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| 1 | Numerical Simulation and Analysis of Solid-liquid Two-phase Flow in Centrifugal Pump显示文摘The flow with solid-liquid two-phase media inside centrifugal pumps is very complicated and the relevant method for the hydraulic design is still immature so far.There exist two main problems in the operation of the two-phase flow pumps,i.e.,low overall efficiency and severe abrasion.In this study,the three-dimensional,steady,incompressible,and turbulent solid-liquid two-phase flows in a low-specific-speed centrifugal pump are numerically simulated and analyzed by using a computational fluid dynamics(CFD) code based on the mixture model of the two-phase flow and the RNG k-two-equation turbulence model,in which the influences of rotation and curvature are fully taken into account.The coupling between impeller and volute is implemented by means of the frozen rotor method.The simulation results predicted indicate that the solid phase properties in two-phase flow,especially the concentration,the particle diameter and the density,have strong effects on the hydraulic performance of the pump.Both the pump head and the efficiency are reduced with increasing particle diameter or concentration.However,the effect of particle density on the performance is relatively minor.An obvious jet-wake flow structure is presented near the volute tongue and becomes more remarkable with increasing solid phase concentration.The suction side of the blade is subject to much more severe abrasion than the pressure side.The obtained results preliminarily reveal the characteristics of solid-liquid two-phase flow in the centrifugal pump,and are helpful for improvement and empirical correction in the hydraulic design of centrifugal pumps. | ZHANG Yuliang LI Yi CUI Baoling ZHU Zuchao DOU Huashu | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 55 |
| 2 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 3 | Origin and Superposition Metallogenic Model of the Sandstone-type Uranium Deposit in the Northeastern Ordos Basin,China显示文摘这份报纸从铀来源,移植和免职的方面在东北 Ordos 盆应付沙岩类型铀存款的 metallogenic 模特儿。一个重叠 metallogenic 模型与油气体减小和热改革的重叠由于复杂的铀矿化作用过程被建立了。 | LI Ziying CHEN Anping FANG Xiheng OU Guangxi XIA Yuliang SUN Ye | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 19 |
| 4 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 5 | Computational Analysis of Centrifugal Pump Delivering Solid-liquid Two-phase Flow during Startup Period显示文摘The transient behavior of centrifugal pumps during transient operating periods,such as startup and stopping,has drawn more and more attention recently because of urgent needs in engineering.Up to now,almost all the existing studies on this behavior are limited to using water as working fluid.The study on the transient behavior related to solid-liquid two-phase flow has not been seen yet.In order to explore the transient characteristics of a high specific-speed centrifugal pump during startup period delivering the pure water and solid-liquid two-phase flow,the transient flows inside the pump are numerically simulated using the dynamic mesh method.The variable rotational speed and flow rate with time obtained from experiment are best fitted as the function of time,and are written into computational fluid dynamics(CFD)code-FLUENT by using a user defined function.The predicted heads are compared with experimental results when pumping pure water.The results show that the difference in the transient performance during startup period is very obvious between water and solid-liquid two-phase flow during the later stage of startup process.Moreover,the time for the solid-liquid two-phase flow to achieve a stable condition is longer than that for water.The solid-liquid two-phase flow results in a higher impeller shaft power,a larger dynamic reaction force,a more violent fluctuation in pressure and a reduced stable pressure rise comparing with water.The research may be useful to understanding on the transient behavior of a centrifugal pump under a solid-liquid two-phase flow during startup period. | ZHANG Yuliang LI Yi ZHU Zuchao CUI Baoling | 2014 | Chinese Journal of Mechanical Engineering2014，27，1： | 13 |
| 6 | Meta-analysis of cognitive function in Chinese first-episode schizophrenia: MATRICS Consensus Cognitive Battery (MCCB) profile of impairment显示文摘Background Compromised neurocognition is a core feature of schizophrenia. With increasing studies researching cognitive function of Chinese patients with first-episode schizophrenia (FES) using MATRICS Consensus Cognitive Battery (MCCB), it is not clear about the level and pattern of cognitive impairment among this population. Aim To provide a meta-analysis systematically analysing studies of neurocognitive function using MCCB in Chinese patients with FES. Methods An independent literature search of both Chinese and English databases up to 13 March 2019 was conducted by two reviewers. Standardised mean difference (SMD) was calculated using the random effects model to evaluate the effect size. Results 56 studies (FES=3167, healthy controls (HC)=3017) were included and analysed. No study was rated as 'high quality' according to Strengthening the Reporting of Observational Studies in Epidemiology. Compared with HCs, Chinese patients with FES showed impairment with large effect size in overall cognition (SMD=-1.60,95% Cl -1.82 to -1.38,厂=67%) and all seven cognitive domains, with the SMD ranging from -0.87 to -1.41. In nine MCCB subtests, patients with FES showed significant difference in Symbol Coding (SMD=-1.90), Trail Making Test (TMT)(SMD=-1.36), Continuous Performance Test-Identical Pairs (SMD=-1.33), Hopkins Verbal Learning Test (SMD=-1.24), Brief Visuospatial Memory Test (SMD=-1.18), Mazes (SMD=-1.16), Category Fluency (SMD=-1.01), Spatial Span (SMD=-0.69) and Mayer-Salovey-Caruso Emotional Intelligence Test (SMD=-0.38). Conclusions Our meta-analysis demonstrates that Chinese patients with FES show neurocognitive deficits across all seven MCCB cognitive domains and all nine subtests, particularly in two neurocognitive domains: speed of processing and attention/vigilance, with the least impairment shown in social cognition. Symbol Coding and TMT may be the most sensitive tests to detect cognitive deficit in Chinese patients with FES. | Huijuan Zhang Yao Wang Yuliang Hu Yikang Zhu Tian hong Zhang Jijun Wang Ke Ma Chuan Shi Xin Yu Chunbo Li | 2019 | General Psychiatry2019，32，3： | 13 |
| 7 | Real-time Health Condition Evaluation on Wind Turbines Based on Operational Condition Recognition显示文摘针对大型风电机组运行工况和状态信息复杂,健康状态难以准确评价的问题,提出基于工况辨识的健康状态实时评价方法。该方法充分考虑机组运行工况的复杂性和多变性,采用工况辨识实现运行工况空间的划分。在各运行工况子空间,建立基于高斯混合模型(gaussianmixturemodel,GMM)多状态特征融合的健康状态评价模型。采用健康衰退指数(healthdegradationindex,HDI)作为机组健康状态评价指标,并给出健康衰退报警限的确定方法。该方法用于某1.5MW风电机组传动系统故障前的健康状态评价。结果表明,该方法提前监测到机组健康状态的衰退趋势,可实现故障的早期预报,避免严重故障发生,并为合理调整运行和安排维修提供依据。 | DONG Yuliang LI Yaqiong CAO Haibin HE Chengbing GU Yujiong | 2013 | 中国电机工程学报2013，33，11： | 12 |
| 8 | The signal selection and processing method for polarization measurement radar显示文摘Based on the ambiguity function, a novel signal processing method for the polarization measurement radar is developed. One advantage of this method is that the two orthogonal polarized signals do not have to be perpendicular to each other, which is required by traditional methods. The error due to the correlation of the two transmitting signals in the traditional method, can be reduced by this new approach. A concept called ambiguity function matrix (AFM) is introduced based on this method. AFM is a promising tool for the signal selection and design in the polarization scattering matrix measurement. The waveforms of the polarimetric radar are categorized and analyzed based on AFM in this paper. The signal processing flow of this method is explained. And the polarization scattering matrix measurement performance is testified by simulation. Furthermore, this signal processing method can be used in the inter-pulse interval measurement technique as well as in the instantaneous measurement technique. | CHANG YuLiang WANG XueSong LI YongZhen XIAO ShunPing | 2009 | Science in China(Series F)2009，52，10： | 8 |
| 9 | 2D graphdiyne materials:challenges and opportunities in energy field显示文摘Graphdiyne(GDY),a novel two-dimensional(2D)carbon allotrope featuring one-atom-thick planar layers of sp andhybridized carbon network,is a rapidly rising star on the horizon of materials science.Because of its unparalleled structural,electronic,chemical and physical properties,it has been receiving unprecedented increases from fundamental studies to practical applications,particularly the field of energetic materials.In this review,we aim at providing an up-to-date comprehensive overview on the state-of-the-art research into GDY,from theoretical studies to the key achievements in the development of new GDY-based energetic materials for energy storage and conversion.By reviewing the state-of-the-art achievements,we aim to address the benefits and issues of GDY-based materials,as well as highlighting the existing key challenges and future opportunities in this exciting field. | Yurui Xue Yuliang Li Jin Zhang Zhongfan Liu Yuliang Zhao | 2018 | Science China Chemistry2018，61，7： | 7 |
| 10 | Genome-wide association study of vitamin E in sweet corn kernels显示文摘Vitamin E,consisting of tocopherols and tocotrienols,serves as a lipid-soluble antioxidant in sweet corn kernels,providing nutrients to both plants and humans.Though the key genes involved in the vitamin E biosynthesis pathway have been identified in plants,the genetic architecture of vitamin E content in sweet corn kernels remains largely unclear.In the present study,an association panel of 204 inbred lines of sweet corn was constructed.Seven compounds of vitamin E were quantified in sweet corn kernels at 28 days after pollination.A total of 119 loci for vitamin E were identified using a genome-wide association study based on genotyping by sequencing,and a genetic network of vitamin E was constructed.Candidate genes identified were involved mainly in RNA regulation and protein metabolism.The known gene ZmVTE4,encodingγ-tocopherol methyltransferase,was significantly associated with four traits(α-tocopherol,α-tocotrienol,theα/γ-tocopherol ratio,and theα/γ-tocotrienol ratio).The effects of two causative markers on ZmVTE4 were validated by haplotype analysis.Finally,two elite cultivars(Yuetian 9 and Yuetian 22)with a 4.5-fold increase in the sum ofα-andγ-tocopherols were developed by marker-assisted selection,demonstrating the successful biofortification of sweet corn.Three genes(DAHPS,ADT2,and cmu2)involved in chorismate and tyrosine synthesis were significantly associated with theα/γ-tocotrienol ratio.These results shed light on the genetic architecture of vitamin E and may accelerate the nutritional improvement of sweet corn. | Yingni Xiao Yongtao Yu Gaoke Li Lihua Xie Xinbo Guo Jiansheng Li Yuliang Li Jianguang Hu | 2020 | The Crop Journal2020，8，2： | 7 |
| 11 | Calibration method of phase distortions for cross polarization channel of instantaneous polarization radar system显示文摘A novel polarimetric calibration method for new target property measurement radar system is presented.Its application in the real radar system is also discussed.The analysis indicates that instantaneous polarization radar(IPR) has inherent cross-polarization measurement error.The proposed method can effectively eliminate this error,and thus enhance the polarization scattering matrix(PSM) measurement precision.The phase error caused by digital receiver's direct IF sampling and mixing of two orthogonal polarization channels can be removed.Consequently,the inherent error of target polarization scattering measurement of the instantaneous polarization radar system is well revised.It has good reference value for further ploarimetric calibration and high practical application prospect. | Huanyao Dai Yuliang Chang Dahai Dai Yongzhen Li XuesongWang | 2010 | Journal of Systems Engineering and Electronics2010，21，2： | 7 |
| 12 | Fiber Laser Sensing System and Its Applications显示文摘An overview of fiber laser sensing is presented.The design and the characteristics of distributed feedback(DFB)fiber lasers for high performance sensing applications are described.Demodulation techniques based on unbalanced fiber interferometer are discussed,especially for the noise level,the dynamic range,and the crosstalk in dense-wavelength-division multiplexing.Finally,the fiber laser sensing system configurations and field demonstrations for different applications are illustrated. | Yuliang LIU Wentao ZHANG Tuanwei XU Jun HE Faxiang ZHANG Fang LI | 2011 | Photonic Sensors2011，1，1： | 7 |
| 13 | Recent progress in fingerprint recognition显示文摘指纹识别逐渐地被用来认识到在平民的日常生活的个人鉴定例如身份证,等等采指纹硬盘。大改进在察觉到技术和自动指纹识别算法的联机指纹被完成了。各种各样的指纹识别技术包括指纹获得,分类,改进并且匹配,高度被改进。这篇论文概述最近在指纹识别进展并且总结与低质量的指纹并且匹配弄歪的指纹图象的改进的特殊焦点为每步建议的算法。两个问题被相信是重要、挑战性的任务。另外,我们也为指纹确认比赛 2004 的指纹识别算法(FVC2004 ) 和指纹供应商技术评估讨论普通评估 2003 (FpVTE2003 ) ,基于哪个我们能客观地并且一致地测量识别算法的表演。 | TIAN Jie CHEN Xinjian ZHANG Yangyang YANG Xin HE Yuliang LI Liang XIE Weihua ZHENG Zhipeng | 2006 | Progress in Natural Science:Materials International2006，16，3： | 7 |
| 14 | Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China显示文摘The cognitive disease consensus was prepared by panels of health and public representatives based on actual clinical practice in Geriatric Departments in Chinese hospitals and a systematic literature review. This consensus reflects the medical knowledge accumulated by those experts and provides information about professional medical care and advice.A multidisciplinary panel of specialists(neurologists,psychiatrists, and nursing specialists) reports an expert consensus on the medical knowledge accumulated from those experts and provides information about professional medical care and advice. The recommendations focus on the care and management of older adults with mild cognitive impairment,the objectives and methods of maintaining cognition and training, the assessments and measures of daily care for patients at different stages of dementia, the assessments and coping strategies for the behavioral and psychological symptoms of dementia, principles and suggestions for an appropriate living environment, arrangements for recreational activities, the care and management of patients with endstage dementia, and suggestions for addressing stress in caregivers. | 无 Yuliang Han Jianjun Jia Xia Li Yang Lv Xuan Sun Shanshan Wang Yongjun Wang Zhiwen Wang Jintao Zhang Jiong Zhou Yuying Zhou | 2020 | Neuroscience Bulletin2020，36，3： | 7 |
| 15 | Mesoporous silica SBA-15 functionalized with phosphonate and amino groups for uranium uptake显示文摘Mesoporous silicas have a very attractive ability of sorption and enrichment of metal ions due to their huge surface area and facile functionalization by organic ligands.In this work,phosphonate-amino bifunctionalized mesoporous silica SBA-15(PA-SBA-15) as U(VI) sorbent was fabricated through post-grafting method.The obtained mesoporous silica was characterized by SEM,XRD,NMR and nitrogen sorption/desorption experiments,which revealed the existence of ordered mesoporous structure with uniform pore diameter and large surface area.The adsorptivity of PA-SBA-15 for U(VI) from aqueous solution was investigated using batch sorption technique under different experimental conditions.The preliminary results show that the U(VI) sorption by PA-SBA-15 is very quick with equilibrium time of less than 1 h,and the U(VI) uptake is as large as 373 mg/g at pH 5.5 under 95 ℃.The sorption isotherm has been successfully modeled by the Langmuir isotherm,suggesting a monolayer homogeneous sorption of U(VI) in PA-SBA-15.The sorption is pH-dependent due to the pH-dependent charge of sorbent in the aqueous solution.The thermodynamics research shows that the sorption is a feasible and endothermic process.Based on these results,PA-SBA-15 could be a promising solid phase sorbent for highly-efficient removal of U(VI) ions from waste water and enrichment of U(VI) from a solution at a very low level. | WANG XiaoLiang YUANLiYong WANG YanFei LI ZiJie LIU YaLan FENG YiXiao ZHAO YuLiang CHAI ZhiFang SHI WeiQun | 2012 | Science China Chemistry2012，55，9： | 6 |
| 16 | Research on instantaneous polarization radar system and external experiment显示文摘Instantaneous polarization radar can obtain radar target polarization scattering matrix (PSM) by using single pulse echo.The system overcomes the defects of inter-pulse interval polarization measurement radar and accurately measures the PSM of the moving target.Thus the capabilities of detection,anti-jamming and target identification can be improved.The present paper reports the first international self-developed instantaneous polarization radar experimental system and,by using this system,the measurement experiments of target polarization characteristics are conducted.The results show that the performance of target instantaneous polarization measurement by different waveforms is good.The basic and common problems in polarization scattering feature extraction and recognition domain are solved. | WANG XueSong LI YongZhen DAI HuanYao CHANG YuLiang DAI DaHai MA Liang LIU Yong | 2010 | Chinese Science Bulletin2010，55，15： | 5 |
| 17 | Direct imaging and determination of the crystal structure of six-layered graphdiyne显示文摘自从它的发现,因为它在由一根电子横梁的照耀下面是太精细的,很少层 graphdiyne 的水晶结构的直接成像和决心证明了困难。在这个工作,六分层的 graphdiyne nanosheet 的水晶结构被低电压的传播电子显微镜学(TEM ) 直接用低当前的密度观察。高分辨率的 TEM (HRTEM ) 模拟,电子精力损失光谱学,和电子衍射的联合使用表明同样综合的 nanosheet 是有 2.19 nm 的厚度的水晶的 graphdiyne (相应于六层的厚度) 并且叠的显示出的 ABC。因此,这个工作为存在和很少层 graphdiyne 的水晶结构提供直接证据,它是对 graphene 补足的二维的碳材料的一种新类型。 | Chao Li Xiuli Lu Yingying Han Shangfeng Tang Yi Ding Ruirui Liu Haihong Bao Yuliang Li Jun Luo Tongbu Lu | 2018 | Nano Research2018，11，3： | 5 |
| 18 | Crack nucleation and propagation simulation in brittle two-phase perforated/particulate composites by a phase field model显示文摘Fracture is a very common failure mode of the composite materials,which seriously affects the reliability and service-life of composite materials.Therefore,the study of the fracture behavior of the composite materials is of great significance and necessity,which demands an accurate and efficient numerical tool in general cases because of the complexity of the arising boundary-value or initial-boundary value problems.In this paper,a phase field model is adopted and applied for the numerical simulation of the crack nucleation and propagation in brittle linear elastic two-phase perforated/particulate composites under a quasi-static tensile loading.The phase field model can well describe the initiation,propagation and coalescence of the cracks without assuming the existence and the geometry of the initial cracks in advance.Its numerical implementation is realized within the framework of the finite element method(FEM).The accuracy and the efficiency of the present phase field model are verified by the available reference results in literature.In the numerical examples,we first study and discuss the influences of the hole/particle size on the crack propagation trajectory and the force-displacement curve.Then,the effects of the hole/particle shape on the crack initiation and propagation are investigated.Furthermore,numerical examples are presented and discussed to show the influences of the hole/particle location on the crack initiation and propagation characteristics.It will be demonstrated that the present phase field model is an efficient tool for the numerical simulation of the crack initiation and propagation problems in brittle two-phase composite materials,and the corresponding results may play an important role in predicting and preventing possible hazardous crack initiation and propagation in engineering applications. | Xingxue Lu Yuliang Hou Ying Tie Cheng Li Chuanzeng Zhang | 2020 | Acta Mechanica Sinica2020，36，2： | 5 |
| 19 | Experimental Study on a Centrifugal Pump with an Open Impeller during Startup Period显示文摘Transient performance of fluid machinery during transient operating periods,such as startup and stopping,has been drawn more attentions recently due to the growing engineering needs.In this paper,the transient behavior of a prototype centrifugal pump with an open impeller during rapid startup period is studied experimentally.The variations of the rotational speed,flow rate,head,and shaft power during rapid startup period are recorded in experiments at different discharge valve openings.In addition,the non-dimensional flow rate and head are also used to analyze the transient behavior.The research result shows that the rise characteristic of the rotational speed is not basically changed by working points,while mainly depends on the startup characteristics of the driving motor.Compared with the rapid rise of the rotational speed,the flow rate rises slowly in the initial stage of startup.Moreover,the flow rate lags behind the rotational speed to rise to final stable value,and the delay becomes more severe with the increase of the discharge valve opening.The shaft power impact phenomenon generally exists in the process of startup.The non-dimensional analysis shows that the non-dimensional head is very high at the very beginning of startup,and quickly falls to the minimum,then gradually rises to final stable value,while the non-dimensional flow rate always shows the rise tendency during whole startup period.In conclusion,it is found from the non-dimensional results that the quasi-steady analysis is unable to accurately assess the transient flow during startup period. | Yuliang Zhang Zuchao Zhu Yingzi Jin Baoling Cui Yi Li Huashu Dou | 2013 | Journal of Thermal Science2013，22，1： | 5 |
| 20 | Screen efficiency comparisons of decision tree and neural network algorithms in machine learning assisted drug design显示文摘In view of huge search space in drug design, machine learning has become a powerful method to predict the affinity between small molecular drug and targeting protein with the development of artificial intelligence technology. However, various machine learning algorithms including massive different parameters make the prediction framework choice to be quite difficult. In this work, we took a recent drug design competition(from XtalPi company on the DataCastle platform) as the typical case to find the optimized parameters for different machines learning algorithms and the most effective algorithm. After the parameter optimizations, we compared the typical machine learning methods as decision tree(XGBoost, LightGBM) and artificial neural network(MLP, CNN) with root-mean-square error(RMSE) and coefficient of determination(R^2) evaluation. As a result, decision tree is more effective than the neural network as LightGBM>XGBoost>CNN>MLP in the affinity prediction of the specific drug design problem with ~160000 samples. For a much larger screening task in a more complicated drug design study, the sophisticated neural network model may go beyond the decision tree algorithm after generalization enhancing and overfitting reducing. The advanced machine learning methods could extract more information of protein-ligand bindings than traditional ones and improve the screen efficiency of drug design up to 200–1000 times. | Qiumei Pu Yinghao Li Hong Zhang Haodong Yao Bo Zhang Bingji Hou Lin Li Yuliang Zhao Lina Zhao | 2019 | Science China Chemistry2019，62，4： | 5 |
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