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| 1 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 2 | Pulmonary Function After Lobectomy Versus Segmentectomy in Patients with Stage I Non-Small Cell Lung Cancer显示文摘 | Hajime Saito Taku Nakagawa Manabu Ito Kazuhiro Imai Takashi Ono Yoshihiro Minamiya | 2014 | World Journal of Surgery2014，，8： | 2 |
| 3 | Free jejunal graft for hypopharyngeal and esophageal reconstruction显示文摘 | Yasuhiro Shirakawa Yoshio Naomoto Kazuhiro Noma Ryoko Ono Tetsuji Nobuhisa Masahiko Kobayashi Toshiya Fujiwara Hirofumi Noguchi Takaomi Ohkawa Tomoki Yamatsuji Minoru Haisa Junji Matsuoka Mehmet Gunduz Noriaki Tanaka | 2004 | Langenbeck’s Archives of Surgery2004，，5： | 1 |
| 4 | Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains显示文摘 | Kazuhiro Imamura Nozomi Hishikawa Kenji Ono Hiromi Suzuki Makoto Sawada Toshiharu Nagatsu Mari Yoshida Yoshio Hashizume | 2005 | Acta Neuropathologica2005，，2： | 1 |
| 5 | Effect of board density and layer structure on the mechanical properties of bamboo oriented strandboard显示文摘 | Ihak Sumardi Kazuhiro Ono Shigehiko Suzuki | 2007 | J Wood Sci2007，53，： | 1 |
| 6 | Calibration method for determination of nitrogen content in steel by thermo-conductimetry after fusion in the current of an inter gas显示文摘 | Akihiro ONO Yasuhiro HAYAKAWA Kazuhiro UEKI | 1994 | Analytical Sciences1994，10，3： | 1 |
| 7 | Changes in Characters of soybean Glycinin Groups Ⅰ, Ⅱ a and Ⅱ b caused by Heating 显示文摘 | Masanori Tezuka Kazuhiro Yagasaki Tomotada Ono | 2004 | Journal of agricultural and food chemistry2004，52，6： | 1 |
| 8 | Calibration method for determination of nitrogen content in steel by thermo-conductimetry after fusion in the current of an inter gas显示文摘 | Akihiro ONO Yasuhiro HAYAKAWA Kazuhiro UEKI | | 0，，03： | 1 |
| 9 | Interactive effects of milk basic protein supplements and habitual physical activity on bone health in older women: A 1-year randomized controlled trial显示文摘 | Yukitoshi Aoyagi Hyuntae Park Sungjin Park Kazuhiro Yoshiuchi Hiroe Kikuchi Hiroshi Kawakami Yoshikazu Morita Aiko Ono Roy J. Shephard | 2010 | International Dairy Journal2010，，10： | 1 |
| 10 | Recombinant human interleukin-11 improved carboplatin-induced thrombocytopenia without affecting antitumor activities in mice bearing Lewis lung carcinoma cells显示文摘 | Minori Saitoh Katsunari Taguchi Kazuhiro Momose Kazutaka Suga Noriyuki Yamazaki Chizuko Ono Tatsuo Suzuki Osamu Takeuchi Shuhei Yasuda Keiji Miyata | 2001 | Cancer Chemotherapy and Pharmacology2001，，2： | 1 |
| 11 | Defects in D-Rhamnosyl Residue Biosynthetic Genes Affect Lipopolysaccharide Structure, Motility, and Cell-Surface Hydrophobicity in Pseudomonas syringae Pathovar glycinea Race 4显示文摘 | Kazuhiro CHIKU Kazuhiko TSUNEMI Masanobu YAMAMOTO Mayumi OHNISHI-KAMEYAMA Mitsuru YOSHIDA Tadashi ISHII Fumiko TAGUCHI Masako IWAKI Yuki ICHINOSE Hiroshi ONO | 2013 | Bioscience, Biotechnology, and Biochemistry2013，，： | 1 |
| 12 | SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models显示文摘 | Yoko Ono Hirotaka Tanaka Masafumi Takata Yuki Nagahara Yasuhiro Noda Kazuhiro Tsuruma Masamitsu Shimazawa Isao Hozumi Hideaki Hara | 2014 | Neuroscience Letters2014，，： | 1 |
| 13 | Induction of adrenomedullin 2/intermedin expression by thyroid stimulating hormone in thyroid显示文摘 | Shuji Nagasaki Motoko Fukui Satoko Asano Katsuhiko Ono Yasuhiro Miki Sei-ichi Araki Mitsui Isobe Noriaki Nakashima Kazuhiro Takahashi Hironobu Sasano Jun Sato | 2014 | 2014 (1-2)2014，，： | 1 |
| 14 | A p53 codon 72 polymorphism associated with prostate cancer development and progression in Japanese显示文摘 | Assoc. Prof. Kazuhiro Suzuki MD Hiroshi Matsui Nobuaki Ohtake Seiji Nakata Tomoyuki Takei Haruki Nakazato Hironobu Okugi Hidekazu Koike Yoshihiro Ono Kazuto Ito Kohei Kurokawa Hidetoshi Yamanaka | 2003 | Journal of Biomedical Science2003，，4： | 1 |
| 15 | 固溶碳和晶界对超低碳细晶钢应变时效的影响显示文摘我们采用碳含量为1~3 ppm、铁素体晶粒尺寸为9.5 um和183 um的含Nb超低碳钢.在70℃-400℃时效条件下,研究了溶质C和晶界对多晶铁素体钢应变时效现象的影响作用。这种钢呈现出两个明显的硬化阶段。无论是细晶粒试样或是粗晶粒试样,都有第一个硬化阶段,在这个硬化阶段,屈服点YP的增量(△YP】最高达到30 MPa。根据表观活化能和硬化动力学可知,硬化的原因是由于C原子对位错的钉扎。第二个硬化阶段主要表现在细晶粒试样中,伴随着HaJl—Petch系数的增大,△YP也很大,达到了90 MPa。在时效试样中,用透射电镜(rrEM)和三维原子探4t(3DAP)没有检测到细小的析出物。溶质C向晶界的偏析和晶界上Fe原子的扩散是出现第二个硬化阶段的原因。因此,晶界硬化是多晶铁素体钢应变时效硬化的原因。 | Yoshihiko ONO Yoshimasa FUNAKAWA Kaneharu OKUDA Kazuhiro SETO Naoki EBISAWA Koji INOUE Yasuyoshi NAGAI | 2017 | 水钢科技2017，0，4： | 0 |
| 16 | Clinical efficacy and safety of second line and salvage aflibercept for advanced colorectal cancer in Akita prefecture显示文摘BACKGROUND Angiogenesis inhibitors(AIs)combination with cytotoxic chemotherapy is a promising treatment for patients with colorectal cancer(CRC).Aflibercept(AFL)is an option for second-line treatment of CRC,according to the‘VELOUR’trial.Currently,we can choose from three AIs,including bevacizumab,ramucirumab,and AFL.Different AIs can be used in subsequent treatment because of their distinctive mechanisms of action.We addressed the uncertainty regarding AFL efficacy and safety in heavily-treated patients by comparing outcomes of survival treatment with second-line treatment.AIM To determine and compare the efficacy and safety profiles of AFL in the secondline and salvage therapy settings.METHODS Clinical data of 41 patients with advanced CRC who received intravenous AFL combined with the folinic acid-fluorouracil-irinotecan(FOLFIRI)regimen were collected retrospectively from six institutions in Japan,for the period from May 2017 to March 2019.Patient characteristics collected included age,sex,tumor location,RAS and RAF status,metastatic sites,number of previous treatment cycles,therapeutic response,adverse events,duration of previous AI treatment,and survival time.The end points were time to AFL treatment failure(aTTF)and median survival time post-AFL(aMST).Statistical analyses were performed to compare the efficacy and safety in the second-line setting with those of the salvage therapy setting,which was defined as the days since the end of secondline therapy.RESULTS All 41 patients who received AFL+FOLFIRI for advanced CRC had metastatic or unresectable cancer.Twenty-two patients received AFL in the second-line setting and nineteen in the salvage therapy setting.The patient characteristics were similar in the two groups,except for two factors.The median duration of the previous AI administration was shorter in the second-line patients compared with that in the salvage therapy patients(144 d vs 323 d,P=0.006).In the second-line and salvage therapy groups,the objective response rates were 11%and 0%,respectively(P=0.50),and the disease control rates were 53%and 50%,respectively(P=1.00).In the second-line and salvage therapy groups,the aTTF(123 d vs 71 d,respectively),aMST(673 d vs 396 d,respectively),and incidence of adverse events of grade 3[8(36%)vs 9(47%)]were not significantly different between the two groups.CONCLUSION AFL can be used to treat advanced CRC patients,with a similar safety and efficacy in the salvage therapy setting as in the second-line setting. | Taichi Yoshida Kentaro Takahashi Kengo Shibuya Osamu Muto Yuko Yoshida Daiki Taguchi Kazuhiro Shimazu Koji Fukuda Fuminori Ono Kyoko Nomura Hiroyuki Shibata | 2021 | World Journal of Gastrointestinal Oncology2021，13，4： | 0 |
| 17 | Microfluidic-based flexible reflective multicolor display显示文摘This paper describes a microfluidic-based flexible reflective display constructed using dyed water droplets and air gaps as pixel elements.Our display is composed of a flexible polydimethylsiloxane sheet with a connected pixel-patterned microchannel.Several types of dyed water droplets and air gaps are sequentially introduced to the microchannel through a suction process to display a multicolor image.The displayed image is stable and can be retained without an energy supply.To ensure that images are displayed correctly,the geometric parameters of the dot pixel design and minimum differential pressure necessary to drive the water droplets are evaluated.As a demonstration,we successfully display three-color dot-matrix reflective images and bitmap characters in the microchannel.Our proposed method can be applied to energy-less and color-changeable displays for use in future daily-life accessories,such as bags,shoes,and clothes,and can change the surface color and pattern of these accessories. | Kazuhiro Kobayashi Hiroaki Onoe | 2018 | Microsystems & Nanoengineering2018，4，1： | 0 |
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