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| 1 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | The Lancet2008，，9636： | 7 |
| 2 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 3 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | The Lancet . 2008 (9636)2008，，： | 4 |
| 4 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | The Lancet2008，，9636： | 3 |
| 5 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | 2008 (9636)2008，，9636： | 2 |
| 6 | Long-Term Survival After Report Resection of Pulmonary Metastases from Hepatocellular Carcinoma: Report of Two Cases显示文摘 | Toru Nakamura Taizo Kimura Yasuhiko Umehara Kenji Suzuki Kazuya Okamoto Takuya Okumura Sei Morizumi Toshiki Kawabata Akira Komiyama | 2005 | Surgery Today2005，，10： | 1 |
| 7 | Relationship Between Screw Trajectory of C1 Lateral Mass Screw and Internal Carotid Artery显示文摘 | Satona Murakami Jun Mizutani Muneyoshi Fukuoka Kenji Kato Isato Sekiya Hideki Okamoto Kuniyoshi Abumi Takanobu Otsuka | 2008 | Spine2008，，24： | 1 |
| 8 | Efficient xylose fermentation by the brown rot fungus Neolentinus lepideus 显示文摘 | Kenji Okamoto Ryuichi Kanawaku Masaru Masumoto | 2012 | Enzyme and Microbiology Technology2012，50，： | 1 |
| 9 | Biosynthesis of p - anisaldehyde by the white - rot basidiomycete pleurotus ostreatus 显示文摘 | KENJI OKAMOTO SHINJI NARAYAMA AKIHISA KATSUO | 2002 | Journal of Bioscience and Bioengineering2002，93，2： | 1 |
| 10 | The elimination of the ‘artifact’ in the electrostatic force measurement using a novel noncontact atomic force microscope/electrostatic force microscope显示文摘 | Kenji Okamoto Yasuhiro Sugawara Seizo Morita | 2002 | Applied Surface Science2002，，3： | 1 |
| 11 | Generalized peritonitis due to spontaneously perforated pyometra presenting as pneumoperitoneum: Report of a case显示文摘 | Atsunori Nakao Hisashi Mimura Kenji Fujisawa Kazuhiko Ezawa Takahiro Okamoto Hiromi Iwagaki Hiroshi Isozaki Norihisa Takakura Noriaki Tanaka | 2000 | Surgery Today2000，，5： | 1 |
| 12 | Single-port Laparoscopic Adhesiolysis for Torsion Ileus显示文摘 | Hirotaka Okamoto Hiroyuki Wakana Kenji Kawashima Toshio Fukasawa Hideki Fujii | 2012 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2012，，4： | 1 |
| 13 | A high-yield regiospecific synthesis of keto oximes from aryl- conjugated ethylenes and ethyl nitrite in the presence of cobalt complex and BH4- ion 显示文摘 | Tadashi Okamoto Kenji Kobayashi Shinzaburo Oka | 1988 | Journal of Organic Chemistry1988，53，21： | 1 |
| 14 | Ethanol production from wood hydrolysate using genetically engineered Zymomonas mobilis显示文摘 | Yananse H Miyawaki H Sakurai M Kawakami A Matsumoto M Haga Kenji Kojima M Okamoto K | | 0，，： | 1 |
| 15 | Purification and characterization of extracellular laccase from Pleurotus ostreatus 显示文摘 | Kenji Okamoto | 2000 | Myeoscienee2000，41，： | 1 |
| 16 | Antimicrobial substances Coixindens A and B in Etiolated Seedlings of Adlay显示文摘 | YUKIO ISHIGURO KENJI OKAMOTO HIDEKI SAKA MOTO | | 0，，： | 1 |
| 17 | Automatic Diagnosis of Plant Disease显示文摘 | Yutaka SASAKI Tsuguo OKAMOTO Kenji IMOU | 1999 | Journal of JSAM1999，61，2： | 1 |
| 18 | Phase Transition and Electrical Conductivity of ScandiaStabilized Zirconia Prepared by Spark Plasma Sintering Process显示文摘 | Yoshio Akimuffe Kenji Fhruya | 2005 | Solid State Ionics2005，176，： | 1 |
| 19 | Automatic diagnosis of plant disease recognition between healthy and diseased leaf显示文摘 | Yutaka Sasaki Tsuguo Okamoto Kenji Imov | 1999 | Journal of TSAM Japan1999，61，2： | 1 |
| 20 | ‘Working’ cardiomyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cells显示文摘 | Kazuma Okamoto Shunichiro Miyoshi Masashi Toyoda Naoko Hida Yukinori Ikegami Hatsune Makino Nobuhiro Nishiyama Hiroko Tsuji Chang-Hao Cui Kaoru Segawa Taro Uyama Daisuke Kami Kenji Miyado Hironori Asada Kenji Matsumoto Hirohisa Saito Yasunori Yoshimura Sa | 2007 | Experimental Cell Research2007，，12： | 1 |
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