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| 1 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 2 | An area-based position and attitude estimation for unmanned aerial vehicle navigation显示文摘The paper aims to challenge non-GPS navigation problems by using visual sensors and geo-referenced images. An area-based method is proposed to estimate full navigation parameters(FNPs), including attitude, altitude and horizontal position, for unmanned aerial vehicle(UAV) navigation. Our method is composed of three main modules: geometric transfer function, local normalized sobel energy image(LNSEI) based objective function and simplex-simulated annealing(SSA) based optimization algorithm. The adoption of relatively rich scene information and LNSEI, makes it possible to yield a solution robustly even in the presence of very noisy cases, such as multi-modal and/or multi-temporal images that differ in the type of visual sensor, season, illumination, weather, and so on, and also to handle the sparsely textured regions where features are barely detected or matched. Simulation experiments using many synthetic images clearly support noise resistance and estimation accuracy, and experimental results using 2367 real images show the maximum estimation error of 5.16(meter) for horizontal position, 9.72(meter) for altitude and 0.82(degree) for attitude. | LIU XiaoChun WANG Hou FU Dan YU QiFeng GUO PengYu LEI ZhiHui SHANG Yang | 2015 | Science China(Technological Sciences)2015，58，5： | 7 |
| 3 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 4 | “Giant pressure shadow” structure and ore-finding method of tectonic stress field in the Tongchang Cu-Au polymetallic orefield,Shaanxi,China:Ⅱ.Dynamics of tectonic ore-forming processes and prognosis of concealed ores显示文摘The Tongchang orefield is located in the central part of the Mianxian-Lueyang-Yangpingguan area that is celebrated as a 'gold triangle' area,at the juncture of the latitudinal tectonic zone of South Qinling,the Longmenshan Cathysian tectonic zone and the Sichuan-Yunnan longitudinal tectonic zone,where there are distributed Cu-Au polymetallic ore deposits(occurrences) including the Tongchang,Chenjiaba,Qinjiabian,Hongtushi,Yinshangou and Xiakouyi ore deposits(mineralization).Based on the 'giant pressure shadow' structure put forward and demonstrated by numerical modeling of the tectonic stress field and the static photoelasticity experiments on the basis of tectonic ore-controlling laws in the orefield,tectonic metallogenesis driven by orefield tectonic stress has been discussed in terms of its geological setting,orefield geomechanics,and tectonic stress field.It is thought that the dynamic evolution model of the tectonic stress field controls the whole process of formation of the polymetallic ore deposits(mineralization) in the orefield,as well as the deformation field.As a result,it controls the emplacement of rockbodies and the transformation of ore-source bodies,and provides both the channel-ways for ore-forming fluids and ore-hosting space.Furthermore,it controls the migration potential field of fluids and,thereafter,its flow direction,rate and volume;the tectonic stress field also controls the energy field and hence controls the position of occurrence of ore deposits and their scale.The method of tectonic stress field has been applied to ore prognosis in the orefield.The rules of magmatic emplacement and metallogenic fluid migrating and concentrating under the control of the structural stress field were expounded,hence providing the theoretical basis for the prognosis of concealed ores.In addition,a number of important target areas have been defined. | HAN Runsheng WANG Lei MA Deyun GU Xiaochun FAN Zhuguo | 2010 | Chinese Journal Of Geochemistry2010，29，4： | 4 |
| 5 | The Phytol Phosphorylation Pathway Is Essential for the Biosynthesis of Phylloquinone, which Is Required for Photosystem I Stability in Arabidopsis显示文摘Phytyl-diphosphate,在 tocopherol 和 phylloquinone 生合成作为普通底层提供 phytyl 一半,经由 phytol phosphorylation 源于 de novo isoprenoid 生合成或一条抢救小径。然而,很,很少为 phylloquinone 生合成对 phytyl 一半的角色和起源被知道。自从 VTE6, phytyl 磷酸盐 kinase,是为 phytol phosphorylation 的关键酶,我们描绘了 Arabidopsis vte6 异种在 photosystem 在 phylloquinone 生合成并且 phylloquinone 获得卓见进 phytyl 一半的角色我(希腊语的第二十三个字母) 生物的续生说。VTE6 猛烈异种 vte6-1 和 vte6-2 缺乏可检测的 phylloquinone,而在 VTE6 击倒的变异的 vte6-3 的 phylloquinone 内容是 90% 比那低在里面野类型。在 vte6 异种,希腊语的第二十三个字母功能被损害, PSI 建筑群的累积是有缺点的。希腊语的第二十三个字母核心子单元 PsaA/B 高效地在 vte6-3 被综合并且集合进 PSI 建筑群。然而,在装配希腊语的第二十三个字母建筑群的希腊语的第二十三个字母子单元的降级率比在在 vte6-3 是更快速的野类型。在 vte6-3,希腊语的第二十三个字母是更易受影响的加亮损坏比在里面野类型。我们的结果提供 phytol phosphorylation 小径为 phylloquinone 生合成是必要的,并且那 phylloquinone 为希腊语的第二十三个字母复杂稳定性被要求的第一条基因证据。 | Lei Wang Qingwei Li Aihong Zhang Wen Zhou Rui Jiang Zhipan Yang Huixia Yang Xiaochun Qin Shunhua Ding Qingtao Lu Xiaogang wen Congming Lu | 2017 | Molecular Plant2017，10，1： | 4 |
| 6 | Damage characteristics and catastrophic failure mechanism of coal rock induced by gas adsorption under compression显示文摘To reveal the damage characteristics and catastrophic failure mechanism of coal rock caused by gas adsorption,physical tests and theoretical methods are employed.The results show that adsorption swelling can damage coal rock,which can be distinguished by fractal dimension.A fitting relationship between the adsorption damage and fractal dimension is proposed by experimental testing and theoretical analysis.High gas adsorption pressure proves to be the dominant factor that leads to coal failure softening and gas outburst disasters.Three main parameters concerning adsorption damage include the change rate of released energy density,the transition difference in the post-peak acoustic emission(AE)b value and the change rate of cumulative AE energy.Results show that all the three parameters present a step-type decreasing change with the increase in fractal dimension,and the fractal dimension shows a linear relationship within the same failure mode.Finally,a method is proposed to evaluate coal rock disaster transformation,based on the aforementioned three main parameters of adsorption damage. | Xiaochun Xiao Lei Wang Jun Xu Xiangfeng Lv Pengfei Guo Yishan Pan | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，3： | 3 |
| 7 | Optical super-resolution microscopy and its applications in nano-catalysis显示文摘常规光显微镜学的分辨率仅仅是 200 nm,它为许多应用程序正在变得越来越不足够。为了超过衍射,限制了分辨率,超级决定的显微镜学(SRM ) 被开发了完成一~十纳米的高分辨率。涉及 SRM 的技术能被分配进二个宽广范畴,也就是真的超级决定的技术和功能的超级决定的技术。在功能的超级决定的技术,随机的超级决定的显微镜学(SSRM ) 广泛地由于它的低开销,简单操作,和高分辨率被使用。在 SSRM 的原则进程是积累许多衍射有限 emitters 的坐标(例如,单个荧光灯分子) 在由本地化点的矩心的对象上散布函数(PSF ) ,然后重建用这些的对象的图象协调。什么时候衍射有限 emitters 由 nanoparticles 参加关于催化作用的催化反应,活动分发和运动信息能被 SSRM 获得。SSRM 被使用了并且在催化作用的几块地里展出了突出的优点,例如金属 nanoparticle 催化作用,分子的筛催化作用,和光催化。因为 SSRM 能在一 nanoparticle 以内解决催化活动,它答应加速新、更好的催化剂的发展和发现。这评论将在 nano 催化作用介绍简短介绍给 SRM,和对 SSRM 和它的应用的详细描述。 | Wenhui Wang Junnan Gu Ting He Yangbin Shen Shaobo Xi Lei Tian Feifei Li Haoyuan Li Liuming Yan Xiaochun Zhou | 2015 | Nano Research2015，8，2： | 3 |
| 8 | The clinical practice of ^(252)Cf neutron brachytherapy devices on malignant tumor in China显示文摘The 252Cf neutron brachytherapy devices were designed and manufactured after solving those problems:the shield difficulties for 252Cf neutron;the method and facilities for 252Cf neutron source deliver;the dose calculation and measurement for 252Cf neutron.From 1999 to 2009,more than twenty 252Cf neutron brachytherapy devices had been installed in China.The Chinese radiation oncologists implemented the 252Cf neutron brachytherapy on more than 5 000 different kinds of cancer patients,including cervix cancer;endometrium cancer and achieved ideal results.For special presentation,they had breakthrough on radical treatment for low lying rectal adenocarcinoma with sphincter preservation and melanoma patients after the modification of 252Cf neutron intracavitary applicator and dose calibration. | Lei Xin Xu Xiaochun | 2009 | Engineering Sciences2009，7，4： | 3 |
| 9 | Full-parameter vision navigation based on scene matching for aircrafts显示文摘Vision navigation based on scene matching between real-time images and a reference image has many advantages over the commonly used inertial navigation system(INS),such as no cumulative measurement errors for long-endurance flight.Recent developments in vision navigation are mainly used for partial navigation parameters measurements,such as the position and the relative velocity,which cannot meet the requirements of completely autonomous navigation.We present the concept,principle and method of full-parameter vision navigation(FPVN)based on scene matching.The proposed method can obtain the three-dimensional(3D)position and attitude angles of an aircraft by the scene matching for multiple feature points instead of a single point in existing vision navigations.Thus,FPVN can achieve the geodetic position coordinates and attitude angles of the aircraft and then the velocity vector,attitude angular velocity and acceleration can be derived by the time differentials,which provide a full set of navigation parameters for aircrafts and unmanned aerial vehicles(UAVs).The method can be combined with the INS and the cumulative errors of the INS can be corrected using the measurements of FPVN rather than satellite navigation systems.The approach provides a completely autonomous and accurate navigation method for long-endurance flight without the help of satellites. | YU QiFeng SHANG Yang LIU XiaoChun LEI ZhiHui LI Xiang ZHU XianWei LIU XiaoLin YANG Xia SU Ang ZHANG XiaoHu ZHANG HongLiang | 2014 | Science China(Information Sciences)2014，57，5： | 3 |
| 10 | LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice显示文摘The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–extracellular matrix interaction and adhesion.Here,we report that deleting Pinch1 in limb mesenchymal stem cells(MSCs)and Pinch2 globally(double knockout;dKO)in mice causes severe chondrodysplasia,while single mutant mice do not display marked defects.Pinch deletion decreases chondrocyte proliferation,accelerates cell differentiation and disrupts column formation.Pinch loss drastically reduces Smad2/3 protein expression in proliferative zone(PZ)chondrocytes and increases Runx2 and Col10a1 expression in both PZ and hypertrophic zone(HZ)chondrocytes.Pinch loss increases sclerostin and Rankl expression in HZ chondrocytes,reduces bone formation,and increases bone resorption,leading to low bone mass.In vitro studies revealed that Pinch1 and Smad2/3 colocalize in the nuclei of chondrocytes.Through its C-terminal region,Pinch1 interacts with Smad2/3 proteins.Pinch loss increases Smad2/3 ubiquitination and degradation in primary bone marrow stromal cells(BMSCs).Pinch loss reduces TGF-β-induced Smad2/3 phosphorylation and nuclear localization in primary BMSCs.Interestingly,compared to those from single mutant mice,BMSCs from dKO mice express dramatically lower protein levels ofβ-catenin and Yap1/Taz and display reduced osteogenic but increased adipogenic differentiation capacity.Finally,ablating Pinch1 in chondrocytes and Pinch2 globally causes severe osteopenia with subtle limb shortening.Collectively,our findings demonstrate critical roles for Pinch1/2 and a functional redundancy of both factors in the control of chondrogenesis and bone mass through distinct mechanisms. | Yiming Lei Xuekun Fu Pengyu Li Sixiong Lin Qinnan Yan Yumei Lai Xin Liu Yishu Wang Xiaochun Bai Chuanju Liu Di Chen Xuenong Zou Xu Cao Huiling Cao Guozhi Xiao | 2020 | Bone Research2020，8，4： | 2 |
| 11 | Effect of the disruption of three cytoskeleton components on chondrocyte metabolism in rabbit knee cartilage显示文摘 | Duan Wangping Wei Lei Cao Xiaoming Guo Heng Wang Lei Hao Yongzhuang Wei Xiaochun | 2014 | Chinese Medical Journal2014，，21： | 2 |
| 12 | Sampling Methods for Efficient Training of Graph Convolutional Networks:A Survey显示文摘Graph convolutional networks(GCNs)have received significant attention from various research fields due to the excellent performance in learning graph representations.Although GCN performs well compared with other methods,it still faces challenges.Training a GCN model for large-scale graphs in a conventional way requires high computation and storage costs.Therefore,motivated by an urgent need in terms of efficiency and scalability in training GCN,sampling methods have been proposed and achieved a significant effect.In this paper,we categorize sampling methods based on the sampling mechanisms and provide a comprehensive survey of sampling methods for efficient training of GCN.To highlight the characteristics and differences of sampling methods,we present a detailed comparison within each category and further give an overall comparative analysis for the sampling methods in all categories.Finally,we discuss some challenges and future research directions of the sampling methods. | Xin Liu Mingyu Yan Lei Deng Guoqi Li Xiaochun Ye Dongrui Fan | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，2： | 2 |
| 13 | Induction of priming by cold stress via inducible volatile cues in neighboring tea plants^FA显示文摘Plants have evolved sophisticated defense mechanisms to overcome their sessile nature.However,if and how volatiles from cold‐stressed plants can trigger interplant communication is still unknown.Here,we provide the first evidence for interplant communication via inducible volatiles in cold stress.The volatiles,including nerolidol,geraniol,linalool,and methyl salicylate,emitted from cold‐stressed tea plants play key role(s)in priming cold tolerance of their neighbors via a C‐repeatbinding factors‐dependent pathway.The knowledge will help us to understand how plants respond to volatile cues in cold stress and agricultural ecosystems. | Mingyue Zhao Lu Wang Jingming Wang Jieyang Jin Na Zhang Lei Lei Ting Gao Tingting Jing Shangrui Zhang Yi Wu Bin Wu Yunqing Hu Xiaochun Wan Wilfried Schwab Chuankui Song | 2020 | Journal of Integrative Plant Biology2020，62，10： | 2 |
| 14 | Dynamic mathematical models of batch experiments and fed-batch cultures for cyclic adenosine monophosphate production by Arthrobacter A302显示文摘 | LI LEI CHEN XIAOCHUN REN HUAJIANG | 2011 | World Journal of Microbiology&Biotechnology2011，27，10： | 1 |
| 15 | Characterization of Water Constituents Spectra Absorption in Chagan Lake of Jilin Province, Northeast China显示文摘Research on the optical characteristics of water color constituents in Chagan Lake of Jilin Province,Northeast China was carried out in order to investigate the variability of the spectra absorption parameters as inputs to bio-optical models and remote sensing algorithms for converting observed spectral signals into water quality information.Samples of total particulates,non-algal particles and colored dissolved organic matter (CDOM) were first prepared by quantitative filter technique (QFT) and then absorption coefficients of these color producing agents were determined by spectrophotometry.Spectral characteristics of absorption coefficients by total particulate matter,spectral specific absorption dependency on chlorophyll concentration (Chl-a) of phytoplankton,spectral absorption slopes variation for CDOM and non-algal particles and their corresponding reasons were examined and clarified over five months of 2009 and 2010 in this study.Results suggest that total particulate spectral absorption in Chagan Lake is mainly dominated by non-algal particles in most cases,but phytoplankton could be the dominant contributor when chlorophyll concentration is high (up to 84.48 mg/m3 in autumn 2010).The specific absorption coefficients of phytoplankton particulate (a*ph(λ)) dependency on Chl-a is significantly variable due to relative contributions of package effect and accessory pigments,and the parameters of power function are clearly biased on a long time span.The sources of variability in spectral absorption slopes of CDOM and non-algal particles are mainly attributed to the changing proportions of high molecular weight humic acids and mineral suspended sediments in waters,respectively. | WANG Yuandong LIU Dianwei SONG Kaishan DU Jia WANG Zongming ZHANG Bai TANG Xuguang LEI Xiaochun WU Yanqing | 2011 | Chinese Geographical Science2011，21，3： | 1 |
| 16 | Feasibility of sparing lung and other thoracic structures with intensity-modulated radiotherapy for non–small-cell lung cancer显示文摘 | H.Helen Liu Xiaochun Wang Lei Dong Qiuwen Wu Zhongxing Liao Craig W Stevens Thomas M Guerrero Ritsuko Komaki James D Cox Radhe Mohan | 2004 | International Journal of Radiation Oncology Biology Physics2004，，4： | 1 |
| 17 | A constitutive model incorporating grain refinement strengthening on metallic alloys显示文摘Surface nano-crystallization techniques have been recently developed as one of the most effient ways to optimize materials'structure,and therefore develop the local and global mechanical behavior as to increase strength without compromising ductility.In this work,we present a constitutive model incorporating grain refinement hardening to simulate the nano-crystallization technique,specifically,surface mechanical attrition treatment.The computation is implemented using user-defined VUMAT subroutines.As an example of its application,a geometry model with full coverage of random impacts are employed.The results show that the model has rather precise predictability of grain size evolution during plastic deformation.The readily embedded with a computational code of material dynamics enables this novel model to be a promising tool to study the dynamic evolution of microstructures under plastic deformation. | Shan Cecilia Cao Xiaochun Zhang Yuan Yuan Pengyau Wang Lei Zhang Na Liu Yi Liu Jian Lu | 2021 | Journal of Materials Science & Technology2021，，29： | 1 |
| 18 | Development and Impacts of the Sierra Leone-China Laboratory for Parasitic Diseases Testing and Surveillance显示文摘BACKGROUND The Republic of Sierra Leone is located on the west coast of Africa,bordering Guinea and Liberia,with a population of 7.8 million in 2019(1).It has a tropical monsoon climate,with high temperatures and plentiful precipitation.As one of the least developed countries in the world(2),Sierra Leone has long struggled with poor health outcomes with a life expectancy at birth of 59 for male and 61 for female,and high maternal and neonatal mortality,threatened by infectious diseases such as malaria,tuberculosis,typhoid fever,cholera,and Lassa fever(3). | Lei Duan Lili Wang Shenning Lu Bei Wang Yanbing Li Qiuli Xu Lulu Huang Wei Ding Yingjun Qian Hongmei Li Xuejiao Ma Duoquan Wang Yayi Guan Xiaochun Wang Ning Xiao Xiao-nong Zhou | 2021 | China CDC weekly2021，3，15： | 1 |
| 19 | Developmental validation of the novel six-dye Goldeneye^(TM)DNA ID System 35InDel kit for forensic application显示文摘Insertion/deletion polymorphisms(InDels)have been treated as a prospective and helpful genetic marker in the fields of forensic human identification,anthropology and population genetics for the past few years.In this study,we developed a six-dye multiplex typing system consisting of 34 autosomal InDels and Amelogenin for forensic application.The contained InDels were specifically selected for Chinese population with the MAF≥0.25 in East Asia,which do not overlap with the markers of Investigator^(■)DIPplex kit.The typing system was named as GoldeneyeTM DNA ID System 35InDel Kit,and a series of developmental validation studies including repeatability/reproducibility,concordance,accuracy,sensitivity,stability,species specificity and population genetics were conducted on this kit.We confirmed that the 35InDel kit is precise,sensitive,species specific and robust for forensic practice.Moreover,the 35InDel kit is capable of typing DNA extracted from forensic routine case-type samples as well as degraded samples and mixture samples.All markers are proved to be highly polymorphic with an average observed heterozygosity(He)of 0.4582.The combined power of discrimination(CPD)is 0.999999999999978 and the combined power of exclusion in duos(CPE_(D))and trios(CPE_(T))are 0.978837 and 0.999573,respectively,which are higher than those of the Investigator^(■)DIPplex kit.Thus,the GoldeneyeTM DNA ID System 35InDel kit is suitable for forensic human identification and could serve as a supplementary typing system for paternity testing. | Qi Yang Huan Yu Yiling Qu Xiaochun Zhang Ruocheng Xia Ziwei Wang Rui Tan Lei Xiong Shihan Xi Jun Wu Yuzhen Gao Suhua Zhang Chengtao Li | 2022 | Forensic Sciences Research2022，7，4： | 0 |
| 20 | PdCI2(Ph3P)2/Salicylaldimine Catalyzed Diarylation of Anilines with Unactivated Aryl Chlorides显示文摘 | Xiaochun Tao Lei Li Yu Zhou Xuanying Qian Min Zhao Liangzhen Cai Xiaomin Xie | 2017 | Chinese Journal of Chemistry2017，35，11： | 0 |
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