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| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | Off-axis multi-wavelength dispersion controllingmetalens for multi-color imaging显示文摘Dispersion control is crucial in optical systems,and chromatic aberration is an important factor affecting imaging quality in imaging systems.Due to the inherent property of materials,dispersion engineering is complex and needs to trade off other aberration in traditional ways.Although metasurface offers an effective method to overcome these limits and results in well-engineered dispersion,off-axis dispersion control is still a challenging topic.In this paper,we design a single-layer metalens which is capable of focusing at three wavelengths(473 nm,532 nm,and 632 nm)with different incident angles(0°,-17°and 17°)into the same point.We also demonstrate that this metalens can provide an alternative for the bulky color synthetic prism in a 3-chips digital micromirror device(DMD)laser projection system.Through this approach,various off-axis dispersion controlling optical devices could be realized. | Kaihua Dou Xin Xie Mingbo Pu Xiong Li Xiaoliang Ma Changtao Wang Xiangang Luo | 2020 | Opto-Electronic Advances2020，3，4： | 7 |
| 3 | Crosstalk-free achromatic full Stokes imaging polarimetry metasurface enabled by polarization-dependent phase optimization显示文摘Imaging polarimetry is one of the most widely used analytical technologies for object detection and analysis.To date,most metasurface-based polarimetry techniques are severely limited by narrow operating bandwidths and inevitable crosstalk,leading to detrimental effects on imaging quality and measurement accuracy.Here,we propose a crosstalkfree broadband achromatic full Stokes imaging polarimeter consisting of polarization-sensitive dielectric metalenses,implemented by the principle of polarization-dependent phase optimization.Compared with the single-polarization optimization method,the average crosstalk has been reduced over three times under incident light with arbitrary polarization ranging from 9μm to 12μm,which guarantees the measurement of the polarization state more precisely.The experimental results indicate that the designed polarization-sensitive metalenses can effectively eliminate the chromatic aberration with polarization selectivity and negligible crosstalk.The measured average relative errors are 7.08%,8.62%,7.15%,and 7.59%at 9.3,9.6,10.3,and 10.6μm,respectively.Simultaneously,the broadband full polarization imaging capability of the device is also verified.This work is expected to have potential applications in wavefront detection,remote sensing,light-field imaging,and so forth. | Yaxin Zhang Mingbo Pu Jinjin Jin Xinjian Lu Yinghui Guo Jixiang Cai Fei Zhang Yingli Ha Qiong He Mingfeng Xu Xiong Li Xiaoliang Ma Xiangang Luo | 2022 | Opto-Electronic Advances2022，5，11： | 6 |
| 4 | All‐metallic wide‐angle metasurfaces for multifunctional polarization manipulation显示文摘Optical camouflage is a magical capability of animals as first noticed in 1794 by Erasmus Darwin in Zoonomia,but current biomimetic camouflage strategies cannot be readily applied in complex environments involving multispectral and in particular multi-polarization detection.Here we develop a plasmonic approach toward broadband infrared polarimetric crypsis,where the polarized thermal emission near the pseudo-Brewster angle is the main signal source and no existing polarizing camouflage technique has been discovered in nature.Based on all-metallic subwavelength structures,an electrodynamic resistance-reduction mechanism is proposed to avoid the significant polarization-dependent infrared absorption/radiation.It is also found that the structured metal surface presents giant extrinsic anisotropy regarding the phase shift between orthogonal polarization states,which helps to realize ultrahigh-efficiency and tunable polarization conversion in an unprecedented manner.Finally,we note that the catenary optical theory may provide a useful means to explain and predict these unusual performances. | Xiaoliang Ma Mingbo Pu Xiong Li Yinghui Guo Xiangang Luo | 2019 | Opto-Electronic Advances2019，2，3： | 6 |
| 5 | Preparation and characterization of 3-aminopropyl-triethoxysilane grafted montmorillonite and acid-activated montmorillonite显示文摘3-aminopropyltriethoxysilane grafted montmorillonites were synthesized with montmorillonite, acidactivated montmorillonites and 3-aminopropyltriethoxysilane in ethanol-water mixture. The resulting products were investigated using Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TG). XRD patterns demonstrated that silane was intercalated into the montmorillonite gallery, indicated by increasing basal spacings. These intercalated silanes probably adopt bilayer arrangement models within the montmorillonite and acid-activated montmorillonites interlayer spaces. TG and DTG curves indicate that acidification results in a decrease of the thermal stability of the resultant montmorillonites. Silane grafting leads to a surface property transformation of montmorillonite from hydrophilicity to lipophilicity and an increase of the thermal stability of the condensed silanes. | SHEN Wei HE HongPing ZHU JianXi YUAN Peng MA YueHong LIANG XiaoLiang | 2009 | Chinese Science Bulletin2009，54，2： | 6 |
| 6 | The influence of hydrogen sulfide on corrosion of iron under different conditions显示文摘 | Houyi Ma Xiaoliang Cheng Guiqiu Li Shenhao Chen Zhenlan Quan Shiyong Zhao Lin Niu | 2000 | Corrosion Science2000，，10： | 4 |
| 7 | High-Performance Solid-State Supercapacitors Fabricated by Pencil Drawing and Polypyrrole Depositing on Paper Substrate显示文摘A solid-state powerful supercapacitor(SC) is fabricated with a substrate of Xerox paper. Its current collector based on a foldable electronic circuit is developed by simply pencil drawing. Thin graphite sheets on paper provide effective channels for electron transmission with a low resistance of 95 X sq-1. The conductive organic material of polypyrrole coated on thin graphite sheets acts as the electrode material of the device. The as-fabricated SC exhibits a high specific capacitance of 52.9 F cm-3at a scan rate of 1 m V s-1. An energy storage unit fabricated by three full-charged series SCs can drive a commercial light-emitting diode robustly. This work demonstrated a simple, versatile and costeffective method for paper-based devices. | Jiayou Tao Wenzhen Ma Nishuang Liu Xiaoliang Ren Yuling Shi Jun Su Yihua Gao | 2015 | Nano-Micro Letters2015，7，3： | 4 |
| 8 | Tailoring active color rendering and multiband photodetection in a vanadium-dioxide-based metamaterial absorber显示文摘Metamaterials have demonstrated exotic electromagnetic properties, which offer a good platform for realizing light absorption, photodetection, filtering, and so on. However, broadband multifunctional metamaterial absorbers are restricted in cascaded structures. Here, broadband multifunctional properties were realized by introducing vanadium dioxide into a metamaterial absorber. Through the modified design and highly efficient utilization of multiple resonant modes, both plasmonic tunable color filters and near-infrared photodetectors can be simultaneously achieved by this construction. Meanwhile, active color and a photodetection band in the near-infrared range can become tunable with the insulating–metallic transition of vanadium dioxide. Thus, the variations of rendering colors could correspondingly indicate shifts of the near-infrared photodetection bands. This method theoretically confirms the feasibility of designing multifunctional devices via a vanadium-dioxide-based metamaterial absorber, which holds great promise for future versatile utilization of multiple physical mechanisms to achieve numerous functionalities in a simple nanostructure or device. | SHICHAO SONG XIAOLIANG MA MINGBO PU XIONG LI YINGHUI GUO PING GAO XIANGANG LUO | 2018 | Photonics Research2018，6，6： | 4 |
| 9 | Control of Aggregate Size of Polyethyleneimine-Coated Magnetic Nanoparticles for Magnetofection显示文摘Using magnetic nanoparticles to enhance gene transfection,a recently developed technique termed magnetofection,has been shown to be a powerful technology in gene delivery.The most widely used magnetic nanoparticles in this area are those coated with polyethyleneimine,which is a well known non-viral transfection agent.In this article,we report methods to control the aggregate size of polyethyleneimine-coated magnetite particles.These particles were then used to enhance transfection of green fluorescent protein(GFP)into NIH 3T3 cells in vitro.We find that the aggregate size of the particles has a great effect on their performance in magnetofection,with less aggregated magnetic particles being more effective in enhancing the gene transfection. | Xiaoliang Wang Linzhu Zhou Yongjie Ma Xu Li Hongchen Gu | 2009 | Nano Research2009，2，5： | 4 |
| 10 | Perfect electromagnetic and sound absorption via subwavelength holes array显示文摘 | Yanqin Wang Xiaoliang Ma Xiong Li Mingbo Pu Xiangang Luo | 2018 | Opto-Electronic Advances2018，1，8： | 3 |
| 11 | The influence of hydrogen sulfide on corrosion of iron under different conditions显示文摘 | Houyi Ma Xiaoliang Cheng Guiqiu Li Shenhao Chen Zhenlan Quan Shiyong Zhao Lin Niu | 2000 | Corrosion Science2000，，10： | 2 |
| 12 | Dual-band and ultra-broadband photonic spin-orbit interaction for electromagnetic shaping based on single-layer silicon metasurfaces显示文摘Achieving electromagnetic wave scattering manipulation in the multispectral and broad operation band has been a long pursuit in stealth applications. Here, we present an approach by using single-layer metasurfaces composed of space-variant amorphous silicon ridges tiled on a metallic mirror, to generate high-efficiency dual-band and ultra-wideband photonic spin-orbit interaction and geometric phase. Two scattering engineered metasurfaces have been designed to reduce specular reflection;the first one can suppress both specular reflectances at 1.05–1.08 μm and 5–12 μm below 10%. The second one is designed for an ultra-broadband of 4.6–14 μm, which is actually implemented by cleverly connecting two bands of 4.6–6.1 μm and 6.1–14 μm. Furthermore, the presented structures exhibit low thermal emission at the same time due to the low absorption loss of silicon in the infrared spectrum, which can be regarded as an achievement of laser–infrared compatible camouflage.We believe the proposed strategy may open a new route to implement multispectral electromagnetic modulation and multiphysical engineering applications. | XIN XIE MINGBO PU XIONG LI KAIPENG LIU JINJIN JIN XIAOLIANG MA XIANGANG LUO | 2019 | Photonics Research2019，7，5： | 2 |
| 13 | Potassium 2-(1-hydroxypentyl)-benzoate improves depressive-like behaviors in rat model显示文摘Potassium 2-(1-hydroxypentyl)-benzoate(PHPB) is a novel drug candidate for acute ischemic stroke. PHPB has been also shown to be beneficial for some neurodegenerative diseases. In this study, we demonstrated that PHPB improved depressive-like behaviors induced by chronic unpredictable mild stress(CUMS) in rats. Male SD rats were subjected to the stress for five weeks. PHPB(30 and 100 mg/kg) or fluoxetine(FLX 10 mg/kg, as positive control) was administered orally from the third week in CUMS procedure. The behavioral tests were applied and then the biochemical studies were carried out. PHPB or FLX treatment rescued the behavioral deficiency in CUMS-exposed rats. Meanwhile, PHPB normalized the enhanced level of serum corticosterone, improved hippocampal and serum BDNF levels, as well as p-CREB level in hippocampus. In addition, PHPB could reverse the reduced level of extracellular 5-HT and its metabolite 5-HIAA in prefrontal cortex(PFC) of depressed rats. In summary, our results showed that PHPB improved depression-like behaviors in CUMS-exposed rats. The mechanisms might relate to the reverse of neurotrophic disturbance in the brain, reducing excessive HPA axis response and facilitating the release of 5-HT. | Hao Ma Weiping Wang Shaofeng Xu Ling Wang Xiaoliang Wang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 2 |
| 14 | Enhancement of the efficiency of PEI/liposome transfection by magnetofectins formed via electrostatic self-assembly显示文摘One of the major challenges for successful gene therapy is improving the transfection efficiency of non-viral vectors. Magnetic nanoparticles (MNPs) have been developed as enhancers of non-viral vehicles. We prepared MNPs and modified them with polyethyleneimine (PEI), citric acid (CA) or carboxylmethyl-dextran (CMD). Both positively charged MNPs (MNPs@PEI) and negatively charged MNPs (MNPs@CA, MNPs@CMD) could spontaneously form transfection complexes (magnetofectins) with plasmid DNA and PEI/liposome via electrostatic self-assembly. Our results showed as-prepared magnetofectins apparently enhanced PEI/liposome transfection efficiency and/or gene expression level into COS-7 cells with reduced transfection time from 4 h to 15 min under a magnetic field in vitro. Meanwhile, the effect of magnetofection was cell line-dependant. These results suggest that charged MNPs could improve transfection efficiency for non-viral vectors by simply mixing with them and by exerting a magnetic force. Thus such MNPs provide a convenient platform for further applications of gene delivery. | MA YongJie WANG XiaoLiang GU HongChen | 2012 | Chinese Science Bulletin2012，57，31： | 2 |
| 15 | Snapshot multi-dimensional computational imaging through a liquid crystal diffuser显示文摘Multi-dimensional optical imaging systems that simultaneously gather intensity,depth,polarimetric,and spectral information have numerous applications in medical sciences,robotics,and surveillance.Nevertheless,most current approaches require mechanical moving parts or multiple modulation processes and thus suffer from long acquisition time,high system complexity,or low sampling resolution.Here,a methodology to build snapshot multi-dimensional lensless imaging is proposed by combining planar-optics and computational technology,benefiting from sufficient flexibilities in optical engineering and robust information reconstructions.Specifically,a liquid crystal diffuser based on geometric phase modulation is designed to simultaneously encode the spatial,spectral,and polarization information of an object into a snapshot detected speckle pattern.At the same time,a post-processing algorithm acts as a special decoder to recover the hidden information in the speckle with the independent and unique point spread function related to the position,wavelength,and chirality.With the merits of snapshot acquisition,multi-dimensional perception ability,simple optical configuration,and compact device size,our approach can find broad potential applications in object recognition and classification. | YUNSONG LEI QI ZHANG YINGHUI GUO MINGBO PU FANG ZOU XIONG LI XIAOLIANG MA XIANGANG LUO | 2023 | Photonics Research2023，11，3： | 2 |
| 16 | Vasopressin decreases neuronal apoptosis during cardiopulmonary resuscitation显示文摘The American Heart Association and the European Resuscitation Council recently recommended that vasopressin can be used for cardiopulmonary resuscitation, instead of epinephrine. However, the guidelines do not discuss the effects of vasopressin during cerebral resuscitation. In this study, we intraperitoneally injected epinephrine and/or vasopressin during cardiopulmonary resuscitation in a rat model of asphyxial cardiac arrest. The results demonstrated that, compared with epinephrine alone, the pathological damage to nerve cells was lessened, and the levels of c-Jun N-terminal kinase and p38 expression were significantly decreased in the hippocampus after treatment with vasopressin alone or the vasopressin and epinephrine combination. No significant difference in resuscitation effects was detected between vasopressin alone and the vasopressin and epinephrine combination. These results suggest that vasopressin alone or the vasopressin and epinephrine combination suppress the activation of mitogen-activated protein kinase and c-Jun N-terminal kinase signaling pathways and reduce neuronal apoptosis during cardiopulmonary resuscitation. | Chi Ma Zhe Zhu Xu Wang Gang Zhao Xiaoliang Liu Rui Li | 2014 | Neural Regeneration Research2014，9，6： | 2 |
| 17 | Classical and generalized geometric phase in electromagnetic metasurfaces显示文摘The geometric phase concept has profound implications in many branches of physics,from condensed matter physics to quantum systems.Although geometric phase has a long research history,novel theories,devices,and applications are constantly emerging with developments going down to the subwavelength scale.Specifically,as one of the main approaches to implement gradient phase modulation along a thin interface,geometric phase metasurfaces composed of spatially rotated subwavelength artificial structures have been utilized to construct various thin and planar meta-devices.In this paper,we first give a simple overview of the development of geometric phase in optics.Then,we focus on recent advances in continuously shaped geometric phase metasurfaces,geometric–dynamic composite phase metasurfaces,and nonlinear and high-order linear Pancharatnam–Berry phase metasurfaces.Finally,conclusions and outlooks for future developments are presented. | Yinghui Guo Mingbo Pu Fei Zhang Mingfeng Xu Xiong Li Xiaoliang Ma Xiangang Luo | 2022 | Photonics Insights2022，1，1： | 2 |
| 18 | Synthetic vector optical fields with spatial and temporal tunability显示文摘As an intrinsic nature of light,polarization plays a critical role in the vectorial characteristic of optical fields.Vector optical fields with an inhomogeneous polarization distribution show many exotic phenomena and applications not existing in scalar optical fields.Existing polarization optics,however,mainly focuses on the manipulation of polarization distribution on a single transverse plane.Here,we propose a synthetic approach to realize polarization manipulation with spatial and temporal degrees.The underlying mechanism relies on decoupling two orthogonal polarization states through asymmetric photonic spin-orbit interactions to obtain customer-tailored phase and amplitude difference in both transverse and longitudinal space,thereby changing the resulting polarization distribution at will in three-dimensional(3 D)space.Remarkably,a longitudinally varied cylindrical vector field is experimentally demonstrated by a monolayer metasurface,in which the polarization distribution switches continuously and periodically between radial and azimuthal polarization.Furthermore,the vector field can be dynamically tuned by rotating the incident polarization state.Our work extends polarization optics from two-dimensional space to 3 D space,allowing the arbitrary generation and manipulation of 3D vector optical fields with temporal tunability. | Fei Zhang MingBo Pu YingHui Guo XiaoLiang Ma Xiong Li Ping Gao XianGang Luo | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，5： | 2 |
| 19 | Broadband high-efficiency polymerized liquid crystal metasurfaces with spin-multiplexed functionalities in the visible显示文摘Traditional optical components are usually designed for a single functionality and narrow operation band,leading to the limited practical applications.To date,it is still quite challenging to efficiently achieve multifunctional performances within broadband operating bandwidth via a single planar optical element.Here,a broadband high-efficiency polarization-multiplexing method based on a geometric phase polymerized liquid crystal metasurface is proposed to yield the polarization-switchable functionalities in the visible.As proofs of the concept,two broadband high-efficiency polymerized liquid crystal metalenses are designed to obtain the spin-controlled behavior from diffraction-limited focusing to sub-diffraction focusing or focusing vortex beams.The experimental results within a broadband range indicate the stable and excellent optical performance of the planar liquid crystal metalenses.In addition,low-cost polymerized liquid crystal metasurfaces possess unique superiority in large-scale patterning due to the straightforward processing technique rather than the point-by-point nanopatterning method with high cost and low throughput.The high-efficiency liquid crystal metasurfaces also have unrivalled advantages benefiting from the characteristic with low waveguide absorption.The proposed strategy paves the way toward multifunctional and high-integrity optical systems,showing great potential in mobile devices,optical imaging,robotics,chiral materials,and optical interconnections. | XINJIAN LU XIAOYIN LI YINGHUI GUO MINGBO PU JIANGYU WANG YAXIN ZHANG XIONG LI XIAOLIANG MA XIANGANG LUO | 2022 | Photonics Research2022，10，6： | 2 |
| 20 | Three unprecedented biphenyl derivatives bearing C6-C3 carbon skeleton from the bark of Magnolia officinalis var.biloba显示文摘(+)-Magoilgomer A[(±)-1]and magoilgomer B(2)were identified from the bark of Magnolia officinalis var.biloba.(+)-1 and(-)-1 were a pair of novel biphenyl derivatives featuring three C6-C3 subunits.2 was an unprecedented adduct containing magnolol and honokiol.These three oligomers possessed new parallel mode which should be biosynthesized from the coupling of three or four C6-C3 subunits.The structures of(±)-1 and 2 were elucidated based on the spectroscopic data analyses and electronic circular dichroism(ECD)calculations.2 exhibited neuroprotective effects of oxygen glucose deprivation-induced SK-N-SH cell injury. | Chuan Li Kailing Xu Chuangjun Li Jie Ma Xiaoliang Wang Dongming Zhang | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
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