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| 1 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 2 | Photo-controlled release of paclitaxel and model drugs from RNA pyramids显示文摘Stimuli-resp on sive release of drugs from a nano carrier in spatial-,temporal-,and dosage-controlled fashi ons is of great interest in the pharmaceutical industry.Paclitaxel is one of the most effective and popular chemotherapeutic drugs against a number of cancers such as metastatic or non metastatic breast can cer,non-small cell lung can cer,refractory ovaria n cancer,AIDS-related Kaposi's sarcoma,and head and neck can cers.Here,by taki ng the adva ntage of RNA nanotechno logy in biomedical and material scie nee,we developed a three-dime nsional pyramid-shaped RNA nanocage for a photocontrolled release of cargo,using paclitaxel as a model drug.The light-triggered release of paclitaxel or fluorophore Cy5 was achieved by incorporation of photocleavable spacers into the RNA nanoparticles.Upon irradiation with ultraviolet light,cargos were rapidly released(within 5 min).In vitro treatment of breast can cer cells with the RNA nano particles harbori ng photocleavable paclitaxel showed higher cytotoxicity as compared to RNA nanoparticles without the photocleavable spacer.The methodology provides proof of con cept for the applicati on of the light-triggered con trolled release of drugs from RNA nano cages. | Congcong Xu Hui Li Kaiming Zhang Daniel W.Binzel Hongran Yin Wah Chiu Peixuan Guo | 2019 | Nano Research2019，12，1： | 3 |
| 3 | Numerical modeling of radionuclide migration in porous media with nonequilibrium sorption显示文摘Numericalmodelingofradionuclidemigrationinporousmediawithnonequilibriumsorption￥ChenJiajun;DaiJie(DepartmentofEnvironmentalEn... | Chen Jiajun Dai Jie(Department of Environmental Engineering,Tsinghua University,Beijing 100084,China)(Tianjin Institute of Geological Investigation and Research,Tianjin 300191,China)Xu Zhaoyi Tian Kaiming(Changchun University of Earth Sciences,Changchun 1 | 1996 | Journal of Environmental Sciences1996，8，1： | 3 |
| 4 | Ti3C2Tx/PEDOT:PSS hybrid materials for room-temperature methanol sensor显示文摘It is essential to develop a methanol gas sensor with high selectivity and low working temperature for human health and environmental monitoring.In this work,a blend of PEDOT:PSS and Ti3C2Tx with the mass ratio of 4:1 is used to fabricate a methanol gas sensor.It possesses a high response ratio of the largest response and the second largest response(5.54)and an enhanced response compared to pure PEDOT:PSS and pure Ti3C2Tx tested at room temperature.These findings may pave the way towards design of the MXenes based high-performance gas-sensing materials in the future. | Xiaofeng Wang Kaiming Sun Ke Li Xu Li Yury Gogotsi | 2020 | Chinese Chemical Letters2020，31，4： | 3 |
| 5 | Advances in Researches on the Middle and Upper Atmosphere in 2008-2010显示文摘This paper summarizes the results of the researches on the middle and upper atmosphere obtained by Chinese scientists in 2008-2010.The focuses are specifically placed on the researches being associated with ground-based observation capability development,dynamical processes,the property of atmospheric circulation and the chemistry-climate coupling of the middle atmospheric layers. | Chen Zeyu Chen Hongbin Lue Daren Xu Jiyao Chen Wen Tian Wenshou Ren Rongcai Hu Yongyun Huang Kaiming | 2010 | 空间科学学报2010，30，5： | 2 |
| 6 | Crystallization mechanism and microstructure evolution of Li2O–Al2O3–SiO2 glass-ceramics with Ta2O5 as nucleating agent显示文摘 | Yaohui Li Kaiming Liang Bo Xu JianWei Cao | 2010 | Journal of Thermal Analysis and Calorimetry2010，，3： | 1 |
| 7 | Circ_ASPH promotes cholangiocarcinoma growth and metastasis through the miR-581/ATP-binding cassette transporter G1 signaling pathway显示文摘Dear Editor,Cholangiocarcinoma(CCA)is an aggressive malignant tumor of the hepatobiliary system,mainly originating from the cholangiocytes of small intrahepatic bile ducts[1].The overall survival of patients with CCA is still unfavorable[1].Circular RNAs(circRNAs)are a type of non-coding RNAs with limited protein-coding capacity[2]and have shown to exert regulatory effects in multiple diseases by interacting with certain miRNAs to inhibit their expression and functions[3].Emerging evidence indicates that circRNAs can directly bind to several RNA-binding proteins to execute their biological functions.Hence,determining the mechanisms underlying the progression of CCA and searching for new drugs from the perspective of circRNAs are imperative. | Yi Xu Pengcheng Kang Kaiming Leng Yue Yao Guanqun Liao Yi Han Guangjun Shi Xiangyu Zhong Yunfu Cui | 2020 | Cancer Communications2020，40，10： | 1 |
| 8 | A variable threshold visual sensing and image reconstruction method based on pulse sequence显示文摘Dear editor,Pulsed-based CMOS image sensor(CIS)outperforms classic CIS in terms of data rate,and is able to achieve ultra-highspeed imaging[1].A pulsed-based CIS which is able to capture the movement of the hard disk rotating at 6000 r/min,was designed in our previous work[2,3].The main problems of the pulse-based sensing mechanism are nonlinearity and readout noise.Nonlinearity.As light intensity is inversely proportional to the pulse interval[4],reconstructed images will involve loss of gray levels or lag in various light conditions[5]. | Jiangtao XU Peng LIN Zhiyuan GAO Kaiming NIE Liang XU | 2022 | Science China(Information Sciences)2022，65，2： | 1 |
| 9 | Transcription Factor Interactions Mediate EGF-Dependent COX-2 Expression显示文摘 | Kaiming Xu Hui-Kuo G. Shu | 2013 | Molecular Cancer Research2013，，8： | 1 |
| 10 | Thermal conductivity of nanofluids and size distribution of nanoparticles by Monte Carlo simulations显示文摘 | Yongjin Feng Boming Yu Kaiming Feng Peng Xu Mingqing Zou | 2008 | Journal of Nanoparticle Research2008，，8： | 1 |
| 11 | Application of CALPHAD approach in simulation of liquid phase migration of cellular cemented carbide显示文摘 | Cheng Kaiming Xu Tao Zhang Hao | 2014 | International Journal of Refractory Metals and Hard Materials2014，42，： | 1 |
| 12 | Diffusion growth of Φ ternary intermetallic compound in the Mg-Al-Zn alloy system:In-situ observation and modeling显示文摘Study on the diffusion growth of ternary intermetallic compounds in Mg-Al-Zn based light-weight alloys is important due to its close interrelation with alloy property.However,there is a very lack of existing data due to difficulties in both experimental and computational aspects.The current work aims at presenting the experimental observation on the diffusion growth behavior of Φ phase at 360℃ as well as calculating its composition-dependent interdiffu sion coefficients.We designed and succes s fully fabricated four Mg-τ ternary diffusion couples annealed at 360℃ for different times,where the diffusion path goes across the Φ phase region and the diffusion growth of ternary intermetallic compound can be solely detected.In-situ observation of the time-dependent growth of Φ phase was performed to accurately determine the parabolic growth constant.The experimental data were then subjected to a numerical inverse method to generate a set of self-consistent interdiffusivities of the ternary intermetallic compounds,which can reproduce the presently observed diffusion growth behavior of Φ ternary intermetallic compound in Mg-τ diffusion couples. | Kaiming Cheng Jiaxing Sun Huixia Xu Jin Wang Chengwei Zhan Reza Ghomashchi Jixue Zhou Shouqiu Tang Lijun Zhang Yong Du | 2021 | Journal of Materials Science & Technology2021，，1： | 0 |
| 13 | Motion detection for high-speed high-brightness objects based on a pulse array image sensor显示文摘We describe a method of optical flow extraction for high-speed high-brightness targets based on a pulse array image sensor(PAIS).PAIS is a retina-like image sensor with pixels triggered by light;it can convert light into a series of pulse intervals.This method can obtain optical flow from pulse data directly by accumulating continuous pulses.The triggered points can be used to filter redundant data when the target is brighter than the background.The method takes full advantage of the rapid response of PAIS to high-brightness targets.We applied this method to extract the optical flow of high-speed turntables with different background brightness,with the sensor model and actual data,respectively.Under the sampling condition of 2×10^(4) frames/s,the optical flow could be extracted from a high-speed turntable rotating at 1000 r/min.More than 90%of redundant points could be filtered by our method.Experimental results showed that the optical flow extraction algorithm based on pulse data can extract the optical flow information of high-brightness objects efficiently without the need to reconstruct images. | Peiwen ZHANG Jiangtao XU Huafeng NIE Zhiyuan GAO Kaiming NIE | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，1： | 0 |
| 14 | Cilia regeneration requires an RNA splicing factor from the ciliary base显示文摘Cilia are microtubule-based organelles projected from most eukaryotic cell surfaces performing cell motility and signaling.Several previously recognized non-ciliary proteins play crucial roles in cilium formation and function.Here,we provide additional evidence that the Caenorhabditis elegans RNA splicing factor PRP-8/PRPF8 regulates ciliogen-esis and regeneration from the ciliary base.Live imaging of GFP knock-in animals reveals that the endogenous PRP-8 localizes in the nuclei and the ciliary base.A weak loss-of-function allele of prp-8 affects ciliary structure but with little impact on RNA splicing.Conditional degradation of PRP-8 within ciliated sensory neurons showed its direct and spe-cific roles in cilium formation.Notably,the penetrance of ciliary defects correlates with the reduction of PRP-8 at the ciliary base but not nuclei,and sensory neurons regenerated cilia accompanying PRP-8 recovery from the ciliary base rather than the nuclei.We suggest that PRP-8 at the ciliary base contributes to cilium formation and regeneration. | Kaiming Xu Guangshuo Ou | 2022 | Cell Regeneration2022，11，1： | 0 |
| 15 | A Two-dimensional Dual-pore Covalent Organic Framework for Efficient Iodine Capture显示文摘Effectively capturing volatile radioiodine generated during the nuclear fission process is considered to be a safe way to the utilization of nuclear power. Here we report a new two-dimensional covalent organic framework(2D COF), ETTA-PyTTA-COF, as a highly efficient iodine adsorbent, which is constructed through the condensation reaction between 4,4’,4’’,4’’’-(ethene-1,1,2,2-tetrayl)-tetrabenzaldehyde(ETTA) and 1,3,6,8-tetrakis(4-aminophenyl)pyrene(PyTTA). The ETTA-PyTTA-COF possesses a permanent 1D channel porous structure with a high Brunauer-Emmet-Teller(BET) surface area of 1519 m2/g and excellent chemical and thermal stability. It shows ultrahigh iodine adsorption capability, which can reach up to 4.6 g/g in vapor owing to its high BET surface area, large π-conjugated structure and plenty of imine groups in the skeleton of the COF as effective iodine sorption sites. | WEN Zhongliang WANG Shenglin FU Siyao QIAN Jiaying YAN Qianqian XU Huanjun ZUO Kaiming SU Xiaofang ZENG Chaoyuan GAO Yanan | 2022 | Chemical Research in Chinese Universities2022，38，2： | 0 |
| 16 | 3D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the in vivo biodistribution显示文摘Ribonucleic acid(RNA)nanotechnology platforms have the potential of harboring therapeutics for in vivo delivery in disease treatment.However,the nonspecific interaction between the harbored hydrophobic drugs and cells or other components before reaching the diseased site has been an obstacle in drug delivery.Here we report an encapsulation strategy to prevent such nonspecific hydrophobic interactions in vitro and in vivo based on a self-assembled three-dimensional(3D)RNA nanocage.By placing an RNA three-way junction(3WJ)in the cavity of the nanocage,the conjugated hydrophobic molecules were specifically positioned within the nanocage,preventing their exposure to the biological environment.The assembly of the nanocages was characterized by native polyacrylamide gel electrophoresis(PAGE),atomic force microscopy(AFM),and cryogenic electron microscopy(cryo-EM)imaging.The stealth effect of the nanocage for hydrophobic molecules in vitro was evaluated by gel electrophoresis,flow cytometry,and confocal microscopy.The in vivo sheathing effect of the nanocage for hydrophobic molecules was assessed by biodistribution profiling in mice.The RNA nanocages with hydrophobic biomolecules underwent faster clearance in liver and spleen in comparison to their counterparts.Therefore,this encapsulation strategy holds promise for in vivo delivery of hydrophobic drugs for disease treatment. | Congcong Xu Kaiming Zhang Hongran Yin Zhefeng Li Alexey Krasnoslobodtsev Zhen Zheng Zhouxiang Ji Sijin Guo Shanshan Li Wah Chiu Peixuan Guo | 2020 | Nano Research2020，13，12： | 0 |
| 17 | Correction: Cilia regeneration requires an RNA splicing factor from the ciliary base显示文摘Following publication of the original article(Xu and Ou 2022),it is reported that the supplement figure S1-S5 were missing from the article.Additional file 1:Fig.S1 contains only figure legends but no figures. | Kaiming Xu Guangshuo Ou | 2022 | Cell Regeneration2022，11，1： | 0 |
| 18 | A high dynamic range pixel using lateral overflow integration capacitor and adaptive feedback structure in CMOS image sensors显示文摘This letter proposes a novel high dynamic range(HDR)pixel using lateral overflow integration capacitor(LOFIC)and adaptive feedback structure.Through detailed analysis of the voltage feedback mechanism,the conversion gain(CG),full well capacity(FWC)and dynamic range(DR)performances of the feedback LOFIC pixel are analytically expressed.The verification results reveal that the equivalent FWC of the feedback LOFIC pixel is 1.89 times of conventional LOFIC pixel,and the DR extension is 5.5 dB.Based on 110 nm CMOS process,a 5.0µm pixel layout is presented,using 13.3 fF capacitance to achieve 83 ke-FWC and 102.8 dB DR,which are 44 ke-and 97.3 dB of conventional LOFIC pixel under the same design conditions.This also demonstrates that the feedback LOFIC pixel can reduce the dependence of extended DR on capacitor area,and can be used as a reference for HDR pixels design. | YANG Yuejin XU Jiangtao MA Biao CHEN Quanmin NIE Kaiming | 2023 | Optoelectronics Letters2023，19，12： | 0 |
| 19 | RNA structure determination:From 2D to 3D显示文摘RNA molecules serve a wide range of functions that are closely linked to their structures.The basic structural units of RNA consist of single-and double-stranded regions.In order to carry out advanced functions such as catalysis and ligand binding,certain types of RNAs can adopt higher-order structures.The analysis of RNA structures has progressed alongside advancements in structural biology techniques,but it comes with its own set of challenges and corresponding solutions.In this review,we will discuss recent advances in RNA structure analysis techniques,including structural probing methods,X-ray crystallography,nuclear magnetic resonance,cryo-electron microscopy,and small-angle X-ray scattering.Often,a combination of multiple techniques is employed for the integrated analysis of RNA structures.We also survey important RNA structures that have been recently determined using various techniques. | Jie Deng Xianyang Fang Lin Huang Shanshan Li Lilei Xu Keqiong Ye Jinsong Zhang Kaiming Zhang Qiangfeng Cliff Zhang | 2023 | Fundamental Research2023，3，5： | 0 |
| 20 | Advances in the Researches of the Middle and Upper Atmosphere in China显示文摘In this report we summarize the research results by Chinese scientists in 2018–2020.The focuses are placed on the researches of the middle and upper atmosphere,specifically the researches on atmospheric structure and composition,climate and chemistry-climate coupling and climate modelling,dynamics in particular those inducing the coupling of the atmospheric layers. | CHEN Zeyu CHEN Hongbin XU Jiyao HUANG Kaiming XUE Xianghui HU Dingzhu CHEN Wen YANG Guotao TIAN Wenshou HU Yongyun XIA Yan | 2020 | 空间科学学报2020，40，5： | 0 |
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