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| 1 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 2 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 3 | Factors Determining Diagnostic Yield of Endoscopic Ultrasound Guided Fine-Needle Aspiration for Pancreatic Cystic Lesions: A Multicentre Asian Study显示文摘 | Lee Guan Lim Sandeep Lakhtakia Tiing Leong Ang Charles K. F. Vu Frederick Dy Vui Heng Chong Christopher J. L. Khor Wee Chian Lim Bhavesh Kishor Doshi Shyam Varadarajulu Kenjiro Yasuda Jennie Y. Y. Wong Yiong Huak Chan Min En Nga Khek Yu Ho | 2013 | Digestive Diseases and Sciences2013，，6： | 2 |
| 4 | itomycin C induces apoptosis in cultured corneal ilbroblasts derived from type II granular corneal dystrophy corneas 显示文摘 | Kim TI Choi SI Lee HK | 2008 | Mol Vis2008，14，： | 1 |
| 5 | Widespread cerebral cortical mineralization in Wilson’s disease detected by susceptibility-weighted imaging显示文摘 | Lee JH Yang TI Cho M | 2012 | Neurol Sci2012，313，12： | 1 |
| 6 | In vivo imaging of tumorapoptosis using histone HI-targeting peptide 显示文摘 | Wang K Purushotham S Lee Ti | 2010 | J Control Re-lease2010，148，3： | 1 |
| 7 | Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma显示文摘 | Xu MZ Yao Ti Lee NP | 2009 | Cancer2009，115，19： | 1 |
| 8 | A Human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells 显示文摘 | Park KJ Lee SH Kim TI | 2007 | Cancer Res2007，67，15： | 1 |
| 9 | Core transcriptional regulatory circuitry in human embryonic stem cells显示文摘 | Boyer LA Lee TI Cole MF | 2005 | Cell2005，122，6： | 1 |
| 10 | An Autologous Platelet-rich Plasma Hydrogel Compound Restores Left Ventricular Structure, Function and Ameliorates Adverse Remodeling in a Minimally Invasive Large Animal Myocardial Restoration Model: A Translational Approach显示文摘 | Thang Duc Vu Shripad N. Pal Lian-Kah Ti Eliana C. Martinez Abdul Jalil Rufaihah Lieng H. Ling Chuen-Neng Lee Arthur Mark Richards Theo Kofidis | 2014 | Biomaterials2014，，： | 1 |
| 11 | Core transcriptional regulatory circuitry in human embryonic stem cells显示文摘 | Boyer LA Lee TI Cole MF | 2005 | Cell2005，122，： | 1 |
| 12 | New titanium alloys for biomaterials:a study of mechanical and corrosion properties and cytotoxicity显示文摘 | Kim TI Han JH Lee IS | 1997 | Biomed Mater Eng1997，，7： | 1 |
| 13 | Adjunctive effects of cyclosporine and macrolide in rapidly progressive cryptogenic organizing pneumonia with no prompt response to steroid 显示文摘 | Lee J Cha SI Park TI | 2011 | Intern Med2011，50，： | 1 |
| 14 | A guanidinylated bioreducible polymer with high nuclear localzation ability for genedelivery systems 显示文摘 | Kim TI Lee M Kim SW | 2010 | Biomaterials2010，3197，7： | 1 |
| 15 | Comparison of a newly designed double-layered combination covered stent and D-weave uncovered stent for decompression of obstru-ction colorectal cancer:a prospective multicenter study显示文摘 | Moon CM Kim TI Lee MS | 2010 | Dis Colon Rectum2010，53，： | 1 |
| 16 | The accuracy of fine- needle aspiration biopsy and frozen section in patients with thyroid cancer显示文摘 | Lee TI Yang HJ Lin SY | 2002 | Thyroid2002，12，7： | 1 |
| 17 | Prognostic significance of tetraspanin CD151 in newly diagnosed glioblastomas 显示文摘 | Lee D Suh YL Park TI | | J Surg Oncol0，107，6： | 1 |
| 18 | Cardiac metabolism, inflammation, and peroxisome proliferator-activated receptors modulated by 1, 25-di- hydroxyvitamirt D3 in diabetic rats 显示文摘 | Lee TI Kao YH Chen YC | 2014 | Int I Cardiol2014，176，： | 1 |
| 19 | Effects of Nonsteroidal anti-inflammatory drugs on helicobacter pylori-Infected gastric mucosae of mice: apoptosis, cell proliferation,and inflammatory activity 显示文摘 | Kim TI Lee YC Lee KH | 2001 | Infect Immun2001，69，8： | 1 |
| 20 | Accuracy of RTVue optical coherence tomography, Pentacam, and ultrasonic pachymetry for the measurement of central corneal thickness 显示文摘 | Nam SM Im CY Lee HK Kim EK Kim TI Seo KY | 2010 | Ophthalmology2010，117，11： | 1 |
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