cycles).In additio n,the catalyst demonstrates great promise as an alternative to traditional Pt/C catalyst in zinc-air batteries while maintaining high performance in terms of high specific capacity of(796.1 mAh/g_(Zn)),power density(175.4 mW/cm^(2)),and long-term cycling stability(140 h).This study presents a facile approach to design SACs with highly accessible active sites for electrochemical transformations. | Zhijun Li Leipeng Leng Siqi Ji Mingyang Zhang Hongxue Liu Jincheng Gao Jiangwei Zhang J.Hugh Horton Qian Xu Junfa Zhu | 2022 | Journal of Energy Chemistry2022，31，10： | 1 |
| 5 | Thermal transient response of GaAs FETs under intentional electromagnetic interference (IE- MI)显示文摘 | Xu Jianfeng Yin Wenyan Mao Junfa | 2008 | IEEE Trans on Electromagn Compat2008，50，2： | 1 |
| 6 | Alkali ion-promoted palladium subnanoclusters stabilized on porous alumina nanosheets with enhanced catalytic activity for benzene oxidation显示文摘Catalytic C−H bond activation is one of the backbones of the chemical industry.Supported metal subnanoclusters consisting of a few atoms have shown attractive properties for heterogeneous catalysis.However,the creation of such catalyst systems with high activity and excellent anti-sintering ability remains a grand challenge.Here,we report on alkali ion-promoted Pd subnanoclusters supported over defectiveγ-Al_(2)O_(3) nanosheets,which display exceptional catalytic activity for C−H bond activation in the benzene oxidation reaction.The presence of Pd subnanoclusters is verified by aberration-corrected high-angle annular dark-field scanning transmission electron microscopy,X-ray absorption spectroscopy,and X-ray photoelectron spectroscopy.This catalyst shows excellent catalytic activity,with a turnover frequency of 280 h^(−1) and yield of 98%,in benzene oxidation reaction to give phenol under mild conditions.Moreover,the introduction of alkali ion greatly retards the diffusion and migration of metal atoms when tested under high-temperature sintering conditions.Density functional theory(DFT)calculations reveal that the addition of alkali ion to Pd nanoclusters can significantly impact the catalyst’s structure and electronic properties,and eventually promote its activity and stability.This work sheds light on the facile and scalable synthesis of highly active and stable catalyst systems with alkali additives for industrially important reactions. | Zhijun Li Minghui Di Wei Wei Leipeng Leng Zhijun Li Cheng He Qiang Tan Qian Xu J.Hugh Horton Li Li Junfa Zhu | 2022 | Nano Research2022，15，7： | 1 |
| 7 | Generation ofone-or two-dimensional arrays of hollow optical microtrapsfor cold atoms, molecules, or microparticles on a chip显示文摘 | Mu Renwang Lu Junfa Xu Shuwu | 2009 | Journal of the Optical Society of America B2009，26，1： | 1 |
| 8 | Epitaxial growth of ultrathin ZrO_2(111) films on Pt(111)显示文摘Ordered epitaxial ZrO2 films were grown on Pt(111) and characterized by low energy electron diffraction (LEED), synchrotron radiation photoemission spectroscopy (SRPES) and X-ray photoelectron spectroscopy (XPS). The films were prepared by vapor deposition of zirconium in an O2 atmosphere followed by annealing under ultra high vacuum. At low coverages, the films grew as discontinuous two-dimentional islands with ordered structures. The size and structure of these islands were dependent on the coverage of ZrO2 films. At coverage <0.5 monolayer (ML), ( 19^(1/2) × 19^(1/2)) R23.4° and (5×5) structures coexisted on the surface. As the coverage increased, the (19^(1/2) × 19^(1/2) ) R23.4° structure developed with increasing degree of long-range order, while the (5×5) structure gradually faded. When the coverage reached >6 ML, a continuous ZrO2(111) film was formed with a (1×1) surface LEED pattern coexisting with a (2×2) pattern. These ordered thin ZrO2 films provide good model surfaces of bulk ZrO2 and can be used for further fundamental studies of the surface chemistry of ZrO2 using modern surface science techniques. | GAO Yan ZHANG Liang PAN YongHe WANG GuoDong XU Yang ZHANG WenHua ZHU JunFa | 2011 | Chinese Science Bulletin2011，56，6： | 1 |
| 9 | Synchrotron radiation photoemission study on growth of gadolinium film over Ni(110)surface显示文摘The growth of Gd film on Ni(110) surfaco was studied by synchrotron radiation photoemission spectroscopy and XPS techniques. It is revealed that in the coverage range of 0—0.22 nm Gd4f core level showed a single-peak structure, therefore Gd film grows over Ni(110) in the layer-by-layer mode. However, when Gd coverage was larger than 0.22, nm the Gd4f peak turned gradually into double-peak and a double-peak structure with 2.3 eV separation was formed at 1.51 nm, meanwhile similar phenomenon was observed in the Gd4d XPS spectra. It is suggested that the double-peak structure of Gd4f was derived from the growth of Gd film in cluster mode and the Gd atomic clusters may exhibit different electronic states from Gd metal owing to their special structures. The Gd4f double-peak evolved into a single-peak on annealing at 600 K, implying that Gd clusters are thermodynamically unstable. | Faqiang Xu Junfa Zhu Yuming Sun Xianfeng Wang Erdong Lu Pengshou Xu Xinyi Zhang Shuxian Zhuang | 1999 | Chinese Science Bulletin1999，44，4： | 1 |
| 10 | Fabrication of oxygen-doped MoSe2 hierarchical nanosheets for highly sensitive and selective detection of trace trimethylamine at room temperature in air显示文摘Nano Research volume 13,pages1704–1712(2020)Cite this article 191 Accesses Metrics details Abstract Intelligent gas sensors based on the layered transition metal dichalcogenides(TMDs)have attracted great interest in the field of gas sensing due to their multiple active sites,fast electron,mass transfer capability and large surface-to-volume ratio.However,conventional TMDs-based sensors typically work at elevated temperature in inert atmosphere,which would largely limit the corresponding practical applications.Herein,novel oxygen-doped MoSe2 hierarchical nanostructures composed of ultrathin nanosheets with large specific surface area have been designed and generated typically at 200°C in air for fast and facile gas sensing of trimethylamine(TMA),effectively.Benefited from the gas-accessible hierarchical morphology and high surface area with abundant nanochannels,highly sensitive and selective detection of trace TMA has been achieved under ambient condition,and as detected the theoretical limit of detection(LOD)is 8 ppb,which is the lowest for TMA detection under ambient condition among the reported studies.The mechanism of oxygen doping on the improved gas-sensing performance has been investigated,revealing that the oxygen doping could greatly optimize the electronic structure,thus regulate the Fermi level of MoSe2 as well as the affinity between TMA molecule and sensor surface.It is expected that the oxygen doping strategy developed for the highly efficient gas sensors based on TMDs in present work may also be applicable to other types of gas-sensing semiconductors,which could open up a new direction for the rational design of high-performance gas sensors working under ambient condition. | Nannan Hou Qianqian Sun Jing Yang Su You Yun Cheng Qian Xu Wei Li Shiqi Xing Li Zhang Junfa Zhu Qing Yang | 2020 | Nano Research2020，13，6： | 0 |
| 11 | High-rate CH_(4)-to-C_(2)H_(6) photoconversion enabled by Au/ZnO porous nanosheets under oxygen-free system显示文摘Photocatalytic CH_(4) coupling into high-valued C_(2)H_(6) is highly attractive,whereas the photosynthetic rate,especially under oxygen-free system,is still unsatisfying.Here,we designed the negatively charged metal supported on metal oxide nanosheets to activate the inert C-H bond in CH_(4)and hence accelerate CH_(4) coupling performance.As an example,the synthetic Au/ZnO porous nanosheets exhibit the C_(2)H_(6) photosynthetic rate of 1,121.6μmol g^(-1)_(cat)h^(-1)and the CH_(4) conversion rate of 2,374.6μmol g^(-1)_(cat)h^(-1) under oxygen-free system,2 orders of magnitude higher than those of previously reported photocatalysts.By virtue of several in situ spectroscopic techniques,it is established that the generated Au^(δ-)and O^-species together polarized the C-H bond,while the Au^(δ-)and O^-species jointly stabilized the CH_(3) intermediates,which favored the coupling of CH_(3) intermediate to photosynthesize C_(2)H_(6) instead of overoxidation into CO_(x).Thus,the design of dual active species is beneficial for achieving high-efficient CH_(4)-to-C_(2)H_(6) photoconversion. | Kai Zheng Xiaojing Zhang Jun Hu Chengbin Xu Juncheng Zhu Jing Li Mingyu Wu Shan Zhu Li Li Shumin Wang Yumei Lv Xin He Ming Zuo Chengyuan Liu Yang Pan Junfa Zhu Yongfu Sun Yi Xie | 2024 | Science China Chemistry2024，67，3： | 0 |
| 12 | Generating oxygen adatoms on Au(997) by thermal decomposition of NO_2显示文摘We report our investigation of the interaction of NO2 with the Au(997)vicinal surface by high-resolution photoelectron spectroscopy using synchrotron radiation as the excitation source.At 170 K,both core-level and valence-band photoemission results illustrate the decomposition of NO2 on the Au(997)surface at low NO2 exposures,forming coadsorbed NO(a)and O(a)species.After annealing at 300 K,NO(a)desorbs from Au(997)whereas O(a)remains on the surface.Upon annealing at 750 K,we observe no signal for adsorbed oxygen on Au(997).These results clearly demonstrate that thermal decomposition of NO2 is an effective method to generate oxygen adatoms on Au(997)under ultrahigh-vacuum conditions. | ZHANG YuLin WU ZongFang CHEN BoHao XU LingShun PAN HaiBin MA YunSheng JIANG ZhiQuan ZHU JunFa HUANG WeiXin | 2010 | Chinese Science Bulletin2010，55，34： | 0 |
| 13 | Atmospheric CO_(2) capture and photofixation to near-unity CO by Ti^(3+)-V_(o)-Ti^(3+) sites confined in TiO_(2) ultrathin layers显示文摘To realize efficient atmospheric CO_(2) chemisorption and activation,abundant Ti^(3+) sites and oxygen vacancies in TiO_(2) ultrathin layers were designed.Positron annihilation lifetime spectroscopy and theoretical calculations first unveil each oxygen vacancy is associated with the formation of two Ti^(3+)sites,giving a Ti^(3+)-V_(o)-Ti^(3+) configuration.The Ti^(3+)-V_(o)-Ti^(3+) sites could bond with CO_(2) molecules to form a stable configuration,which converted the endoergic chemisorption step to an exoergic process,verified by in-situ Fourier-transform infrared spectra and theoretical calculations.Also,the adjacent Ti^(3+)sites not only favor CO_(2) activation into COOH*via forming a stable Ti^(3+)–C–O–Ti^(3+) configuration,but also facilitate the rate-limiting COOH^(*)scission to CO^(*)by reducing the energy barrier from 0.75 to 0.45 e V.Thus,the Ti^(3+)-V_(o)-TiO_(2) ultrathinlayers could directly capture and photofix atmospheric CO_(2) into near-unity CO,with the corresponding CO_(2)-to-CO conversion ratio of ca.20.2%. | Liang Liang Peiquan Ling Yuhuan Li Li Li Jiandang Liu Qiquan Luo Hongjun Zhang Qian Xu Yang Pan Junfa Zhu Bangjiao Ye Yongfu Sun | 2021 | Science China Chemistry2021，64，6： | 0 |
| 14 | An in-situ spectroscopy investigation of alkali metal interaction mechanism with the imide functional group显示文摘Organic anode materials have attracted considerable interest owing to their high tunability by adopting various active functional groups.However,the interaction mechanisms between the alkali metals and the active functional groups in host materials have been rarely studied systematically.Here,a widely used organic semiconductor of perylene-3,4,9,10-tetracarboxylic diimide(PTCDI)was selected as a model system to investigate how alkali metals interact with imide functional groups and induce changes in chemical and electronic structures of PTCDI.The interaction at the alkali/PTCDI interface was probed by in-situ X-ray photoelectron spectroscopy(XPS),ultraviolet photoelectron spectroscopy(UPS),synchrotron-based near edge X-ray absorption fine structure(NEXAFS),and corroborated by density functional theory(DFT)calculations.Our results indicate that the alkali metal replaces the hydrogen atoms in the imide group and interact with the imide nitrogen of PTCDI.Electron transfer induced gap states and downward band-bending like effects are identified on the alkali-deposited PTCDI surface.It was found that Na shows a stronger electron transfer effect than Li.Such a model study of alkali insertion/intercalation in PTCDI gives insights for the exploration of the potential host materials for alkali storage applications. | Xu Lian Zhirui Ma Zhonghan Zhang Jinlin Yang Shuo Sun Chengding Gu Yuan Liu Honghe Ding Jun Hu Xu Cao Junfa Zhu Shuzhou Li Wei Chen | 2020 | Nano Research2020，13，12： | 0 |
| 15 | Study on the Deformation Behavior of Mg-Gd-Y-Zn-Mn Wrought Magnesium Alloys by Visco-plastic Self-consistent Modeling显示文摘The plastic deformation behavior of new Mg-Gd-Y-Zn-Mn magnesium alloys gains great necessity to clarify and understand the mechanism deeply. In the present work,the tensile mechanical property test and visco-plastic self-consistent (VPSC) model are used to investigate the activities of deformation modes of VW84M and VW94M magnesium alloys during the tensile deformation. The results show that the mechanical properties of the above extruded alloys are similar but VW94M has higher strength than VW84M after the same aging process. Compared with the extruded alloys,the as-aged alloys have significantly higher activation of pyramidal slip at the later stage of plastic deformation. In addition,the as-aged VW94M alloy with higher strength has the largest activity of pyramidal slip. In summary,the addition of Gd increases the critical resolved shear stress (CRSS)in each slip system of VW94M,while the increase in the strength and the decrease in the elongation of as-aged alloys are associated with the significant activation of pyramidal slip. | WANG Yuye ZHANG Junfa WANG Shiwei KANG Jing MENG Jiajie WANG Yanbo XU Yuling ZHOU Haitao | 2022 | 上海航天(中英文)2022，39，1： | 0 |
| 16 | Plastics-to-syngas photocatalysed by Co-Ga_(2)O_(3) nanosheets显示文摘Plastics take hundreds of years to degrade naturally,while their chemical degradation typically requires high temperature and pressure.Here,we first utilize solar energy to realize the sustainable and efficient plastic-to-syngas conversion with the aid of water at ambient conditions.As an example,the commercial plastic bags could be efficiently photoconverted into renewable syngas by Co-Ga_(2) O_(3) nanosheets,with hydrogen and carbon monoxide formation rates of 647.8 and 158.3μmol g^(-1) h^(-1).In situ characterizations and labelling experiments unveil water is photoreduced into hydrogen,while non-recyclable plastics including polyethylene bags,polypropylene boxes and polyethylene terephthalate bottles are photodegraded into carbon dioxide,which is further selectively photoreduced into carbon monoxide.In-depth investigation illustrates that the efficiency of syngas production mainly depends on the carbon dioxide reduction process and hence photo catalysts of high carbon dioxide reduction activity should be designed to promote the efficiency of plastic-to-syngas conversion in the future.The concept for the photoreforming of non-recyclable plastics into renewable syngas helps to eradicate’white pollution’and alleviate the energy crisis simultaneously. | Jiaqi Xu Xingchen Jiao Kai Zheng Weiwei Shao Shan Zhu Xiaodong Li Junfa Zhu Yang Pan Yongfu Sun Yi Xie | 2022 | National Science Review2022，9，9： | 0 |
| 17 | Unraveling the advantages of Pd/CeO_(2)single-atom catalysts in the NO+CO reaction by model catalysts显示文摘Selective catalytic reduction of NO by CO is challenging in environmental catalysis but attractive owing to the advantage of simultaneous elimination of NO and CO.Here,model catalysts consisting of Pd nanoparticles(NPs)and single-atom Pd supported on a CeO_(2)(111)film grown on Cu(111)(denoted as Pd NPs/CeO_(2)and Pd_(1)/CeO_(2),respectively)were successfully prepared and characterized by synchrotron radiation photoemission spectroscopy(SRPES)and infrared reflection absorption spectroscopy(IRAS).The NO+CO adsorption/reaction on the Pd_(1)/CeO_(2)and Pd NPs/CeO_(2)catalysts were carefully investigated using SRPES,temperature-programmed desorption(TPD),and IRAS.It is found that the reaction products on both model catalysts are in good agreement with those on real catalysts,demonstrating the good reliability of using these model catalysts to study the reaction mechanism of the NO+CO reaction.On the Pd NPs/CeO_(2)surface,N_(2)is formed by the combination of atomic N coming from the dissociation of NO on Pd NPs at higher temperatures.N_(2)O formation occurs probably via chemisorbed NO combined with atomic N on the surface.While on the single-atom Pd_(1)/CeO_(2)surface,no N_(2)O is detected.The 100%N_(2)selectivity may stem from the formation of O-N-N-O^(*)intermediate on the surface.Through this study,direct experimental evidence for the reaction mechanisms of the NO+CO reaction is provided,which supports the previous density functional theory(DFT)calculations. | Qian Xu Xingwang Cheng Ningqiang Zhang Yi Tu Lihui Wu Haibin Pan Jun Hu Honghe Ding Junfa Zhu Yadong Li | 2023 | Nano Research2023，16，7： | 0 |
| 18 | Single palladium atoms stabilized byβ-FeOOH nanorod with superior performance for selective hydrogenation of cinnamaldehyde显示文摘Atomically dispersed single atom catalysts represent an ideal means of converting less valuable organics into value-added chemicals of interest with high efficiency.Herein,we describe a facile synthetic approach to create defect-containingβ-FeOOH doped with isolated palladium atoms that bond covalently to the nearby oxygen and iron atoms.The presence of singly dispersed palladium atoms is confirmed by spherical aberration correction electron microscopy and extended X-ray absorption fine structure measurements.This single palladium atom catalyst manifests outstanding catalytic efficiency(conversion:99%;selectivity 99%;turnover frequency:2,440 h^(-1))in the selective hydrogenation of cinnamaldehyde to afford hydrocinnamaldehyde.Experimental measurements and density functional theory(DFT)calculations elucidate the high catalytic activity and the strong metal-support interaction stem from the unique coordination environment of the isolated palladium atoms.These findings may pave the way for the facile construction of single atom catalysts in a defect-mediated strategy for efficient organic transformations in heterogeneous catalysis. | Zhijun Li Leipeng Leng Xiaowen Lu Mingyang Zhang Qian Xu J.Hugh Horton Junfa Zhu | 2022 | Nano Research2022，15，4： | 0 |
| 19 | Effects of telmisartan on hypertensive patients with dyslipidemia and insulin resistance显示文摘Objective To investigate the effects of telmisartan on the blood glucose,blood lipid,blood insulin,and insulin resistance in the hypertensive patients with dyslipidemia,and also its effect on controlling blood pressure. Patients and Methods A total of 96 hypertensive patients(34 females,62 males) with dyslipidemia were included(mean age 51.2±9.6,range 42-65 years) . Patients were randomized to receive either telmisartan 80 mg/day(n=46) or enalapril 10 mg/day(n=50) for 6 months. The levels of blood pressure(BP) ,heart rate(HR) ,and biochemical data were measured before therapy and at the end of the 3-month treatment and 6-month treatment,respectively. Meanwhile,insulin resistance was evaluated by using a homeostasis model assessment of insulin resistance(HOMA-IR) and insulin sensitivity(HOMA-IS) . Results In the telmisartan group,the mean blood pressure was obviously lower than that of pre-therapy(P< 0.05) ,and the levels of triglyceride(TG) ,HOMA-IR,and HOMA-IS were all obviously lower than those of pre-therapy and of the enalapril group at the end of the 3-month-treatment period(P<0.05) . After 6 months of treatment,the levels of TG,HOMA-IR,and HOMA-IS in the telmisartan group were significantly lower in comparison with those of pre-therapy,the enalapril group(P<0.01) ,and 3-month-treatment(P<0.05) . Post-prandial12 hour blood glucose(P2HBG) in the telmisartan group decreased significantly after 6-month treatment compared with that of pre-therapy and the enalapril group(P<0.05) . The level of high density lipoprotein(HDL) cholesterol was significantly higher after 6-month treatment in the telmisartan group than with pre-therapy and the enalapril group(P<0.05) . Conclusions Telmisartan could not only control blood pressure steadily and effectively,but also decrease blood TG,increase HDL cholesterol and insulin sensitivity,and lower insulin resistance. | Dongxiu Xu Junfa Liu Cuiling Ji Liping Zhou Hong Guo | 2007 | Journal of Geriatric Cardiology2007，4，3： | 0 |
| 20 | Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8显示文摘Alcoholic liver disease(ALD)is a growing global health concern,and its early pathogenesis includes steatosis and steatohepatitis.Inhibiting lipid accumulation and inflammation is a crucial step in relieving ALD.Evidence shows that puerarin(Pue),an isoflavone isolated from Pueraria lobata,exerts cardio-protective,neuroprotective,anti-inflammatory,antioxidant activities.However,the therapeutic potential of Pue on ALD remains unknown.In the study,both the NIAAA model and ethanol(EtOH)-induced AML-12 cell were used to explore the protective effect of Pue on alcoholic liver injury in vivo and in vitro and related mechanism.The results showed that Pue(100 mg·kg^(−1))attenuated EtOH-induced liver injury and inhibited the levels of SREBP-1c,TNF-α,IL-6 and IL-1β,compared with silymarin(Sil,100 mg·kg^(−1)).In vitro results were consistent with in vivo results.Mechanistically,Pue might suppress liver lipid accumulation and inflammation by regulating MMP8.In conclusion,Pue might be a promising clinical candidate for ALD treatment. | HU Ying WANG Shuxian WU Lan YANG Kai YANG Fan YANG Junfa HU Shuang YAO Yan XIA Xun LIU Yixin PENG Li WAN Jihong SHEN Chuanpu XU Tao | 2023 | Chinese Journal of Natural Medicines2023，21，9： | 0 |
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