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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | Polymorphism Analyses of Hepatitis B Virus X Gene in Hepatocellular Carcinoma Patients from Southern China显示文摘长期的肝炎 B 病毒( HBV )感染是主要原因 ofhepatocellular 癌( HCC )之一,并且 HBV X ( HBx )基因在HBV相关的 HCC.We 的分子的致病起一个关键作用调查了是否有特别 HBx 基因变化,从南部的中国在病人与 HCC 联系。HBx 基因被嵌套的聚合酶链反应(PCR ) 从 HBVcarrier 与 HCC 和 25 件浆液样品从病人在 51paraffin-embedded 肿瘤织物样品检验,搁浅单人赛的 conformational 多型性 andheteroduplex 分析。有从肿瘤织物样品的潜在地重要的变化的 HBx 基因被克隆,在肿瘤织物样品与出版 HBx 基因 sequence.HBV 遗传型定序并且排列被在肿瘤织物的31.3% HBx 基因碎片取样的基因多型性显示出的 HBx 的嵌套的 PCR.Analyses 分析有特殊 pattern.A 在 29 点突变伴随的 HBxgene 的 nt 382-400 的普通删除随机在四被检测有在 HBx 开的读物引起了框架移动的这个模式的选择肿瘤织物样品在 atnt 上与一条新站鳕鱼装裱 1818 ,导致 HBx 多肽链在这些情况中在 C 结束截断了。在四件随机选择的样品之中,三是 HBV 遗传型 B ,并且一个人没被我们的现在的 assay.Inanother 肿瘤织物样品检测,全身的 HBx 基因的扩大产出揭示的这碎片的 shorterfragment.Sequencing 在 1577 HBVgene.These 和 1840 结果建议的 nt 之间的 264 bp 删除那个 HBx 基因变化在 HCC 样品经常发生,并且在 HBx 基因的 nt 382-400 的删除可能在南部的中国在 HCC 的 carcinogenesis 起一个作用。 | Ping'an ZHU Deming TAN Zhongtian PENG Fei LIU Lin SONG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，4： | 29 |
| 3 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 4 | DESIGN METHODOLOGY OF NETWORKED SOFTWARE EVOLUTION GROWTH BASED ON SOFTWARE PATTERNS显示文摘最近,建筑群的新特征联网的一些在不同领域里吸引科学家的注意,并且导致许多种新兴的研究方向。到目前为止,大多数研究工作被结构分析在大规模软件系统在复杂网络特征的发现限制了。这篇论文论述理论基础,设计方法,算法和研究的实验结果。它第一为网络拓扑学强调进化生长的设计方法的意义面向对象(OO ) 软件系统,并且主张有各种各样的拓扑学特征的网络模型的选择和调整将在设计的进程和 OO 软件系统的实现上带不可忽略的效果。然后,我们与不同拓扑学特征和软件建模方法的发展分析“在网络模型的进化之间的否定和妥协的否定”的类似的纪律。根据软件模式的生长特征的分析,我们连续建议一个面向对象的软件网络进化生长方法和它的算法。另外,我们也基于复杂网络理论为 OO 软件系统度量标准建议参数系统。基于这些参数系统,它能分析各种各样的节点的特征,连接并且本地世界,调制网络拓扑学并且指导软件度量标准。所有这些能对详细设计,实现和表演分析有用。最后,我们集中于进化算法的应用程序并且由案例研究表明它。在实验软件工程从我们的早实验把结果与方法论作比较,我们相信建议软件工程设计方法基于复杂网络理论是一条计算软件工程途径。我们主张这个方法应该是极大地为在大规模 OO 的功能,结构和性能的设计,实现,调整和度量标准有益软件建筑群系统。 | Keqing HE Rong PENG Jing LIU Fei HE Peng LIANG Bing LI | 2006 | Journal of Systems Science & Complexity2006，19，2： | 24 |
| 5 | Wheel/rail dynamic interaction due to excitation of rail corrugation in high-speed railway显示文摘Characteristics of wheel-rail dynamic interaction due to the rail corrugation in a high-speed railway are analyzed based on the theory of vehicle-track coupled dynamics in this paper.Influences of the corrugation wavelength and depth on the wheel-rail dynamic performance are investigated.The results show that,under the excitation of a measured rail corrugation,the wheel-rail dynamic interaction of high-speed railway is enhanced obviously,and the high-frequency dynamic force between wheel and rail is generated,which has an obvious impact on the vibrations of the wheelset and rail,and little effect on the vibration of the frame and carbody.If the corrugation wavelength is shorter than the sensitive wavelength,the wheel-rail vertical force will increase with the growth of the corrugation wavelength,otherwise,it will decrease.However,the wheel-rail vertical force keeps increasing with the growth of corrugation depth.Furthermore,if the corrugation wavelength is shorter than the sensitive wavelength,the wheel-rail vertical force will increase with the decrease of the running speed,otherwise,it will decrease.It is also found that the critical wavelength of corrugation increases with the growth of the corrugation depth and the running speed,and the critical depth of corrugation is nonlinearly related to the sensitive wavelength. | WANG Kai Yun LIU Peng Fei ZHAI Wan Ming HUANG Chao CHEN Zai Gang GAO JianMin | 2015 | Science China(Technological Sciences)2015，58，2： | 17 |
| 6 | Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality显示文摘Severe fever with thrombocytopenia syndrome (SFTS),an emerging tick-borne infectious disease caused by a novel phlebovirus (SFTS virus, SFTSV), was listed among the top 10 priority infectious diseases by the World Health Organization due to its high fatality of 12%-50% and possibility of pandemic transmission. Currently, effective anti-SFTSV intervention remains unavailable. Here, by screening a library of FDA-approved drugs, we found that benidipine hydrochloride, a calcium channel blocker (CCB), inhibited SFTSV replication in vitro. Benidipine hydrochloride was revealed to inhibit virus infection through impairing virus internalization and genome replication. Further experiments showed that a broad panel of CCBs, including nifedipine, inhibited SFTSV infection. The anti-SFTSV effect of these two CCBs was further an a lyzed in a humanized mouse model in which CCB treatment resulted in reduced viral load and decreased fatality rate. Importantly, by performing a retrospective clinical investigation on a large cohort of 2087 SFTS patients, we revealed that nifedipine administration enhaneed virus clearance, improved clinical recovery, and remarkably reduced the case fatality rate by >5-fold. These findings are highly valuable for developing potential host-oriented therapeutics for SFTS and other lethal acute viral infections known to be inhibited by CCBs in vitro. | Hao Li Lei-Ke Zhang Shu-Fen Li Shao-Fei Zhang Wei-Wei Wan Yu-Lan Zhang Qi-Lin Xin Ke Dai Yuan-Yuan Hu Zhi-Bo Wang Xiang-Tao Zhu Yu-Jie Fang Ning Cui Pan-He Zhang Chun Yuan Qing-Bin Lu Jie-Ying Bai Fei Deng Geng-Fu Xiao Wei Liu Ke Peng | 2019 | Cell Research2019，29，9： | 15 |
| 7 | Effects of warming and clipping on plant and soil properties of an alpine meadow in the Qinghai-Tibetan Plateau, China显示文摘Climate warming and livestock grazing are known to have great influences on alpine ecosystems like those of the Qinghai-Tibetan Plateau(QTP) in China. However, it is lacking of studies on the effects of warming and grazing on plant and soil properties in these alpine ecosystems. In this study, we reported the related research from manipulative experiment in 2010–2012 in the QTP. The aim of this study was to investigate the individual and combined effects of warming and clipping on plant and soil properties in the alpine meadow ecosystem. Infrared radiators were used to simulate climate warming starting in July 2010, while clipping was performed once in October 2011 to simulate the local livestock grazing. The experiment was designed as a randomized block consisting of five replications and four treatments: control(CK), warming(W), clipping(C) and warming+clipping combination(WC). The plant and soil properties were investigated in the growing season of the alpine meadow in 2012. The results showed that W and WC treatments significantly decreased relative humidity at 20-cm height above ground as well as significantly increases air temperature at the same height, surface temperature, and soil temperature at the depth of 0–30 cm. However, the C treatment did not significantly decrease soil moisture and soil temperature at the depth of 0–60 cm. Relative to CK, vegetation height and species number increased significantly in W and WC treatment, respectively, while vegetation aboveground biomass decreased significantly in C treatment in the early growing season. However, vegetation cover, species diversity, belowground biomass and soil properties at the depth of 0–30 cm did not differ significantly in W, C and WC treatments. Soil moisture increased at the depth of 40–100 cm in W and WC treatments, while belowground biomass, soil activated carbon, organic carbon and total nitrogen increased in the 30–50 cm soil layer in W, C and WC treatments. Although the initial responses of plant and soil properties to experimental warming and clipping were slow and weak, the drought induced by the downward shift of soil moisture in the upper soil layers may induce plant belowground biomass to transfer to the deeper soil layers. This movement would modify the distributions of soil activated carbon, organic carbon and total nitrogen. However, long-term data collection is needed to further explain this interesting phenomenon. | Man Hou XU Fei PENG Quan Gang YOU Jian GUO Xia Fei TIAN Min LIU Xian XUE | 2015 | Journal of Arid Land2015，7，2： | 14 |
| 8 | Genotypic Characterization of Methicillin-resistant Staphylococcus aureus Isolated from Pigs and Retail Foods in China显示文摘Objective To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus(MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. Methods Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing(MLST), spa typing, multiple-locus variable number of tandem repeat analysis(MLVA), pulsed-field gel electrophoresis(PFGE), and antimicrobial susceptibility testing. Results All isolated MRSA exhibited multi-drug resistance(MDR). Greater diversity was found in food-associated MRSA(7 STs, 8 spa types, and 10 MLVA patterns) compared to pig-associated MRSA(3 STs, 1 spa type, and 6 MLVA patterns). PFGE patterns were more diverse for pig-associated MRSA than those of food-associated isolates(40 vs. 11 pulse types). Among the pig-associated isolates, CC9-ST9-t899-MC2236 was the most prevalent clone(96.4%), and CC9-ST9-t437-MC621(20.0%) was the predominant clone among the food-associated isolates. The CC9-ST9 isolates showed significantly higher antimicrobial resistance than other clones. Interestingly, CC398-ST398-t034 clone was identified from both pig-and food-associated isolates. Of note, some community-and hospital-associated MRSA strains(t030, t172, t1244, and t4549) were also identified as food-associated isolates. Conclusion CC9-ST9-t899-MC2236-MDR was the most predominant clone in pigs, but significant genetic diversity was observed in food-associated MRSA. Our results demonstrate the great need for improved surveillance of MRSA in livestock and food and effective prevention strategies to limit MDR-MRSA infections in China. | WANG Wei LIU Feng ZULQARNAIN Baloch ZHANG Cun Shan MA Ke PENG Zi Xin YAN Shao Fei HU Yu Jie GAN Xin DONG Yin Ping BAI Yao LI Feng Qin YAN Xiao Mei MA Ai Guo XU Jin | 2017 | Biomedical and Environmental Sciences2017，30，8： | 13 |
| 9 | Synthesis and curing of a novel amino-containing phthalonitrile derivative显示文摘A novel phthalonitrile derivative containing an amino group, 3,5-bis(3,4-dicyanophenoxy)aniline (CPA), was synthesized via a nucleophilic displacement of 4-nitrophthalonitrile and 5-aminoresorcinol hydrochloride. The structure of CPA was confirmed by Fourier transform infrared spectra (FT-IR) and nuclear magnetic resonance (1H NMR). Thermal analysis performed on CPA revealed that the novel phthalonitrile derivative showed a self-promotion curing behavior and the resulting polymer exhibited outstanding heat-resistance. | Ke Zeng Ke Zhou Wen Rui Tang Yan Tang Hong Fei Zhou Tao Liu Yi Peng Wang Hai Bing Zhou Gang Yang | 2007 | Chinese Chemical Letters2007，18，5： | 12 |
| 10 | Changes of serum Tau, GFAP, TNF-α and malonaldehyde after blast-related traumatic brain injury显示文摘 | Liu Mengdong Luo Peng Wang Zhanjiang Fei Zhou | 2014 | Chinese Journal of Traumatology2014，17，6： | 12 |
| 11 | Fluid Inclusion and H-O Isotope Geochemistry of the Phapon Gold Deposit, NW Laos: Implications for Fluid Source and Ore Genesis显示文摘The Phapon gold deposit, located in northern Laos, is a unique large-scale gold deposit in Luang Prabang-Loei metallogenic belt. It is hosted in the Lower Permian limestone and controlled by a NE-trending ductile-brittle fault system. There are three types of primary ore including auriferous calcite vein type, disseminated type, and breccia type, and the first two are important in the Phapon gold deposit. Based on fluid inclusion petrography and microthermometry, three types of primary fluid inclusions including type 1 liquid-rich aqueous, type 2 vapor-rich aqueous and type 3 daughter mineralbearing aqueous were identified in hydrothermal calcite grains. The ore-forming fluids are normally homogeneous, as indicated by the widespread type 1 inclusions with identical composition. The coexistence of type 1 and type 2 inclusions, showing similar final homogenization temperature but different compositions, indicate that fluid immiscibility did locally take place in both two types of ores. The results of microthermometry and H-O isotopes geochemistry indicate that there are little differences on ore-fluid geochemistry between the auriferous calcite vein-type and disseminated type ores. The oreforming fluids are characterized by medium-low temperatures(157–268 oC) and low salinity(1.6 wt.%–9.9 wt.% NaCl eq.). It is likely to have a metamorphic-dominant mixed source, which could be associated with dehydration and decarbonisation of Lower Permian limestone and Middle–Upper Triassic sandstones during the dynamic metamorphism. The fluid-wallrock interaction played a major role, and the locally occurred fluid-immiscible processes played a subordinate role in gold precipitation. Combined with the regional and ore deposit geology, and ore-fluid geochemistry, we suggest that the Phapon gold deposit is best considered to be a member of the epizonal orogenic deposit class. | Linnan Guo Shusheng Liu Lin Hou Jieting Wang Meifeng Shi Qiming Zhang Fei Nie Yongfei Yang Zhimin Peng | 2019 | Journal of Earth Science2019，30，1： | 11 |
| 12 | Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells显示文摘Objective:To assess if casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer ceils.Methods:Human non-small-cell lung carcinoma cell lines H460,AS49 and H157 were cultured in vitro.The cytotoxic activities were determined using MTT assay.The apoptotic cells death was examined by flow cytometry using PI staining and DMA agarose gel electrophoresis.The activities of caspase-3, -8 and -9 were measured via ELISA.Cellular fractionation was determined by flow cytometry to assess release of cytochrome c and the mitochondrial transmembrane potential.Bcl-2/Bcl-XL/ XIAP/Bid/ DR5 and DR4 proteins were analyzed using western blot.Results:The concentrations required for a 50%decrease in cell growth(IC50) ranged from 1.8 to 3.2 Jt M.Casticin induced rapid apoptosis and triggered a series of effects associated with apoptosis by way of mitochondrial pathway,including the depolarization of the mitochondrial membrane,release of cytochrome c from mitochondria,activation of procaspase-9 and -3,and increase of DNA fragments.Moreover, the pan caspase inhibitor zVAD-FMK and the caspase-3 inhibitor zOEVD-FMK suppressed casticin-induced apoptosis.In addition,casticin induced XIAP and Bcl-XL down-regulation, Bax upregulation and Bid clearage.In H157 cell line,casticin increased expression of DRS at protein levels but not affect the expression of DR4.The prelreatmenl with DR5/Fc chimera protein effectively attenuated casticin-induced apoptosis in H157 cells.No correlation was found between cell sensitivity to casticin and that to p53 status,suggesting that casticin induce a p53- independent apoptosis.Conclusions:Our results demonstrate that casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DRS in human lung cancer cells. | Yuan Zhou Yi Peng Qi-Qi Mao Xia Li Ming-Wu Chen Ting Su Li Tian Nai-Quan Mao Ling-Zhi Long Mei-Fang Quan Fei Liu Su-Fang Zhou Yong-Xiang Zhao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，5： | 11 |
| 13 | Synthesis of a benzoxazine monomer containing maleimide and allyloxy groups显示文摘新奇 benzoxazine 单体 3-(4-allyloxy )phenyl-3,4-dihydro-2H-6-(N-maleimido )-1,3-benzoxazine (AMB ) 被综合,结构被英尺红外证实,(1 ) H NMR。AMB 的热分析(DSC ) 证明烯丙氧基组的介绍减少了熔点并且展出了一扇狭窄、对称的治好的发热的窗户。 | Yan Tang Qing Lai Zhao Ke Zeng Pei Kai Miao Ke Zhou Wen Rui Tang Hong Fei Zhou Tao Liu Yi Peng Wang Gang Yang | 2007 | Chinese Chemical Letters2007，18，8： | 10 |
| 14 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 15 | Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy显示文摘病理学的心脏的肥大是心失败的不可避免的 forerunner。不管心脏的肥大的病原学, cardiomyocyte mitochondrial 改变总是在这上下文被观察。mitochondrial 先锋蛋白质的进口调节在 pathophysiological 下面维持 mitochondrial 功能的外部膜(汤姆) 建筑群管理的 mitochondrial 的 translocases;然而,它在病理学的心脏的肥大的发展的角色仍然保持不清楚。这里,我们证明 Tom70 是在从人和试验性的动物的病理学的 hypertrophic 心的 downregulated。在 Tom70 表示的减小在 vivo 并且在 vitro 生产了不同病理学的 cardiomyocyte 肥大。指向 Tom70 的眼的 atrophy-1 的有缺点的 mitochondrial 进口触发了细胞内部的氧化应力,它导致了病理学的细胞的回答。重要地,如果有到多样的 pro-hypertrophic 的完整的抵抗的 cardiomyocytes 侮辱,增加了 Tom70 层次。一起,这些结果表明 Tom70 充当安排 hypertrophic 压力和 mitochondrial 回答决定病理学的心脏的肥大的一个分子的开关。 | Jun Li Man Qi Changming Li Dan Shi Dasheng Zhang Duanyang Xie Tianyou Yuan Jing Feng Yi Liu Dandan Liang Xinran Xu Jinjin Chen Liang Xu Hong Zhang Jiangchuan Ye Fei LV Jian Huang Luying Peng Yi-Han Chen | 2014 | Cell Research2014，24，8： | 9 |
| 16 | A numerical study of macro-mesoscopic mechanical properties of gangue backfill under biaxial compression显示文摘Based on the Particle Flow Code(PFC^(2D)) program,we set up gangue backfill models with different gangue contents and bond strength,and studied the stress-strain behaviours,the pattern of shear band and force chains,motion and fragmentation of particles under biaxial compression.The results show that when the bond strength or contents of gangue are high,the peak strength is high and the phenomena of post-peak softening and fluctuation are obvious.When gangue contents are low,the shape of the shear band is symmetrical and most strong force chains transfer in soil particles.With an increase in gangue content,the shape of the shear band becomes irregular and the majority of strong force chains turn to transfer in gangue particles gradually,most of which distribute along the axial direction.When the gangue content is higher than 50%,the interconnectivity of strong force chains decreases gradually:at the same time,the strong force chains become tilted and the stability of the system tends to decrease.With an increase in external loading,the coordination numbers of the system increase at first and then decrease and the main pattern of force chains changes into columnar from annular.However,after the forming of the advantageous shear band,the force chains external to the shear band maintain their columnar shape while the inner ones bend obviously.As a result,annular force chains form. | Huang Zhimin Ma Zhanguo Zhang Lei Gong Peng Zhang Yankun Liu Fei | 2016 | International Journal of Mining Science and Technology2016，26，2： | 8 |
| 17 | Magnetic nanoparticles based cancer therapy: current status and applications显示文摘Nanotechnology holds a promising potential for developing biomedical nanoplatforms in cancer therapy. The magnetic nanoparticles, which integrate uniquely appealing features of magnetic manipulation, nanoscale heat generator, localized magnetic field and enzyme-mimics, prompt the development and application of magnetic nanoparticles-based cancer medicine. Considerable success has been achieved in improving the magnetic resonance imaging(MRI) sensitivity, and the therapeutic function of the magnetic nanoparticles should be given adequate attention. This work reviews the current status and applications of magnetic nanoparticles based cancer therapy. The advantages of magnetic nanoparticles that may contribute to improved therapeutics efficacy of clinic cancer treatment are highlighted here. | Huan Zhang Xiao Li Liu Yi Fan Zhang Fei Gao Ga Long Li Yuan He Ming Li Peng Hai Ming Fan | 2018 | Science China(Life Sciences)2018，61，4： | 8 |
| 18 | An engraved artifact from Shuidonggou,an Early Late Paleolithic Site in Northwest China显示文摘Cognition and symbolic thinking are viewed as important features of modern human behavior.Engraved objects are seen as a hallmark of cognition and symbolism,and even as evidence for language.Accumulated evidences including engraved bones,ochre,ostrich eggshells and stone artifacts were unearthed from Africa,Europe,Levant even Siberia Paleolithic sites.But the archaeological evidence for this,including beads,ornaments,burials,performed objects and engraved objects,is rarely discovered in the Pleistocene of East Asia.The present paper reports an engraved stone object unearthed in the Early Late Paleolithic levels about 30 ka BP at the Shuidonggou site(SDG) in northwestern China.It was unearthed in the 1980's excavation from Lower culture unit of SDG1 but was identified in 2011 when the first author of this article observed the collection from the 1980's excavations stored in the Institute of Archaeology of Ningxia Hui Autonomous Region for further detailed lithic analysis.This lithic artifact is the first engraved non-organic object of the Paleolithic period found in China.In order to clarify the details of the incisions and to document the human intentional modifications,we used a KEYENCE VHX-600 Digital Microscope to measure and observe all the incisions in 3-dimensional perspective.Comparing the natural cracks and analyzing many details of the incisions,we argue that incisions on this stone artifact are the result of intentional behaviors by ancient humans.Also,we exclude the possible other causes including animal-induced damages,post-depositional phenomenon and unintentional by-products.Combining all these features,we suggest that the incisions were made by an intentional behavior and were probably of a non-utilitarian character.Because the nature of most other engraved objects in China is debate,we cannot get a clear scenario of the emergence and progress of modern human behavior in North China.But we infer the possible existence of a counting or recording system,or other symbolic behaviors,which reflect considerably evolved cognitive capacities or modern human behavior in the Early Late Paleolithic of East Asia. | PENG Fei GAO Xing WANG HuiMin CHEN FuYou LIU DeCheng PEI ShuWen | 2012 | Chinese Science Bulletin2012，57，35： | 8 |
| 19 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 20 | CuFe2O4@GO nanocomposite as an effective and recoverable catalyst of peroxymonosulfate activation for degradation of aqueous dye pollutants显示文摘Recently,heterogeneous activation of peroxymonosulfate(PMS) to oxidatively degrade organic pollutants has been a hotspot.In the present work,copper ferrite-graphite oxide hybrid(CuFe2 O4@GO)was prepared and used as catalyst to activate PMS for degradation of methylene blue(MB) in aqueous solution.A high degradation efficiency(93.3%) was achieved at the experimental conditions of20 mg/L MB,200 mg/L CuFe2 O4@GO,0.8 mmol/L PMS,and 25℃temperature.Moreover,CuFe2 O4@GO showed an excellent reusability and stability.The effects of various operational parameters including pollutant type,solution pH,catalyst dosage,PMS dosage,pollutant concentration,temperature,natural organic matter(NOM),and inorganic anions on the catalytic degradation process were comprehensively investigated and elucidated.The further mechanistic study revealed the Cu(Ⅱ)/Cu(Ⅰ) redox couple on CuFe2 O4@GO played the dominant role in PMS activation,where both hydroxyl and sulfate radicals were generated and proceeded the degradation of pollutants.In general,CuFe2 O4@GO is a promising heterocatalyst for PMS-based advanced oxidation processes(AOPs) in wastewater treatment. | Xiaoman Lei Menghan You Fei Pan Min Liu Peng Yang Dongsheng Xia Qiang Li Yanting Wang Jie Fu | 2019 | Chinese Chemical Letters2019，30，12： | 8 |
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